CZ299418B6 - DNA konstrukt, ovlivnující expresi endogenního IFNA2 genu, izolovaná nukleová kyselina, homologne rekombinantní savcí bunka, zpusob ovlivnení expreseendogenního IFNA2 genu a zpusob produkce IFNA2 - Google Patents

DNA konstrukt, ovlivnující expresi endogenního IFNA2 genu, izolovaná nukleová kyselina, homologne rekombinantní savcí bunka, zpusob ovlivnení expreseendogenního IFNA2 genu a zpusob produkce IFNA2 Download PDF

Info

Publication number
CZ299418B6
CZ299418B6 CZ20003705A CZ20003705A CZ299418B6 CZ 299418 B6 CZ299418 B6 CZ 299418B6 CZ 20003705 A CZ20003705 A CZ 20003705A CZ 20003705 A CZ20003705 A CZ 20003705A CZ 299418 B6 CZ299418 B6 CZ 299418B6
Authority
CZ
Czechia
Prior art keywords
seq
sequence
cells
endogenous
ifna2
Prior art date
Application number
CZ20003705A
Other languages
Czech (cs)
English (en)
Other versions
CZ20003705A3 (cs
Inventor
A. Treco@Douglas
W. Heartlein@Michael
R. Selden@Richard
Original Assignee
Shire Human Genetic Therapies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Human Genetic Therapies, Inc. filed Critical Shire Human Genetic Therapies, Inc.
Publication of CZ20003705A3 publication Critical patent/CZ20003705A3/cs
Publication of CZ299418B6 publication Critical patent/CZ299418B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CZ20003705A 1998-05-07 1999-05-05 DNA konstrukt, ovlivnující expresi endogenního IFNA2 genu, izolovaná nukleová kyselina, homologne rekombinantní savcí bunka, zpusob ovlivnení expreseendogenního IFNA2 genu a zpusob produkce IFNA2 CZ299418B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8464898P 1998-05-07 1998-05-07
US8655598P 1998-05-21 1998-05-21

Publications (2)

Publication Number Publication Date
CZ20003705A3 CZ20003705A3 (cs) 2001-04-11
CZ299418B6 true CZ299418B6 (cs) 2008-07-16

Family

ID=26771248

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20003705A CZ299418B6 (cs) 1998-05-07 1999-05-05 DNA konstrukt, ovlivnující expresi endogenního IFNA2 genu, izolovaná nukleová kyselina, homologne rekombinantní savcí bunka, zpusob ovlivnení expreseendogenního IFNA2 genu a zpusob produkce IFNA2

Country Status (14)

Country Link
EP (1) EP1075531A1 (fr)
JP (1) JP2002513580A (fr)
KR (1) KR20010052278A (fr)
CN (1) CN1309710A (fr)
AR (1) AR016264A1 (fr)
AU (1) AU3788899A (fr)
CA (1) CA2328459A1 (fr)
CZ (1) CZ299418B6 (fr)
HU (1) HUP0102517A3 (fr)
IL (1) IL139433A0 (fr)
NO (1) NO20005585L (fr)
PL (1) PL344517A1 (fr)
TR (1) TR200003271T2 (fr)
WO (1) WO1999057292A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1647501A (en) 1999-12-10 2001-06-18 Cytos Biotechnology Ag Replicon based activation of endogenous genes
FR2817559B1 (fr) * 2000-12-06 2003-12-12 Genodyssee Procede de determination d'un ou plusieurs polymorphisme(s) fontionnel(s) dans la sequence nucleique d'un gene "candidat" fonctionnel preselectionne et ses applications
WO2012139195A1 (fr) * 2011-04-13 2012-10-18 National Research Council Of Canada Système d'expression à un élément sar d'ifnα2

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031560A1 (fr) * 1994-05-13 1995-11-23 Transkaryotic Therapies, Inc. Produit de recombinaison d'adn permettant d'effectuer une recombinaison homologue et utilisations de ce produit

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995031560A1 (fr) * 1994-05-13 1995-11-23 Transkaryotic Therapies, Inc. Produit de recombinaison d'adn permettant d'effectuer une recombinaison homologue et utilisations de ce produit

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Geisel C. et al. : "The sequence of Homo sapiens PAC clone DJ0320J15", " EMBL Database AC004081", 3.2.1998 *
Strong C. et al.: "The sequence of H. sapiens BAC clone GS009G13", EMBL database AC002479, 26.8.1997 *

Also Published As

Publication number Publication date
CN1309710A (zh) 2001-08-22
EP1075531A1 (fr) 2001-02-14
CA2328459A1 (fr) 1999-11-11
IL139433A0 (en) 2001-11-25
KR20010052278A (ko) 2001-06-25
HUP0102517A2 (hu) 2001-11-28
NO20005585D0 (no) 2000-11-06
WO1999057292A9 (fr) 1999-12-16
CZ20003705A3 (cs) 2001-04-11
WO1999057292A1 (fr) 1999-11-11
AU3788899A (en) 1999-11-23
JP2002513580A (ja) 2002-05-14
AR016264A1 (es) 2001-06-20
HUP0102517A3 (en) 2004-06-28
TR200003271T2 (tr) 2001-03-21
PL344517A1 (en) 2001-11-05
NO20005585L (no) 2001-01-05

Similar Documents

Publication Publication Date Title
Schultz et al. Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart.
KR20150027752A (ko) 인간화된 il-7 설치류
JPH11502122A (ja) タンパク質生産および輸送
JPH10500570A (ja) 相同組換えに効果的なｄｎａ構築物及びその利用
NZ507451A (en) Genomic sequences upstream of the coding region of the g-csf gene for protein production and delivery and enhancement of g-csf transcription and translation trasfection and infection into mamalian cell
CN113544257A (zh) 中国仓鼠卵巢细胞中内源性逆转录病毒的表征及灭活
RU2229309C2 (ru) МОДИФИЦИРОВАНИЕ ЭКСПРЕССИИ ГЕНА FSHβ С ПОМОЩЬЮ ГОМОЛОГИЧНОЙ РЕКОМБИНАЦИИ
CZ299418B6 (cs) DNA konstrukt, ovlivnující expresi endogenního IFNA2 genu, izolovaná nukleová kyselina, homologne rekombinantní savcí bunka, zpusob ovlivnení expreseendogenního IFNA2 genu a zpusob produkce IFNA2
LU501908B1 (en) Preparation Method of Adeno-associated Virus with Epigenetic Modification Function and Application Thereof
JPH0568560A (ja) ウシ筋原性因子の遺伝子
CN1297910A (zh) 新的人鸟苷酸释放因子及其编码序列
CN1297943A (zh) 人脑表达的x染色体连锁蛋白及其编码序列
WO2004033493A1 (fr) Proteine humaine de promotion de transformation de cellule 3t3 et sa sequence codante
WO1999058556A2 (fr) Proteine liee a la paraplegie spastique hereditaire
CN1303929A (zh) 一种新的多肽——核糖体蛋白18和编码这种多肽的多核苷酸
CN1303938A (zh) 一种新的多肽——人math37和编码这种多肽的多核苷酸
CN1292386A (zh) 一种新的多肽——hrmt35和编码这种多肽的多核苷
CN1510045A (zh) 一种多肽——人kringle蛋白8和编码这种多肽的多核苷酸

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of fee

Effective date: 20090505