CA2372197A1 - Functionalized heterocycles as chemokine receptor modulators - Google Patents
Functionalized heterocycles as chemokine receptor modulators Download PDFInfo
- Publication number
- CA2372197A1 CA2372197A1 CA002372197A CA2372197A CA2372197A1 CA 2372197 A1 CA2372197 A1 CA 2372197A1 CA 002372197 A CA002372197 A CA 002372197A CA 2372197 A CA2372197 A CA 2372197A CA 2372197 A1 CA2372197 A1 CA 2372197A1
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- carboxylic acid
- benzopyrano
- quinolizine
- decahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11565499P | 1999-01-13 | 1999-01-13 | |
| US60/115,654 | 1999-01-13 | ||
| PCT/US1999/030434 WO2000042045A2 (en) | 1999-01-13 | 1999-12-20 | Functionalized heterocycles as chemokine receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2372197A1 true CA2372197A1 (en) | 2000-07-20 |
Family
ID=22362668
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002372197A Abandoned CA2372197A1 (en) | 1999-01-13 | 1999-12-20 | Functionalized heterocycles as chemokine receptor modulators |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1144415A2 (pt) |
| JP (1) | JP2002534526A (pt) |
| KR (1) | KR20010086166A (pt) |
| CN (1) | CN1344270A (pt) |
| AP (1) | AP2001002228A0 (pt) |
| AU (1) | AU1940900A (pt) |
| BR (1) | BR9916905A (pt) |
| CA (1) | CA2372197A1 (pt) |
| CZ (1) | CZ20012502A3 (pt) |
| EA (1) | EA200100774A1 (pt) |
| HK (1) | HK1044539A1 (pt) |
| HU (1) | HUP0202932A3 (pt) |
| IL (1) | IL144289A0 (pt) |
| MX (1) | MXPA01007033A (pt) |
| NO (1) | NO20013456L (pt) |
| OA (1) | OA11820A (pt) |
| PL (1) | PL349348A1 (pt) |
| SK (1) | SK9972001A3 (pt) |
| WO (1) | WO2000042045A2 (pt) |
| ZA (1) | ZA200106592B (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002072549A1 (en) * | 2001-03-12 | 2002-09-19 | Millennium Pharmaceuticals, Inc. | Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor |
| EP1379239B1 (en) * | 2001-03-29 | 2007-09-12 | Eli Lilly And Company | N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor |
| WO2003035650A1 (fr) * | 2001-09-25 | 2003-05-01 | Takeda Chemical Industries, Ltd. | Inhibiteur d'entree |
| JP4736043B2 (ja) | 2003-03-14 | 2011-07-27 | 小野薬品工業株式会社 | 含窒素複素環誘導体およびそれらを有効成分とする薬剤 |
| WO2004092169A1 (ja) | 2003-04-18 | 2004-10-28 | Ono Pharmaceutical Co., Ltd. | スピロピペリジン化合物およびその医薬用途 |
| TWI400232B (zh) | 2004-09-13 | 2013-07-01 | Ono Pharmaceutical Co | 含氮雜環衍生物及以該含氮雜環衍生物為有效成分之藥劑 |
| JPWO2006129679A1 (ja) | 2005-05-31 | 2009-01-08 | 小野薬品工業株式会社 | スピロピペリジン化合物およびその医薬用途 |
| WO2007031838A1 (en) | 2005-09-16 | 2007-03-22 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
| EP2657235A1 (en) | 2005-10-28 | 2013-10-30 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
| ES2407115T3 (es) | 2005-11-18 | 2013-06-11 | Ono Pharmaceutical Co., Ltd. | Compuesto que contiene un grupo básico y uso del mismo |
| CN101460458A (zh) | 2006-02-15 | 2009-06-17 | 阿勒根公司 | 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物 |
| NZ570528A (en) * | 2006-02-15 | 2011-09-30 | Allergan Inc | Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity |
| AU2007225836A1 (en) | 2006-03-10 | 2007-09-20 | Ono Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient |
| US8618122B2 (en) | 2006-05-16 | 2013-12-31 | Ono Pharmaceutical Co., Ltd. | Compound having acidic group which may be protected, and use thereof |
| EP2036889A4 (en) * | 2006-05-23 | 2009-11-04 | Alla Chem Llc | SUBSTITUTED INDOLES AND PROCESS FOR PRODUCTION AND USE THEREOF |
| JP5245827B2 (ja) | 2006-07-31 | 2013-07-24 | 小野薬品工業株式会社 | スピロ結合した環状基を含有する化合物およびその用途 |
| US8524917B2 (en) | 2007-01-11 | 2013-09-03 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| JP2010515750A (ja) * | 2007-01-11 | 2010-05-13 | アラーガン インコーポレイテッド | スフィンゴシン−１−ホスフェート（ｓ１ｐ）受容体アンタゴニスト生物活性を有する６−置換インドール−３−カルボン酸アミド化合物 |
| WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
