CZ20012502A3 - Funkcionalizované heterocykly jako modulátory chemokinových receptorů - Google Patents
Funkcionalizované heterocykly jako modulátory chemokinových receptorů Download PDFInfo
- Publication number
- CZ20012502A3 CZ20012502A3 CZ20012502A CZ20012502A CZ20012502A3 CZ 20012502 A3 CZ20012502 A3 CZ 20012502A3 CZ 20012502 A CZ20012502 A CZ 20012502A CZ 20012502 A CZ20012502 A CZ 20012502A CZ 20012502 A3 CZ20012502 A3 CZ 20012502A3
- Authority
- CZ
- Czechia
- Prior art keywords
- benzopyrano
- quinolizine
- decahydro
- carboxylic acid
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11565499P | 1999-01-13 | 1999-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ20012502A3 true CZ20012502A3 (cs) | 2002-03-13 |
Family
ID=22362668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CZ20012502A CZ20012502A3 (cs) | 1999-01-13 | 1999-12-20 | Funkcionalizované heterocykly jako modulátory chemokinových receptorů |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1144415A2 (pt) |
| JP (1) | JP2002534526A (pt) |
| KR (1) | KR20010086166A (pt) |
| CN (1) | CN1344270A (pt) |
| AP (1) | AP2001002228A0 (pt) |
| AU (1) | AU1940900A (pt) |
| BR (1) | BR9916905A (pt) |
| CA (1) | CA2372197A1 (pt) |
| CZ (1) | CZ20012502A3 (pt) |
| EA (1) | EA200100774A1 (pt) |
| HK (1) | HK1044539A1 (pt) |
| HU (1) | HUP0202932A3 (pt) |
| IL (1) | IL144289A0 (pt) |
| MX (1) | MXPA01007033A (pt) |
| NO (1) | NO20013456L (pt) |
| OA (1) | OA11820A (pt) |
| PL (1) | PL349348A1 (pt) |
| SK (1) | SK9972001A3 (pt) |
| WO (1) | WO2000042045A2 (pt) |
| ZA (1) | ZA200106592B (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1377549A1 (en) * | 2001-03-12 | 2004-01-07 | Millennium Pharmaceuticals, Inc. | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
| ATE372768T1 (de) | 2001-03-29 | 2007-09-15 | Lilly Co Eli | N-(2-arylethyl) benzylamine als 5-ht6 rezeptor- antagoniste |
| WO2003035650A1 (fr) * | 2001-09-25 | 2003-05-01 | Takeda Chemical Industries, Ltd. | Inhibiteur d'entree |
| TW201018661A (en) | 2003-03-14 | 2010-05-16 | Ono Pharmaceutical Co | Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient |
| EP2364982A1 (en) | 2003-04-18 | 2011-09-14 | ONO Pharmaceutical Co., Ltd. | Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof |
| ES2457041T3 (es) | 2004-09-13 | 2014-04-24 | Ono Pharmaceutical Co., Ltd. | Derivados de N-4-piperidilurea y medicamentos que los contienen como principio activo |
| JPWO2006129679A1 (ja) | 2005-05-31 | 2009-01-08 | 小野薬品工業株式会社 | スピロピペリジン化合物およびその医薬用途 |
| WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| DK1942108T3 (da) | 2005-10-28 | 2013-12-09 | Ono Pharmaceutical Co | Forbindelse indeholdende basisk gruppe samt anvendelse deraf |
| ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
| CN101460458A (zh) | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
| JP2009526863A (ja) * | 2006-02-15 | 2009-07-23 | アラーガン、インコーポレイテッド | スフィンゴシン−１−リン酸（ｓ１ｐ）受容体アンタゴニスト生物学的活性を有するアリールまたはヘテロアリール基を持つインドール−３−カルボン酸アミド、エステル、チオアミドおよびチオールエステル化合物 |
| JPWO2007105637A1 (ja) | 2006-03-10 | 2009-07-30 | 小野薬品工業株式会社 | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| JP5257068B2 (ja) | 2006-05-16 | 2013-08-07 | 小野薬品工業株式会社 | 保護されていてもよい酸性基を含有する化合物およびその用途 |
