WO2000042045A3 - Functionalized heterocycles as chemokine receptor modulators - Google Patents

Functionalized heterocycles as chemokine receptor modulators Download PDF

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Publication number
WO2000042045A3
WO2000042045A3 PCT/US1999/030434 US9930434W WO0042045A3 WO 2000042045 A3 WO2000042045 A3 WO 2000042045A3 US 9930434 W US9930434 W US 9930434W WO 0042045 A3 WO0042045 A3 WO 0042045A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemokine receptor
receptor modulators
useful
functionalized heterocycles
modulators
Prior art date
Application number
PCT/US1999/030434
Other languages
French (fr)
Other versions
WO2000042045A2 (en
Inventor
Geraldine C Harriman
Christine Nylund Kolz
Jay R Luly
Bruce David Roth
Yuntao Song
Bharat Kalidas Trivedi
Original Assignee
Warner Lambert Co
Geraldine C Harriman
Christine Nylund Kolz
Jay R Luly
Bruce David Roth
Yuntao Song
Bharat Kalidas Trivedi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EA200100774A priority Critical patent/EA200100774A1/en
Priority to EP99963110A priority patent/EP1144415A2/en
Priority to SK997-2001A priority patent/SK9972001A3/en
Priority to KR1020017008905A priority patent/KR20010086166A/en
Priority to HU0202932A priority patent/HUP0202932A3/en
Priority to AU19409/00A priority patent/AU1940900A/en
Priority to IL14428999A priority patent/IL144289A0/en
Priority to BR9916905-3A priority patent/BR9916905A/en
Application filed by Warner Lambert Co, Geraldine C Harriman, Christine Nylund Kolz, Jay R Luly, Bruce David Roth, Yuntao Song, Bharat Kalidas Trivedi filed Critical Warner Lambert Co
Priority to PL99349348A priority patent/PL349348A1/en
Priority to CA002372197A priority patent/CA2372197A1/en
Priority to APAP/P/2001/002228A priority patent/AP2001002228A0/en
Priority to JP2000593612A priority patent/JP2002534526A/en
Priority to MXPA01007033A priority patent/MXPA01007033A/en
Publication of WO2000042045A2 publication Critical patent/WO2000042045A2/en
Publication of WO2000042045A3 publication Critical patent/WO2000042045A3/en
Priority to NO20013456A priority patent/NO20013456L/en
Priority to HK02106357.2A priority patent/HK1044539A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems

Abstract

The present invention is a novel series of functionalized heterocycles as chemokine receptor modulators of Formula (I) useful as modulators of chemokine receptor activity. The compounds are useful in the treatment and prevention of the AIDS virus. Intermediates useful in the prepartion of the final products, pharmaceutical compositions containing the final products are also taught.
PCT/US1999/030434 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators WO2000042045A2 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
PL99349348A PL349348A1 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
EP99963110A EP1144415A2 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
CA002372197A CA2372197A1 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
HU0202932A HUP0202932A3 (en) 1999-01-13 1999-12-20 Heterocyclic compounds and pharmaceutical compositions can be used as chemokine receptor modulators
AU19409/00A AU1940900A (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
IL14428999A IL144289A0 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators
BR9916905-3A BR9916905A (en) 1999-01-13 1999-12-20 Compound, pharmaceutical composition, methods to modulate the activity of a chemokine receptor, to prevent HIV infection, to treat HIV infection, to delay the onset of AIDS, or to treat AIDS and to treat an inflammatory disease, and, combination
EA200100774A EA200100774A1 (en) 1999-01-13 1999-12-20 HYDRONIC
SK997-2001A SK9972001A3 (en) 1999-01-13 1999-12-20 Quinolizine derivative, pharmaceutical composition containing same and use thereof
KR1020017008905A KR20010086166A (en) 1999-01-13 1999-12-20 Functionalized Heterocycles as Chemokine Receptor Modulators
APAP/P/2001/002228A AP2001002228A0 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators.
JP2000593612A JP2002534526A (en) 1999-01-13 1999-12-20 Functionalized heterocycles as modulators of chemokine receptors
MXPA01007033A MXPA01007033A (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators.
NO20013456A NO20013456L (en) 1999-01-13 2001-07-12 Functionalized heterocycles as chemokine receptor modulators
HK02106357.2A HK1044539A1 (en) 1999-01-13 2002-08-28 Functionalized heterocycles as chemokine receptor modulators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11565499P 1999-01-13 1999-01-13
US60/115,654 1999-01-13

