DE102004012068A1 - Neue alkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel - Google Patents
Neue alkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel Download PDFInfo
- Publication number
- DE102004012068A1 DE102004012068A1 DE102004012068A DE102004012068A DE102004012068A1 DE 102004012068 A1 DE102004012068 A1 DE 102004012068A1 DE 102004012068 A DE102004012068 A DE 102004012068A DE 102004012068 A DE102004012068 A DE 102004012068A DE 102004012068 A1 DE102004012068 A1 DE 102004012068A1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- group
- amino
- phenyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CC(C(CC1C=CC(C(C)=*)=C[C@]1C1=C(c2cccc(O)c2)O)C1=O)=O Chemical compound CC(C(CC1C=CC(C(C)=*)=C[C@]1C1=C(c2cccc(O)c2)O)C1=O)=O 0.000 description 2
- NBNONOCIMLTNMT-ZPHPHTNESA-N CC(C(C1=O)Nc(ccc(C(C)=O)c2)c2/C1=C(\c(cc1)ccc1F)/O)=O Chemical compound CC(C(C1=O)Nc(ccc(C(C)=O)c2)c2/C1=C(\c(cc1)ccc1F)/O)=O NBNONOCIMLTNMT-ZPHPHTNESA-N 0.000 description 1
- AUGSLUMEPWALBS-HNENSFHCSA-N CC(C)CN/C(/c1ccncc1)=C(/c(cc(cc1)C(C)=O)c1N1)\C1=O Chemical compound CC(C)CN/C(/c1ccncc1)=C(/c(cc(cc1)C(C)=O)c1N1)\C1=O AUGSLUMEPWALBS-HNENSFHCSA-N 0.000 description 1
- OHOMACQEPMGFSR-ZCXUNETKSA-N CC(C)CN/C(/c1cnccn1)=C(/c(cc(cc1)C(C)=O)c1N1)\C1=O Chemical compound CC(C)CN/C(/c1cnccn1)=C(/c(cc(cc1)C(C)=O)c1N1)\C1=O OHOMACQEPMGFSR-ZCXUNETKSA-N 0.000 description 1
- HSYXKXQLACXPMP-WUKNDPDISA-N CC(c(cc1)cc(/C2=C(/c3ccncc3)\O)c1N(C(C)=O)C2=O)=O Chemical compound CC(c(cc1)cc(/C2=C(/c3ccncc3)\O)c1N(C(C)=O)C2=O)=O HSYXKXQLACXPMP-WUKNDPDISA-N 0.000 description 1
- ARZRKKAUAMLKAA-FOCLMDBBSA-N CC(c(cc1/C2=C(/c3nccnc3)\Cl)ccc1N(C(C)=O)C2=O)=O Chemical compound CC(c(cc1/C2=C(/c3nccnc3)\Cl)ccc1N(C(C)=O)C2=O)=O ARZRKKAUAMLKAA-FOCLMDBBSA-N 0.000 description 1
- RXQKFBPYAYARHE-DQRAZIAOSA-N CC(c(cc1/C2=C(\c3ccc(CCC(OC)=O)cc3)/O)ccc1N(C(C)=O)C2=O)=O Chemical compound CC(c(cc1/C2=C(\c3ccc(CCC(OC)=O)cc3)/O)ccc1N(C(C)=O)C2=O)=O RXQKFBPYAYARHE-DQRAZIAOSA-N 0.000 description 1
- RBBAGFWHBUGFMP-LNVKXUELSA-N CCO/C(/c1ccccc1)=C1/c2cc(C(C=C)=O)ccc2C(C(C)=O)C1=O Chemical compound CCO/C(/c1ccccc1)=C1/c2cc(C(C=C)=O)ccc2C(C(C)=O)C1=O RBBAGFWHBUGFMP-LNVKXUELSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004012068A DE102004012068A1 (de) | 2004-03-12 | 2004-03-12 | Neue alkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
JP2007502261A JP2007528883A (ja) | 2004-03-12 | 2005-03-05 | 新規なアルキル含有5−アシルインドリノン、その製法及びその医薬品としての使用 |
DE502005006424T DE502005006424D1 (de) | 2004-03-12 | 2005-03-05 | Neue alkyl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel |
EP05715811A EP1727799B1 (de) | 2004-03-12 | 2005-03-05 | Neue alkyl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel |
CA002559139A CA2559139A1 (en) | 2004-03-12 | 2005-03-05 | Novel alkyl-containing 5-acylindolinones, their preparation and their use as pharmaceutical products |
ES05715811T ES2320905T3 (es) | 2004-03-12 | 2005-03-05 | Nuevas 5-acilindolinonas con contenido en alquilo, su preparacion y su uso como medicamentos. |
PCT/EP2005/002406 WO2005087727A1 (de) | 2004-03-12 | 2005-03-05 | Neue alkyl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel |
AT05715811T ATE420072T1 (de) | 2004-03-12 | 2005-03-05 | Neue alkyl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel |
US11/077,399 US7560480B2 (en) | 2004-03-12 | 2005-03-10 | Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments |
PE2005000280A PE20060017A1 (es) | 2004-03-12 | 2005-03-10 | Compuestos 5-acilindolinonas con contenido en alquilo, como inhibidores de gsk-3 y su preparacion |
ARP050100966A AR048009A1 (es) | 2004-03-12 | 2005-03-11 | Nuevas 5-acilindolinonas conteniendo alquilo, su preparacion y uso como medicamentos |
TW94107401A TW200539884A (en) | 2004-03-12 | 2005-03-11 | New alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments |
UY28804A UY28804A1 (es) | 2004-03-12 | 2005-03-11 | Nuevas 5-acilindolinonas con contenido en alquilo, su preparación y su uso como medicamentos. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004012068A DE102004012068A1 (de) | 2004-03-12 | 2004-03-12 | Neue alkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
US55947104P | 2004-04-05 | 2004-04-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE102004012068A1 true DE102004012068A1 (de) | 2005-09-29 |
Family
ID=34987190
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE102004012068A Withdrawn DE102004012068A1 (de) | 2004-03-12 | 2004-03-12 | Neue alkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
DE502005006424T Expired - Fee Related DE502005006424D1 (de) | 2004-03-12 | 2005-03-05 | Neue alkyl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE502005006424T Expired - Fee Related DE502005006424D1 (de) | 2004-03-12 | 2005-03-05 | Neue alkyl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel |
Country Status (10)
Country | Link |
---|---|
US (1) | US7560480B2 (pt-PT) |
EP (1) | EP1727799B1 (pt-PT) |
JP (1) | JP2007528883A (pt-PT) |
AR (1) | AR048009A1 (pt-PT) |
AT (1) | ATE420072T1 (pt-PT) |
CA (1) | CA2559139A1 (pt-PT) |
DE (2) | DE102004012068A1 (pt-PT) |
ES (1) | ES2320905T3 (pt-PT) |
UY (1) | UY28804A1 (pt-PT) |
WO (1) | WO2005087727A1 (pt-PT) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109293551A (zh) * | 2011-11-14 | 2019-02-01 | 利亘制药公司 | 与粒细胞集落刺激因子受体相关的方法和组合物 |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1891008B1 (en) * | 2005-06-10 | 2010-06-30 | Merck Patent GmbH | Oxindoles as kinase inhibitors |
EP2061767B1 (de) | 2006-08-08 | 2014-12-17 | Sanofi | Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
MX2010007949A (es) * | 2008-01-25 | 2010-08-04 | Boehringer Ingelheim Int | Procedimiento para la fabricacion de un derivado de 6-fluoro-1,2-dihidro-2-oxo-3h-indol-3-ilideno. |
TW201014822A (en) | 2008-07-09 | 2010-04-16 | Sanofi Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
DK2470552T3 (en) | 2009-08-26 | 2014-02-17 | Sanofi Sa | NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
WO2012120050A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120057A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19949209A1 (de) * | 1999-10-13 | 2001-04-19 | Boehringer Ingelheim Pharma | In 5-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel |
DE102004012069A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue aryl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
-
2004
- 2004-03-12 DE DE102004012068A patent/DE102004012068A1/de not_active Withdrawn
-
2005
- 2005-03-05 DE DE502005006424T patent/DE502005006424D1/de not_active Expired - Fee Related
- 2005-03-05 WO PCT/EP2005/002406 patent/WO2005087727A1/de not_active Application Discontinuation
- 2005-03-05 ES ES05715811T patent/ES2320905T3/es active Active
- 2005-03-05 EP EP05715811A patent/EP1727799B1/de not_active Not-in-force
- 2005-03-05 CA CA002559139A patent/CA2559139A1/en not_active Abandoned
- 2005-03-05 JP JP2007502261A patent/JP2007528883A/ja active Pending
- 2005-03-05 AT AT05715811T patent/ATE420072T1/de not_active IP Right Cessation
- 2005-03-10 US US11/077,399 patent/US7560480B2/en active Active
- 2005-03-11 AR ARP050100966A patent/AR048009A1/es unknown
- 2005-03-11 UY UY28804A patent/UY28804A1/es not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109293551A (zh) * | 2011-11-14 | 2019-02-01 | 利亘制药公司 | 与粒细胞集落刺激因子受体相关的方法和组合物 |
Also Published As
Publication number | Publication date |
---|---|
AR048009A1 (es) | 2006-03-15 |
US20050209302A1 (en) | 2005-09-22 |
JP2007528883A (ja) | 2007-10-18 |
ATE420072T1 (de) | 2009-01-15 |
EP1727799B1 (de) | 2009-01-07 |
CA2559139A1 (en) | 2005-09-22 |
UY28804A1 (es) | 2005-10-31 |
US7560480B2 (en) | 2009-07-14 |
EP1727799A1 (de) | 2006-12-06 |
DE502005006424D1 (de) | 2009-02-26 |
ES2320905T3 (es) | 2009-05-29 |
WO2005087727A1 (de) | 2005-09-22 |
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