DD273839A5 - Verfahren zur herstellung neuer insulinderivate - Google Patents
Verfahren zur herstellung neuer insulinderivate Download PDFInfo
- Publication number
- DD273839A5 DD273839A5 DD87305161A DD30516187A DD273839A5 DD 273839 A5 DD273839 A5 DD 273839A5 DD 87305161 A DD87305161 A DD 87305161A DD 30516187 A DD30516187 A DD 30516187A DD 273839 A5 DD273839 A5 DD 273839A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- human insulin
- gln
- lys
- insulin
- arg
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK347086A DK347086D0 (da) | 1986-07-21 | 1986-07-21 | Novel peptides |
Publications (1)
Publication Number | Publication Date |
---|---|
DD273839A5 true DD273839A5 (de) | 1989-11-29 |
Family
ID=8123250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DD87305161A DD273839A5 (de) | 1986-07-21 | 1987-07-20 | Verfahren zur herstellung neuer insulinderivate |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0254516B1 (no) |
JP (1) | JPS6399096A (no) |
KR (1) | KR880001701A (no) |
CN (1) | CN87104988A (no) |
AT (1) | ATE99699T1 (no) |
AU (1) | AU612324B2 (no) |
DD (1) | DD273839A5 (no) |
DE (2) | DE10075024I1 (no) |
DK (1) | DK347086D0 (no) |
ES (1) | ES2061504T3 (no) |
FI (1) | FI873185A (no) |
HU (1) | HU203371B (no) |
IL (1) | IL83243A (no) |
MY (1) | MY102873A (no) |
NL (1) | NL300018I1 (no) |
NO (1) | NO170978C (no) |
NZ (1) | NZ221130A (no) |
PT (1) | PT85355B (no) |
YU (1) | YU135387A (no) |
ZA (1) | ZA875295B (no) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ223630A (en) * | 1987-02-25 | 1989-11-28 | Novo Industri As | Insulin derivative and pharmaceutical compositions |
DK336188D0 (da) * | 1988-06-20 | 1988-06-20 | Nordisk Gentofte | Propeptider |
WO1990001038A1 (en) * | 1988-07-20 | 1990-02-08 | Nordisk Gentofte A/S | Human insulin analogs and preparations containing them |
DE3827533A1 (de) * | 1988-08-13 | 1990-02-15 | Hoechst Ag | Pharmazeutische zubereitung zur behandlung des diabetes mellitus |
DE3837825A1 (de) * | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
US5716927A (en) * | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
AU641631B2 (en) * | 1988-12-23 | 1993-09-30 | Novo Nordisk A/S | Human insulin analogues |
US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
DE3936876A1 (de) * | 1989-11-06 | 1991-05-23 | Hoechst Ag | Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
US7316999B2 (en) | 2000-06-02 | 2008-01-08 | Novo Nordisk A/S | Glucose dependent release of insulin from glucose sensing insulin derivatives |
DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
ATE464390T1 (de) | 2001-11-19 | 2010-04-15 | Novo Nordisk As | Verfahren zur herstellung von insulinverbindungen |
GB0206792D0 (en) | 2002-03-22 | 2002-05-01 | Leuven K U Res & Dev | Normoglycemia |
DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
WO2005000580A1 (en) | 2003-06-27 | 2005-01-06 | Novo Nordisk A/S | High moisture barrier container for medical liquid compositions |
WO2005061222A1 (en) | 2003-12-22 | 2005-07-07 | Novo Nordisk A/S | Transparent, flexible, impermeable plastic container for storage of pharmaceutical liquids |
RU2385879C2 (ru) | 2004-01-21 | 2010-04-10 | Ново Нордиск Хелс Кеа Аг | Способ конъюгации пептидов, опосредованной трансглутаминазой |
DE102006031962A1 (de) * | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Amidiertes Insulin Glargin |
DE102006031955A1 (de) | 2006-07-11 | 2008-01-17 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende |
WO2008049711A1 (en) | 2006-10-27 | 2008-05-02 | Novo Nordisk A/S | Peptide extended insulins |
BRPI0907119A2 (pt) | 2008-01-09 | 2015-07-14 | Sanofi Aventis Deutschland | Derivados de insulina tendo um perfil de ação de tempo extremamente retardado |
KR20100111682A (ko) | 2008-01-09 | 2010-10-15 | 사노피-아벤티스 도이칠란트 게엠베하 | 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체 |
PT2254906T (pt) | 2008-03-18 | 2017-01-03 | Novo Nordisk As | Análogos de insulina acilados, estabilizados contra proteases |
TWI451876B (zh) | 2008-06-13 | 2014-09-11 | Lilly Co Eli | 聚乙二醇化之離脯胰島素化合物 |
RU2458989C1 (ru) | 2008-08-07 | 2012-08-20 | Байокон Лимитид | Способ получения аналогов инсулина из их соответствующих предшественников (варианты) |
KR101820024B1 (ko) | 2008-10-17 | 2018-01-18 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린과 glp-1 효능제의 병용물 |
US20120241356A1 (en) * | 2009-07-06 | 2012-09-27 | Sanofi-Aventis Deutschland Gmbh | Heat- and vibration-stable insulin preparations |
