CZ286411B6 - Thermoplastic material - Google Patents
Thermoplastic material Download PDFInfo
- Publication number
- CZ286411B6 CZ286411B6 CZ19952235A CZ223595A CZ286411B6 CZ 286411 B6 CZ286411 B6 CZ 286411B6 CZ 19952235 A CZ19952235 A CZ 19952235A CZ 223595 A CZ223595 A CZ 223595A CZ 286411 B6 CZ286411 B6 CZ 286411B6
- Authority
- CZ
- Czechia
- Prior art keywords
- thermoplastic material
- weight
- methacrylic acid
- coatings
- dosage forms
- Prior art date
Links
- 239000012815 thermoplastic material Substances 0.000 title claims abstract description 15
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims abstract description 21
- 229920000642 polymer Polymers 0.000 claims abstract description 16
- 238000000576 coating method Methods 0.000 claims abstract description 14
- 230000000968 intestinal effect Effects 0.000 claims abstract description 13
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims abstract description 11
- 125000005907 alkyl ester group Chemical group 0.000 claims abstract description 5
- 239000002775 capsule Substances 0.000 claims description 33
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 22
- 239000000463 material Substances 0.000 claims description 22
- 239000002552 dosage form Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000155 melt Substances 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 7
- 238000001746 injection moulding Methods 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract description 8
- 239000000126 substance Substances 0.000 abstract description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000000178 monomer Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 4
- -1 alkyl mercaptans Chemical class 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 238000007720 emulsion polymerization reaction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- UIERETOOQGIECD-UHFFFAOYSA-N Angelic acid Natural products CC=C(C)C(O)=O UIERETOOQGIECD-UHFFFAOYSA-N 0.000 description 3
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 3
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 238000001694 spray drying Methods 0.000 description 3
- 229920001169 thermoplastic Polymers 0.000 description 3
- 239000004416 thermosoftening plastic Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
- 239000004830 Super Glue Substances 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- FGBJXOREULPLGL-UHFFFAOYSA-N ethyl cyanoacrylate Chemical compound CCOC(=O)C(=C)C#N FGBJXOREULPLGL-UHFFFAOYSA-N 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000003856 thermoforming Methods 0.000 description 2
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229960000503 bisacodyl Drugs 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000007922 dissolution test Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 239000006082 mold release agent Substances 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002959 polymer blend Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000010526 radical polymerization reaction Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004260 weight control Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Closures For Containers (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE9414065U DE9414065U1 (de) | 1994-08-31 | 1994-08-31 | Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CZ223595A3 CZ223595A3 (en) | 1996-03-13 |