| CA2799154A1 (en) | 2010-05-12 | 2011-11-17 | Abbvie Inc. | Indazole inhibitors of kinase |
| US20140271680A1 (en) | 2011-08-12 | 2014-09-18 | Universite Paris-Est Creteil Val De Marne | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| CN104193669B (zh) * | 2014-08-01 | 2016-12-07 | 大连理工大学 | 一类阿比朵尔类似物或其盐、其制备方法及应用 |
| WO2016112088A1 (en) * | 2015-01-06 | 2016-07-14 | Spero Therapeutics, Inc. | Aryloxyacetylindoles and analogs as antibiotic tolerance inhibitors |
| CN110256324A (zh) * | 2019-06-13 | 2019-09-20 | 苏州莱安医药化学技术有限公司 | 一种2-甲基-5-羟基吲哚的制备方法 |
| US11629196B2 (en) | 2020-04-27 | 2023-04-18 | Incelldx, Inc. | Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3549641A (en) * | 1966-06-28 | 1970-12-22 | Warner Lambert Pharmaceutical | Pyrano pyridines and process for their production |
| US3518258A (en) * | 1967-05-09 | 1970-06-30 | Warner Lambert Pharmaceutical | Pyrano(3,2-i)quinolizine and process for the production |
| US3565903A (en) * | 1967-11-24 | 1971-02-23 | Warner Lambert Pharmaceutical | Pyrano(2,3-b)quinolines and process for their production |
| US5635510A (en) * | 1993-05-06 | 1997-06-03 | Merrell Pharmaceuticals Inc. | Substituted pyrrolidin-3-yl-alkyl-piperidines |
| HRP960352A2 (en) * | 1996-07-26 | 1998-08-31 | Pliva Pharm & Chem Works | Novel coumarin quinoline carboxylic acids |
| CN1248968A (zh) * | 1997-02-26 | 2000-03-29 | 辉瑞大药厂 | 杂芳基－己酸酰胺衍生物、其制备方法及其作为MIP－1α与其CCRI受体结合的选择性抑制剂的用途 |
| JP2002501898A (ja) * | 1998-02-02 | 2002-01-22 | メルク エンド カムパニー インコーポレーテッド | ケモカイン受容体活性の環状アミン調節剤 |
-
1999
- 1999-12-20 MX MXPA01007033A patent/MXPA01007033A/es unknown
- 1999-12-20 OA OA1200100187A patent/OA11820A/en unknown
- 1999-12-20 JP JP2000593612A patent/JP2002534526A/ja active Pending
- 1999-12-20 PL PL99349348A patent/PL349348A1/xx not_active Application Discontinuation
- 1999-12-20 IL IL14428999A patent/IL144289A0/xx unknown
- 1999-12-20 CZ CZ20012502A patent/CZ20012502A3/cs unknown
- 1999-12-20 CN CN99816475A patent/CN1344270A/zh active Pending
- 1999-12-20 WO PCT/US1999/030434 patent/WO2000042045A2/en not_active Application Discontinuation
- 1999-12-20 KR KR1020017008905A patent/KR20010086166A/ko not_active Application Discontinuation
- 1999-12-20 CA CA002372197A patent/CA2372197A1/en not_active Abandoned
- 1999-12-20 AU AU19409/00A patent/AU1940900A/en not_active Abandoned
- 1999-12-20 AP APAP/P/2001/002228A patent/AP2001002228A0/en unknown
- 1999-12-20 EA EA200100774A patent/EA200100774A1/ru unknown
- 1999-12-20 HU HU0202932A patent/HUP0202932A3/hu unknown
- 1999-12-20 BR BR9916905-3A patent/BR9916905A/pt not_active Application Discontinuation
- 1999-12-20 EP EP99963110A patent/EP1144415A2/en not_active Withdrawn
- 1999-12-20 SK SK997-2001A patent/SK9972001A3/sk unknown
-
2001
- 2001-07-12 NO NO20013456A patent/NO20013456L/no not_active Application Discontinuation
- 2001-08-10 ZA ZA200106592A patent/ZA200106592B/en unknown
-
2002
- 2002-08-28 HK HK02106357.2A patent/HK1044539A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA01007033A (es) | 2003-07-21 |
| AU1940900A (en) | 2000-08-01 |
| SK9972001A3 (en) | 2002-03-05 |
| OA11820A (en) | 2005-08-17 |
| IL144289A0 (en) | 2002-05-23 |
| BR9916905A (pt) | 2002-01-29 |
| PL349348A1 (en) | 2002-07-15 |
| CN1344270A (zh) | 2002-04-10 |
| NO20013456D0 (no) | 2001-07-12 |
| JP2002534526A (ja) | 2002-10-15 |
| EA200100774A1 (ru) | 2002-02-28 |
| EP1144415A2 (en) | 2001-10-17 |
| WO2000042045A2 (en) | 2000-07-20 |
| ZA200106592B (en) | 2002-08-12 |
| CZ20012502A3 (cs) | 2002-03-13 |
| HUP0202932A3 (en) | 2003-07-28 |
| WO2000042045A3 (en) | 2000-11-09 |
| NO20013456L (no) | 2001-09-12 |
| HK1044539A1 (zh) | 2002-10-25 |
| AP2001002228A0 (en) | 2001-09-30 |
| KR20010086166A (ko) | 2001-09-08 |
| HUP0202932A2 (hu) | 2002-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |