DD209633A5 - Verfahren zur herstellung von 3-thienopyridinium- und 3-furopyridiniumcephalosporinen - Google Patents

Verfahren zur herstellung von 3-thienopyridinium- und 3-furopyridiniumcephalosporinen Download PDF

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Publication number
DD209633A5
DD209633A5 DD82243071A DD24307182A DD209633A5 DD 209633 A5 DD209633 A5 DD 209633A5 DD 82243071 A DD82243071 A DD 82243071A DD 24307182 A DD24307182 A DD 24307182A DD 209633 A5 DD209633 A5 DD 209633A5
Authority
DD
German Democratic Republic
Prior art keywords
general formula
group
cephem
carboxylate
alkyl
Prior art date
Application number
DD82243071A
Other languages
German (de)
English (en)
Inventor
William H W Lunn
Robert Th Vasileff
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of DD209633A5 publication Critical patent/DD209633A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DD82243071A 1981-09-08 1982-09-07 Verfahren zur herstellung von 3-thienopyridinium- und 3-furopyridiniumcephalosporinen DD209633A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30035781A 1981-09-08 1981-09-08
US34062882A 1982-01-19 1982-01-19

Publications (1)

Publication Number Publication Date
DD209633A5 true DD209633A5 (de) 1984-05-16

Family

ID=26971737

Family Applications (1)

Application Number Title Priority Date Filing Date
DD82243071A DD209633A5 (de) 1981-09-08 1982-09-07 Verfahren zur herstellung von 3-thienopyridinium- und 3-furopyridiniumcephalosporinen

Country Status (17)

Country Link
EP (1) EP0074268A3 (fr)
KR (1) KR840001585A (fr)
CS (1) CS232735B2 (fr)
DD (1) DD209633A5 (fr)
DK (1) DK399282A (fr)
ES (2) ES515548A0 (fr)
FI (1) FI823088L (fr)
GB (1) GB2105719A (fr)
GR (1) GR76701B (fr)
HU (1) HU187575B (fr)
IL (1) IL66726A0 (fr)
NZ (1) NZ201833A (fr)
PH (1) PH19756A (fr)
PL (1) PL238158A1 (fr)
PT (1) PT75518B (fr)
RO (1) RO84456B (fr)
SU (1) SU1169542A3 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE30724T1 (de) * 1982-06-28 1987-11-15 Bristol Myers Co Cephalosporinderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten.
US4480098A (en) * 1982-11-12 1984-10-30 Eli Lilly And Company Preparation of alkali metal thieno(furo)pyridines
US4525473A (en) * 1983-03-30 1985-06-25 Bristol-Myers Company Cephalosporins
EP0137442A3 (fr) * 1983-10-08 1986-01-15 Hoechst Aktiengesellschaft Dérivés de céphalosporine et procédé pour leur préparation
ZA847926B (en) * 1983-10-17 1986-05-28 Lilly Co Eli 3-bicyclicpyridinium-methyl cephalosporins
US4868173A (en) * 1984-11-20 1989-09-19 Ici Pharma Cephalosporin derivatives
EP0187456A1 (fr) * 1984-11-29 1986-07-16 Ici Pharma Dérivés de céphalosporine
ATE89826T1 (de) * 1985-03-01 1993-06-15 Takeda Chemical Industries Ltd Antibakterielle verbindungen, ihre herstellung und verwendung.
US4703118A (en) * 1985-04-08 1987-10-27 Eli Lilly And Company Synthesis of 3-iodomethyl cephalosporins
US4714760A (en) * 1985-08-20 1987-12-22 Bristol-Myers Company Cephalosporin intermediates
GB8626245D0 (en) * 1985-11-27 1986-12-03 Ici Pharma Cephalosporin compounds
US4868294A (en) * 1986-07-11 1989-09-19 Bristol-Myers Company Process for preparing cephalosporin intermediates
US4918067A (en) * 1986-07-24 1990-04-17 Beecham Group P.L.C. Heterocyclic substituted penicillin antibiotics
TW526202B (en) 1998-11-27 2003-04-01 Shionogi & Amp Co Broad spectrum cephem having benzo[4,5-b]pyridium methyl group of antibiotic activity
US6642238B2 (en) 2000-02-10 2003-11-04 Pharmacia And Upjohn Company Oxazolidinone thioamides with piperazine amide substituents
ES2248284T3 (es) * 2000-02-10 2006-03-16 PHARMACIA & UPJOHN COMPANY LLC Oxazolidinontioamidas con sustituyentes piperazinamida.
US7847093B2 (en) 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
PL1618114T3 (pl) 2003-04-16 2010-12-31 Sandoz Ag Sposoby otrzymywania cefepimy

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
FR2440738A1 (fr) * 1978-11-13 1980-06-06 Parcor Medicament a base de derives des thieno (2,3-c) et (3,2-c) pyridines
DE3118732A1 (de) * 1981-05-12 1982-12-02 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"

Also Published As

Publication number Publication date
RO84456A (fr) 1984-06-21
CS232735B2 (en) 1985-02-14
ES527763A0 (es) 1985-05-16
ES8505374A1 (es) 1985-05-16
PH19756A (en) 1986-06-26
GR76701B (fr) 1984-08-29
PL238158A1 (en) 1984-11-19
FI823088L (fi) 1983-03-09
CS650582A2 (en) 1984-06-18
NZ201833A (en) 1985-09-13
RO84456B (ro) 1984-08-30
ES8404361A1 (es) 1984-04-16
HU187575B (en) 1986-01-28
IL66726A0 (en) 1982-12-31
FI823088A0 (fi) 1982-09-07
GB2105719A (en) 1983-03-30
DK399282A (da) 1983-03-09
ES515548A0 (es) 1984-04-16
EP0074268A2 (fr) 1983-03-16
PT75518B (en) 1985-11-12
EP0074268A3 (fr) 1984-05-23
KR840001585A (ko) 1984-05-07
SU1169542A3 (ru) 1985-07-23
PT75518A (en) 1982-10-01

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Legal Events

Date Code Title Description
NAB Public notice for inspection of provisional exclusive patent accord. to par 17/1 dd-patg.