DD253642A5 - Verfahren zur Synthese der rekombinanten DNA eines Einzelpolypeptidkettenproteaseinhibitors - Google Patents

Verfahren zur Synthese der rekombinanten DNA eines Einzelpolypeptidkettenproteaseinhibitors Download PDF

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Publication number
DD253642A5
DD253642A5 DD28386885A DD28386885A DD253642A5 DD 253642 A5 DD253642 A5 DD 253642A5 DD 28386885 A DD28386885 A DD 28386885A DD 28386885 A DD28386885 A DD 28386885A DD 253642 A5 DD253642 A5 DD 253642A5
Authority
DD
German Democratic Republic
Prior art keywords
inhibitor
dna
gene
dna sequence
item
Prior art date
Application number
DD28386885A
Other languages
German (de)
English (en)
Inventor
Pradip K Bandyopadhyay
Stephen P Eisenberg
Gary L Stetler
Robert C Thompson
Original Assignee
Synergen Biolog Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27102096&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD253642(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synergen Biolog Inc filed Critical Synergen Biolog Inc
Publication of DD253642A5 publication Critical patent/DD253642A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
DD28386885A 1984-12-06 1985-12-06 Verfahren zur Synthese der rekombinanten DNA eines Einzelpolypeptidkettenproteaseinhibitors DD253642A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67882284A 1984-12-06 1984-12-06
US80347185A 1985-12-02 1985-12-02

Publications (1)

Publication Number Publication Date
DD253642A5 true DD253642A5 (de) 1988-01-27

Family

ID=27102096

Family Applications (1)

Application Number Title Priority Date Filing Date
DD28386885A DD253642A5 (de) 1984-12-06 1985-12-06 Verfahren zur Synthese der rekombinanten DNA eines Einzelpolypeptidkettenproteaseinhibitors

Country Status (18)

Country Link
EP (1) EP0205475B2 (fr)
JP (1) JP2683500B2 (fr)
AT (1) ATE108205T1 (fr)
AU (1) AU590238B2 (fr)
CA (1) CA1296273C (fr)
DD (1) DD253642A5 (fr)
DE (1) DE3587875T3 (fr)
DK (1) DK372086D0 (fr)
FI (1) FI108943B (fr)
GR (1) GR852940B (fr)
HU (1) HU204563B (fr)
IE (1) IE64175B1 (fr)
IL (3) IL95223A (fr)
MX (1) MX9203519A (fr)
NO (1) NO301122B1 (fr)
NZ (1) NZ214456A (fr)
PT (1) PT81624B (fr)
WO (1) WO1986003519A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5871956A (en) * 1984-12-06 1999-02-16 Amgen Inc. Recombinant methods for production of serine inhibitors and DNA sequences useful for same
US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
US5900400A (en) * 1984-12-06 1999-05-04 Amgen Inc. Serine protease inhibitor analogs
ATE92935T1 (de) * 1984-12-06 1993-08-15 Synergen Biolog Inc Serinproteaseinhibitoren und isolierungsverfahren dazu.
EP0188312A3 (fr) * 1985-01-07 1988-01-13 Celltech Limited Procédé de production d'une protéine
DE3600571A1 (de) * 1986-01-10 1987-08-06 Gruenenthal Gmbh Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel
US5278049A (en) * 1986-06-03 1994-01-11 Incyte Pharmaceuticals, Inc. Recombinant molecule encoding human protease nexin
JPH0616716B2 (ja) * 1986-10-14 1994-03-09 塩野義製薬株式会社 酵母におけるヒトｐｓｔｉの製造法
AU8172787A (en) * 1986-10-30 1988-05-25 Synergen Biologicals, Inc. Human pancreatic secretory trypsin inhibitors produced by recombinant dna methods and processes for the production of same
GB2199582A (en) * 1987-01-07 1988-07-13 Bayer Ag Analogues of pancreatic secretory trypsin inhibitor
US5851983A (en) * 1987-12-28 1998-12-22 Teijin Limited Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology
ATE103930T1 (de) * 1988-03-07 1994-04-15 Ciba Geigy Ag Modifizierte proteine.
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
US5223407A (en) * 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
US5646015A (en) * 1988-08-31 1997-07-08 Astra Ab Excretion of heterologous proteins from E. coli
US6869925B1 (en) * 1992-09-09 2005-03-22 Amgen Inc. Inhibition of retrovirus infection
US6017880A (en) * 1994-03-09 2000-01-25 Amgen Inc. Inhibition of retrovirus infection
KR970701561A (ko) * 1994-03-23 1997-04-12 아사이 이뻬이 신규 기도부 바이러스 질환 치료제(Novel Remedy for Respiratory-Tract Viral Disease)
US5633227A (en) * 1994-09-12 1997-05-27 Miles, Inc. Secretory leukocyte protease inhibitor as an inhibitor of tryptase
SE9702401D0 (sv) 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
US7247704B2 (en) 2000-12-18 2007-07-24 Arriva Pharmaceuticals, Inc. Multifunctional protease inhibitors and their use in treatment of disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
GR79124B (fr) * 1982-12-22 1984-10-02 Genentech Inc
DE3247922A1 (de) * 1982-12-24 1984-06-28 Boehringer Ingelheim International GmbH, 6507 Ingelheim Dna-sequenzen, deren herstellung, diese sequenzen enthaltende plasmide und deren verwendung zur synthese eukaryotischer genprodukte in prokaryoten
JPH06102034B2 (ja) * 1983-03-25 1994-12-14 セルテク リミテツド タンパク質の生産方法
JPS60186290A (ja) * 1983-08-10 1985-09-21 チモ−ジエネテイツクス　インコ−ポレ−テツド アルフア−１−アンチトリプシンを細菌に表現させる方法
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin

Also Published As

Publication number Publication date
FI863188A (fi) 1986-08-05
HUT41442A (en) 1987-04-28
EP0205475A1 (fr) 1986-12-30
EP0205475B1 (fr) 1994-07-06
IL95223A (en) 1992-08-18
AU590238B2 (en) 1989-11-02
PT81624A (en) 1986-01-01
ATE108205T1 (de) 1994-07-15
NO301122B1 (no) 1997-09-15
GR852940B (fr) 1986-04-07
DE3587875T2 (de) 1994-10-13
DK372086A (da) 1986-08-05
DE3587875T3 (de) 2003-01-02
DK372086D0 (da) 1986-08-05
EP0205475A4 (fr) 1990-06-27
FI863188A0 (fi) 1986-08-05
PT81624B (pt) 1987-10-20
JP2683500B2 (ja) 1997-11-26
HU204563B (en) 1992-01-28
JPH06315384A (ja) 1994-11-15
FI108943B (fi) 2002-04-30
DE3587875D1 (de) 1994-08-11
NO863182L (no) 1986-08-06
AU5202986A (en) 1986-07-01
EP0205475B2 (fr) 2002-09-04
NO863182D0 (no) 1986-08-06
IE64175B1 (en) 1995-07-12
CA1296273C (fr) 1992-02-25
NZ214456A (en) 1988-02-12
IE853083L (en) 1986-06-06
IL95223A0 (en) 1991-06-10
IL77227A (en) 1992-08-18
MX9203519A (es) 1992-08-01
WO1986003519A1 (fr) 1986-06-19

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Legal Events

Date Code Title Description
RPV Change in the person, the name or the address of the representative (searches according to art. 11 and 12 extension act)

Free format text: GRÜNECKER, KINKELDEY, STOCKMAIR & SCHWANHÄUSSER, 80538 MÜNCHEN

RPI Change in the person, name or address of the patentee (searches according to art. 11 and 12 extension act)
ASS Change of applicant or owner

Owner name: AMGEN INC., THOUSAND OAKS, CA 91320-1789

Effective date: 19991011

IF04 In force in the year 2004

Expiry date: 20051207