ES2061504T3 - Nuevos peptidos. - Google Patents

Nuevos peptidos.

Info

Publication number
ES2061504T3
ES2061504T3 ES87306405T ES87306405T ES2061504T3 ES 2061504 T3 ES2061504 T3 ES 2061504T3 ES 87306405 T ES87306405 T ES 87306405T ES 87306405 T ES87306405 T ES 87306405T ES 2061504 T3 ES2061504 T3 ES 2061504T3
Authority
ES
Spain
Prior art keywords
amino acid
solutions
insulin
asn
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87306405T
Other languages
English (en)
Inventor
Jan Markussen
Kjeld Norris
Liselotte Langkjaer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8123250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2061504(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of ES2061504T3 publication Critical patent/ES2061504T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

DERIVADOS DE INSULINA QUE TIENEN UNA CARGA QUE ES POSITIVA COMPARADA CON LA CARGA DE LA INSULINA HUMANA A UN PH NEUTRO, PUEDEN USARSE PARA PREPARAR SOLUCIONES CON UNA PROLONGADA ACCION DE INSULINA. EN LOS NUEVOS DERIVADOS DE INSULINA SE HA SUSTITUIDO UN AMINOACIDO BASICO EN LA POSICION B27- Y SE HA INSERTADO UN AMINOACIDO NEUTRO EN LA POSICION A4-, A17-, B-13 Y/O B21-. EL TERMINAL C- DE LA CADENA A- ASN A21, PUEDE SUSTITUIRSE POR OTRO AMINOACIDO PARA AUMENTAR LA ESTABILIDAD DE LAS SOLUCIONES AL PH LIGERAMENTE ACIDO, DE LAS SOLUCIONES FARMACEUTICAS. ADEMAS, EL GRUPO CARBOXILO CON TERMINAL C- DE LA CADENA B- PUEDE BLOQUEARSE CON UN RESTO AMIDO O ESTER. EN CASO DE QUE A21 SEA ASN, EL GRUPO DE ACIDO CARBOXILICO DE B30 ES LIBRE.
ES87306405T 1986-07-21 1987-07-20 Nuevos peptidos. Expired - Lifetime ES2061504T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK347086A DK347086D0 (da) 1986-07-21 1986-07-21 Novel peptides

Publications (1)

Publication Number Publication Date
ES2061504T3 true ES2061504T3 (es) 1994-12-16

Family

ID=8123250

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87306405T Expired - Lifetime ES2061504T3 (es) 1986-07-21 1987-07-20 Nuevos peptidos.

Country Status (20)