| CZ286411B6 true CZ286411B6 (en) | 2000-04-12 |
Family
ID=6913070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ19952235A CZ286411B6 (en) | 1994-08-31 | 1995-08-31 | Thermoplastic material |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5705189A (de) |
| EP (1) | EP0704207B1 (de) |
| JP (1) | JPH0873378A (de) |
| AT (1) | ATE203401T1 (de) |
| CZ (1) | CZ286411B6 (de) |
| DE (2) | DE9414065U1 (de) |
| DK (1) | DK0704207T3 (de) |
| ES (1) | ES2160653T3 (de) |
| HU (1) | HU221431B (de) |
| SK (1) | SK280407B6 (de) |
Families Citing this family (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19715794C1 (de) | 1997-04-16 | 1998-12-03 | Roehm Gmbh | Laminare Arzneiform und Verfahren zu ihrer Herstellung |
| CN1326400A (zh) | 1998-09-18 | 2001-12-12 | 罗姆两合公司 | 用于信息载体盘毛坯的模具 |
| WO2000018377A1 (en) | 1998-09-28 | 2000-04-06 | Warner-Lambert Company | Enteric and colonic delivery using hpmc capsules |
| DE10220470A1 (de) * | 2002-04-30 | 2003-11-20 | Roehm Gmbh | ph-sensitives Polymer |
| US6270807B1 (en) | 1999-03-02 | 2001-08-07 | L. Perrigo Company | Taste-masked pharmaceutical composition |
| JP4902918B2 (ja) * | 1999-07-30 | 2012-03-21 | スミスクライン ビーチャム ピー エル シー | 多成分医薬剤形 |
| DE19958007A1 (de) * | 1999-12-02 | 2001-06-07 | Roehm Gmbh | Spritzgußverfahren für (Meth)acrylat-Copolymere mit teritiären Ammoniumgruppen |
| DE19961334A1 (de) * | 1999-12-17 | 2001-06-21 | Roehm Gmbh | Spritzgußverfahren für neutrale und säuregruppenhaltige (Meth)acrylat-Copolymere |
| JP2004504264A (ja) * | 2000-01-07 | 2004-02-12 | ユニバーシティ オブ シンシナティ | Ｔｈ１又はｔｈ２リンパ球に制御される免疫応答の選択的活性化 |
| GB0001752D0 (en) * | 2000-01-27 | 2000-03-15 | Ciba Spec Chem Water Treat Ltd | Particulate compositions and their manufacture |
| DE10043868A1 (de) * | 2000-09-04 | 2002-04-04 | Roehm Gmbh | PMMA Formmassen mit verbesserter Schlagzähigkeit |
| DE10065492A1 (de) * | 2000-12-28 | 2003-06-26 | Roehm Gmbh | Diffus ausgestattete Formmassen und hieraus erhältliche Formkörper |
| US7883721B2 (en) * | 2001-01-30 | 2011-02-08 | Smithkline Beecham Limited | Pharmaceutical formulation |
| GB0102342D0 (en) | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US7842308B2 (en) * | 2001-01-30 | 2010-11-30 | Smithkline Beecham Limited | Pharmaceutical formulation |
| US20050175687A1 (en) * | 2001-01-30 | 2005-08-11 | Mcallister Stephen M. | Pharmaceutical formulations |
| DE10104880A1 (de) * | 2001-01-31 | 2002-08-08 | Roehm Gmbh | Multipartikuläre Arzneiform, enthaltend mindestens zwei unterschiedlich überzogene Pelletformen |
| CN1233765C (zh) * | 2001-02-07 | 2005-12-28 | 罗姆两合公司 | 用于对聚丙烯和聚苯乙烯施用的铝箔的热封物料 |
| DE10127134A1 (de) * | 2001-06-05 | 2002-12-12 | Roehm Gmbh | verfahren zur Herstellung von Formkörpern aus (Meth)acrylat-Copolymeren mittels Spritzguß |
| US7217381B2 (en) * | 2001-09-28 | 2007-05-15 | Mcneil-Ppc, Inc. | Systems, methods and apparatuses for manufacturing dosage forms |