| EA016633B1 (ru) * | 2006-05-23 | 2012-06-29 | Общество С Ограниченной Ответственностью "Инновационная Фармацевтика" | Замещенные индолы, способ их получения и применения |
| JP5245827B2 (ja) | 2006-07-31 | 2013-07-24 | 小野薬品工業株式会社 | スピロ結合した環状基を含有する化合物およびその用途 |
| MX2009007334A (es) | 2007-01-11 | 2009-07-15 | Allergan Inc | Compuestos de amida del acido indol-3-carboxilico 6-substituido que tienen actividad antagonista biologica del receptor esfingosina-1-fosfato (s1p). |
| US8524917B2 (en) | 2007-01-11 | 2013-09-03 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| WO2011143430A1 (en) | 2010-05-12 | 2011-11-17 | Abbott Laboratories | Indazole inhibitors of kinase |
| US20140271680A1 (en) | 2011-08-12 | 2014-09-18 | Universite Paris-Est Creteil Val De Marne | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| CN104193669B (zh) * | 2014-08-01 | 2016-12-07 | 大连理工大学 | 一类阿比朵尔类似物或其盐、其制备方法及应用 |
| WO2016112088A1 (en) * | 2015-01-06 | 2016-07-14 | Spero Therapeutics, Inc. | Aryloxyacetylindoles and analogs as antibiotic tolerance inhibitors |
| CN110256324A (zh) * | 2019-06-13 | 2019-09-20 | 苏州莱安医药化学技术有限公司 | 一种2-甲基-5-羟基吲哚的制备方法 |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3549641A (en) * | 1966-06-28 | 1970-12-22 | Warner Lambert Pharmaceutical | Pyrano pyridines and process for their production |
| US3518258A (en) * | 1967-05-09 | 1970-06-30 | Warner Lambert Pharmaceutical | Pyrano(3,2-i)quinolizine and process for the production |
| US3565903A (en) * | 1967-11-24 | 1971-02-23 | Warner Lambert Pharmaceutical | Pyrano(2,3-b)quinolines and process for their production |
| US5635510A (en) * | 1993-05-06 | 1997-06-03 | Merrell Pharmaceuticals Inc. | Substituted pyrrolidin-3-yl-alkyl-piperidines |
| HRP960352A2 (en) * | 1996-07-26 | 1998-08-31 | Pliva Pharm & Chem Works | Novel coumarin quinoline carboxylic acids |
| CN1248968A (zh) * | 1997-02-26 | 2000-03-29 | 辉瑞大药厂 | 杂芳基－己酸酰胺衍生物、其制备方法及其作为MIP－1α与其CCRI受体结合的选择性抑制剂的用途 |
| WO1999038514A1 (en) * | 1998-02-02 | 1999-08-05 | Merck & Co., Inc. | Cyclic amine modulators of chemokine receptor activity |
-
1999
- 1999-12-20 CN CN99816475A patent/CN1344270A/zh active Pending
- 1999-12-20 EA EA200100774A patent/EA200100774A1/ru unknown
- 1999-12-20 JP JP2000593612A patent/JP2002534526A/ja active Pending
- 1999-12-20 CZ CZ20012502A patent/CZ20012502A3/cs unknown
- 1999-12-20 SK SK997-2001A patent/SK9972001A3/sk unknown
- 1999-12-20 AU AU19409/00A patent/AU1940900A/en not_active Abandoned
- 1999-12-20 HU HU0202932A patent/HUP0202932A3/hu unknown
- 1999-12-20 IL IL14428999A patent/IL144289A0/xx unknown
- 1999-12-20 CA CA002372197A patent/CA2372197A1/en not_active Abandoned
- 1999-12-20 AP APAP/P/2001/002228A patent/AP2001002228A0/en unknown
- 1999-12-20 WO PCT/US1999/030434 patent/WO2000042045A2/en not_active Application Discontinuation
- 1999-12-20 MX MXPA01007033A patent/MXPA01007033A/es unknown
- 1999-12-20 EP EP99963110A patent/EP1144415A2/en not_active Withdrawn
- 1999-12-20 BR BR9916905-3A patent/BR9916905A/pt not_active Application Discontinuation
