CZ130992A3 - Process of enzymatic hydrolysis of carboxylic acids derivatives - Google Patents
Process of enzymatic hydrolysis of carboxylic acids derivatives Download PDFInfo
- Publication number
- CZ130992A3 CZ130992A3 CS921309A CS130992A CZ130992A3 CZ 130992 A3 CZ130992 A3 CZ 130992A3 CS 921309 A CS921309 A CS 921309A CS 130992 A CS130992 A CS 130992A CZ 130992 A3 CZ130992 A3 CZ 130992A3
- Authority
- CZ
- Czechia
- Prior art keywords
- water
- solution
- organic
- hydrolase
- saturated
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 45
- 230000008569 process Effects 0.000 title claims abstract description 26
- 230000007071 enzymatic hydrolysis Effects 0.000 title claims description 8
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 title claims description 8
- 150000001735 carboxylic acids Chemical class 0.000 title claims description 5
- 238000006243 chemical reaction Methods 0.000 claims abstract description 92
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 83
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims abstract description 40
- 229920006395 saturated elastomer Polymers 0.000 claims abstract description 32
- 239000003960 organic solvent Substances 0.000 claims abstract description 24
- 230000007062 hydrolysis Effects 0.000 claims abstract description 21
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 21
- 108090001060 Lipase Proteins 0.000 claims description 66
- 239000004367 Lipase Substances 0.000 claims description 66
- 102000004882 Lipase Human genes 0.000 claims description 66
- 235000019421 lipase Nutrition 0.000 claims description 66
- 239000000203 mixture Substances 0.000 claims description 62
- 102000004157 Hydrolases Human genes 0.000 claims description 53
- 108090000604 Hydrolases Proteins 0.000 claims description 53
- 239000008346 aqueous phase Substances 0.000 claims description 41
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 31
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 16
- 239000012074 organic phase Substances 0.000 claims description 14
- 239000000017 hydrogel Substances 0.000 claims description 10
- 238000006053 organic reaction Methods 0.000 claims description 9
- 150000002148 esters Chemical class 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 5
- 150000007513 acids Chemical class 0.000 claims description 2
- -1 hydroxide ions Chemical class 0.000 claims 1
- 238000009738 saturating Methods 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 63
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 29
- 230000003287 optical effect Effects 0.000 description 27
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 26
- 230000000694 effects Effects 0.000 description 17
- 241000179532 [Candida] cylindracea Species 0.000 description 16
- 239000000047 product Substances 0.000 description 16
- 102000004190 Enzymes Human genes 0.000 description 14
- 108090000790 Enzymes Proteins 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 14
- 239000012071 phase Substances 0.000 description 14
- 239000002904 solvent Substances 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
- 239000007858 starting material Substances 0.000 description 11
- 239000007864 aqueous solution Substances 0.000 description 10
- NPSJHQMIVNJLNN-UHFFFAOYSA-N 2-ethylhexyl 4-nitrobenzoate Chemical compound CCCCC(CC)COC(=O)C1=CC=C([N+]([O-])=O)C=C1 NPSJHQMIVNJLNN-UHFFFAOYSA-N 0.000 description 8
- 239000004808 2-ethylhexylester Substances 0.000 description 8
- MONMFXREYOKQTI-REOHCLBHSA-N (2s)-2-bromopropanoic acid Chemical compound C[C@H](Br)C(O)=O MONMFXREYOKQTI-REOHCLBHSA-N 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 6
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 6
- GAWAYYRQGQZKCR-UHFFFAOYSA-N 2-chloropropionic acid Chemical compound CC(Cl)C(O)=O GAWAYYRQGQZKCR-UHFFFAOYSA-N 0.000 description 5
- 238000004821 distillation Methods 0.000 description 5
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Inorganic materials [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 5
