DD222305A5 - Verfahren zur herstellung von 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile - Google Patents
Verfahren zur herstellung von 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile Download PDFInfo
- Publication number
- DD222305A5 DD222305A5 DD84262957A DD26295784A DD222305A5 DD 222305 A5 DD222305 A5 DD 222305A5 DD 84262957 A DD84262957 A DD 84262957A DD 26295784 A DD26295784 A DD 26295784A DD 222305 A5 DD222305 A5 DD 222305A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- pyrroline
- carbonitrile
- oxo
- general formula
- animals
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 6
- 230000008569 process Effects 0.000 title claims abstract description 6
- 150000001875 compounds Chemical class 0.000 claims abstract description 22
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 abstract description 9
- 239000000203 mixture Substances 0.000 abstract description 5
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- 239000000243 solution Substances 0.000 description 17
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- 238000012360 testing method Methods 0.000 description 16
- -1 pyrrolidino, Piperidino- Chemical class 0.000 description 13
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- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833317653 DE3317653A1 (de) | 1983-05-14 | 1983-05-14 | 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile, verfahren zu deren herstellung sowie deren verwendung bei der prophylaxe und therapie thrombotischer zustaende |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD222305A5 true DD222305A5 (de) | 1985-05-15 |
Family
ID=6199021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD84262957A DD222305A5 (de) | 1983-05-14 | 1984-05-11 | Verfahren zur herstellung von 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4499089A (cs) |
| EP (1) | EP0125684B1 (cs) |
| JP (1) | JPS59212469A (cs) |
| AT (1) | ATE28189T1 (cs) |
| AU (1) | AU2798884A (cs) |
| CS (1) | CS244815B2 (cs) |
| DD (1) | DD222305A5 (cs) |
| DE (2) | DE3317653A1 (cs) |
| DK (1) | DK239084A (cs) |
| ES (3) | ES8502868A1 (cs) |
| GR (1) | GR82094B (cs) |
| HU (1) | HUT34158A (cs) |
| SU (1) | SU1251800A3 (cs) |
| YU (1) | YU83284A (cs) |
| ZA (1) | ZA843615B (cs) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL176372B (nl) * | 1952-02-26 | Salvat Editores | Werkwijze voor het bereiden van drukinkt alsmede werkwijze voor het bereiden van een preparaat om aan drukinkt te worden toegevoegd. | |
| US4070470A (en) * | 1974-06-24 | 1978-01-24 | Otsuka Pharmaceutical Co., Ltd. | Platelet aggregation inhibiting carbostyrils, their compositions and method of use |
| NZ182264A (en) * | 1975-10-25 | 1979-01-11 | Beecham Group Ltd | 2-carboxyalkyl-1-hydroxyalkyl-pyrrolidin-3,5-dione or-piperidin-3,6-dione derivatives prarmaceutical compostions |
| US4329347A (en) * | 1978-02-17 | 1982-05-11 | Boehringer Ingelheim Gmbh | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril |
| DK75779A (da) * | 1978-03-13 | 1979-09-14 | Du Pont | 4,5-diaryl-2- (substitueret thio) pyrroler og sulfoxider og sulfoner deraf samt fremgangsmaader til deres fremstilling og anvendelse |
| DE3212591A1 (de) * | 1982-04-03 | 1983-10-13 | Gödecke AG, 1000 Berlin | 2-pyrrolin-3-carbonitril-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
-
1983
- 1983-05-14 DE DE19833317653 patent/DE3317653A1/de not_active Ceased
-
1984
- 1984-05-04 CS CS843308A patent/CS244815B2/cs unknown
- 1984-05-10 GR GR74677A patent/GR82094B/el unknown
- 1984-05-10 US US06/608,828 patent/US4499089A/en not_active Expired - Fee Related
- 1984-05-11 DD DD84262957A patent/DD222305A5/de unknown
- 1984-05-11 ES ES532445A patent/ES8502868A1/es not_active Expired
- 1984-05-11 SU SU843737938A patent/SU1251800A3/ru active
- 1984-05-11 HU HU841851A patent/HUT34158A/hu unknown
- 1984-05-11 ES ES532438A patent/ES532438A0/es active Granted
- 1984-05-11 YU YU00832/84A patent/YU83284A/xx unknown
- 1984-05-11 JP JP59093126A patent/JPS59212469A/ja active Pending
- 1984-05-11 ES ES532446A patent/ES8502421A1/es not_active Expired
- 1984-05-14 AT AT84105457T patent/ATE28189T1/de not_active IP Right Cessation
- 1984-05-14 EP EP84105457A patent/EP0125684B1/de not_active Expired
- 1984-05-14 DK DK239084A patent/DK239084A/da not_active Application Discontinuation
- 1984-05-14 AU AU27988/84A patent/AU2798884A/en not_active Abandoned
- 1984-05-14 DE DE8484105457T patent/DE3464601D1/de not_active Expired
- 1984-05-14 ZA ZA843615A patent/ZA843615B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| YU83284A (en) | 1986-10-31 |
| DE3464601D1 (en) | 1987-08-13 |
| HUT34158A (en) | 1985-02-28 |
| ES8502867A1 (es) | 1985-02-01 |
| CS244815B2 (en) | 1986-08-14 |
| ES532438A0 (es) | 1985-02-01 |
| US4499089A (en) | 1985-02-12 |
| SU1251800A3 (ru) | 1986-08-15 |
| ES532446A0 (es) | 1985-01-01 |
| CS330884A2 (en) | 1985-09-17 |
| EP0125684B1 (de) | 1987-07-08 |
| ES8502421A1 (es) | 1985-01-01 |
| AU2798884A (en) | 1984-11-15 |
| JPS59212469A (ja) | 1984-12-01 |
| ES532445A0 (es) | 1985-02-01 |
| EP0125684A1 (de) | 1984-11-21 |
| DK239084A (da) | 1984-11-15 |
| DE3317653A1 (de) | 1984-11-15 |
| ZA843615B (en) | 1984-12-24 |
| GR82094B (cs) | 1984-12-13 |
| ATE28189T1 (de) | 1987-07-15 |
| DK239084D0 (da) | 1984-05-14 |
| ES8502868A1 (es) | 1985-02-01 |
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