DE102008008614A1 - Plama-Gerät zur selektiven Behandlung elektroporierter Zellen - Google Patents

Plama-Gerät zur selektiven Behandlung elektroporierter Zellen Download PDF

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Publication number
DE102008008614A1
DE102008008614A1 DE102008008614A DE102008008614A DE102008008614A1 DE 102008008614 A1 DE102008008614 A1 DE 102008008614A1 DE 102008008614 A DE102008008614 A DE 102008008614A DE 102008008614 A DE102008008614 A DE 102008008614A DE 102008008614 A1 DE102008008614 A1 DE 102008008614A1
Authority
DE
Germany
Prior art keywords
cells
treatment
electroporation
plasma
plama
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE102008008614A
Other languages
German (de)
English (en)
Inventor
Manfred Dr. Stieber
Klaus-Dieter Prof. Dr. Weltmann
Thomas von Priv.-Doz. Dr. Woedtke
Christian Prof. Dr. Wilke
Uwe Dipl.-Ing. Ehrenberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leibniz Institut fuer Plasmaforschung und Technologie eV
Original Assignee
Leibniz Institut fuer Plasmaforschung und Technologie eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leibniz Institut fuer Plasmaforschung und Technologie eV filed Critical Leibniz Institut fuer Plasmaforschung und Technologie eV
Priority to DE102008008614A priority Critical patent/DE102008008614A1/de
Priority to EP09710903.7A priority patent/EP2254664B1/de
Priority to PCT/EP2009/051650 priority patent/WO2009101143A1/de
Priority to JP2010546337A priority patent/JP5319709B2/ja
Priority to ES09710903T priority patent/ES2422260T3/es
Publication of DE102008008614A1 publication Critical patent/DE102008008614A1/de
Priority to US12/855,177 priority patent/US8894644B2/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/44—Applying ionised fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/02—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using physical processes
    • A61L2/14—Plasma, i.e. ionised gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0412—Specially adapted for transcutaneous electroporation, e.g. including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/02—Electrical or electromagnetic means, e.g. for electroporation or for cell fusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H1/00—Generating plasma; Handling plasma
    • H05H1/24—Generating plasma
    • H05H1/2406—Generating plasma using dielectric barrier discharges, i.e. with a dielectric interposed between the electrodes
    • H05H1/2439—Surface discharges, e.g. air flow control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2103/00—Materials or objects being the target of disinfection or sterilisation
    • A61L2103/05—Living organisms or biological materials
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/32—Surgery, e.g. scalpels, blades or bistoury; Treatments inside the body
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
    • H05H2245/00—Applications of plasma devices
    • H05H2245/30—Medical applications
    • H05H2245/34—Skin treatments, e.g. disinfection or wound treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Plasma & Fusion (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Electromagnetism (AREA)
  • Cell Biology (AREA)
  • Sustainable Development (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
DE102008008614A 2008-02-12 2008-02-12 Plama-Gerät zur selektiven Behandlung elektroporierter Zellen Withdrawn DE102008008614A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE102008008614A DE102008008614A1 (de) 2008-02-12 2008-02-12 Plama-Gerät zur selektiven Behandlung elektroporierter Zellen
EP09710903.7A EP2254664B1 (de) 2008-02-12 2009-02-12 Plasma-gerät zur selektiven behandlung elektroporierter zellen
PCT/EP2009/051650 WO2009101143A1 (de) 2008-02-12 2009-02-12 Plasma-gerät zur selektiven behandlung elektroporierter zellen
JP2010546337A JP5319709B2 (ja) 2008-02-12 2009-02-12 電気穿孔された細胞を選択的に治療するプラズマ機器
ES09710903T ES2422260T3 (es) 2008-02-12 2009-02-12 Aparato de plasma para el tratamiento selectivo de células electroporadas
US12/855,177 US8894644B2 (en) 2008-02-12 2010-08-12 Plasma device for selective treatment of electropored cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102008008614A DE102008008614A1 (de) 2008-02-12 2008-02-12 Plama-Gerät zur selektiven Behandlung elektroporierter Zellen

Publications (1)

Publication Number Publication Date
DE102008008614A1 true DE102008008614A1 (de) 2009-08-13

Family

ID=40688466

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102008008614A Withdrawn DE102008008614A1 (de) 2008-02-12 2008-02-12 Plama-Gerät zur selektiven Behandlung elektroporierter Zellen

