PT84493B - Processo para a preparacao de novos polipeptideos activadores do plasminogenio tipo tecido humanos - Google Patents

Processo para a preparacao de novos polipeptideos activadores do plasminogenio tipo tecido humanos

Info

Publication number
PT84493B
PT84493B PT84493A PT8449387A PT84493B PT 84493 B PT84493 B PT 84493B PT 84493 A PT84493 A PT 84493A PT 8449387 A PT8449387 A PT 8449387A PT 84493 B PT84493 B PT 84493B
Authority
PT
Portugal
Prior art keywords
preparation
plasminogene
fabrics
type human
new polypeptide
Prior art date
Application number
PT84493A
Other languages
English (en)
Other versions
PT84493A (en
Inventor
Adair J Hotchkiss
John V O'connor
Michael W Spellman
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of PT84493A publication Critical patent/PT84493A/pt
Publication of PT84493B publication Critical patent/PT84493B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
PT84493A 1986-03-18 1987-03-17 Processo para a preparacao de novos polipeptideos activadores do plasminogenio tipo tecido humanos PT84493B (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84107586A 1986-03-18 1986-03-18
US2189387A 1987-03-04 1987-03-04

Publications (2)

Publication Number Publication Date
PT84493A PT84493A (en) 1987-04-01
PT84493B true PT84493B (pt) 1989-11-10

Family

ID=26695219

Family Applications (1)

Application Number Title Priority Date Filing Date
PT84493A PT84493B (pt) 1986-03-18 1987-03-17 Processo para a preparacao de novos polipeptideos activadores do plasminogenio tipo tecido humanos

Country Status (19)

Country Link
EP (1) EP0238304B1 (pt)
JP (1) JP2972812B2 (pt)
AT (1) ATE139569T1 (pt)
AU (1) AU602510B2 (pt)
CA (1) CA1341597C (pt)
DD (1) DD258999A5 (pt)
DE (2) DE3751842T2 (pt)
DK (1) DK175490B1 (pt)
ES (1) ES2088860T3 (pt)
FI (1) FI100802B (pt)
FR (1) FR2597883B1 (pt)
GB (1) GB2189249B (pt)
GR (1) GR3020850T3 (pt)
HU (1) HU202276B (pt)
IE (1) IE81073B1 (pt)
IL (1) IL81937A (pt)
NO (1) NO172133C (pt)
NZ (1) NZ219654A (pt)
PT (1) PT84493B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124613B1 (en) * 1982-10-29 1992-12-30 MITSUI TOATSU CHEMICALS, Inc. Novel plasminogen activator derived from human kidneys, process for its preparation, and thrombolytic drug containing the same
NZ213647A (en) * 1984-10-01 1989-05-29 Integrated Genetics Inc Recombinant human tissue plasminogen activator (tpa) modified in n-linked glycosylation pattern
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
EP0293394B2 (en) * 1986-01-31 2003-10-29 Genetics Institute, LLC Novel thrombolytic proteins
US4927630A (en) * 1986-02-26 1990-05-22 Monsanto Company Tissue plasminogen activator from normal human colon cells
US4851517A (en) * 1986-02-26 1989-07-25 Monsanto Company Tissue plasminogen activator oligosaccharide from normal human colon cells
JPH084501B2 (ja) * 1987-03-20 1996-01-24 エーザイ株式会社 糖鎖に関する変異ｔＰＡ
IE64782B1 (en) * 1987-06-04 1995-09-06 Eisai Co Ltd Mutant t-PA with kringle replacement
DK359888A (da) * 1987-07-01 1989-01-02 Beecham Group Plc Fibrinolytisk enzym
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
IL88247A0 (en) * 1987-11-06 1989-06-30 Genentech Inc Novel human tissue-type plasminogen activator variant
IL90146A (en) * 1988-05-20 1994-10-07 Genentech Inc Glycosylation derivatives of tissue plasminogen activator
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3841296A1 (de) * 1988-12-08 1990-06-13 Bosch Gmbh Robert Antiblockierregelsystem
US5070021A (en) * 1989-01-10 1991-12-03 Monsanto Company Method of modifying oligosaccharide structure of tissue plasminogen activator
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
DK0643772T3 (da) 1992-06-03 1998-02-02 Genentech Inc Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
JP4543131B2 (ja) 1999-04-26 2010-09-15 ジェネンテック， インコーポレイテッド 糖タンパク質のための細胞培養方法
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR840004781A (ko) * 1982-05-05 1984-10-24 월터 에이치·드레거 인체의 조직 플라스미노겐 활성화제
WO1984001786A1 (en) * 1982-10-28 1984-05-10 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
WO1984001960A1 (en) * 1982-11-11 1984-05-24 Beecham Group Plc Pharmaceutically active compounds
NZ213647A (en) * 1984-10-01 1989-05-29 Integrated Genetics Inc Recombinant human tissue plasminogen activator (tpa) modified in n-linked glycosylation pattern
JPS61247384A (ja) * 1984-10-18 1986-11-04 チモ−ジエネテイツクス　インコ−ポレ−テツド 酵母中でプラスミノ−ゲン活性化因子を発現する方法
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
HU206520B (en) * 1985-04-22 1992-11-30 Genentech Inc Process for producing new human tissue plasminogen activator /tpa/ mutants and pharmaceutical compositions containing them
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
ATE74379T1 (de) * 1985-12-23 1992-04-15 Chiron Corp Peptidplasminogenaktivatoren.
EP0293394B2 (en) * 1986-01-31 2003-10-29 Genetics Institute, LLC Novel thrombolytic proteins

