CZ305984B6 - V podstatě nevodná farmaceutická gelová kompozice pro aplikaci na kůži obsahující vitamin D nebo jeho analog a kortikosteroid - Google Patents
V podstatě nevodná farmaceutická gelová kompozice pro aplikaci na kůži obsahující vitamin D nebo jeho analog a kortikosteroid Download PDFInfo
- Publication number
- CZ305984B6 CZ305984B6 CZ2003-1162A CZ20031162A CZ305984B6 CZ 305984 B6 CZ305984 B6 CZ 305984B6 CZ 20031162 A CZ20031162 A CZ 20031162A CZ 305984 B6 CZ305984 B6 CZ 305984B6
- Authority
- CZ
- Czechia
- Prior art keywords
- dihydroxy
- hydroxy
- vitamin
- triene
- composition
- Prior art date
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- BIABMEZBCHDPBV-UHFFFAOYSA-N dipalmitoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24347100P | 2000-10-27 | 2000-10-27 |
Publications (1)
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| CZ305984B6 true CZ305984B6 (cs) | 2016-06-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ2003-1162A CZ305984B6 (cs) | 2000-10-27 | 2001-09-26 | V podstatě nevodná farmaceutická gelová kompozice pro aplikaci na kůži obsahující vitamin D nebo jeho analog a kortikosteroid |
Country Status (21)
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| US (1) | US6787529B2 (https=) |
| EP (1) | EP1331927B1 (https=) |
| JP (3) | JP4451061B2 (https=) |
| KR (1) | KR100844285B1 (https=) |
| CN (1) | CN100382803C (https=) |
| AT (1) | ATE380542T1 (https=) |
| AU (2) | AU2001291637B2 (https=) |
| BR (1) | BRPI0114927B8 (https=) |
| CA (1) | CA2423930C (https=) |
| CY (1) | CY1107294T1 (https=) |
| CZ (1) | CZ305984B6 (https=) |
| DE (1) | DE60131881T2 (https=) |
| DK (1) | DK1331927T3 (https=) |
| ES (1) | ES2298264T3 (https=) |
| HU (1) | HU230005B1 (https=) |
| IL (2) | IL154888A0 (https=) |
| MX (1) | MXPA03003511A (https=) |
| PL (1) | PL212660B1 (https=) |
| PT (1) | PT1331927E (https=) |
| RU (1) | RU2271810C2 (https=) |
| WO (1) | WO2002034235A1 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8263580B2 (en) * | 1998-09-11 | 2012-09-11 | Stiefel Research Australia Pty Ltd | Vitamin formulation |
| US20090098065A1 (en) * | 2000-01-11 | 2009-04-16 | Avikam Harel | Composition and methods for the treatment of skin disorders |
| KR100844285B1 (ko) * | 2000-10-27 | 2008-07-09 | 레오 파마 에이/에스 | 하나 이상의 비타민 ｄ 또는 비타민 ｄ 동족체 및 하나이상의 코르티코스테로이드를 함유하는 국부용 조성물 |
| US20090143328A1 (en) * | 2001-08-13 | 2009-06-04 | Mcdonald George | Method of Treating Cancer by Administration of Topical Active Corticosteroids |
| MXPA05003805A (es) * | 2002-12-17 | 2005-06-08 | Galderma Sa | Composiciones farmaceuticas que comprenden una combinacion de calcitriol y propionato de clobetasol. |
| FR2854802B1 (fr) * | 2003-05-12 | 2005-06-24 | Galderma Res & Dev | Procede de preparation d'une formulation contenant un principe actif microdose |
| US8404667B2 (en) * | 2006-12-29 | 2013-03-26 | Wisconsin Alumni Research Foundation | Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog |
| FR2871696B1 (fr) * | 2004-06-17 | 2006-11-10 | Galderma Sa | Composition topique pour le traitement du psoriasis |