Country Status (6)

Country Link
US (1) US8894644B2 (https=)
EP (1) EP2254664B1 (https=)
JP (1) JP5319709B2 (https=)
DE (1) DE102008008614A1 (https=)
ES (1) ES2422260T3 (https=)
WO (1) WO2009101143A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009047220A1 (de) 2009-11-27 2011-06-01 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Erzeugung eines gepulsten Anisothermen Atmosphärendruck-Plasmas
CN102321606A (zh) * 2011-08-04 2012-01-18 大连大学 一种利用大气压冷等离子体提高细胞膜通透性的方法
US11013100B2 (en) 2016-10-10 2021-05-18 University Of Strathclyde Plasma accelerator
EP3525706B1 (en) * 2016-10-15 2021-06-16 Wirtz, Michelle Cold atmospheric plasma treatment of actinic keratosis and non-melanoma skin cancer

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WO2010146438A1 (en) 2009-06-16 2010-12-23 Plasmedica Technologies Limited Wound healing device
DE102009028462A1 (de) * 2009-08-11 2011-03-24 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Behandlung von lebenden Zellen mittels eines Plasmas
DE202009011521U1 (de) * 2009-08-25 2010-12-30 INP Greifswald Leibniz-Institut für Plasmaforschung und Technologie e. V. Plasma-Manschette
JP5870109B2 (ja) 2010-11-02 2016-02-24 ユーエス パテント イノベーションズＵ．Ｓ． Ｐａｔｅｎｔ Ｉｎｎｏｖａｔｉｏｎｓ 電気手術用導電性ガスによる焼痂を改善するための切開ならびに血管および組織のシーリングを可能に成すためのシステムおよび方法
WO2012167089A1 (en) * 2011-06-01 2012-12-06 U.S. Patent Innovations, LLC System and method for cold plasma therapy
DE102011055326A1 (de) * 2011-11-14 2013-05-16 Adelheid Mirwald Verfahren zur Sterilisation von Personen
JP2013191404A (ja) * 2012-03-14 2013-09-26 Toyota Gakuen サンプルと密着可能なマイクロプラズマ用ノズル
GB2509063A (en) * 2012-12-18 2014-06-25 Linde Ag Plasma device with earth electrode
WO2014106258A1 (en) * 2012-12-31 2014-07-03 Cold Plasma Medical Technologies, Inc. Cold plasma electroporation of medication and associated methods
US9339572B2 (en) 2013-03-15 2016-05-17 EP Technologies LLC Methods and solutions for killing or deactivating spores
DE102014105720A1 (de) 2014-04-23 2015-10-29 Inp Greifswald E.V. Wirkauflage und Verfahren zur Behandlung einer Oberfläche
US10405913B2 (en) 2014-10-06 2019-09-10 Us Patent Innovations, Llc Cold plasma scalpel
US11006994B2 (en) 2014-11-19 2021-05-18 Technion Research & Development Foundation Limited Cold plasma generating system
CA3225537A1 (en) 2015-05-15 2016-11-24 Clear Intradermal Technologies, Inc. Systems and methods for tattoo removal using cold plasma
US11490947B2 (en) 2015-05-15 2022-11-08 Clear Intradermal Technologies, Inc. Tattoo removal using a liquid-gas mixture with plasma gas bubbles
CA2993803A1 (en) 2015-07-28 2017-02-02 EP Technologies LLC Scrubbing device for cleaning, sanitizing or disinfecting
US10897894B2 (en) 2015-08-31 2021-01-26 Gojo Industries, Inc. Methods of and system for generating antimicrobial wipes
CN109070137A (zh) 2016-02-01 2018-12-21 瑞德科技有限公司 用于递送治疗剂的系统和方法
US10765850B2 (en) 2016-05-12 2020-09-08 Gojo Industries, Inc. Methods and systems for trans-tissue substance delivery using plasmaporation
KR101773847B1 (ko) * 2016-05-30 2017-09-01 광운대학교 산학협력단 가스 공급형 비열 플라즈마 피부 미용기 및 이의 용도
KR101773846B1 (ko) * 2016-05-30 2017-09-01 광운대학교 산학협력단 가스 공급형 비열 플라즈마 피부염 치료기 및 이의 용도
WO2018089577A1 (en) 2016-11-10 2018-05-17 EP Technologies LLC Methods and systems for generating plasma activated liquid
DE102017107210A1 (de) 2017-04-04 2018-10-04 Universität Rostock Vorrichtung zur keimlastreduktion
DE102017120902A1 (de) * 2017-09-11 2019-03-14 Cinogy Gmbh Plasma-Behandlungsgerät
US11690998B2 (en) 2017-10-31 2023-07-04 Theradep Technologies, Inc. Methods of treating bacterial infections
KR101970644B1 (ko) * 2017-11-22 2019-08-13 주식회사 하이로닉 경피 전달 촉진을 위한 복합 시술 장치
KR102132370B1 (ko) * 2018-03-13 2020-08-05 주식회사 지씨에스 피부관리장치, 피부관리장치의 구동방법 및 컴퓨터 판독가능 기록매체
KR102030528B1 (ko) * 2018-03-29 2019-11-08 주식회사 지씨에스 피부관리장치 및 그 장치의 구동방법
US12383753B2 (en) 2018-06-01 2025-08-12 George Washington University Method and system of sensitizing cancer cells to chemical treatment by plasma based activation
EP3607909A1 (en) * 2018-08-10 2020-02-12 Albert-Ludwigs-Universität Freiburg Atmospheric pressure plasma jet device
JP2022514758A (ja) 2018-12-19 2022-02-15 クリアイット エルエルシー 印加電場を用いた入れ墨除去システム及び方法
PL248086B1 (pl) * 2021-07-06 2025-10-20 Politechnika Wroclawska Sposób ochrony roślin istotnych gospodarczo, zwłaszcza roślin naczyniowych, przed patogenami bakteryjnymi
DE102022100053A1 (de) 2022-01-03 2023-07-06 Snejan Dimitrov Ivantchev Topisches Mittel zur Behandlung von Alopecia areata (SNEZHALIN))