| WO2003026625A1 (en) * | 2001-09-28 | 2003-04-03 | Mcneil-Ppc, Inc. | Modified release dosage forms |
| US7122143B2 (en) | 2001-09-28 | 2006-10-17 | Mcneil-Ppc, Inc. | Methods for manufacturing dosage forms |
| IL160190A0 (en) * | 2001-10-15 | 2004-07-25 | Roehm Gmbh | Use of copolymer to produce a galenic form containining a peptide or a protein as active agent |
| DE10208335A1 (de) * | 2002-02-27 | 2003-09-04 | Roehm Gmbh | Arzneiform und Verfahren zu ihrer Herstellung |
| DE10214002A1 (de) * | 2002-03-27 | 2003-10-09 | Roehm Gmbh | Pharmazeutische Formulierung für den Wirkstoff Budesonid |
| TWI336260B (en) | 2002-07-25 | 2011-01-21 | Glaxo Group Ltd | Dosage form suitable for retaining drug substance |
| DE10243062A1 (de) * | 2002-09-16 | 2004-03-25 | Röhm GmbH & Co. KG | Heißwasserwechseltestbeständiges Sanitärmaterial aus PMMA-Formmasse oder schlagzäher PMMA-Formmasse |
| DE10250543A1 (de) * | 2002-10-29 | 2004-05-19 | Röhm GmbH & Co. KG | Mehrschichtige Arzneiform |
| DE10260065A1 (de) * | 2002-12-19 | 2004-07-01 | Röhm GmbH & Co. KG | Kern-Schale-Teilchen zur Schlagzähmodifizierung von Poly(meth)acrylat-Formmassen |
| DE10260089A1 (de) * | 2002-12-19 | 2004-07-01 | Röhm GmbH & Co. KG | Verfahren zur Herstellung von wässrigen Dispersionen |
| MXPA04010956A (es) * | 2003-01-30 | 2005-01-25 | Roehm Gmbh | Forma de dosis farmaceutica y metodo para la produccion de la misma. |
| TW200526274A (en) | 2003-07-21 | 2005-08-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| DE10345045A1 (de) * | 2003-09-26 | 2005-04-14 | Röhm GmbH & Co. KG | Verfahren zur Oberflächenvergütung von Werkstoffen durch Aufbringen insbesondere transparenter Schichten auf Basis von Polymethacrylaten |
| DE10349144A1 (de) * | 2003-10-17 | 2005-05-12 | Roehm Gmbh | Polymermischung für mattierte Spritzgußteile |
| MX2007008855A (es) * | 2003-10-18 | 2008-03-13 | Roehm Gmbh | Masas de pieza moldeada de poli (met) acrilato resistentes a impactos con alta estabilidad termica. |
| DE10351535A1 (de) * | 2003-11-03 | 2005-06-09 | Röhm GmbH & Co. KG | Mehrschichtfolie aus (Meth)acrylatcopolymer und Polycarbonat |
| DE10354379A1 (de) | 2003-11-20 | 2005-06-23 | Röhm GmbH & Co. KG | Formmasse, enthaltend ein Mattierungsmittel |
| TW200539903A (en) * | 2004-03-12 | 2005-12-16 | Smithkline Beecham Plc | Pharmaceutical formulations |
| DE102004022540A1 (de) | 2004-05-05 | 2005-12-08 | Röhm GmbH & Co. KG | Formmasse für Formkörper mit hoher Witterungsbeständigkeit |
| DE102004045296A1 (de) * | 2004-09-16 | 2006-03-23 | Röhm GmbH & Co. KG | Verwendung von Polyalkyl (meth) acrylat-Perlpolymerisaten und Formmasse zur Herstellung von extrudierten Formteilen mit mattierter Oberfläche |
| DE102004058083A1 (de) | 2004-12-01 | 2006-06-08 | Röhm GmbH & Co. KG | Gedeckt eingefärbte, infrarotreflektierende Kunststoffformmasse |
| RU2409600C2 (ru) * | 2005-04-18 | 2011-01-20 | Эвоник Рем ГмбХ | Формовочная масса и формованное изделие из термопластичной пластмассы, содержащей наноскалярные неорганические частицы, способ получения формовочной массы и формованного изделия, а также их применение |
