BRPI0518616A - métodos para tratar doenças relacionadas com retinol, degeneração ou distrofia macular e diabetes tipo i ou tipo ii - Google Patents
métodos para tratar doenças relacionadas com retinol, degeneração ou distrofia macular e diabetes tipo i ou tipo iiInfo
- Publication number
- BRPI0518616A BRPI0518616A BRPI0518616-1A BRPI0518616A BRPI0518616A BR PI0518616 A BRPI0518616 A BR PI0518616A BR PI0518616 A BRPI0518616 A BR PI0518616A BR PI0518616 A BRPI0518616 A BR PI0518616A
- Authority
- BR
- Brazil
- Prior art keywords
- type
- methods
- macular degeneration
- retinol
- related diseases
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 title abstract 4
- 201000010099 disease Diseases 0.000 title abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 208000002780 macular degeneration Diseases 0.000 title abstract 4
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 title abstract 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 title abstract 2
- 229960003471 retinol Drugs 0.000 title abstract 2
- 235000020944 retinol Nutrition 0.000 title abstract 2
- 239000011607 retinol Substances 0.000 title abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 2
- 208000035719 Maculopathy Diseases 0.000 title 1
- 108010071690 Prealbumin Proteins 0.000 abstract 3
- 102000009190 Transthyretin Human genes 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000018127 Idiopathic intracranial hypertension Diseases 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 201000010934 exostosis Diseases 0.000 abstract 1
- 201000010930 hyperostosis Diseases 0.000 abstract 1
- 208000038015 macular disease Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000004845 protein aggregation Effects 0.000 abstract 1
- 208000001381 pseudotumor cerebri Diseases 0.000 abstract 1
- 102000029752 retinol binding Human genes 0.000 abstract 1
- 108091000053 retinol binding Proteins 0.000 abstract 1
- 238000009097 single-agent therapy Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/203—Retinoic acids ; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/16—Ophthalmology
- G01N2800/164—Retinal disorders, e.g. retinopathy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63444904P | 2004-12-08 | 2004-12-08 | |
US66092405P | 2005-03-10 | 2005-03-10 | |
US66090405P | 2005-03-11 | 2005-03-11 | |
US67240505P | 2005-04-18 | 2005-04-18 | |
US69851205P | 2005-07-11 | 2005-07-11 | |
PCT/US2005/044416 WO2006063128A2 (en) | 2004-12-08 | 2005-12-07 | Methods, assays and compositions for treating retinol-related diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518616A true BRPI0518616A (pt) | 2008-01-15 |
Family
ID=35735778
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518616-1A BRPI0518616A (pt) | 2004-12-08 | 2005-12-07 | métodos para tratar doenças relacionadas com retinol, degeneração ou distrofia macular e diabetes tipo i ou tipo ii |
BRPI0520207-8A BRPI0520207A2 (pt) | 2004-12-08 | 2005-12-07 | uso de uma quantidade eficaz de um primeiro composto, e, medicamento sistemicamente formulado |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0520207-8A BRPI0520207A2 (pt) | 2004-12-08 | 2005-12-07 | uso de uma quantidade eficaz de um primeiro composto, e, medicamento sistemicamente formulado |
Country Status (18)
Country | Link |
---|---|
US (3) | US20060135460A1 (pt) |
EP (3) | EP2289500A1 (pt) |
JP (3) | JP4178281B2 (pt) |
KR (2) | KR100971695B1 (pt) |
CN (3) | CN101072555B (pt) |
AU (3) | AU2005314039B2 (pt) |
BR (2) | BRPI0518616A (pt) |
CA (2) | CA2638753A1 (pt) |
EA (2) | EA011154B1 (pt) |
GB (1) | GB2421433B (pt) |
GE (1) | GEP20094644B (pt) |
IL (2) | IL182837A0 (pt) |
LV (1) | LV13666B (pt) |
MX (1) | MX2007006245A (pt) |
NO (2) | NO20073510L (pt) |
NZ (2) | NZ561148A (pt) |
SG (1) | SG144145A1 (pt) |
WO (1) | WO2006063128A2 (pt) |
Families Citing this family (61)
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US9228186B2 (en) | 2002-11-14 | 2016-01-05 | Thermo Fisher Scientific Inc. | Methods and compositions for selecting siRNA of improved functionality |
