DK175490B1 - Human-vævstype-plasminogenaktivator-polypeptider og fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse - Google Patents

Human-vævstype-plasminogenaktivator-polypeptider og fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse Download PDF

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Publication number
DK175490B1
DK175490B1 DK198701358A DK135887A DK175490B1 DK 175490 B1 DK175490 B1 DK 175490B1 DK 198701358 A DK198701358 A DK 198701358A DK 135887 A DK135887 A DK 135887A DK 175490 B1 DK175490 B1 DK 175490B1
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DK
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Prior art keywords
human tissue
plasminogen activator
type plasminogen
tissue type
amino acid
Prior art date
Application number
DK198701358A
Other languages
Danish (da)
English (en)
Other versions
DK135887A (da
DK135887D0 (da
Inventor
Adair John Hotchkiss
John Vincent O'connor
Michael Walter Spellman
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK135887D0 publication Critical patent/DK135887D0/da
Publication of DK135887A publication Critical patent/DK135887A/da
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Publication of DK175490B1 publication Critical patent/DK175490B1/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198701358A 1986-03-18 1987-03-17 Human-vævstype-plasminogenaktivator-polypeptider og fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse DK175490B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84107586A 1986-03-18 1986-03-18
US84107586 1986-03-18
US2189387A 1987-03-04 1987-03-04
US2189387 1987-03-04

Publications (3)

Publication Number Publication Date
DK135887D0 DK135887D0 (da) 1987-03-17
DK135887A DK135887A (da) 1987-09-19
DK175490B1 true DK175490B1 (da) 2004-11-08

Family

ID=26695219

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198701358A DK175490B1 (da) 1986-03-18 1987-03-17 Human-vævstype-plasminogenaktivator-polypeptider og fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse

Country Status (19)

Country Link
EP (1) EP0238304B1 (pt)
JP (1) JP2972812B2 (pt)
AT (1) ATE139569T1 (pt)
AU (1) AU602510B2 (pt)
CA (1) CA1341597C (pt)
DD (1) DD258999A5 (pt)
DE (2) DE3751842T2 (pt)
DK (1) DK175490B1 (pt)
ES (1) ES2088860T3 (pt)
FI (1) FI100802B (pt)
FR (1) FR2597883B1 (pt)
GB (1) GB2189249B (pt)
GR (1) GR3020850T3 (pt)
HU (1) HU202276B (pt)
IE (1) IE81073B1 (pt)
IL (1) IL81937A (pt)
NO (1) NO172133C (pt)
NZ (1) NZ219654A (pt)
PT (1) PT84493B (pt)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1984001714A1 (en) * 1982-10-29 1984-05-10 Mitsui Toatsu Chemicals Novel plasminogen activator, process for its preparation, and thrombolytic drug containing the same
DK175327B1 (da) * 1984-10-01 2004-08-23 Integrated Genetics Inc Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA)
US5108909A (en) * 1985-03-22 1992-04-28 Chiron Corporation Expression of TPA in mammalian cells
AU605124B2 (en) * 1985-12-23 1991-01-10 Behringwerke Aktiengesellschaft Novel peptide plasminogen activators
JP2527454B2 (ja) * 1986-01-31 1996-08-21 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新しい血栓溶解タンパク質
US4851517A (en) * 1986-02-26 1989-07-25 Monsanto Company Tissue plasminogen activator oligosaccharide from normal human colon cells
US4927630A (en) * 1986-02-26 1990-05-22 Monsanto Company Tissue plasminogen activator from normal human colon cells
JPH084501B2 (ja) * 1987-03-20 1996-01-24 エーザイ株式会社 糖鎖に関する変異ｔＰＡ
ATE110772T1 (de) * 1987-06-04 1994-09-15 Zymogenetics Inc Mutierter t-pa mit kringle-ersatz.
DE3883453T2 (de) * 1987-07-01 1994-03-17 Beecham Group Plc Hybride Plasminogenaktivatoren.
US5244676A (en) * 1987-10-09 1993-09-14 Monsanto Company Modified tissue plasminogen activator with modified glycosylation site
IL88247A0 (en) * 1987-11-06 1989-06-30 Genentech Inc Novel human tissue-type plasminogen activator variant
IL90146A (en) * 1988-05-20 1994-10-07 Genentech Inc Glycosylation derivatives of tissue plasminogen activator
US5346824A (en) * 1988-05-20 1994-09-13 Genentech, Inc. DNA encoding variants of tissue plasminogen activators and expression vectors and hosts thereof
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5108901A (en) * 1988-09-02 1992-04-28 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3841296A1 (de) * 1988-12-08 1990-06-13 Bosch Gmbh Robert Antiblockierregelsystem
US5070021A (en) * 1989-01-10 1991-12-03 Monsanto Company Method of modifying oligosaccharide structure of tissue plasminogen activator
US5242688A (en) * 1990-12-24 1993-09-07 Eli Lilly And Company Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants
US5223408A (en) * 1991-07-11 1993-06-29 Genentech, Inc. Method for making variant secreted proteins with altered properties
AU664469B2 (en) * 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
EP1171615B1 (en) 1999-04-26 2006-12-13 Genentech, Inc. Cell culture process for glycoproteins
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX197183A (es) * 1982-05-05 1994-02-28 Genentech Inc Activador de plasminogeno de tejido humano
EP0125254A1 (en) * 1982-10-28 1984-11-21 Beecham Group Plc Enzyme derivatives and their use in the treatment of thrombosis
EP0125269A1 (en) * 1982-11-11 1984-11-21 Beecham Group Plc Pharmaceutically active compounds
DK175327B1 (da) * 1984-10-01 2004-08-23 Integrated Genetics Inc Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA)
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
JPS61247384A (ja) * 1984-10-18 1986-11-04 チモ−ジエネテイツクス　インコ−ポレ−テツド 酵母中でプラスミノ−ゲン活性化因子を発現する方法
EP0199574B1 (en) * 1985-04-22 1991-10-23 Genentech, Inc. Human tissue plasminogen activator mutants, methods and intermediates therefor, and compositions using such mutants
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
AU605124B2 (en) * 1985-12-23 1991-01-10 Behringwerke Aktiengesellschaft Novel peptide plasminogen activators
JP2527454B2 (ja) * 1986-01-31 1996-08-21 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド 新しい血栓溶解タンパク質