| US8912908B2 (en) | 2005-04-28 | 2014-12-16 | Proteus Digital Health, Inc. | Communication system with remote activation |
| CA2789262C (en) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Pharma-informatics system |
| US9198608B2 (en) | 2005-04-28 | 2015-12-01 | Proteus Digital Health, Inc. | Communication system incorporated in a container |
| US8836513B2 (en) | 2006-04-28 | 2014-09-16 | Proteus Digital Health, Inc. | Communication system incorporated in an ingestible product |
| US8802183B2 (en) | 2005-04-28 | 2014-08-12 | Proteus Digital Health, Inc. | Communication system with enhanced partial power source and method of manufacturing same |
| US8730031B2 (en) | 2005-04-28 | 2014-05-20 | Proteus Digital Health, Inc. | Communication system using an implantable device |
| DE102005021335A1 (de) * | 2005-05-04 | 2006-11-09 | Röhm Gmbh | Verfahren zur Herstellung von Perlpolymerisaten mit einer mittleren Teilchengröße im Bereich von 1 µm bis 40 µm sowie Perlpolymerisat aufweisende Formmassen und Formkörper |
| US8547248B2 (en) * | 2005-09-01 | 2013-10-01 | Proteus Digital Health, Inc. | Implantable zero-wire communications system |
| DE102005055793A1 (de) | 2005-11-21 | 2007-05-24 | Röhm Gmbh | Transparente TPU (thermoplastische Polyurethane)/ PMMA (Polymethyl(meth)acrylat) Abmischungen mit verbesserter Kältesschlagzähigkeit |
| CN101496042A (zh) | 2006-05-02 | 2009-07-29 | 普罗秋斯生物医学公司 | 患者定制的治疗方案 |
| DE102006029613A1 (de) * | 2006-06-26 | 2007-12-27 | Röhm Gmbh | Transparenter Kunststoff-Verbund |
| US20080020037A1 (en) * | 2006-07-11 | 2008-01-24 | Robertson Timothy L | Acoustic Pharma-Informatics System |
| KR101611240B1 (ko) | 2006-10-25 | 2016-04-11 | 프로테우스 디지털 헬스, 인코포레이티드 | 복용 가능한 제어된 활성화 식별자 |
| EP2069004A4 (de) | 2006-11-20 | 2014-07-09 | Proteus Digital Health Inc | Persönliche gesundheitssignalempfänger mit aktiver signalverarbeitung |
| NO2118279T3 (de) | 2007-01-16 | 2018-04-21 | ||
| DE102007005432A1 (de) * | 2007-01-30 | 2008-07-31 | Evonik Röhm Gmbh | Formmassen für mattierte Polyacrylat-Formkörper |
| US8858432B2 (en) | 2007-02-01 | 2014-10-14 | Proteus Digital Health, Inc. | Ingestible event marker systems |
| MY154556A (en) | 2007-02-14 | 2015-06-30 | Proteus Digital Health Inc | In-body power source having high surface area electrode |
| DE102007009243A1 (de) | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit einer Wirkstoff-Matrix und einem Polymerüberzug, sowie ein Verfahren zur Herstellung der Pellets |
| DE102007009242A1 (de) | 2007-02-22 | 2008-09-18 | Evonik Röhm Gmbh | Pellets mit magensaftresistenter Wirkstoff-Matix |
| US9270025B2 (en) | 2007-03-09 | 2016-02-23 | Proteus Digital Health, Inc. | In-body device having deployable antenna |
| US8540632B2 (en) | 2007-05-24 | 2013-09-24 | Proteus Digital Health, Inc. | Low profile antenna for in body device |
| DE102007024428A1 (de) | 2007-05-25 | 2008-11-27 | Hermann, Holger Lars, Dr. med. | Verwendung von Naloxon als Abususschutz bei Nicht-Opioiden und Nicht-Opiaten |
| DE102007026201A1 (de) * | 2007-06-04 | 2008-12-11 | Evonik Röhm Gmbh | Eingefärbte Zusammensetzung mit erhöhter Spannungsrissbeständigkeit |