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DE60106901T2 (de) 2000-04-21 2005-11-10 Igea S.R.L. Vorrichtung zur Elektroporation unter kontinuierlichen Steuerung der Zellendurchlässigkeit
DE69928383T2 (de) 1998-03-31 2006-08-03 Aditus Medical Ab Gerät zur steuerung der generierung elektrischer felder
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DE69604509T2 (de) 1995-06-06 2000-01-13 Genetronics, Inc. Vorrichtung zur verabreichung von medikamenten und genen durch elektroporation
DE69928383T2 (de) 1998-03-31 2006-08-03 Aditus Medical Ab Gerät zur steuerung der generierung elektrischer felder
DE60106901T2 (de) 2000-04-21 2005-11-10 Igea S.R.L. Vorrichtung zur Elektroporation unter kontinuierlichen Steuerung der Zellendurchlässigkeit
US20070029500A1 (en) * 2005-08-05 2007-02-08 Sylvain Coulombe Plasma source and applications thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009047220A1 (de) 2009-11-27 2011-06-01 Leibniz-Institut für Plasmaforschung und Technologie e.V. Vorrichtung und Verfahren zur Erzeugung eines gepulsten Anisothermen Atmosphärendruck-Plasmas
WO2011063798A2 (de) 2009-11-27 2011-06-03 Leibniz-Institut Für Plasmaforschung Und Technologie E. V. Vorrichtung und verfahren zur erzeugung eines gepulsten anisothermen atmosphärendruck-plasmas
CN102321606A (zh) * 2011-08-04 2012-01-18 大连大学 一种利用大气压冷等离子体提高细胞膜通透性的方法
US11013100B2 (en) 2016-10-10 2021-05-18 University Of Strathclyde Plasma accelerator
EP3525706B1 (en) * 2016-10-15 2021-06-16 Wirtz, Michelle Cold atmospheric plasma treatment of actinic keratosis and non-melanoma skin cancer

Also Published As

Publication number Publication date
JP5319709B2 (ja) 2013-10-16
ES2422260T3 (es) 2013-09-10
US20110112528A1 (en) 2011-05-12
JP2011514814A (ja) 2011-05-12
WO2009101143A1 (de) 2009-08-20
EP2254664A1 (de) 2010-12-01
US8894644B2 (en) 2014-11-25
EP2254664B1 (de) 2013-04-24

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Effective date: 20140902