ZA843615B - 2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles,processes for their preparation,as well as their use in the prophylaxis and therapy of thrombotic states - Google Patents

2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles,processes for their preparation,as well as their use in the prophylaxis and therapy of thrombotic states

Info

Publication number
ZA843615B
ZA843615B ZA843615A ZA843615A ZA843615B ZA 843615 B ZA843615 B ZA 843615B ZA 843615 A ZA843615 A ZA 843615A ZA 843615 A ZA843615 A ZA 843615A ZA 843615 B ZA843615 B ZA 843615B
Authority
ZA
South Africa
Prior art keywords
carbonitriles
pyrroline
aminoalkyl
prophylaxis
alkylthio
Prior art date
Application number
ZA843615A
Other languages
English (en)
Inventor
Hubert Barth
Johannes Hartenstein
Gerhard Satzinger
Edgar Fritschi
Volker Ganser
Horst-Dietmar Tauschel
Guenter Wolf
Original Assignee
Goedecke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Goedecke Ag filed Critical Goedecke Ag
Publication of ZA843615B publication Critical patent/ZA843615B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
ZA843615A 1983-05-14 1984-05-14 2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles,processes for their preparation,as well as their use in the prophylaxis and therapy of thrombotic states ZA843615B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19833317653 DE3317653A1 (de) 1983-05-14 1983-05-14 2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitrile, verfahren zu deren herstellung sowie deren verwendung bei der prophylaxe und therapie thrombotischer zustaende

Publications (1)

Publication Number Publication Date
ZA843615B true ZA843615B (en) 1984-12-24

Family

ID=6199021

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA843615A ZA843615B (en) 1983-05-14 1984-05-14 2-alkylthio-1-aminoalkyl-2-pyrroline-3-carbonitriles,processes for their preparation,as well as their use in the prophylaxis and therapy of thrombotic states

Country Status (15)

Country Link
US (1) US4499089A (xx)
EP (1) EP0125684B1 (xx)
JP (1) JPS59212469A (xx)
AT (1) ATE28189T1 (xx)
AU (1) AU2798884A (xx)
CS (1) CS244815B2 (xx)
DD (1) DD222305A5 (xx)
DE (2) DE3317653A1 (xx)
DK (1) DK239084A (xx)
ES (3) ES532445A0 (xx)
GR (1) GR82094B (xx)
HU (1) HUT34158A (xx)
SU (1) SU1251800A3 (xx)
YU (1) YU83284A (xx)
ZA (1) ZA843615B (xx)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE517938A (xx) * 1952-02-26
FI59246C (fi) * 1974-06-24 1981-07-10 Otsuka Pharma Co Ltd Foerfarande foer framstaellning av benscykloamidderivat anvaendbara vid trombos- och emboliterapin
NZ182264A (en) * 1975-10-25 1979-01-11 Beecham Group Ltd 2-carboxyalkyl-1-hydroxyalkyl-pyrrolidin-3,5-dione or-piperidin-3,6-dione derivatives prarmaceutical compostions
US4329347A (en) * 1978-02-17 1982-05-11 Boehringer Ingelheim Gmbh Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril
DK75779A (da) * 1978-03-13 1979-09-14 Du Pont 4,5-diaryl-2- (substitueret thio) pyrroler og sulfoxider og sulfoner deraf samt fremgangsmaader til deres fremstilling og anvendelse
DE3212591A1 (de) * 1982-04-03 1983-10-13 Gödecke AG, 1000 Berlin 2-pyrrolin-3-carbonitril-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
CS244815B2 (en) 1986-08-14
CS330884A2 (en) 1985-09-17
DD222305A5 (de) 1985-05-15
EP0125684B1 (de) 1987-07-08
AU2798884A (en) 1984-11-15
ES8502868A1 (es) 1985-02-01
YU83284A (en) 1986-10-31
US4499089A (en) 1985-02-12
DK239084D0 (da) 1984-05-14
DE3317653A1 (de) 1984-11-15
ES532438A0 (es) 1985-02-01
ES8502421A1 (es) 1985-01-01
HUT34158A (en) 1985-02-28
DE3464601D1 (en) 1987-08-13
ES8502867A1 (es) 1985-02-01
SU1251800A3 (ru) 1986-08-15
DK239084A (da) 1984-11-15
EP0125684A1 (de) 1984-11-21
ES532445A0 (es) 1985-02-01
GR82094B (xx) 1984-12-13
ES532446A0 (es) 1985-01-01
JPS59212469A (ja) 1984-12-01
ATE28189T1 (de) 1987-07-15

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