Also Published As

Publication number Publication date
JPS62282582A (ja) 1987-12-08
DD258999A5 (de) 1988-08-10
AU602510B2 (en) 1990-10-18
HUT43108A (en) 1987-09-28
FI100802B (fi) 1998-02-27
EP0238304B1 (en) 1996-06-19
NO871086L (no) 1987-09-21
DE3751842D1 (de) 1996-07-25
GB8706249D0 (en) 1987-04-23
EP0238304A3 (en) 1988-07-06
JP2972812B2 (ja) 1999-11-08
FR2597883A1 (fr) 1987-10-30
FI871175A0 (fi) 1987-03-18
FR2597883B1 (fr) 1990-04-20
DE3751842T2 (de) 1996-11-28
FI871175A (fi) 1987-09-19
EP0238304A2 (en) 1987-09-23
NZ219654A (en) 1990-08-28
ATE139569T1 (de) 1996-07-15
NO172133B (no) 1993-03-01
GB2189249B (en) 1990-10-31
IE81073B1 (en) 2000-01-12
DK175490B1 (da) 2004-11-08
NO172133C (no) 1993-06-09
GB2189249A (en) 1987-10-21
IE870691L (en) 1987-09-18
CA1341597C (en) 2009-06-23
ES2088860T3 (es) 1996-10-01
GR3020850T3 (en) 1996-11-30
DE3708681C2 (de) 1995-08-17
HU202276B (en) 1991-02-28
IL81937A0 (en) 1987-10-20
AU7008887A (en) 1987-09-24
IL81937A (en) 1994-07-31
DK135887D0 (da) 1987-03-17
DE3708681A1 (de) 1987-10-01
DK135887A (da) 1987-09-19
PT84493A (en) 1987-04-01
NO871086D0 (no) 1987-03-17

Similar Documents

Publication Publication Date Title
PT84493B (pt) Processo para a preparacao de novos polipeptideos activadores do plasminogenio tipo tecido humanos
FI870113A0 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 4,5,6-substioitujenN-(substituoitu-fenyyli)-2-pyrimidiiniamiinien valmistamiseksi
FI864654A0 (fi) Menetelmä modifioidun ihmisen t-PA-proteiinin valmistamiseksi
DE68923123D1 (de) Herstellung von Proteinen.
NO901760L (no) Substituerte arylureaforbindelser som soetningsmidler med hoey styrke.
DE69126049D1 (de) Vektoren und Zusammensetzungen zur Expression von Glykosilationsmutanten des menschlichen Proteins-C
PT86233A (fr) Procede de preparation d:une variant de l:hirudine
RO89363A (ro) Procedeu pentru prepararea unor cefalosporine
PT84011A (fr) Procede de preparation de nouveaux analogues de composes polypeptidiques hypocalcemiants epargnant de calcium de l:organisme
IT1184145B (it) Prodotto per la sostituzione di tessuti corporei
ES549399A0 (es) Procedimiento para la preparacion del (+n-) 14,15-dihidro- (3b,14x,16x)-20,21-dinoreburnamenin-14-ol
ES2001042A6 (es) Un metodo para la preparacion de acidos 5,6-dialcoxiantranilicos
IT8583398A0 (it) Procedimento per la realizzazione di collezioni di campioni e macchina per l'esecuzione del procedimento.
IT1184132B (it) Procedimento e macchina per la sfioccatura di tessuto a pelo
ATE58189T1 (de) Verfahren zum beschreiben von kunststoffgeweben, insbesondere planen.
IT206980Z2 (it) Struttura perfezionata di materassino pneumatico comprendente mezzi per l'unione laterale con altri simili.