Country Link
EP (1) EP0254516B1 (es)
JP (1) JPS6399096A (es)
KR (1) KR880001701A (es)
CN (1) CN87104988A (es)
AT (1) ATE99699T1 (es)
AU (1) AU612324B2 (es)
DD (1) DD273839A5 (es)
DE (2) DE10075024I1 (es)
DK (1) DK347086D0 (es)
ES (1) ES2061504T3 (es)
FI (1) FI873185A (es)
HU (1) HU203371B (es)
IL (1) IL83243A (es)
MY (1) MY102873A (es)
NL (1) NL300018I1 (es)
NO (1) NO170978C (es)
NZ (1) NZ221130A (es)
PT (1) PT85355B (es)
YU (1) YU135387A (es)
ZA (1) ZA875295B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU612141B2 (en) * 1987-02-25 1991-07-04 Novo Nordisk A/S Novel insulin derivatives
DK336188D0 (da) * 1988-06-20 1988-06-20 Nordisk Gentofte Propeptider
KR900701842A (ko) * 1988-07-20 1990-12-04 헨리 브뢰늄 인간 인슐린 동족체와 그를 포함하는 제제
DE3827533A1 (de) * 1988-08-13 1990-02-15 Hoechst Ag Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5716927A (en) * 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
JPH04502465A (ja) * 1988-12-23 1992-05-07 ノボ　ノルディスク　アクティーゼルスカブ ヒトインシュリン類似物質
US5514646A (en) * 1989-02-09 1996-05-07 Chance; Ronald E. Insulin analogs modified at position 29 of the B chain
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5474978A (en) * 1994-06-16 1995-12-12 Eli Lilly And Company Insulin analog formulations
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US7316999B2 (en) 2000-06-02 2008-01-08 Novo Nordisk A/S Glucose dependent release of insulin from glucose sensing insulin derivatives
DE10114178A1 (de) 2001-03-23 2002-10-10 Aventis Pharma Gmbh Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE60236014D1 (de) 2001-11-19 2010-05-27 Novo Nordisk As Verfahren zur herstellung von insulinverbindungen
GB0206792D0 (en) 2002-03-22 2002-05-01 Leuven K U Res & Dev Normoglycemia
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
RU2381103C2 (ru) 2003-06-27 2010-02-10 Ново Нордиск А/С Контейнер для жидких фармацевтических композиций с высокими влагозащитными свойствами
ATE483580T1 (de) 2003-12-22 2010-10-15 Novo Nordisk As Durchsichtiger, flexibler, undurchlässiger kunststoffbehälter zur lagerung von pharmazeutischen flüssigkeiten
CN1909930B (zh) 2004-01-21 2015-12-16 诺和诺德医疗保健公司 转谷氨酰胺酶介导的肽的接合
DE102006031962A1 (de) 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
DE102006031955A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Insulinanaloga mit dibasischem B-Kettenende
WO2008049711A1 (en) 2006-10-27 2008-05-02 Novo Nordisk A/S Peptide extended insulins
KR20100111683A (ko) * 2008-01-09 2010-10-15 사노피-아벤티스 도이칠란트 게엠베하 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체
JP5694779B2 (ja) 2008-01-09 2015-04-01 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 極度に遅延した時間作用プロファイルを有する新規なインスリン誘導体
US8691759B2 (en) 2008-03-18 2014-04-08 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
KR20110059602A (ko) 2008-08-07 2011-06-02 바이오콘 리미티드 인슐린 화합물의 제조방법
PT3228320T (pt) 2008-10-17 2020-03-26 Sanofi Aventis Deutschland Combinação de uma insulina e de um agonista do glp-1
US20120241356A1 (en) * 2009-07-06 2012-09-27 Sanofi-Aventis Deutschland Gmbh Heat- and vibration-stable insulin preparations
US10029011B2 (en) 2009-11-13 2018-07-24 Sanofi-Aventis Deutschland Gmbh Pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine
PT2498801T (pt) 2009-11-13 2018-05-02 Sanofi Aventis Deutschland Composição farmacêutica compreendendo despro36exendin-4(1-39)-lys6-nh2 e metionina
EP2460527A1 (en) 2010-01-21 2012-06-06 Sanofi Pharmaceutical composition for treating a metabolic syndrome
AR080884A1 (es) 2010-04-14 2012-05-16 Sanofi Aventis Conjugados de insulina-sirna
SG187904A1 (en) 2010-08-30 2013-04-30 Sanofi Aventis Deutschland Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
EP2548570A1 (en) 2011-07-19 2013-01-23 Sanofi Pharmaceutical composition for treating a metabolic syndrome
KR101983982B1 (ko) 2011-08-29 2019-05-30 사노피-아벤티스 도이칠란트 게엠베하 2형 당뇨병 환자의 혈당 조절에 사용하기 위한 약제학적 병용물
AR087744A1 (es) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
BR112014025132A2 (pt) 2012-04-11 2017-07-11 Novo Nordisk As formulações de insulina
US9656017B2 (en) 2014-06-20 2017-05-23 Howard E. Greene Infusion delivery devices and methods
NZ733670A (en) 2014-12-12 2021-12-24 Sanofi Aventis Deutschland Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
JP6690062B2 (ja) 2016-12-16 2020-04-28 ノヴォ ノルディスク アー／エス インスリン含有医薬組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3033127A1 (de) * 1980-09-03 1982-04-08 Hoechst Ag, 6000 Frankfurt Neue analoga des insulins
DE3327709A1 (de) * 1983-07-29 1985-02-07 Hoechst Ag, 6230 Frankfurt Insulin-derivat-kristallsuspensionen, verfahren zu deren herstellung und deren verwendung
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DK113585D0 (da) * 1985-03-12 1985-03-12 Novo Industri As Nye peptider
DK119785D0 (da) * 1985-03-15 1985-03-15 Nordisk Gentofte Insulinpraeparat

Also Published As

Publication number Publication date
PT85355B (pt) 1990-04-30
DE3788684D1 (de) 1994-02-17
AU7591687A (en) 1988-01-28
ATE99699T1 (de) 1994-01-15
EP0254516A2 (en) 1988-01-27
ZA875295B (en) 1988-01-21
KR880001701A (ko) 1988-04-26
EP0254516B1 (en) 1994-01-05
PT85355A (en) 1987-08-01
HU203371B (en) 1991-07-29
AU612324B2 (en) 1991-07-11
DK347086D0 (da) 1986-07-21
FI873185A (fi) 1988-01-22
JPS6399096A (ja) 1988-04-30
MY102873A (en) 1993-03-31
IL83243A (en) 1993-01-14
FI873185A0 (fi) 1987-07-20
YU135387A (en) 1988-10-31
NO873018D0 (no) 1987-07-20
NO170978B (no) 1992-09-28
EP0254516A3 (en) 1990-06-27
NL300018I1 (nl) 2000-11-01
CN87104988A (zh) 1988-03-02
NO170978C (no) 1993-01-06
NO873018L (no) 1988-01-22
DE10075024I1 (de) 2000-11-09
DD273839A5 (de) 1989-11-29
NZ221130A (en) 1990-08-28
HUT45271A (en) 1988-06-28
IL83243A0 (en) 1987-12-31
DE3788684T2 (de) 1994-05-19

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Publication Publication Date Title
ES2061504T3 (es) Nuevos peptidos.
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