CA2328459A1 - Sequences genomiques en amont de la region codante du gene ifn-alpha2 destinees a la production et a l'administration de proteines - Google Patents

Sequences genomiques en amont de la region codante du gene ifn-alpha2 destinees a la production et a l'administration de proteines Download PDF

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Publication number
CA2328459A1
CA2328459A1 CA002328459A CA2328459A CA2328459A1 CA 2328459 A1 CA2328459 A1 CA 2328459A1 CA 002328459 A CA002328459 A CA 002328459A CA 2328459 A CA2328459 A CA 2328459A CA 2328459 A1 CA2328459 A1 CA 2328459A1
Authority
CA
Canada
Prior art keywords
cell
alpha
interferon
seq
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002328459A
Other languages
English (en)
Inventor
Douglas A. Treco
Michael W. Heartlein
Richard F. Selden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Human Genetics Therapies Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2328459A1 publication Critical patent/CA2328459A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une molécule isolée d'acide nucléique capable de s'hybrider, dans des conditions précises, ou de présenter une identité de séquence d'au moins 80 % avec une région génomique définie en amont de la région codant du gène IFNA2. L'invention concerne également une structure d'ADN contenant cette molécule d'ADN comme séquence cible pour la recombinaison homologue.
CA002328459A 1998-05-07 1999-05-05 Sequences genomiques en amont de la region codante du gene ifn-alpha2 destinees a la production et a l'administration de proteines Abandoned CA2328459A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8464898P 1998-05-07 1998-05-07
US60/084,648 1998-05-07
US8655598P 1998-05-21 1998-05-21
US60/086,555 1998-05-21
PCT/US1999/009925 WO1999057292A1 (fr) 1998-05-07 1999-05-05 Sequences genomiques en amont de la region codante du gene ifn-alpha2 destinees a la production et a l'administration de proteines

Publications (1)

Publication Number Publication Date
CA2328459A1 true CA2328459A1 (fr) 1999-11-11

Family

ID=26771248

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002328459A Abandoned CA2328459A1 (fr) 1998-05-07 1999-05-05 Sequences genomiques en amont de la region codante du gene ifn-alpha2 destinees a la production et a l'administration de proteines

Country Status (14)

Country Link
EP (1) EP1075531A1 (fr)
JP (1) JP2002513580A (fr)
KR (1) KR20010052278A (fr)
CN (1) CN1309710A (fr)
AR (1) AR016264A1 (fr)
AU (1) AU3788899A (fr)
CA (1) CA2328459A1 (fr)
CZ (1) CZ299418B6 (fr)
HU (1) HUP0102517A3 (fr)
IL (1) IL139433A0 (fr)
NO (1) NO20005585L (fr)
PL (1) PL344517A1 (fr)
TR (1) TR200003271T2 (fr)
WO (1) WO1999057292A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001042442A2 (fr) 1999-12-10 2001-06-14 Cytos Biotechnology Ag Activation de genes endogenes basee sur un replicon
FR2817559B1 (fr) * 2000-12-06 2003-12-12 Genodyssee Procede de determination d'un ou plusieurs polymorphisme(s) fontionnel(s) dans la sequence nucleique d'un gene "candidat" fonctionnel preselectionne et ses applications
DK2697375T3 (en) * 2011-04-13 2018-01-15 Nat Res Council Canada EXPRESSION SYSTEM WITH A SAR (SCAFFOLD ATTACHMENT REGION) ELEMENT OF INTERFERON 2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery

Also Published As

Publication number Publication date
CZ299418B6 (cs) 2008-07-16
CN1309710A (zh) 2001-08-22
AU3788899A (en) 1999-11-23
WO1999057292A9 (fr) 1999-12-16
NO20005585L (no) 2001-01-05
HUP0102517A3 (en) 2004-06-28
IL139433A0 (en) 2001-11-25
WO1999057292A1 (fr) 1999-11-11
JP2002513580A (ja) 2002-05-14
PL344517A1 (en) 2001-11-05
HUP0102517A2 (hu) 2001-11-28
TR200003271T2 (tr) 2001-03-21
NO20005585D0 (no) 2000-11-06
EP1075531A1 (fr) 2001-02-14
AR016264A1 (es) 2001-06-20
CZ20003705A3 (cs) 2001-04-11
KR20010052278A (ko) 2001-06-25

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Legal Events

Date Code Title Description
FZDE Discontinued