DE102005009217A1 - Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen - Google Patents

Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen Download PDF

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Publication number
DE102005009217A1
DE102005009217A1 DE102005009217A DE102005009217A DE102005009217A1 DE 102005009217 A1 DE102005009217 A1 DE 102005009217A1 DE 102005009217 A DE102005009217 A DE 102005009217A DE 102005009217 A DE102005009217 A DE 102005009217A DE 102005009217 A1 DE102005009217 A1 DE 102005009217A1
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Prior art keywords
pain
drug
polymorph
measured
phosphoric acid
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DE102005009217A
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German (de)
English (en)
Inventor
Michael Dr. Gruss
Andreas Dr. Fischer
Wolfgang Dr. Hell
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Gruenenthal GmbH
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Gruenenthal GmbH
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Priority to DE102005009217A priority Critical patent/DE102005009217A1/de
Priority to TW095104476A priority patent/TW200640840A/zh
Priority to US11/885,039 priority patent/US8309610B2/en
Priority to MX2007010361A priority patent/MX2007010361A/es
Priority to BRPI0606234-2A priority patent/BRPI0606234A2/pt
Priority to JP2007556543A priority patent/JP2008531511A/ja
Priority to JP2007556542A priority patent/JP2008531510A/ja
Priority to AU2006218133A priority patent/AU2006218133B8/en
Priority to KR1020077021682A priority patent/KR20070112812A/ko
Priority to NZ560204A priority patent/NZ560204A/en
Priority to PCT/EP2006/001548 priority patent/WO2006089708A1/en
Priority to BRPI0606146-0A priority patent/BRPI0606146A2/pt
Priority to EP06707123A priority patent/EP1851191A1/de
Priority to EP06707124A priority patent/EP1851192A1/en
Priority to CN2006800062321A priority patent/CN101128417B/zh
Priority to CNA2006800059649A priority patent/CN101137615A/zh
Priority to AU2006218132A priority patent/AU2006218132B2/en
Priority to MX2007010192A priority patent/MX2007010192A/es
Priority to NZ556338A priority patent/NZ556338A/en
Priority to CA002598845A priority patent/CA2598845A1/en
Priority to KR1020077021974A priority patent/KR20070107162A/ko
Priority to CA002598579A priority patent/CA2598579A1/en
Priority to RU2007135271/04A priority patent/RU2007135271A/ru
Priority to RU2007135270/04A priority patent/RU2007135270A/ru
Priority to PCT/EP2006/001547 priority patent/WO2006089707A1/de
Priority to ARP060100684A priority patent/AR053145A1/es
Priority to US11/361,954 priority patent/US20060211887A1/en
Priority to PE2006000228A priority patent/PE20061100A1/es
Publication of DE102005009217A1 publication Critical patent/DE102005009217A1/de
Priority to IL185468A priority patent/IL185468A0/en
Priority to IL185467A priority patent/IL185467A0/en
Priority to NO20074673A priority patent/NO20074673L/no
Priority to NO20074676A priority patent/NO20074676L/no
Priority to ZA200708153A priority patent/ZA200708153B/xx
Priority to IL212291A priority patent/IL212291A0/en
Priority to IL212292A priority patent/IL212292A0/en
Withdrawn legal-status Critical Current

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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
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    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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DE102005009217A 2005-02-25 2005-02-25 Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen Withdrawn DE102005009217A1 (de)

Priority Applications (35)