Publications (2)

Publication Number Publication Date
WO2000042045A2 WO2000042045A2 (en) 2000-07-20
WO2000042045A3 true WO2000042045A3 (en) 2000-11-09

Family

ID=22362668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/030434 WO2000042045A2 (en) 1999-01-13 1999-12-20 Functionalized heterocycles as chemokine receptor modulators

Country Status (20)

Country Link
EP (1) EP1144415A2 (en)
JP (1) JP2002534526A (en)
KR (1) KR20010086166A (en)
CN (1) CN1344270A (en)
AP (1) AP2001002228A0 (en)
AU (1) AU1940900A (en)
BR (1) BR9916905A (en)
CA (1) CA2372197A1 (en)
CZ (1) CZ20012502A3 (en)
EA (1) EA200100774A1 (en)
HK (1) HK1044539A1 (en)
HU (1) HUP0202932A3 (en)
IL (1) IL144289A0 (en)
MX (1) MXPA01007033A (en)
NO (1) NO20013456L (en)
OA (1) OA11820A (en)
PL (1) PL349348A1 (en)
SK (1) SK9972001A3 (en)
WO (1) WO2000042045A2 (en)
ZA (1) ZA200106592B (en)

Families Citing this family (25)

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Publication number Priority date Publication date Assignee Title
US6951848B2 (en) 2001-03-12 2005-10-04 Millennium Pharmaceuticals, Inc., Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
HU230322B1 (en) 2001-03-29 2016-01-28 Eli Lilly And Co. N-(2-arylethyl)-benzylamines as antagonists of the 5-ht6 receptor and pharmaceutical compositions containing them
WO2003035650A1 (en) * 2001-09-25 2003-05-01 Takeda Chemical Industries, Ltd. Entry inhibitor
TWI344955B (en) 2003-03-14 2011-07-11 Ono Pharmaceutical Co Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
US7498323B2 (en) 2003-04-18 2009-03-03 Ono Pharmaceuticals Co., Ltd. Spiro-piperidine compounds and medicinal use thereof
PE20060598A1 (en) 2004-09-13 2006-08-21 Ono Pharmaceutical Co HETEROCYCLE DERIVATIVE CONTAINING NITROGEN AS ANTAGONIST OF CCR5 CHEMOKINE
EP1889622A4 (en) 2005-05-31 2009-12-23 Ono Pharmaceutical Co Spiropiperidine compound and medicinal use thereof
US7915286B2 (en) 2005-09-16 2011-03-29 Ranbaxy Laboratories Limited Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors
WO2007049771A1 (en) 2005-10-28 2007-05-03 Ono Pharmaceutical Co., Ltd. Compound containing basic group and use thereof
ES2407115T3 (en) 2005-11-18 2013-06-11 Ono Pharmaceutical Co., Ltd. Compound containing a basic group and its use
CN101460458A (en) 2006-02-15 2009-06-17 阿勒根公司 Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
EP1984334B1 (en) * 2006-02-15 2014-04-09 Allergan, Inc. Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (s1p) receptor antagonist biological activity
EP1995246A4 (en) 2006-03-10 2010-11-17 Ono Pharmaceutical Co Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
JP5257068B2 (en) 2006-05-16 2013-08-07 小野薬品工業株式会社 Compound containing acidic group which may be protected and use thereof
WO2007136300A2 (en) * 2006-05-23 2007-11-29 Alla Chem, Llc Substituted indoles and a method for the production and use thereof
US20090325992A1 (en) 2006-07-31 2009-12-31 Ono Pharmaceutical Co., Ltd. Compound having cyclic group bound thereto through spiro binding and use thereof
US8524917B2 (en) 2007-01-11 2013-09-03 Allergan, Inc. 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
JP2010515750A (en) * 2007-01-11 2010-05-13 アラーガン インコーポレイテッド 6-Substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
CA2799154A1 (en) 2010-05-12 2011-11-17 Abbvie Inc. Indazole inhibitors of kinase
US20140271680A1 (en) 2011-08-12 2014-09-18 Universite Paris-Est Creteil Val De Marne Methods and pharmaceutical compositions for treatment of pulmonary hypertension
JO3459B1 (en) 2012-09-09 2020-07-05 H Lundbeck As Pharmaceutical compositions for treating alzheimer's disease
CN104193669B (en) * 2014-08-01 2016-12-07 大连理工大学 One class Abiduoer analog or its salt, its preparation method and application
WO2016112088A1 (en) * 2015-01-06 2016-07-14 Spero Therapeutics, Inc. Aryloxyacetylindoles and analogs as antibiotic tolerance inhibitors
CN110256324A (en) * 2019-06-13 2019-09-20 苏州莱安医药化学技术有限公司 A kind of preparation method of 2- methyl -5-OHi