| FR2871697B1 (fr) * | 2004-06-17 | 2007-06-29 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques, une phase alcoolique, au moins un silicone volatile et une phase huileuse non volatile |
| FR2871698B1 (fr) * | 2004-06-17 | 2008-07-04 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques et une phase huileuse |
| FR2871694B1 (fr) * | 2004-06-17 | 2008-07-04 | Galderma Sa | Composition pharmaceutique comprenant un onguent oleagineux et deux principes actifs solubilises |
| FR2871700B1 (fr) * | 2004-06-17 | 2006-11-17 | Galderma Sa | Composition sous forme de spray comprenant une association d'actifs pharmaceutiques, une phase alcoolique, et une phase huileuse |
| FR2871693B1 (fr) * | 2004-06-17 | 2006-08-25 | Galderma Sa | Utilisation d'une composition pharmaceutique comprenant du calcitriol et du propionate de clobetasol pour le traitement du psoriasis |
| WO2006011849A1 (en) * | 2004-07-28 | 2006-02-02 | Lipopeptide Ab | New use |
| US20060078580A1 (en) | 2004-10-08 | 2006-04-13 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| US7740875B2 (en) * | 2004-10-08 | 2010-06-22 | Mediquest Therapeutics, Inc. | Organo-gel formulations for therapeutic applications |
| US9173835B2 (en) | 2005-05-10 | 2015-11-03 | Dermipsor Ltd. | Compositions and methods for treating hyperproliferative epidermal diseases |
| EP2526930B1 (en) | 2005-06-01 | 2013-12-25 | GlaxoSmithKline Intellectual Property Development Limited | Vitamin formulation |
| MX2007015672A (es) * | 2005-06-10 | 2008-02-20 | Galderma Sa | Liberacion controlada de un farmaco a traves de la piel sobre la base de una composicion topica que comprende el farmaco, una silicona formadora de pelicula y al menos un solvente volatil. |
| MXPA05009381A (es) * | 2005-09-02 | 2007-03-01 | Fernando Ahumada Ayala | Preparaciones para el cuidado de la piel que contienen mupirocina y dipropionato de betametasona. |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| EP1844010B1 (en) | 2006-03-17 | 2013-02-13 | Leo Pharma A/S | Isomerisation of pharmaceutical intermediates |
| US20080064669A1 (en) * | 2006-08-29 | 2008-03-13 | Rakefet Cohen | Stable pharmacologically active compositions including vitamin D-containing and corticosteroid compounds with low pH compatibility |
| FR2909284B1 (fr) | 2006-11-30 | 2012-09-21 | Galderma Sa | Nouvelles compositions sous forme d'onguent sans vaseline comprenant un derive de vitamine d et eventuellement un anti-inflammatoire steroidien |
| ES2272198B1 (es) * | 2006-12-28 | 2008-06-01 | Laboratorios Viñas S.A. | Procedimiento para la obtencion de hidrato de calcipotriol. |
| EP1970048A1 (en) * | 2007-03-15 | 2008-09-17 | Drug Delivery Solutions Limited | Polyaphron topical composition with vitamin D |
| US10265265B2 (en) | 2007-03-15 | 2019-04-23 | Drug Delivery Solutions Limited | Topical composition |
| EP1970049A1 (en) * | 2007-03-15 | 2008-09-17 | Drug Delivery Solutions Limited | Polyaphron topical composition with vitamin D and corticosteroid |
| EP2008651A1 (en) | 2007-06-26 | 2008-12-31 | Drug Delivery Solutions Limited | A bioerodible patch |
| US8865692B2 (en) | 2007-11-13 | 2014-10-21 | Meritage Pharma, Inc | Compositions for the treatment of gastrointestinal inflammation |