JP4869942B2 (ja) * | 2003-12-11 | 2012-02-08 | ベス・イスラエル・ディーコネス・メディカル・センター,インコーポレイテッド | インスリン感受性/抵抗性、糖尿病および肥満におけるrbp4 |
US7512436B2 (en) * | 2004-02-12 | 2009-03-31 | The Regents Of The University Of Michigan | Method of evaluating metabolism of the eye |
US7566808B2 (en) | 2004-02-17 | 2009-07-28 | President And Fellows Of Harvard College | Management of ophthalmologic disorders, including macular degeneration |
PL380611A1 (pl) * | 2004-02-17 | 2007-02-19 | President And Fellows Of Harvard College | Postępowanie z zaburzeniami oftalmologicznymi, włącznie ze zwyrodnieniem plamki |
JP2007525496A (ja) * | 2004-02-17 | 2007-09-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 黄班変性症を含む眼科疾患の管理 |
CA2558766A1 (en) | 2004-03-05 | 2005-09-22 | The Trustees Of The University Of Pennsylvania | The use of mtp inhibitors for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects |
EP2277516A1 (en) | 2004-06-23 | 2011-01-26 | ReVision Therapeutics, Inc. | Retinyl derivatives for treating ophtalmic conditions |
EP1807103A4 (en) * | 2004-11-04 | 2009-02-11 | Sirion Therapeutics Inc | MODULATORS OF A COMPLEX RETINOL-RETINOL-BINDING PROTEIN-TRANSTHYRETINE FORMATION |
EA011154B1 (ru) * | 2004-12-08 | 2009-02-27 | Сирион Терапьютикс, Инк. | Композиции для лечения ретинол-ассоциированных заболеваний |
UA81382C2 (en) * | 2005-07-11 | 2007-12-25 | Composition for treating retinol-related diseases by modulation of retinol binding | |
EP1951224A2 (en) * | 2005-10-18 | 2008-08-06 | Aegerion Pharmaceuticals | Methods for treating disorders associated with hyperlipidemia in a mammal |
US20090042835A1 (en) * | 2006-06-02 | 2009-02-12 | Davis Roger A | Compositions and methods for ameliorating hyperlipidemia |
JP2010513534A (ja) * | 2006-12-21 | 2010-04-30 | エージェリオン ファーマシューティカルズ, インコーポレイテッド | Mtpインヒビターおよびコレステロール吸収インヒビターを含む組み合わせを用いて肥満症を処置する方法 |
WO2008131368A2 (en) * | 2007-04-20 | 2008-10-30 | Acucela Inc. | Styrenyl derivative compounds for treating ophthalmic diseases and disorders |
NZ601866A (en) | 2007-06-29 | 2013-12-20 | Acucela Inc | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders |
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CN101452001B (zh) * | 2007-12-06 | 2013-07-24 | 王颖 | 化学发光磁酶免疫法定量检测rbp4试剂盒 |
WO2009089380A2 (en) * | 2008-01-08 | 2009-07-16 | The Trustees Of Columbia University In The City Of New York | Methods for p2ry5 mediated regulation of hair growth and mutants thereof |
CN103251631A (zh) * | 2008-05-13 | 2013-08-21 | 根梅迪卡治疗公司 | 用于治疗代谢性病症的水杨酸盐(酯)缀合物 |
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US8431356B2 (en) | 2009-01-22 | 2013-04-30 | Regents Of The University Of Minnesota | Fluorescence resonance energy transfer assays for sarco/endoplasmic reticulum calcium atpase and phospholamban |
CA2755069A1 (en) * | 2009-03-16 | 2010-09-23 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
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ES2549916T3 (es) * | 2009-05-04 | 2015-11-03 | Acucela, Inc. | Composiciones para usar en el tratamiento de glaucoma o hipertensión ocular |
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CA2783699C (en) | 2009-12-08 | 2019-01-15 | Case Western Reserve University | Primary amine compounds for treating ocular disorders |
CA2792291A1 (en) * | 2010-03-29 | 2011-10-06 | Kumamoto University | Sirna therapy for transthyretin (ttr) related ocular amyloidosis |
AU2015264811A1 (en) * | 2010-03-29 | 2016-01-07 | Alnylam Pharmaceuticals, Inc. | SiRNA therapy for transthyretin (TTR) related ocular amyloidosis |
EP2642998B1 (en) | 2010-11-24 | 2020-09-16 | The Trustees of Columbia University in the City of New York | A non-retinoid rbp4 antagonist for treatment of age-related macular degeneration and stargardt disease |
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KR101972610B1 (ko) * | 2011-05-18 | 2019-04-25 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 망막 질환을 치료하기 위한 조성물 및 방법 |
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US10273243B2 (en) | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
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