CZ2000531A3 - Method of prevention or therapy of estrogen-dependent diseases and disorders - Google Patents

Method of prevention or therapy of estrogen-dependent diseases and disorders

Info

Publication number
CZ2000531A3
CZ2000531A3 CZ2000531A CZ2000531A CZ2000531A3 CZ 2000531 A3 CZ2000531 A3 CZ 2000531A3 CZ 2000531 A CZ2000531 A CZ 2000531A CZ 2000531 A CZ2000531 A CZ 2000531A CZ 2000531 A3 CZ2000531 A3 CZ 2000531A3
Authority
CZ
Czechia
Prior art keywords
estrogen
disorders
therapy
prevention
dependent diseases
Prior art date
Application number
CZ2000531A
Other languages
English (en)
Other versions
CZ300929B6 (cs
Inventor
Donald P Mcdonnell
John Norris
Caroline Connor
Ashini Wijayaratne
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Publication of CZ2000531A3 publication Critical patent/CZ2000531A3/cs
Publication of CZ300929B6 publication Critical patent/CZ300929B6/cs

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CZ20000531A 1997-08-15 1998-08-14 Sloucenina pro použití pri lécení nebo prevenci estrogenem stimulované rakoviny CZ300929B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5588197P 1997-08-15 1997-08-15

Publications (2)

Publication Number Publication Date
CZ2000531A3 true CZ2000531A3 (en) 2001-05-16
CZ300929B6 CZ300929B6 (cs) 2009-09-16

Family

ID=22000784

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20000531A CZ300929B6 (cs) 1997-08-15 1998-08-14 Sloucenina pro použití pri lécení nebo prevenci estrogenem stimulované rakoviny

Country Status (21)

Country Link
US (1) US7307102B2 (cs)
EP (1) EP1019057B1 (cs)
JP (1) JP2001515038A (cs)
KR (1) KR20010022956A (cs)
CN (1) CN1275911A (cs)
AT (1) ATE411016T1 (cs)
AU (1) AU757206B2 (cs)
BR (1) BR9811946A (cs)
CA (1) CA2301032C (cs)
CZ (1) CZ300929B6 (cs)
DE (1) DE69840126D1 (cs)
EE (1) EE200000077A (cs)
ES (1) ES2312189T3 (cs)
HU (1) HUP0002852A3 (cs)
IL (1) IL134445A0 (cs)
NO (1) NO20000752D0 (cs)
NZ (1) NZ502738A (cs)
PL (1) PL338555A1 (cs)
RU (1) RU2214236C2 (cs)
UA (1) UA70925C2 (cs)
WO (1) WO1999008682A1 (cs)

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US6413533B1 (en) * 1998-05-07 2002-07-02 The University Of Tennessee Research Corporation Method for chemoprevention of prostate cancer
WO1999063980A1 (en) * 1998-06-12 1999-12-16 Ligand Pharmaceuticals Inc. Treatment of anti-estrogen resistant breast cancer using rxr modulators
GB9824207D0 (en) * 1998-11-04 1998-12-30 Zeneca Ltd Neurological disorders
JP4790178B2 (ja) * 1999-07-06 2011-10-12 アンドルシェルシュ・インコーポレイテッド 体重増加の処置方法および／または抑制方法
CO5271709A1 (es) 2000-01-12 2003-04-30 Pfizer Prod Inc Composiciones y procedimientos para el y tratamiento de afecciones que responden a estrogenos
US6417394B2 (en) * 2000-04-05 2002-07-09 Bristol Myers Squibb Pharma Company Specific salt forms of triphenylethylene derivatives as selective estrogen receptor modulators
US6528681B2 (en) * 2000-04-05 2003-03-04 Bristol-Meyers Squibb Pharma Company Halogenated triphenylethylene derivatives as selective estrogen receptor modulators
WO2002002006A1 (en) * 2000-07-05 2002-01-10 Seely Andrew J E Method and apparatus for multiple patient parameter variability analysis and display
DE60230017D1 (de) * 2001-02-15 2009-01-08 Janssen Pharmaceutica Nv Farnesyl-protein-transferase hemmer in kombination mit antiöstrogenen
US20020164581A1 (en) * 2001-03-12 2002-11-07 Chawnshang Chang Methods for identifying compounds that do not attenuate the protective effects of estrogen
EP1417169A2 (en) 2001-08-11 2004-05-12 Bristol-Myers Squibb Pharma Company Selective estrogen receptor modulators
US7560589B2 (en) * 2003-07-28 2009-07-14 Smithkline Beecham Corporation Cycloalkylidene compounds as modulators of estrogen receptor
JP4855396B2 (ja) 2004-06-23 2012-01-18 リビジョン セラピューティクス， インコーポレイテッド レチナール誘導体で眼科的な状態を処置するための方法および組成物
AU2005304822B2 (en) 2004-11-04 2008-10-16 Sirion Therapeutics, Inc. Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation
BRPI0518616A (pt) * 2004-12-08 2008-01-15 Sirion Therapeutics Inc métodos para tratar doenças relacionadas com retinol, degeneração ou distrofia macular e diabetes tipo i ou tipo ii
US20060264413A1 (en) * 2005-04-18 2006-11-23 Sri International Method and composition for inhibiting cell proliferation and angiogenesis
UA81382C2 (en) * 2005-07-11 2007-12-25 Composition for treating retinol-related diseases by modulation of retinol binding
CA2739378C (en) 2007-10-03 2016-06-21 Ottawa Hospital Research Institute Method and apparatus for monitoring physiological parameter variability over time for one or more organs
WO2009151683A2 (en) 2008-03-12 2009-12-17 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
WO2010057006A1 (en) 2008-11-13 2010-05-20 Link Medicine Corporation Azaquinolinone derivatives and uses thereof
DK2580210T5 (en) 2010-06-10 2017-06-19 Seragon Pharmaceuticals Inc ESTROGEN RECEPTOR MODULATORS AND APPLICATIONS THEREOF
US8853423B2 (en) 2010-06-17 2014-10-07 Seragon Pharmaceuticals, Inc. Indane estrogen receptor modulators and uses thereof
GB2483736B (en) 2010-09-16 2012-08-29 Aragon Pharmaceuticals Inc Estrogen receptor modulators and uses thereof
WO2013090829A1 (en) 2011-12-14 2013-06-20 Aragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
CN102532073A (zh) * 2011-12-30 2012-07-04 北京赛林泰医药技术有限公司 作为选择性雌激素受体调节剂的乙烯衍生物
CN102584687A (zh) * 2011-12-30 2012-07-18 北京赛林泰医药技术有限公司 作为选择性雌激素受体调节剂的乙烯衍生物
EP2828243B1 (en) 2012-03-20 2018-10-17 Seragon Pharmaceuticals, Inc. Estrogen receptor modulators and uses thereof
US20170166551A1 (en) * 2015-12-09 2017-06-15 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective estrogen receptor downregulator compounds
WO2019023481A1 (en) * 2017-07-28 2019-01-31 Zeno Royalties & Milestones, LLC ANALOGUES OF ACRYLIC ACID