| US20100216754A1 (en) * | 2007-11-13 | 2010-08-26 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| US20090123551A1 (en) * | 2007-11-13 | 2009-05-14 | Meritage Pharma, Inc. | Gastrointestinal delivery systems |
| US20090149433A1 (en) | 2007-11-13 | 2009-06-11 | Meritage Pharma, Inc. | Compositions for the treatment of inflammation of the gastrointestinal tract |
| US20090264392A1 (en) * | 2008-04-21 | 2009-10-22 | Meritage Pharma, Inc. | Treating eosinophilic esophagitis |
| RU2555339C2 (ru) * | 2009-12-22 | 2015-07-10 | Лео Фарма А/С | Нанокристаллы кальципотриола моногидрита |
| US9254296B2 (en) * | 2009-12-22 | 2016-02-09 | Leo Pharma A/S | Pharmaceutical composition comprising vitamin D analogue and cosolvent-surfactant mixture |
| US20120322776A1 (en) * | 2009-12-22 | 2012-12-20 | Leo Pharma A/S | Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants |
| KR101749514B1 (ko) | 2010-06-11 | 2017-06-21 | 레오 파마 에이/에스 | 비타민 ｄ 유사체 및 코르티코스테로이드를 포함하는 약제학적 분무 조성물 |
| RU2429818C1 (ru) * | 2010-06-28 | 2011-09-27 | Государственное учреждение здравоохранения "Кемеровская областная клиническая больница" | Лечебное средство |
| RU2442565C1 (ru) * | 2010-08-27 | 2012-02-20 | Государственное учреждение здравоохранения "Кемеровская областная клиническая больница" | Лечебная мазь |
| US8968755B2 (en) | 2010-10-23 | 2015-03-03 | Joel Schlessinger | Topical base and active agent-containing compositions, and methods for improving and treating skin |
| US8685381B2 (en) * | 2010-10-23 | 2014-04-01 | Joel Schlessinger | Topical base and active agent-containing compositions, and methods for improving and treating skin |
| HRP20191711T1 (hr) | 2011-03-14 | 2019-12-13 | Drug Delivery Solutions Ltd | Oftalmološki pripravak |
| JP5897299B2 (ja) * | 2011-10-14 | 2016-03-30 | 岩城製薬株式会社 | ローション剤 |
| CN104138352B (zh) * | 2013-04-19 | 2018-02-27 | 江苏知原药业有限公司 | 卡泊三醇非水凝胶 |
| TW201636025A (zh) * | 2015-04-15 | 2016-10-16 | Maruho Kk | 皮膚用之醫藥組成物 |
| JP6997624B2 (ja) * | 2015-06-18 | 2022-01-17 | ボシュ ヘルス ユーエス，エルエルシー． | 乾癬を治療するためのコルチコステロイドおよびレチノイドを含む局所用組成物 |
| EP3542788A1 (en) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topical composition comprising calcipotriol and betamethasone dipropionate |
| KR102354028B1 (ko) | 2020-05-13 | 2022-01-24 | 동국대학교 경주캠퍼스 산학협력단 | 건선 예방, 개선 또는 치료용 피부 외용제 조성물 |
| CN114159567B (zh) * | 2020-09-10 | 2023-03-31 | 南京海融医药科技股份有限公司 | 一种治疗皮肤病的混悬凝胶剂 |
| CN115569199B (zh) * | 2022-02-14 | 2024-08-20 | 海勃(上海)医药科技有限公司 | 一种药物组合物及其制备方法和应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0129003A2 (en) * | 1983-03-22 | 1984-12-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Cosmetic and dermatological compositions containing 1-alpha-hydroxycholecalciferol |
| US5185150A (en) * | 1990-08-24 | 1993-02-09 | Wisconsin Alumni Research Fdn. | Cosmetic compositions containing 19-nor-vitamin D compounds |
| WO1994014453A1 (en) * | 1992-12-23 | 1994-07-07 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) | Hydroxy vitamin d3 compounds for treating skin atrophy |
| US5990100A (en) * | 1998-03-24 | 1999-11-23 | Panda Pharmaceuticals, L.L.C. | Composition and method for treatment of psoriasis |
