BR9916905A - Composto, composição farmacêutica, métodos para modular a atividade de um receptor de quimiocina, para prevenir infecção por hiv, tratar infecção por hiv, retardar o ìnicio de aids, ou tratar aids e para tratar uma doença inflamatória, e, combinação - Google Patents

Composto, composição farmacêutica, métodos para modular a atividade de um receptor de quimiocina, para prevenir infecção por hiv, tratar infecção por hiv, retardar o ìnicio de aids, ou tratar aids e para tratar uma doença inflamatória, e, combinação

Info

Publication number
BR9916905A
BR9916905A BR9916905-3A BR9916905A BR9916905A BR 9916905 A BR9916905 A BR 9916905A BR 9916905 A BR9916905 A BR 9916905A BR 9916905 A BR9916905 A BR 9916905A
Authority
BR
Brazil
Prior art keywords
treat
aids
hiv infection
activity
chemokine receptor
Prior art date
Application number
BR9916905-3A
Other languages
English (en)
Inventor
Geraldine C Harriman
Christine Nylund Kolz
Jay R Luly
Bruce David Roth
Yuntao Song
Bharat Kalidas Trivedi
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Publication of BR9916905A publication Critical patent/BR9916905A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA MéTODOS PARA MODULAR A ATIVIDADE DE UM RECEPTOR DE QUIMIOCINA, PARA PREVENIR INFECçãO POR HIV, TRATAR INFECçãO POR HIV, RETARDAR O INìCIO DE AIDS, OU TRATAR AIDS E PARA TRATAR UMA DOENçA INFLAMATóRIA, E, COMBINAçãO". A presente invenção consiste de uma série inédita de heterociclos funcionalizados como moduladores de receptor de quimiocina de fórmula I úteis como moduladores de atividade de receptor de quimiocina. Os compostos são úteis no tratamento e na prevenção do vírus da AIDS. Também se ensina intermediários úteis na preparação dos produtos finais, composições farmacêuticas contendo os produtos finais.
BR9916905-3A 1999-01-13 1999-12-20 Composto, composição farmacêutica, métodos para modular a atividade de um receptor de quimiocina, para prevenir infecção por hiv, tratar infecção por hiv, retardar o ìnicio de aids, ou tratar aids e para tratar uma doença inflamatória, e, combinação BR9916905A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11565499P 1999-01-13 1999-01-13
PCT/US1999/030434 WO2000042045A2 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators

Publications (1)

Publication Number Publication Date
BR9916905A true BR9916905A (pt) 2002-01-29

Family

ID=22362668

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916905-3A BR9916905A (pt) 1999-01-13 1999-12-20 Composto, composição farmacêutica, métodos para modular a atividade de um receptor de quimiocina, para prevenir infecção por hiv, tratar infecção por hiv, retardar o ìnicio de aids, ou tratar aids e para tratar uma doença inflamatória, e, combinação

Country Status (20)

Country Link
EP (1) EP1144415A2 (pt)
JP (1) JP2002534526A (pt)
KR (1) KR20010086166A (pt)
CN (1) CN1344270A (pt)
AP (1) AP2001002228A0 (pt)
AU (1) AU1940900A (pt)
BR (1) BR9916905A (pt)
CA (1) CA2372197A1 (pt)
CZ (1) CZ20012502A3 (pt)
EA (1) EA200100774A1 (pt)
HK (1) HK1044539A1 (pt)
HU (1) HUP0202932A3 (pt)
IL (1) IL144289A0 (pt)
MX (1) MXPA01007033A (pt)
NO (1) NO20013456L (pt)
OA (1) OA11820A (pt)
PL (1) PL349348A1 (pt)
SK (1) SK9972001A3 (pt)
WO (1) WO2000042045A2 (pt)
ZA (1) ZA200106592B (pt)