- MONMFXREYOKQTI-UHFFFAOYSA-N 2-bromopropanoic acid Chemical compound CC(Br)C(O)=O MONMFXREYOKQTI-UHFFFAOYSA-N 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
- 150000001412 amines Chemical class 0.000 description 4
- 238000004587 chromatography analysis Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000001953 recrystallisation Methods 0.000 description 4
- 239000012047 saturated solution Substances 0.000 description 4
- 150000003573 thiols Chemical class 0.000 description 4
- PDCJRGQKSWSMCV-UHFFFAOYSA-N 2-ethylhexyl 2-chloropropanoate Chemical compound CCCCC(CC)COC(=O)C(C)Cl PDCJRGQKSWSMCV-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 241000453701 Galactomyces candidum Species 0.000 description 3
- 235000017388 Geotrichum candidum Nutrition 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- KATNUXHENWPMQJ-UHFFFAOYSA-N butyl 2-chloropropanoate Chemical compound CCCCOC(=O)C(C)Cl KATNUXHENWPMQJ-UHFFFAOYSA-N 0.000 description 3
- 150000001733 carboxylic acid esters Chemical class 0.000 description 3
- 150000001734 carboxylic acid salts Chemical class 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 239000006184 cosolvent Substances 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 239000012266 salt solution Substances 0.000 description 3
- MONMFXREYOKQTI-UWTATZPHSA-N (2r)-2-bromopropanoic acid Chemical compound C[C@@H](Br)C(O)=O MONMFXREYOKQTI-UWTATZPHSA-N 0.000 description 2
- CAMYLFUQIWAANE-UHFFFAOYSA-N 2-ethylhexyl 2-bromopropanoate Chemical compound CCCCC(CC)COC(=O)C(C)Br CAMYLFUQIWAANE-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 2
- 229920005654 Sephadex Polymers 0.000 description 2
- 239000012507 Sephadex™ Substances 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 229910000272 alkali metal oxide Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 2
- 150000007514 bases Chemical class 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 2
- 235000019626 lipase activity Nutrition 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000012064 sodium phosphate buffer Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 150000003566 thiocarboxylic acids Chemical class 0.000 description 2
- WAPNOHKVXSQRPX-SSDOTTSWSA-N (R)-1-phenylethanol Chemical compound C[C@@H](O)C1=CC=CC=C1 WAPNOHKVXSQRPX-SSDOTTSWSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- WAPNOHKVXSQRPX-UHFFFAOYSA-N 1-phenylethanol Chemical compound CC(O)C1=CC=CC=C1 WAPNOHKVXSQRPX-UHFFFAOYSA-N 0.000 description 1
- 108090000531 Amidohydrolases Proteins 0.000 description 1
- 102000004092 Amidohydrolases Human genes 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 108010015598 Chromobacterium viscosum lipase Proteins 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108010093096 Immobilized Enzymes Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 101001003495 Pseudomonas fluorescens Lipase Proteins 0.000 description 1
- 101001064559 Pseudomonas fluorescens Lipase Proteins 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 241000223258 Thermomyces lanuginosus Species 0.000 description 1
- 125000005396 acrylic acid ester group Chemical group 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- XPNGNIFUDRPBFJ-UHFFFAOYSA-N alpha-methylbenzylalcohol Natural products CC1=CC=CC=C1CO XPNGNIFUDRPBFJ-UHFFFAOYSA-N 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- 150000008422 chlorobenzenes Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 150000005690 diesters Chemical class 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 239000002920 hazardous waste Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- XVDQGLUGZORASO-UHFFFAOYSA-N propyl 2-chloropropanoate Chemical compound CCCOC(=O)C(C)Cl XVDQGLUGZORASO-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0088691A AT398081B (de) | 1991-04-29 | 1991-04-29 | Verfahren zur enzymatischen hydrolyse eines carbonsäurederivates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CZ130992A3 true CZ130992A3 (en) | 1994-01-19 |