| DE102007026200A1 (de) * | 2007-06-04 | 2008-12-11 | Evonik Röhm Gmbh | Zusammensetzung mit erhöhter Spannungsrissbeständigkeit |
| DE102007028601A1 (de) * | 2007-06-19 | 2008-12-24 | Evonik Röhm Gmbh | Reaktivgemisch zur Beschichtung von Formkörpern mittels Reaktionsspritzguss sowie beschichteter Formkörper |
| DE102007029263A1 (de) * | 2007-06-22 | 2008-12-24 | Evonik Röhm Gmbh | PMMA/PVDF-Folie mit besonders hoher Witterungsbeständigkeit und hoher UV-Schutzwirkung |
| EP4011289A1 (de) | 2007-09-25 | 2022-06-15 | Otsuka Pharmaceutical Co., Ltd. | Körperinterne vorrichtung mit virtueller dipol-signal-verstärkung |
| DE102007051482A1 (de) * | 2007-10-25 | 2009-04-30 | Evonik Röhm Gmbh | Verfahren zur Herstellung von beschichteten Formkörpern |
| JP2011503048A (ja) | 2007-11-08 | 2011-01-27 | グラクソ グループ リミテッド | 医薬製剤 |
| WO2009070773A1 (en) * | 2007-11-27 | 2009-06-04 | Proteus Biomedical, Inc. | Transbody communication systems employing communication channels |
| EP2268261B1 (de) | 2008-03-05 | 2017-05-10 | Proteus Digital Health, Inc. | Einnehmbare ereignismarker mit multimodus-kommunikation und systeme sowie anwendungsverfahren dafür |
| DE102008001231A1 (de) * | 2008-04-17 | 2009-10-22 | Evonik Röhm Gmbh | Flammfeste PMMA-Formmasse |
| DE102008001695A1 (de) * | 2008-05-09 | 2009-11-12 | Evonik Röhm Gmbh | Poly(meth)acrylimide mit verbesserten optischen und Farbeigenschaften, insbesondere bei thermischer Belastung |
| CA2666036C (en) | 2008-05-16 | 2017-09-12 | Chien-Hung Chen | Novel compositions and methods for treating hyperproliferative diseases |
| JP2012502883A (ja) * | 2008-06-13 | 2012-02-02 | グラクソ グループ リミテッド | 医薬製剤 |
| CN102159134B (zh) | 2008-07-08 | 2015-05-27 | 普罗透斯数字保健公司 | 可摄取事件标记数据框架 |
| WO2010019778A2 (en) * | 2008-08-13 | 2010-02-18 | Proteus Biomedical, Inc. | Ingestible circuitry |
| WO2010045385A2 (en) * | 2008-10-14 | 2010-04-22 | Proteus Biomedical, Inc. | Method and system for incorporating physiologic data in a gaming environment |
| US8055334B2 (en) | 2008-12-11 | 2011-11-08 | Proteus Biomedical, Inc. | Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same |
| AU2010203737B2 (en) * | 2009-01-06 | 2016-09-15 | Otsuka Pharmaceutical Co., Ltd. | Pharmaceutical dosages delivery system |
| KR20110103446A (ko) | 2009-01-06 | 2011-09-20 | 프로테우스 바이오메디컬, 인코포레이티드 | 섭취-관련 바이오피드백 및 개별화된 의료 치료 방법 및 시스템 |
| GB2480965B (en) | 2009-03-25 | 2014-10-08 | Proteus Digital Health Inc | Probablistic pharmacokinetic and pharmacodynamic modeling |
| US8545402B2 (en) | 2009-04-28 | 2013-10-01 | Proteus Digital Health, Inc. | Highly reliable ingestible event markers and methods for using the same |
| US9149423B2 (en) | 2009-05-12 | 2015-10-06 | Proteus Digital Health, Inc. | Ingestible event markers comprising an ingestible component |
| EP2459177A1 (de) * | 2009-07-30 | 2012-06-06 | Evonik Röhm GmbH | Zusammensetzung aus einem anionischen polymer-material und dem salz einer gesättigten monocarbonsäure mit 6 bis 22 kohlenstoffatomen |
| US8558563B2 (en) | 2009-08-21 | 2013-10-15 | Proteus Digital Health, Inc. | Apparatus and method for measuring biochemical parameters |
| TWI517050B (zh) | 2009-11-04 | 2016-01-11 | 普羅托斯數位健康公司 | 供應鏈管理之系統 |
| UA109424C2 (uk) | 2009-12-02 | 2015-08-25 | Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки | |
| PL2538955T3 (pl) | 2010-02-25 | 2016-04-29 | Evonik Roehm Gmbh | Formulacja farmaceutyczna lub nutraceutyczna |
| JP6463599B2 (ja) | 2010-04-07 | 2019-02-06 | プロテウス デジタル ヘルス， インコーポレイテッド | 小型の摂取可能なデバイス |
| TWI557672B (zh) | 2010-05-19 | 2016-11-11 | 波提亞斯數位康健公司 | 用於從製造商跟蹤藥物直到患者之電腦系統及電腦實施之方法、用於確認將藥物給予患者的設備及方法、患者介面裝置 |
| JP2014504902A (ja) | 2010-11-22 | 2014-02-27 | プロテウス デジタル ヘルス， インコーポレイテッド | 医薬品を有する摂取可能なデバイス |
| BR112013027484A8 (pt) | 2011-06-17 | 2022-07-05 | Evonik Roehm Gmbh | Composição farmacêutica ou nutracêutica com resistência gástrica, e uso de um polímero de (met)acrilato |
| EP2720681B1 (de) | 2011-06-17 | 2016-11-23 | Evonik Röhm GmbH | Beschichtungszusammensetzung für pharmazeutische oder nutrazeutische darreichungsformen |
| CA2839689C (en) | 2011-06-17 | 2018-05-01 | Evonik Roehm Gmbh | Coating composition suitable for pharmaceutical or nutraceutical dosage forms |
| WO2015112603A1 (en) | 2014-01-21 | 2015-07-30 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| US9756874B2 (en) | 2011-07-11 | 2017-09-12 | Proteus Digital Health, Inc. | Masticable ingestible product and communication system therefor |
| IN2014MN00183A (de) | 2011-07-21 | 2015-06-19 | Proteus Digital Health Inc | |
| CA2885680C (en) | 2011-09-07 | 2022-10-04 | Roland Saur-Brosch | Formulation for the controlled release of one or several substances in the digestive tract of a mammal. |
| US9235683B2 (en) | 2011-11-09 | 2016-01-12 | Proteus Digital Health, Inc. | Apparatus, system, and method for managing adherence to a regimen |
| AU2013293234B2 (en) | 2012-07-23 | 2017-08-31 | Otsuka Pharmaceutical Co., Ltd. | Techniques for manufacturing ingestible event markers comprising an ingestible component |
| SI2887925T1 (sl) | 2012-08-27 | 2017-06-30 | Evonik Roehm Gmbh | Na želodčne tekočine odporen farmacevtski ali nutracevtski sestavek z odpornostjo na vpliv etanola |
| US9268909B2 (en) | 2012-10-18 | 2016-02-23 | Proteus Digital Health, Inc. | Apparatus, system, and method to adaptively optimize power dissipation and broadcast power in a power source for a communication device |
| TWI659994B (zh) | 2013-01-29 | 2019-05-21 | 美商普羅托斯數位健康公司 | 高度可膨脹之聚合型薄膜及包含彼之組成物 |
| JP5941240B2 (ja) | 2013-03-15 | 2016-06-29 | プロテウス デジタル ヘルス， インコーポレイテッド | 金属検出器装置、システム、および方法 |
| WO2014197402A1 (en) | 2013-06-04 | 2014-12-11 | Proteus Digital Health, Inc. | System, apparatus and methods for data collection and assessing outcomes |
| US9796576B2 (en) | 2013-08-30 | 2017-10-24 | Proteus Digital Health, Inc. | Container with electronically controlled interlock |
| US10084880B2 (en) | 2013-11-04 | 2018-09-25 | Proteus Digital Health, Inc. | Social media networking based on physiologic information |
| MX2017015465A (es) | 2015-06-05 | 2018-03-28 | Evonik Roehm Gmbh | Composicion farmaceutica o nutraceutica con resistencia contra la influencia del etanol. |
| US11051543B2 (en) | 2015-07-21 | 2021-07-06 | Otsuka Pharmaceutical Co. Ltd. | Alginate on adhesive bilayer laminate film |
