DD258999A5 - Verfahren zur Herstellung von Human-Gewebeplasminogen-Aktivator - Google Patents

Verfahren zur Herstellung von Human-Gewebeplasminogen-Aktivator Download PDF

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Publication number
DD258999A5
DD258999A5 DD30090087A DD30090087A DD258999A5 DD 258999 A5 DD258999 A5 DD 258999A5 DD 30090087 A DD30090087 A DD 30090087A DD 30090087 A DD30090087 A DD 30090087A DD 258999 A5 DD258999 A5 DD 258999A5
Authority
DD
German Democratic Republic
Prior art keywords
tissue plasminogen
human tissue
plasminogen activator
amino acid
dna
Prior art date
Application number
DD30090087A
Other languages
German (de)
English (en)
Inventor
Adair J Hotchkiss
John V O'connor
Michael W Spellman
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DD258999A5 publication Critical patent/DD258999A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DD30090087A 1986-03-18 1987-03-18 Verfahren zur Herstellung von Human-Gewebeplasminogen-Aktivator DD258999A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84107586A 1986-03-18 1986-03-18
US2189387A 1987-03-04 1987-03-04

Publications (1)

Publication Number Publication Date
DD258999A5 true DD258999A5 (de) 1988-08-10

Family

ID=26695219

Family Applications (1)

Application Number Title Priority Date Filing Date
DD30090087A DD258999A5 (de) 1986-03-18 1987-03-18 Verfahren zur Herstellung von Human-Gewebeplasminogen-Aktivator

Country Status (19)

Country Link
EP (1) EP0238304B1 (fr)
JP (1) JP2972812B2 (fr)
AT (1) ATE139569T1 (fr)
AU (1) AU602510B2 (fr)
CA (1) CA1341597C (fr)
DD (1) DD258999A5 (fr)
DE (2) DE3751842T2 (fr)
DK (1) DK175490B1 (fr)
ES (1) ES2088860T3 (fr)
FI (1) FI100802B (fr)
FR (1) FR2597883B1 (fr)
GB (1) GB2189249B (fr)
GR (1) GR3020850T3 (fr)
HU (1) HU202276B (fr)
IE (1) IE81073B1 (fr)
IL (1) IL81937A (fr)
NO (1) NO172133C (fr)
NZ (1) NZ219654A (fr)
PT (1) PT84493B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH660742A5 (de) * 1982-10-29 1987-06-15 Mitsui Toatsu Chemicals Plasminogen-aktivator, verfahren zu seiner herstellung und diesen enthaltendes thrombolytisches agens.
ES8702945A1 (es) * 1984-10-01 1987-01-16 Integrated Genetics Inc Un metodo de producir activador de plasminogeno de tejido uterino humano
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
EP0293394B2 (fr) * 1986-01-31 2003-10-29 Genetics Institute, LLC Nouvelles proteines thrombolytiques
US4927630A (en) * 1986-02-26 1990-05-22 Monsanto Company Tissue plasminogen activator from normal human colon cells
US4851517A (en) * 1986-02-26 1989-07-25 Monsanto Company Tissue plasminogen activator oligosaccharide from normal human colon cells
JPH084501B2 (ja) * 1987-03-20 1996-01-24 エーザイ株式会社 糖鎖に関する変異ｔＰＡ
EP0293934B1 (fr) * 1987-06-04 1994-08-31 Zymogenetics, Inc. t-PA mutant avec remplacement de kringle
NO882886L (no) * 1987-07-01 1989-01-02 Beecham Group Plc Nye forbindelser.
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
IL88247A0 (en) * 1987-11-06 1989-06-30 Genentech Inc Novel human tissue-type plasminogen activator variant
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
IL90146A (en) * 1988-05-20 1994-10-07 Genentech Inc Glycosylation derivatives of tissue plasminogen activator
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3841296A1 (de) * 1988-12-08 1990-06-13 Bosch Gmbh Robert Antiblockierregelsystem
US5070021A (en) * 1989-01-10 1991-12-03 Monsanto Company Method of modifying oligosaccharide structure of tissue plasminogen activator
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
JP3559559B2 (ja) * 1992-06-03 2004-09-02 ジェネンテク，インコーポレイテッド 向上した治療特性を有する組織プラスミノーゲン活性化因子グリコシル化変異体
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
ATE348173T1 (de) 1999-04-26 2007-01-15 Genentech Inc Zellenzuchtverfahren für glycoproteine
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1662352A3 (ru) * 1982-05-05 1991-07-07 Генентек, Инк (Фирма) Штамм бактерий ЕSснеRIснIа coLI - продуцент активатора плазминогена тканевого типа
WO1984001786A1 (fr) * 1982-10-28 1984-05-10 Beecham Group Plc Derives d'enzymes et leur utilisation dans le traitement de la thrombose
WO1984001960A1 (fr) * 1982-11-11 1984-05-24 Beecham Group Plc Composes pharmaceutiquement actifs
ES8702945A1 (es) * 1984-10-01 1987-01-16 Integrated Genetics Inc Un metodo de producir activador de plasminogeno de tejido uterino humano
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
JPS61247384A (ja) * 1984-10-18 1986-11-04 チモ−ジエネテイツクス　インコ−ポレ−テツド 酵母中でプラスミノ−ゲン活性化因子を発現する方法
DE3682104D1 (de) * 1985-04-22 1991-11-28 Genentech Inc Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen.
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
EP0293394B2 (fr) * 1986-01-31 2003-10-29 Genetics Institute, LLC Nouvelles proteines thrombolytiques

Also Published As

Publication number Publication date
DK135887D0 (da) 1987-03-17
IL81937A (en) 1994-07-31
DK135887A (da) 1987-09-19
NO871086D0 (no) 1987-03-17
FI100802B (fi) 1998-02-27
ES2088860T3 (es) 1996-10-01
FR2597883B1 (fr) 1990-04-20
FI871175A0 (fi) 1987-03-18
EP0238304A3 (en) 1988-07-06
NO172133C (no) 1993-06-09
PT84493A (en) 1987-04-01
GB2189249A (en) 1987-10-21
HU202276B (en) 1991-02-28
DK175490B1 (da) 2004-11-08
DE3751842D1 (de) 1996-07-25
EP0238304A2 (fr) 1987-09-23
AU7008887A (en) 1987-09-24
IE870691L (en) 1987-09-18
AU602510B2 (en) 1990-10-18
IE81073B1 (en) 2000-01-12
ATE139569T1 (de) 1996-07-15
FI871175A (fi) 1987-09-19
GR3020850T3 (en) 1996-11-30
GB2189249B (en) 1990-10-31
NZ219654A (en) 1990-08-28
FR2597883A1 (fr) 1987-10-30
DE3708681C2 (de) 1995-08-17
JPS62282582A (ja) 1987-12-08
PT84493B (pt) 1989-11-10
NO172133B (no) 1993-03-01
NO871086L (no) 1987-09-21
EP0238304B1 (fr) 1996-06-19
DE3708681A1 (de) 1987-10-01
JP2972812B2 (ja) 1999-11-08
DE3751842T2 (de) 1996-11-28
IL81937A0 (en) 1987-10-20
GB8706249D0 (en) 1987-04-23
CA1341597C (fr) 2009-06-23
HUT43108A (en) 1987-09-28

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Legal Events

Date Code Title Description
IF04 In force in the year 2004

Expiry date: 20070319