Family
ID=3502090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS921309A CZ130992A3 (en) | 1991-04-29 | 1992-04-29 | Process of enzymatic hydrolysis of carboxylic acids derivatives |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5278054A (enExample) |
| EP (1) | EP0511526A1 (enExample) |
| JP (1) | JPH05130881A (enExample) |
| AT (1) | AT398081B (enExample) |
| AU (1) | AU662134B2 (enExample) |
| CA (1) | CA2065550A1 (enExample) |
| CZ (1) | CZ130992A3 (enExample) |
| DK (1) | DK0511526T3 (enExample) |
| HU (1) | HUT62940A (enExample) |
| NZ (1) | NZ242279A (enExample) |
| SK (1) | SK130992A3 (enExample) |
| ZA (1) | ZA923072B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU663549B2 (en) * | 1991-12-23 | 1995-10-12 | Genzyme Limited | Synthesis of homochiral 2-hydroxy acids |
| DE4328231C1 (de) * | 1993-08-23 | 1994-07-28 | Basf Ag | Verfahren zur Herstellung von (L)-2-Chlorpropionsäure und deren Salzen |
| DE19501452A1 (de) * | 1995-01-19 | 1996-07-25 | Basf Ag | Verfahren zur Herstellung von optisch aktiven 2-Halogenpropionsäuren |
| US6022977A (en) * | 1997-03-26 | 2000-02-08 | Dupont Pharmaceuticals Company | Dynamic resolution of isoxazoline thioesters to isoxazoline carboxylic acids |
| KR100378741B1 (ko) * | 2000-06-01 | 2003-04-07 | 에스케이 주식회사 | 효소를 이용하여 R-폼 또는 S-폼의 α-치환 헤테로싸이클릭 카르복실산 및 이와 상반되는 광학특성을 갖는 α-치환 헤테로싸이클릭 카르복실산 에스테르를 제조하는 방법 |
| CA2410438A1 (en) * | 2000-06-01 | 2001-12-06 | Sk Corporation | Method for optically resolving a racemic alpha-substituted heterocyclic carboxylic acid using enzyme |
| JP5266875B2 (ja) * | 2008-05-23 | 2013-08-21 | 三菱瓦斯化学株式会社 | 有機カルボン酸エステルからの光学活性有機カルボン酸の製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4601987A (en) * | 1985-02-27 | 1986-07-22 | Massachusetts Institute Of Technology | Enzymatic production of optical isomers of 2-halopropionic acids |
| US4668628A (en) * | 1985-04-01 | 1987-05-26 | Stauffer Chemical Company | Resolution of racemic mixtures of aliphatic acid esters |
| JPS6352896A (ja) * | 1986-08-22 | 1988-03-07 | ストウフア− ケミカル カンパニ− | リパ−ゼ酵素反応の実施方法 |
| US5032523A (en) * | 1987-01-14 | 1991-07-16 | Lion Corporation | Preparation of optically active esters |
| US4800162A (en) * | 1987-04-01 | 1989-01-24 | Sepracor, Inc. | Method for resolution of steroisomers in multiphase and extractive membrane reactors |
| US5057427A (en) * | 1988-04-07 | 1991-10-15 | Sepracor, Inc. | Method for resolution of stereoisomers |
| US5108916A (en) * | 1989-06-05 | 1992-04-28 | Rhone-Poulenc Rorer, S.A. | Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa |
-
1991
- 1991-04-29 AT AT0088691A patent/AT398081B/de not_active IP Right Cessation
-
1992
- 1992-04-07 CA CA002065550A patent/CA2065550A1/en not_active Abandoned
- 1992-04-08 EP EP92106039A patent/EP0511526A1/de not_active Withdrawn
- 1992-04-08 DK DK92106039.8T patent/DK0511526T3/da active
- 1992-04-08 NZ NZ242279A patent/NZ242279A/xx unknown
- 1992-04-17 US US07/870,429 patent/US5278054A/en not_active Expired - Fee Related
- 1992-04-21 AU AU15024/92A patent/AU662134B2/en not_active Ceased
- 1992-04-28 HU HU9201412A patent/HUT62940A/hu unknown
- 1992-04-28 ZA ZA923072A patent/ZA923072B/xx unknown
- 1992-04-28 JP JP4110468A patent/JPH05130881A/ja not_active Withdrawn
- 1992-04-29 CZ CS921309A patent/CZ130992A3/cs unknown
- 1992-04-29 SK SK1309-92A patent/SK130992A3/sk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA923072B (en) | 1992-12-30 |
| AU662134B2 (en) | 1995-08-24 |
| DK0511526T3 (enExample) | 1992-11-04 |
| JPH05130881A (ja) | 1993-05-28 |
| US5278054A (en) | 1994-01-11 |
| ATA88691A (de) | 1994-01-15 |
| CA2065550A1 (en) | 1992-10-30 |
| EP0511526A1 (de) | 1992-11-04 |
| SK130992A3 (en) | 1995-08-09 |
| NZ242279A (en) | 1993-02-25 |
| HU9201412D0 (en) | 1992-07-28 |
| HUT62940A (en) | 1993-06-28 |
| AT398081B (de) | 1994-09-26 |
| AU1502492A (en) | 1992-11-05 |
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