CZ293582B6 - Polynukleotidová sekvence, vektor, který ji obsahuje, hostitel a expresivní systém s obsahem tohoto vektoru, polypeptid, fúzní protein, způsob výroby polynukleotidové sekvence a její použití - Google Patents

Polynukleotidová sekvence, vektor, který ji obsahuje, hostitel a expresivní systém s obsahem tohoto vektoru, polypeptid, fúzní protein, způsob výroby polynukleotidové sekvence a její použití Download PDF

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Publication number
CZ293582B6
CZ293582B6 CZ19951808A CZ180895A CZ293582B6 CZ 293582 B6 CZ293582 B6 CZ 293582B6 CZ 19951808 A CZ19951808 A CZ 19951808A CZ 180895 A CZ180895 A CZ 180895A CZ 293582 B6 CZ293582 B6 CZ 293582B6
Authority
CZ
Czechia
Prior art keywords
sequence
polypeptide
polynucleotide sequence
protein
dna
Prior art date
Application number
CZ19951808A
Other languages
Czech (cs)
English (en)
Other versions
CZ180895A3 (en
Inventor
Tohru Takahashi
Ryuta Koishi
Ichiro Kawashima
Nobufusa Serizava
Original Assignee
Sankyo Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP30380994A external-priority patent/JP3337178B2/ja
Application filed by Sankyo Company Limited filed Critical Sankyo Company Limited
Publication of CZ180895A3 publication Critical patent/CZ180895A3/cs
Publication of CZ293582B6 publication Critical patent/CZ293582B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0051—Oxidoreductases (1.) acting on a sulfur group of donors (1.8)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5431—IL-11
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
    • C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
CZ19951808A 1994-07-13 1995-07-13 Polynukleotidová sekvence, vektor, který ji obsahuje, hostitel a expresivní systém s obsahem tohoto vektoru, polypeptid, fúzní protein, způsob výroby polynukleotidové sekvence a její použití CZ293582B6 (cs)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP16105394 1994-07-13
JP21839294 1994-09-13
JP30380994A JP3337178B2 (ja) 1994-07-13 1994-12-07 クローバーイエローベインウイルスプロテアーゼ

Publications (2)

Publication Number Publication Date
CZ180895A3 CZ180895A3 (en) 1996-02-14
CZ293582B6 true CZ293582B6 (cs) 2004-06-16

Family

ID=27321781

Family Applications (2)

Application Number Title Priority Date Filing Date
CZ19951808A CZ293582B6 (cs) 1994-07-13 1995-07-13 Polynukleotidová sekvence, vektor, který ji obsahuje, hostitel a expresivní systém s obsahem tohoto vektoru, polypeptid, fúzní protein, způsob výroby polynukleotidové sekvence a její použití
CZ20014056A CZ293745B6 (cs) 1994-07-13 1995-07-13 Polynukleotidová sekvence, DNA, polypeptid, farmaceutický prostředek, vektor, hostitel, expresivní systém, protilátka, způsob čištění proteinu a hybridom

Family Applications After (1)

Application Number Title Priority Date Filing Date
CZ20014056A CZ293745B6 (cs) 1994-07-13 1995-07-13 Polynukleotidová sekvence, DNA, polypeptid, farmaceutický prostředek, vektor, hostitel, expresivní systém, protilátka, způsob čištění proteinu a hybridom

Country Status (14)