| WO2000064450A1 (en) * | 1999-04-23 | 2000-11-02 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) | Pharmaceutical composition |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4569935A (en) * | 1983-03-17 | 1986-02-11 | University Of Tennessee Research Corp. | Topical treatment of psoriasis with imidazole antibiotics |
| SE457055B (sv) * | 1986-08-18 | 1988-11-28 | Ferring Ab | Topisk straalskyddsgel foer mukosa innehaallande kaerlsammandragande substanser |
| IL86170A (en) * | 1987-05-01 | 1992-12-01 | Elan Transdermal Ltd | Preparations and compositions comprising nicotine for percutaneous administration |
| US4847071A (en) | 1987-10-22 | 1989-07-11 | The Procter & Gamble Company | Photoprotection compositions comprising tocopherol sorbate and an anti-inflammatory agent |
| US5002938A (en) * | 1988-03-21 | 1991-03-26 | Bristol-Myers Squibb Company | Antifungal gel formulations |
| DK0437225T3 (da) * | 1990-01-10 | 1994-06-27 | Hoffmann La Roche | Topiske præparater |
| US5763428A (en) * | 1990-09-21 | 1998-06-09 | Bone Care International, Inc. | Methods of treating skin disorders with novel 1a-hydroxy vitamin D4 compounds and derivatives thereof |
| JP2571493B2 (ja) * | 1992-06-04 | 1997-01-16 | 株式会社資生堂 | 皮膚外用剤 |
| EP0614456B1 (en) * | 1992-08-28 | 1999-06-09 | Bone Care International, Inc. | 1alpha,24(s)-dihydroxy vitamin d2, its formation and use |
| DE4328217C2 (de) * | 1993-08-21 | 1996-01-11 | Lohmann Therapie Syst Lts | Therapeutisches System zur Behandlung der Psoriasis |
| US5708017A (en) * | 1995-04-04 | 1998-01-13 | Merck & Co., Inc. | Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors |
| FR2740042B1 (fr) * | 1995-10-23 | 1997-11-14 | Oreal | Support, et composition contenant ce support et un actif cosmetique ou dermatologique stabilise |
| JPH10158147A (ja) * | 1996-11-29 | 1998-06-16 | Kenji Nakamura | 皮膚保護用の被膜組成物とそれを用いた製品 |
| EP0971743B1 (de) * | 1997-04-18 | 2006-07-12 | Fritz Stanislaus | Stabilisiertes arzneimittel enthaltend cysteinylderivate |
| JPH11188054A (ja) * | 1997-12-25 | 1999-07-13 | Lion Corp | 皮膚外用部材 |
| FR2785284B1 (fr) * | 1998-11-02 | 2000-12-01 | Galderma Res & Dev | Analogues de la vitamine d |
| KR100844285B1 (ko) * | 2000-10-27 | 2008-07-09 | 레오 파마 에이/에스 | 하나 이상의 비타민 ｄ 또는 비타민 ｄ 동족체 및 하나이상의 코르티코스테로이드를 함유하는 국부용 조성물 |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0129003A2 (en) * | 1983-03-22 | 1984-12-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Cosmetic and dermatological compositions containing 1-alpha-hydroxycholecalciferol |
| US5185150A (en) * | 1990-08-24 | 1993-02-09 | Wisconsin Alumni Research Fdn. | Cosmetic compositions containing 19-nor-vitamin D compounds |
| WO1994014453A1 (en) * | 1992-12-23 | 1994-07-07 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) | Hydroxy vitamin d3 compounds for treating skin atrophy |
| US5990100A (en) * | 1998-03-24 | 1999-11-23 | Panda Pharmaceuticals, L.L.C. | Composition and method for treatment of psoriasis |
| WO2000064450A1 (en) * | 1999-04-23 | 2000-11-02 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) | Pharmaceutical composition |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4A | Patent expired |
Effective date: 20210926 |