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3518258A (en) * 1967-05-09 1970-06-30 Warner Lambert Pharmaceutical Pyrano(3,2-i)quinolizine and process for the production
US3549641A (en) * 1966-06-28 1970-12-22 Warner Lambert Pharmaceutical Pyrano pyridines and process for their production
US3565903A (en) * 1967-11-24 1971-02-23 Warner Lambert Pharmaceutical Pyrano(2,3-b)quinolines and process for their production
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
EP0820998A2 (en) * 1996-07-26 1998-01-28 PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo Novel coumarin quinolone carboxylic acids and processes for the preparation thereof
WO1998038167A1 (en) * 1997-02-26 1998-09-03 Pfizer Inc. Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
WO1999038514A1 (en) * 1998-02-02 1999-08-05 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3549641A (en) * 1966-06-28 1970-12-22 Warner Lambert Pharmaceutical Pyrano pyridines and process for their production
US3518258A (en) * 1967-05-09 1970-06-30 Warner Lambert Pharmaceutical Pyrano(3,2-i)quinolizine and process for the production
US3565903A (en) * 1967-11-24 1971-02-23 Warner Lambert Pharmaceutical Pyrano(2,3-b)quinolines and process for their production
US5635510A (en) * 1993-05-06 1997-06-03 Merrell Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines
EP0820998A2 (en) * 1996-07-26 1998-01-28 PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija dionicko drustvo Novel coumarin quinolone carboxylic acids and processes for the preparation thereof
WO1998038167A1 (en) * 1997-02-26 1998-09-03 Pfizer Inc. Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of mip-1-alpha binding to its ccr1 receptor
WO1999038514A1 (en) * 1998-02-02 1999-08-05 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. VON STRANDTMANN ET AL.: "Reaction of Phenolic Mannich Bases with Enamines. General Synthesis of Pyran-Containing Fused Ring Systems.", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 7, 1970, HETEROCORPORATION. PROVO., US, pages 1311 - 1319, XP002143638, ISSN: 0022-152X *

Also Published As

Publication number Publication date
KR20010086166A (en) 2001-09-08
CA2372197A1 (en) 2000-07-20
CZ20012502A3 (en) 2002-03-13
OA11820A (en) 2005-08-17
MXPA01007033A (en) 2003-07-21
HK1044539A1 (en) 2002-10-25
NO20013456D0 (en) 2001-07-12
HUP0202932A2 (en) 2002-12-28
JP2002534526A (en) 2002-10-15
EA200100774A1 (en) 2002-02-28
IL144289A0 (en) 2002-05-23
NO20013456L (en) 2001-09-12
PL349348A1 (en) 2002-07-15
WO2000042045A2 (en) 2000-07-20
AP2001002228A0 (en) 2001-09-30
AU1940900A (en) 2000-08-01
ZA200106592B (en) 2002-08-12
SK9972001A3 (en) 2002-03-05
EP1144415A2 (en) 2001-10-17
HUP0202932A3 (en) 2003-07-28
BR9916905A (en) 2002-01-29
CN1344270A (en) 2002-04-10

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