- 1999-12-20 OA OA1200100187A patent/OA11820A/en unknown
- 1999-12-20 KR KR1020017008905A patent/KR20010086166A/ko not_active Application Discontinuation
- 1999-12-20 PL PL99349348A patent/PL349348A1/xx not_active Application Discontinuation
-
2001
- 2001-07-12 NO NO20013456A patent/NO20013456L/no not_active Application Discontinuation
- 2001-08-10 ZA ZA200106592A patent/ZA200106592B/en unknown
-
2002
- 2002-08-28 HK HK02106357.2A patent/HK1044539A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200106592B (en) | 2002-08-12 |
| IL144289A0 (en) | 2002-05-23 |
| BR9916905A (pt) | 2002-01-29 |
| WO2000042045A3 (en) | 2000-11-09 |
| AP2001002228A0 (en) | 2001-09-30 |
| WO2000042045A2 (en) | 2000-07-20 |
| HUP0202932A3 (en) | 2003-07-28 |
| AU1940900A (en) | 2000-08-01 |
| JP2002534526A (ja) | 2002-10-15 |
| KR20010086166A (ko) | 2001-09-08 |
| HUP0202932A2 (hu) | 2002-12-28 |
| CN1344270A (zh) | 2002-04-10 |
| SK9972001A3 (en) | 2002-03-05 |
| NO20013456L (no) | 2001-09-12 |
| EP1144415A2 (en) | 2001-10-17 |
| PL349348A1 (en) | 2002-07-15 |
| NO20013456D0 (no) | 2001-07-12 |
| OA11820A (en) | 2005-08-17 |
| HK1044539A1 (zh) | 2002-10-25 |
| CA2372197A1 (en) | 2000-07-20 |
| MXPA01007033A (es) | 2003-07-21 |
| EA200100774A1 (ru) | 2002-02-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CZ20012502A3 (cs) | Funkcionalizované heterocykly jako modulátory chemokinových receptorů | |
| JP4386639B2 (ja) | セロトニンアゴニストおよびアンタゴニストとしての置換されたピロロキノリン化合物およびピリドキノリン化合物 | |
| ES2223536T3 (es) | Gamma-carbolinas condensadas con heterociclos sustituidas. | |
| US5618833A (en) | 1-benzyl-1,3-dihydroindol-2-one derivatives, their preparation and the pharmaceutical compositions in which they are present | |
| US20030064991A1 (en) | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor | |
| JPH0819099B2 (ja) | アザビシクロキノロンカルボン酸化合物製造用中間体 | |
| JP2008511669A (ja) | 化合物 | |
| JP2008511669A6 (ja) | 化合物 | |
| JP2009507795A (ja) | 化合物 | |
| JP2009524690A (ja) | 化合物 | |
| MXPA02000978A (es) | Antagonistas del receptor de quimioquina y metodosde uso de los mismos. | |
| JP2008531716A (ja) | 化合物 | |
| JP3170584B2 (ja) | 新規なイサチンオキシム誘導体類、その製造および使用 | |
| JP2012072067A (ja) | 含窒素芳香族へテロ環化合物 | |
| WO2003077857A2 (en) | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors | |
| AU631723B2 (en) | Tricyclic-cyclic amines as novel cholinesterase inhibitors | |
| EP0690842A1 (en) | 4-arylisoindole analgesics | |
| JP2010053042A (ja) | カリウムチャネル調節薬 | |
| JPH0322390B2 (pt) | ||
| EP0222703A1 (de) | Hexahydro-[1]-benzo-(pyrano und thiopyrano)-[4,3-c]pyridine | |
| Tadic et al. | Probes for narcotic receptor mediated phenomena. Part 31: Synthesis of rac-(3R, 6aS, 11aS)-2-methyl-1, 3, 4, 5, 6, 11a-hexahydro-2H-3, 6a-methanobenzofuro [2, 3-c] azocine-10-ol, and azocine-8-ol, the ortho-c and the para-c oxide-bridged phenylmorphan isomers | |
| JP3781698B2 (ja) | 新規ピリミジン−４−オン化合物、その調製方法、およびそれらを含む医薬組成物 | |
| US4283536A (en) | Preparation of vincadifformine and related derivatives | |
| Osornio et al. | Formal Synthesis of (±)-γ-Lycorane | |
| EP0115920A2 (en) | Pyrazino(2',3'-3,4)pyrido(1,2-a) indole derivatives |