Also Published As

Publication number Publication date
EP0238304A3 (en) 1988-07-06
NO871086D0 (no) 1987-03-17
FR2597883A1 (fr) 1987-10-30
JP2972812B2 (ja) 1999-11-08
AU7008887A (en) 1987-09-24
EP0238304B1 (en) 1996-06-19
PT84493B (pt) 1989-11-10
GR3020850T3 (en) 1996-11-30
FI871175A0 (fi) 1987-03-18
IL81937A0 (en) 1987-10-20
FR2597883B1 (fr) 1990-04-20
NO172133C (no) 1993-06-09
JPS62282582A (ja) 1987-12-08
HUT43108A (en) 1987-09-28
IE870691L (en) 1987-09-18
NO871086L (no) 1987-09-21
EP0238304A2 (en) 1987-09-23
PT84493A (en) 1987-04-01
DK135887A (da) 1987-09-19
ATE139569T1 (de) 1996-07-15
NZ219654A (en) 1990-08-28
DD258999A5 (de) 1988-08-10
GB8706249D0 (en) 1987-04-23
NO172133B (no) 1993-03-01
DE3751842D1 (de) 1996-07-25
DE3708681A1 (de) 1987-10-01
FI871175A (fi) 1987-09-19
AU602510B2 (en) 1990-10-18
IE81073B1 (en) 2000-01-12
DE3751842T2 (de) 1996-11-28
HU202276B (en) 1991-02-28
DK135887D0 (da) 1987-03-17
ES2088860T3 (es) 1996-10-01
GB2189249B (en) 1990-10-31
FI100802B (fi) 1998-02-27
IL81937A (en) 1994-07-31
GB2189249A (en) 1987-10-21
DE3708681C2 (de) 1995-08-17
CA1341597C (en) 2009-06-23

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