Country Link
US (3) US5955072A (enExample)
EP (2) EP1251176A3 (enExample)
KR (1) KR100417026B1 (enExample)
CN (4) CN1090676C (enExample)
AU (1) AU696358B2 (enExample)
CA (1) CA2153720A1 (enExample)
CZ (2) CZ293582B6 (enExample)
FI (1) FI953422L (enExample)
HU (2) HUT72922A (enExample)
IL (1) IL114582A0 (enExample)
MX (1) MX9503070A (enExample)
NO (1) NO952763L (enExample)
NZ (1) NZ272561A (enExample)
TW (1) TW459046B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9904539D0 (sv) * 1999-12-10 1999-12-10 Alphahelix Ab Method and device for the handling of samples and reagents
FR2824334B1 (fr) * 2001-05-03 2003-10-10 Coletica Procede pour tester une substance eventuellement active dans le domaine de la lipolyse et son utilisation principalement cosmetique
AU2003288474A1 (en) * 2002-06-24 2004-03-19 Exiqon A/S Methods and systems for detection and isolation of a nucleotide sequence
MX2007013725A (es) 2005-05-05 2008-04-09 Sensient Flavors Inc Produccion de beta-glucanos y mananos.
CN101595228A (zh) 2005-07-21 2009-12-02 艾博特公司 包括sorf构建体的多基因表达和使用多蛋白、前体蛋白和蛋白酶解的方法
US20100035300A1 (en) * 2006-02-27 2010-02-11 Wang Andrew H-J Producing a Target Protein Using Intramolecular Cleavage by TEV Protease
US9206431B2 (en) * 2007-09-27 2015-12-08 Academia Sinica Kit for producing recombinant tag-cleavable fusion proteins via at least two different expression vectors allow protein production in two different species host cells
US8501449B2 (en) 2007-12-04 2013-08-06 Proteon Therapeutics, Inc. Recombinant elastase proteins and methods of manufacturing and use thereof
JP2013509188A (ja) * 2009-10-30 2013-03-14 アボット・ラボラトリーズ Ｓｏｒｆ構築物および複数の遺伝子発現

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3885431D1 (de) * 1987-12-23 1993-12-09 Boehringer Ingelheim Int Expression der viral kodierten Protease P2A des HRV2.
US5162601A (en) * 1989-11-22 1992-11-10 The Upjohn Company Plant potyvirus expression vector with a gene for protease
US6077694A (en) * 1990-09-21 2000-06-20 The United States Of America As Represented By The Department Of Health And Human Services Method for over-expression and rapid purification of biosynthetic proteins
RU2206611C2 (ru) * 1991-08-30 2003-06-20 Вертекс Фармасьютикалз Инкорпорейтед ФРАГМЕНТ ДНК, ПЛАЗМИДНЫЙ ВЕКТОР, СПОСОБ ПОЛУЧЕНИЯ ПОЛИПЕПТИДА И ПОЛИПЕПТИД, ОБЛАДАЮЩИЙ IL-1β ПРОТЕАЗНОЙ АКТИВНОСТЬЮ
AU1743795A (en) * 1994-02-03 1995-08-21 Scripps Research Institute, The A cassette to accumulate multiple proteins through synthesis of a self-processing polypeptide

Also Published As

Publication number Publication date
US5955072A (en) 1999-09-21
CN1126759A (zh) 1996-07-17
CZ180895A3 (en) 1996-02-14
AU2497095A (en) 1996-01-25
NZ272561A (en) 1997-03-24
FI953422A0 (fi) 1995-07-13
HU0202280D0 (enExample) 2002-09-28
NO952763L (no) 1996-01-15
HU9502114D0 (en) 1995-09-28
AU696358B2 (en) 1998-09-10
CN1385529A (zh) 2002-12-18
CA2153720A1 (en) 1996-01-14
HUT72922A (en) 1996-06-28
CN1090676C (zh) 2002-09-11
CN1385532A (zh) 2002-12-18
NO952763D0 (no) 1995-07-12
TW459046B (en) 2001-10-11
EP1251176A3 (en) 2002-12-18
MX9503070A (es) 1997-01-31
KR100417026B1 (ko) 2004-05-17
US20030176688A1 (en) 2003-09-18
US6743611B2 (en) 2004-06-01
FI953422A7 (fi) 1996-01-14
FI953422L (fi) 1996-01-14
EP0700999A3 (en) 1997-04-16
US6307038B1 (en) 2001-10-23
EP1251176A2 (en) 2002-10-23
EP0700999A2 (en) 1996-03-13
CZ293745B6 (cs) 2004-07-14
CN1320689A (zh) 2001-11-07
IL114582A0 (en) 1995-11-27

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20050713