ES8502421A1 - Procedimiento para preparar 2-alquiltio-1-aminoalquil-2-pirrolin-3-carbonitrilos - Google Patents
Procedimiento para preparar 2-alquiltio-1-aminoalquil-2-pirrolin-3-carbonitrilosInfo
- Publication number
- ES8502421A1 ES8502421A1 ES532446A ES532446A ES8502421A1 ES 8502421 A1 ES8502421 A1 ES 8502421A1 ES 532446 A ES532446 A ES 532446A ES 532446 A ES532446 A ES 532446A ES 8502421 A1 ES8502421 A1 ES 8502421A1
- Authority
- ES
- Spain
- Prior art keywords
- carbonitriles
- pyrroline
- aminoalkyl
- alkylthio
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 2-ALQUILTIO-1-AMINOALQUIL-2-PIRROLIN-3-CARBONITRILOS, DE FORMULA (I), EN LA QUE R Y R SON ANILLOS AROMATICOS; R ES ALQUILO INFERIOR; Y R PUEDE SER VARIOS RADICALES.CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II), EN LA QUEN VALE 2 O 3, Z ES UN GRUPO AMINO PROTEGIDO, Y R, R Y R SON LOS MISMOS QUE EN LA FORMULA (I), CON UN ACIDO, TAL COMO UNA MEZCLA ETANOLICA DE ACIDO CLORHIDRICO O BROMHIDRICO CONCENTRADOS.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS INHIBIDRORES DE LA AGREGACION DE TROMBOCITOS, Y POR SU ACTIVIDAD ANTIFLOGISTICA, ANTIPIRETICA Y ANTISECRETORA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833317653 DE3317653A1 (de) | 1983-05-14 | 1983-05-14 | 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile, verfahren zu deren herstellung sowie deren verwendung bei der prophylaxe und therapie thrombotischer zustaende |
Publications (2)
Publication Number | Publication Date |
---|---|
ES532446A0 ES532446A0 (es) | 1985-01-01 |
ES8502421A1 true ES8502421A1 (es) | 1985-01-01 |
Family
ID=6199021
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532438A Expired ES8502867A1 (es) | 1983-05-14 | 1984-05-11 | Procedimiento para preparar 2-alquiltio-1-amino-alquil-2-pirrolin-3-carbonitrilos |
ES532446A Expired ES8502421A1 (es) | 1983-05-14 | 1984-05-11 | Procedimiento para preparar 2-alquiltio-1-aminoalquil-2-pirrolin-3-carbonitrilos |
ES532445A Expired ES8502868A1 (es) | 1983-05-14 | 1984-05-11 | Procedimiento para preparar 2-alquiltio-1-aminoalquil-2-pirrolin-3-carbonitrilos |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532438A Expired ES8502867A1 (es) | 1983-05-14 | 1984-05-11 | Procedimiento para preparar 2-alquiltio-1-amino-alquil-2-pirrolin-3-carbonitrilos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532445A Expired ES8502868A1 (es) | 1983-05-14 | 1984-05-11 | Procedimiento para preparar 2-alquiltio-1-aminoalquil-2-pirrolin-3-carbonitrilos |
Country Status (15)
Country | Link |
---|---|
US (1) | US4499089A (es) |
EP (1) | EP0125684B1 (es) |
JP (1) | JPS59212469A (es) |
AT (1) | ATE28189T1 (es) |
AU (1) | AU2798884A (es) |
CS (1) | CS244815B2 (es) |
DD (1) | DD222305A5 (es) |
DE (2) | DE3317653A1 (es) |
DK (1) | DK239084A (es) |
ES (3) | ES8502867A1 (es) |
GR (1) | GR82094B (es) |
HU (1) | HUT34158A (es) |
SU (1) | SU1251800A3 (es) |
YU (1) | YU83284A (es) |
ZA (1) | ZA843615B (es) |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL83557C (es) * | 1952-02-26 | |||
FI59246C (fi) * | 1974-06-24 | 1981-07-10 | Otsuka Pharma Co Ltd | Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin |
NZ182264A (en) * | 1975-10-25 | 1979-01-11 | Beecham Group Ltd | 2-carboxyalkyl-1-hydroxyalkyl-pyrrolidin-3,5-dione or-piperidin-3,6-dione derivatives prarmaceutical compostions |
US4329347A (en) * | 1978-02-17 | 1982-05-11 | Boehringer Ingelheim Gmbh | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril |
DK75779A (da) * | 1978-03-13 | 1979-09-14 | Du Pont | 4,5-diaryl-2- (substitueret thio) pyrroler og sulfoxider og sulfoner deraf samt fremgangsmaader til deres fremstilling og anvendelse |
DE3212591A1 (de) * | 1982-04-03 | 1983-10-13 | Gödecke AG, 1000 Berlin | 2-pyrrolin-3-carbonitril-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel |
-
1983
- 1983-05-14 DE DE19833317653 patent/DE3317653A1/de not_active Ceased
-
1984
- 1984-05-04 CS CS843308A patent/CS244815B2/cs unknown
- 1984-05-10 GR GR74677A patent/GR82094B/el unknown
- 1984-05-10 US US06/608,828 patent/US4499089A/en not_active Expired - Fee Related
- 1984-05-11 JP JP59093126A patent/JPS59212469A/ja active Pending
- 1984-05-11 ES ES532438A patent/ES8502867A1/es not_active Expired
- 1984-05-11 HU HU841851A patent/HUT34158A/hu unknown
- 1984-05-11 ES ES532446A patent/ES8502421A1/es not_active Expired
- 1984-05-11 SU SU843737938A patent/SU1251800A3/ru active
- 1984-05-11 YU YU00832/84A patent/YU83284A/xx unknown
- 1984-05-11 ES ES532445A patent/ES8502868A1/es not_active Expired
- 1984-05-11 DD DD84262957A patent/DD222305A5/de unknown
- 1984-05-14 AT AT84105457T patent/ATE28189T1/de not_active IP Right Cessation
- 1984-05-14 DK DK239084A patent/DK239084A/da not_active Application Discontinuation
- 1984-05-14 AU AU27988/84A patent/AU2798884A/en not_active Abandoned
- 1984-05-14 EP EP84105457A patent/EP0125684B1/de not_active Expired
- 1984-05-14 DE DE8484105457T patent/DE3464601D1/de not_active Expired
- 1984-05-14 ZA ZA843615A patent/ZA843615B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ES532446A0 (es) | 1985-01-01 |
AU2798884A (en) | 1984-11-15 |
US4499089A (en) | 1985-02-12 |
DE3317653A1 (de) | 1984-11-15 |
EP0125684B1 (de) | 1987-07-08 |
CS330884A2 (en) | 1985-09-17 |
DE3464601D1 (en) | 1987-08-13 |
ES532445A0 (es) | 1985-02-01 |
YU83284A (en) | 1986-10-31 |
ZA843615B (en) | 1984-12-24 |
ES532438A0 (es) | 1985-02-01 |
DK239084D0 (da) | 1984-05-14 |
ES8502868A1 (es) | 1985-02-01 |
DD222305A5 (de) | 1985-05-15 |
ATE28189T1 (de) | 1987-07-15 |
JPS59212469A (ja) | 1984-12-01 |
GR82094B (es) | 1984-12-13 |
DK239084A (da) | 1984-11-15 |
EP0125684A1 (de) | 1984-11-21 |
ES8502867A1 (es) | 1985-02-01 |
HUT34158A (en) | 1985-02-28 |
CS244815B2 (en) | 1986-08-14 |
SU1251800A3 (ru) | 1986-08-15 |
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