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BE637389A (cs) 1962-09-13
GB1029221A (en) 1963-09-02 1966-05-11 Ici Ltd Triarylalkane derivatives
GB1079747A (en) 1965-07-07 1967-08-16 Ici Ltd Alkene derivatives
US3637856A (en) 1965-07-12 1972-01-25 Ici Ltd Trans-1-p-(dialkylaminoalkyl) phenyl-1 2-diphenyl-alk-1-enes and salts thereof
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HU178253B (en) 1979-08-15 1982-04-28 Gyogyszerkutato Intezet Process for preparing 1,1,2-triphenyl-propane and -propane derivatives
DE3046719C2 (de) 1980-12-11 1983-02-17 Klinge Pharma GmbH, 8000 München 1,1,2-Triphenyl-but-1-en-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
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US5491173A (en) * 1982-06-25 1996-02-13 Orion-Yhtyma Oy Tri-phenyl alkene derivatives and their preparation and use
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US4760053A (en) 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
US4729999A (en) 1984-10-12 1988-03-08 Bcm Technologies Antiestrogen therapy for symptoms of estrogen deficiency
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DE3736682A1 (de) 1987-10-29 1989-05-11 Klinge Co Chem Pharm Fab Verfahren zur herstellung von trans-1,1,2-triphenyl-but-1-en-derivaten
US5393785A (en) * 1988-10-31 1995-02-28 Endorecherche, Inc. Therapeutic antiestrogens
US5119827A (en) 1990-09-05 1992-06-09 Board Of Regents, The University Of Texas System Mechanisms of antiestrogen resistance in breast cancer
US5189212A (en) * 1990-09-07 1993-02-23 University Of Georgia Research Foundation, Inc. Triarylethylene carboxylic acids with estrogenic activity
JPH06504522A (ja) 1990-10-01 1994-05-26 ボード　オブ　リージェンツ，　ザ　ユニバーシティ　オブ　テキサス　システム 高親和性タモキシフェン誘導体とその使用
CA2109426A1 (en) 1991-04-30 1992-10-31 Hiroyuki Kouji Triphenylethylene derivative and pharmaceutical drug containing the same
JPH09500863A (ja) * 1992-09-15 1997-01-28 メレル ダウ ファーマスーティカルズ インコーポレイテッド タモキシフェン抵抗性腫瘍の処置用の非代謝性クロミフェン類似体類
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Also Published As

Publication number Publication date
KR20010022956A (ko) 2001-03-26
WO1999008682A1 (en) 1999-02-25
US7307102B2 (en) 2007-12-11
JP2001515038A (ja) 2001-09-18
EP1019057A4 (en) 2006-06-14
HUP0002852A3 (en) 2001-11-28
ATE411016T1 (de) 2008-10-15
CA2301032A1 (en) 1999-02-25
PL338555A1 (en) 2000-11-06
IL134445A0 (en) 2001-04-30
RU2214236C2 (ru) 2003-10-20
US20030232795A1 (en) 2003-12-18
AU8906398A (en) 1999-03-08
NO20000752L (no) 2000-02-15
UA70925C2 (uk) 2004-11-15
EP1019057A1 (en) 2000-07-19
CA2301032C (en) 2009-01-13
ES2312189T3 (es) 2009-02-16
NZ502738A (en) 2002-06-28
DE69840126D1 (de) 2008-11-27
CN1275911A (zh) 2000-12-06
AU757206B2 (en) 2003-02-06
CZ300929B6 (cs) 2009-09-16
HUP0002852A2 (hu) 2001-10-28
EP1019057B1 (en) 2008-10-15
NO20000752D0 (no) 2000-02-15
EE200000077A (et) 2000-12-15
BR9811946A (pt) 2000-08-22

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 19980814