| EP3487393A4 (de) | 2016-07-22 | 2020-01-15 | Proteus Digital Health, Inc. | Elektromagnetische erfassung und detektion von einnehmbaren ereignismarkern |
| KR102426632B1 (ko) | 2016-10-26 | 2022-07-29 | 오오쯔까세이야꾸가부시끼가이샤 | 섭취 가능한 이벤트 마커를 갖는 캡슐을 제조하는 방법 |
| AU2022308614A1 (en) | 2021-07-09 | 2024-02-22 | Evonik Operations Gmbh | Hard shell capsules having improved colon release |
| MX2024000522A (es) | 2021-07-09 | 2024-02-02 | Evonik Operations Gmbh | Composicion que comprende un copolimero de (met)acrilato, una sal alcalina o de amonio de un acido monocarboxilico alifatico saturado y deslizantes especificos. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2157435C3 (de) * | 1971-11-19 | 1981-11-19 | Röhm GmbH, 6100 Darmstadt | Herstellung von Arzneimittelkapseln |
| US4058649A (en) * | 1971-10-15 | 1977-11-15 | Mobil Oil Corporation | Coating compositions and thermoplastic film substrates coated therewith |
| JPS57120518A (en) * | 1981-01-19 | 1982-07-27 | Tanabe Seiyaku Co Ltd | Preparation of microcapsule |
| DE3335954A1 (de) * | 1983-10-04 | 1985-04-04 | Roland Dipl.-Kaufm. 7022 Leinfelden-Echterdingen Belz | Verfahren zur durchfuehrung von chemischen reaktionen, insbesondere zur herstellung von kunststoffen mit hilfe von extrudern und anlage hierzu |
| DE3920082A1 (de) * | 1989-06-20 | 1991-03-07 | Roehm Gmbh | Filmbildendes waessriges ueberzugsmittel fuer feste arzneimittel, verfahren zu seiner herstellung und verwendung |
| US5146730A (en) * | 1989-09-20 | 1992-09-15 | Banner Gelatin Products Corp. | Film-enrobed unitary-core medicament and the like |
-
1994
- 1994-08-31 DE DE9414065U patent/DE9414065U1/de not_active Expired - Lifetime
-
1995
- 1995-08-28 AT AT95113467T patent/ATE203401T1/de not_active IP Right Cessation
- 1995-08-28 SK SK1062-95A patent/SK280407B6/sk not_active IP Right Cessation
- 1995-08-28 DE DE59509443T patent/DE59509443D1/de not_active Expired - Fee Related
- 1995-08-28 DK DK95113467T patent/DK0704207T3/da active
- 1995-08-28 ES ES95113467T patent/ES2160653T3/es not_active Expired - Lifetime
- 1995-08-28 EP EP95113467A patent/EP0704207B1/de not_active Expired - Lifetime
- 1995-08-29 HU HU9502529A patent/HU221431B/hu not_active IP Right Cessation
- 1995-08-30 JP JP7222098A patent/JPH0873378A/ja active Pending
- 1995-08-31 US US08/521,738 patent/US5705189A/en not_active Expired - Fee Related
- 1995-08-31 CZ CZ19952235A patent/CZ286411B6/cs not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9502529D0 (en) | 1995-10-30 |
| US5705189A (en) | 1998-01-06 |
| SK280407B6 (sk) | 2000-01-18 |
| EP0704207A2 (de) | 1996-04-03 |
| EP0704207A3 (de) | 1997-08-06 |
| DE59509443D1 (de) | 2001-08-30 |
| SK106295A3 (en) | 1997-01-08 |
| EP0704207B1 (de) | 2001-07-25 |
| DK0704207T3 (da) | 2001-09-24 |
| ES2160653T3 (es) | 2001-11-16 |
| HUT75239A (en) | 1997-05-28 |
| HU221431B (en) | 2002-10-28 |
| DE9414065U1 (de) | 1994-11-03 |
| ATE203401T1 (de) | 2001-08-15 |
| JPH0873378A (ja) | 1996-03-19 |
| CZ223595A3 (en) | 1996-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| IF00 | In force as of 2000-06-30 in czech republic | ||
| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20090831 |