ES2534191T3 (es) | 2009-11-13 | 2015-04-20 | Sanofi-Aventis Deutschland Gmbh | Composición farmacéutica que comprende un agonista de GLP-1, una insulina y metionina |
HUE037735T2 (hu) | 2009-11-13 | 2018-09-28 | Sanofi Aventis Deutschland | DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény |
EP2359843A1 (en) | 2010-01-21 | 2011-08-24 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
AR080884A1 (es) | 2010-04-14 | 2012-05-16 | Sanofi Aventis | Conjugados de insulina-sirna |
BR112013004756B1 (pt) | 2010-08-30 | 2020-04-28 | Sanofi Aventis Deutschland | uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2 |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
EP2548570A1 (en) | 2011-07-19 | 2013-01-23 | Sanofi | Pharmaceutical composition for treating a metabolic syndrome |
RU2650616C2 (ru) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
CA2870313A1 (en) | 2012-04-11 | 2013-10-17 | Novo Nordisk A/S | Insulin formulations |
WO2015196174A1 (en) | 2014-06-20 | 2015-12-23 | Greene Howard E | Infusion delivery devices and methods |
JP6970615B2 (ja) | 2014-12-12 | 2021-11-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | インスリングラルギン/リキシセナチド固定比処方 |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
CN110087674B (zh) | 2016-12-16 | 2023-01-03 | 诺和诺德股份有限公司 | 含胰岛素的药物组合物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3033127A1 (de) * | 1980-09-03 | 1982-04-08 | Hoechst Ag, 6000 Frankfurt | Neue analoga des insulins |
DE3327709A1 (de) * | 1983-07-29 | 1985-02-07 | Hoechst Ag, 6230 Frankfurt | Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung |
DE3333640A1 (de) * | 1983-09-17 | 1985-04-25 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung |
DK113585D0 (da) * | 1985-03-12 | 1985-03-12 | Novo Industri As | Nye peptider |
DK119785D0 (da) * | 1985-03-15 | 1985-03-15 | Nordisk Gentofte | Insulinpraeparat |
-
1986
- 1986-07-21 DK DK347086A patent/DK347086D0/da not_active Application Discontinuation
-
1987
- 1987-07-20 IL IL83243A patent/IL83243A/xx not_active IP Right Cessation
- 1987-07-20 DD DD87305161A patent/DD273839A5/de not_active IP Right Cessation
- 1987-07-20 DE DE2000175024 patent/DE10075024I1/de active Pending
- 1987-07-20 PT PT85355A patent/PT85355B/pt not_active IP Right Cessation
- 1987-07-20 FI FI873185A patent/FI873185A/fi not_active Application Discontinuation
- 1987-07-20 MY MYPI87001062A patent/MY102873A/en unknown
- 1987-07-20 YU YU01353/87A patent/YU135387A/xx unknown
- 1987-07-20 ZA ZA875295A patent/ZA875295B/xx unknown
- 1987-07-20 ES ES87306405T patent/ES2061504T3/es not_active Expired - Lifetime
- 1987-07-20 CN CN198787104988A patent/CN87104988A/zh active Pending
- 1987-07-20 NO NO873018A patent/NO170978C/no unknown
- 1987-07-20 AT AT87306405T patent/ATE99699T1/de not_active IP Right Cessation
- 1987-07-20 AU AU75916/87A patent/AU612324B2/en not_active Ceased
- 1987-07-20 HU HU873343A patent/HU203371B/hu not_active IP Right Cessation
- 1987-07-20 NZ NZ221130A patent/NZ221130A/xx unknown
- 1987-07-20 KR KR1019870007832A patent/KR880001701A/ko not_active Application Discontinuation
- 1987-07-20 EP EP87306405A patent/EP0254516B1/en not_active Expired - Lifetime
- 1987-07-20 DE DE3788684T patent/DE3788684T2/de not_active Expired - Lifetime
- 1987-07-21 JP JP62180168A patent/JPS6399096A/ja active Pending
-
2000
- 2000-09-15 NL NL300018C patent/NL300018I1/nl unknown
Also Published As
Publication number | Publication date |
---|---|
EP0254516A2 (en) | 1988-01-27 |
AU7591687A (en) | 1988-01-28 |
FI873185A (fi) | 1988-01-22 |
ATE99699T1 (de) | 1994-01-15 |
IL83243A0 (en) | 1987-12-31 |
NO873018D0 (no) | 1987-07-20 |
PT85355B (pt) | 1990-04-30 |
EP0254516A3 (en) | 1990-06-27 |
CN87104988A (zh) | 1988-03-02 |
HU203371B (en) | 1991-07-29 |
IL83243A (en) | 1993-01-14 |
DE3788684T2 (de) | 1994-05-19 |
FI873185A0 (fi) | 1987-07-20 |
MY102873A (en) | 1993-03-31 |
PT85355A (en) | 1987-08-01 |
ZA875295B (en) | 1988-01-21 |
NO170978B (no) | 1992-09-28 |
HUT45271A (en) | 1988-06-28 |
NL300018I1 (nl) | 2000-11-01 |
NZ221130A (en) | 1990-08-28 |
DE3788684D1 (de) | 1994-02-17 |
NO873018L (no) | 1988-01-22 |
ES2061504T3 (es) | 1994-12-16 |
YU135387A (en) | 1988-10-31 |
DK347086D0 (da) | 1986-07-21 |
JPS6399096A (ja) | 1988-04-30 |
DE10075024I1 (de) | 2000-11-09 |
KR880001701A (ko) | 1988-04-26 |
EP0254516B1 (en) | 1994-01-05 |
AU612324B2 (en) | 1991-07-11 |
NO170978C (no) | 1993-01-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ENJ | Ceased due to non-payment of renewal fee |