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WO2002072549A1 (en) * 2001-03-12 2002-09-19 Millennium Pharmaceuticals, Inc. Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
AU2002303094B2 (en) * 2001-03-29 2006-11-23 Eli Lilly And Company N-(2-arylethyl)benzylamines as antagonists of the 5-HT6 receptor
WO2003035650A1 (fr) * 2001-09-25 2003-05-01 Takeda Chemical Industries, Ltd. Inhibiteur d'entree
BRPI0408332A (pt) 2003-03-14 2006-03-21 Ono Pharmaceutical Co derivados heterocìclicos contendo nitrogênio e medicamentos contendo os mesmos como ingrediente ativo
US7498323B2 (en) 2003-04-18 2009-03-03 Ono Pharmaceuticals Co., Ltd. Spiro-piperidine compounds and medicinal use thereof
CN101775013A (zh) 2004-09-13 2010-07-14 小野药品工业株式会社 含氮杂环衍生物及含有其作为活性成分的药物
WO2006129679A1 (ja) 2005-05-31 2006-12-07 Ono Pharmaceutical Co., Ltd. スピロピペリジン化合物およびその医薬用途
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
PL1942108T3 (pl) 2005-10-28 2014-03-31 Ono Pharmaceutical Co Związek zawierający grupę zasadową i jego zastosowanie
ES2407115T3 (es) 2005-11-18 2013-06-11 Ono Pharmaceutical Co., Ltd. Compuesto que contiene un grupo básico y uso del mismo
WO2007095561A2 (en) * 2006-02-15 2007-08-23 Allergan, Inc. Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
CN101460458A (zh) 2006-02-15 2009-06-17 阿勒根公司 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物
WO2007105637A1 (ja) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. 含窒素複素環誘導体およびそれらを有効成分とする薬剤
JP5257068B2 (ja) 2006-05-16 2013-08-07 小野薬品工業株式会社 保護されていてもよい酸性基を含有する化合物およびその用途
EA016633B1 (ru) * 2006-05-23 2012-06-29 Общество С Ограниченной Ответственностью "Инновационная Фармацевтика" Замещенные индолы, способ их получения и применения
EP2055705A4 (en) 2006-07-31 2014-08-20 Ono Pharmaceutical Co COMPOUND WITH A CYCLIC GROUP BOUND BY A SPIRO BINDING THEREOF AND APPLY THEREOF
US8524917B2 (en) 2007-01-11 2013-09-03 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
KR20090101307A (ko) * 2007-01-11 2009-09-24 알러간, 인코포레이티드 스핑고신-1-포스페이트(ｓ1ｐ) 수용체 길항제 생물학적 활성을 갖는 6-치환된 인돌-3-카르복실산 아미드 화합물
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
EP2569301A1 (en) 2010-05-12 2013-03-20 Abbvie Inc. Indazole inhibitors of kinase
EP2741777B1 (en) 2011-08-12 2017-01-18 INSERM - Institut National de la Santé et de la Recherche Médicale Methods and pharmaceutical compositions for treatment of pulmonary hypertension
JO3459B1 (ar) 2012-09-09 2020-07-05 H Lundbeck As تركيبات صيدلانية لعلاج مرض الزهايمر
CN104193669B (zh) * 2014-08-01 2016-12-07 大连理工大学 一类阿比朵尔类似物或其盐、其制备方法及应用
WO2016112088A1 (en) * 2015-01-06 2016-07-14 Spero Therapeutics, Inc. Aryloxyacetylindoles and analogs as antibiotic tolerance inhibitors
CN110256324A (zh) * 2019-06-13 2019-09-20 苏州莱安医药化学技术有限公司 一种2-甲基-5-羟基吲哚的制备方法

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US3518258A (en) * 1967-05-09 1970-06-30 Warner Lambert Pharmaceutical Pyrano(3,2-i)quinolizine and process for the production
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Also Published As

Publication number Publication date
AU1940900A (en) 2000-08-01
SK9972001A3 (en) 2002-03-05
EP1144415A2 (en) 2001-10-17
JP2002534526A (ja) 2002-10-15
CZ20012502A3 (cs) 2002-03-13
KR20010086166A (ko) 2001-09-08
HK1044539A1 (zh) 2002-10-25
NO20013456D0 (no) 2001-07-12
CN1344270A (zh) 2002-04-10
WO2000042045A3 (en) 2000-11-09
IL144289A0 (en) 2002-05-23
MXPA01007033A (es) 2003-07-21
AP2001002228A0 (en) 2001-09-30
EA200100774A1 (ru) 2002-02-28
WO2000042045A2 (en) 2000-07-20
HUP0202932A2 (hu) 2002-12-28
OA11820A (en) 2005-08-17
HUP0202932A3 (en) 2003-07-28
PL349348A1 (en) 2002-07-15
ZA200106592B (en) 2002-08-12
CA2372197A1 (en) 2000-07-20
NO20013456L (no) 2001-09-12

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]