Application Number Priority Date Filing Date Title
DE102005009217A DE102005009217A1 (de) 2005-02-25 2005-02-25 Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen
TW095104476A TW200640840A (en) 2005-02-25 2006-02-10 Phosphatsalze der 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1, 3-dihydroxy-cyclohexanverbindungen
MX2007010192A MX2007010192A (es) 2005-02-25 2006-02-21 Formas cristalinas del clorhidrato de (1rs, 3rs, 6rs)-6-dimetilaminometil-1-(3-metoxi-fenil) ciclohexano-1, 3-diol.
CA002598845A CA2598845A1 (en) 2005-02-25 2006-02-21 Phosphate salts of 6-dimethylaminomethyl-l-(3-methoxyphenyl)-1,3-dihydr oxy-cyclohexane compounds
BRPI0606234-2A BRPI0606234A2 (pt) 2005-02-25 2006-02-21 formas cristalinas de cloridrato de (1rs,3rs,6rs)-6-dimetilaminometil-1-(3-metóxi-fenil) ciclo-hexano-1,3-diol
MX2007010361A MX2007010361A (es) 2005-02-25 2006-02-21 Sales de fosfato de los compuestos de 6-dimetilaminometil-1(3-meto xifenil)-1, 3-dihidroxi-ciclohexano.
JP2007556542A JP2008531510A (ja) 2005-02-25 2006-02-21 ６−ジメチルアミノメチル−１−（３−メトキシフェニル）−１，３−ジヒドロキシ−シクロヘキサン化合物のリン酸塩
KR1020077021974A KR20070107162A (ko) 2005-02-25 2006-02-21 6-디메틸아미노메틸-1-(3-메톡시페닐)-1,3-디하이드록시사이클로헥산 화합물의 인산염
KR1020077021682A KR20070112812A (ko) 2005-02-25 2006-02-21 (1ｒｓ,3ｒｓ,6ｒｓ)-6-디메틸아미노메틸-1-(3-메톡시-페닐)사이클로헥산-1,3-디올 하이드로클로라이드의 결정질 형태
NZ560204A NZ560204A (en) 2005-02-25 2006-02-21 Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy- phenyl)cyclohexane-1,3-diol hydrochloride
PCT/EP2006/001548 WO2006089708A1 (en) 2005-02-25 2006-02-21 Crystalline forms of (1rs,3rs,6rs)-6-dimethvlaminomethvl-1-(3-methoxv- phenyl)cyclohexane-1 ,3-diol hydrochloride
BRPI0606146-0A BRPI0606146A2 (pt) 2005-02-25 2006-02-21 compostos de sais fosfato 6-dimetilaminometil-1-(3-metoxifenil)-1,3-dihidroxicicl ohexano
EP06707123A EP1851191A1 (de) 2005-02-25 2006-02-21 Phosphatsalze der 6-dimethylaminomethyl-l- (3-methoxyphenyl) -1,3-dihydroxy- cyclohexanverbindungen
EP06707124A EP1851192A1 (en) 2005-02-25 2006-02-21 Crystalline forms of (1rs,3rs,6rs)-6-dimethvlaminomethvl-1-(3-methoxv- phenyl)cyclohexane-1 ,3-diol hydrochloride
CN2006800062321A CN101128417B (zh) 2005-02-25 2006-02-21 (1rs,3rs,6rs)-6-二甲氨基甲基-1-(3-甲氧基-苯基)环己烷-1,3-二醇盐酸盐的晶形
CNA2006800059649A CN101137615A (zh) 2005-02-25 2006-02-21 6-二甲基氨基甲基-1-（3-甲氧基苯基）-1，3-二羟基-环己烷化合物的磷酸盐
AU2006218132A AU2006218132B2 (en) 2005-02-25 2006-02-21 Phosphate salts of 6-dimethylaminomethyl-l-(3-methoxyphenyl) -1,3-dihydroxycyclohexane compounds
US11/885,039 US8309610B2 (en) 2005-02-25 2006-02-21 Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)cyclohexane-1,3-diol hydrochloride
NZ556338A NZ556338A (en) 2005-02-25 2006-02-21 Phosphate salts of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexane compounds
JP2007556543A JP2008531511A (ja) 2005-02-25 2006-02-21 （１ｒｓ，３ｒｓ，６ｒｓ）−６−ジメチルアミノメチル−１−（３−メトキシ−フェニル）シクロヘキサン−１，３−ジオール塩酸塩の結晶形
AU2006218133A AU2006218133B8 (en) 2005-02-25 2006-02-21 Crystalline forms of (1RS,3RS,6RS)-6-Dimethvlaminomethyl-1-(3-methoxy- phenyl)cyclohexane-1 ,3-diol hydrochloride
CA002598579A CA2598579A1 (en) 2005-02-25 2006-02-21 Crystalline forms of (1rs,3rs,6rs)-6-dimethvlaminomethvl-1-(3-methoxv- phenyl)cyclohexane-1 ,3-diol hydrochloride
RU2007135271/04A RU2007135271A (ru) 2005-02-25 2006-02-21 Фосфатные соли 6-диметиламинометил-1-(3-метоксифенил)-1, 3-дигидрооксициклогексановых соединений
RU2007135270/04A RU2007135270A (ru) 2005-02-25 2006-02-21 Кристаллические модификации гидрохлорида (1rs,3rs,6rs)-6-диметиламиноиетил-1-(3-метоксифенил)циклогексан-1,3-диола
PCT/EP2006/001547 WO2006089707A1 (de) 2005-02-25 2006-02-21 Phosphatsalze der 6-dimethylaminomethyl-l- (3-methoxyphenyl) -1,3-dihydroxy- cyclohexanverbindungen
ARP060100684A AR053145A1 (es) 2005-02-25 2006-02-24 Sales de fosfato del compuesto 6-dimetilaminometil-1 (3-metoxifenil)-1,3-hidroxi-ciclohexano
US11/361,954 US20060211887A1 (en) 2005-02-25 2006-02-27 Phosphate salts of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexane compounds
PE2006000228A PE20061100A1 (es) 2005-02-25 2006-02-27 Sales de fosfato de 6-dimetilaminometil-1-(3-metoxifenil)-1,3-dihidroxicliclohexano
IL185468A IL185468A0 (en) 2005-02-25 2007-08-23 Phosphate salts of 6-dimethylaminomethyl-l -(3-methoxyphenyl)-1,3-dihydroxy cyclohexane compounds
IL185467A IL185467A0 (en) 2005-02-25 2007-08-23 Crystalline forms of (1rs,3rs,6rs)-6-dimethylaminomethyl-1-(3-methoxy-phenyl) cyclohexane-1,3-diol hydrochloride
NO20074673A NO20074673L (no) 2005-02-25 2007-09-13 Fosfatsalter av 6-dimetylaminometyl-L-(3-metoksyfenyl)1,3,dihydroksycykloheksanforbindelser
NO20074676A NO20074676L (no) 2005-02-25 2007-09-13 Krystallinske former av (1 RS, 3RS, 6RS)-6-dimetylaminometyl-1-(3-metoksy-fenyl)cykloheksan-1,3-diol hydroklorid
ZA200708153A ZA200708153B (en) 2005-02-25 2007-09-21 Phosphate salts of 6-dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxycyclohexane
IL212291A IL212291A0 (en) 2005-02-25 2011-04-13 Crystalline form of (1rs,3rs,6rs)-6-dimethylaminomethyl-1-(3-methoxy-phenyl) cyclohexane-1,3-diol hydrochloride, pharmaceutical compositions comprising it and a process for its preparation
IL212292A IL212292A0 (en) 2005-02-25 2011-04-13 Crystalline form of (1rs,3rs,6rs)-6-dimethylaminomethyl-1-(3-methoxy-phenyl) cyclohexane-1,3-diol hydrochloride, a proess, for its preparation and pharmaceutical compositions comprising it

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WO2008138558A1 (de) * 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur schmerzbehandlung bei arthrose
WO2011029614A1 (en) * 2009-09-14 2011-03-17 Grünenthal GmbH Crystalline modifications of 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol

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WO2007008752A2 (en) 2005-07-07 2007-01-18 Farnam Companies, Inc. Sustained release pharmaceutical compositions for highly water soluble drugs

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EP0753506B1 (de) * 1995-07-11 1999-08-18 Grünenthal GmbH 6-Dimethylaminomethyl-1-phenyl-cyclo-hexanverbindungen als pharmazeutische Wirkstoffe

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DE10146275A1 (de) * 2001-09-18 2003-04-24 Gruenenthal Gmbh Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz
DE10333835A1 (de) * 2003-07-24 2005-03-10 Gruenenthal Gmbh 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung

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EP0753506B1 (de) * 1995-07-11 1999-08-18 Grünenthal GmbH 6-Dimethylaminomethyl-1-phenyl-cyclo-hexanverbindungen als pharmazeutische Wirkstoffe

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008138558A1 (de) * 2007-05-11 2008-11-20 Grünenthal GmbH Axomadol zur schmerzbehandlung bei arthrose
WO2011029614A1 (en) * 2009-09-14 2011-03-17 Grünenthal GmbH Crystalline modifications of 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol

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BRPI0606146A2 (pt) 2009-06-02
CA2598845A1 (en) 2006-08-31
CN101137615A (zh) 2008-03-05
NZ556338A (en) 2009-11-27
TW200640840A (en) 2006-12-01
WO2006089707A1 (de) 2006-08-31
AR053145A1 (es) 2007-04-25
EP1851191A1 (de) 2007-11-07
MX2007010361A (es) 2008-02-21
KR20070107162A (ko) 2007-11-06
PE20061100A1 (es) 2007-01-04
AU2006218132A1 (en) 2006-08-31
RU2007135271A (ru) 2010-02-27
IL185468A0 (en) 2008-01-06
ZA200708153B (en) 2008-10-29
JP2008531510A (ja) 2008-08-14
NO20074673L (no) 2007-10-19

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