CZ117294A3 - Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised - Google Patents

Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised Download PDF

Info

Publication number
CZ117294A3
CZ117294A3 CZ941172A CZ117294A CZ117294A3 CZ 117294 A3 CZ117294 A3 CZ 117294A3 CZ 941172 A CZ941172 A CZ 941172A CZ 117294 A CZ117294 A CZ 117294A CZ 117294 A3 CZ117294 A3 CZ 117294A3
Authority
CZ
Czechia
Prior art keywords
group
carbon atoms
straight
branched
different
Prior art date
Application number
CZ941172A
Other languages
Czech (cs)
English (en)
Inventor
Peter Dr Fey
Walter Dr Hubsch
Jurgen Dr Dressel
Rudolf Dr Hanko
Thomas Dr Kramer
Ulrich Dr Muller
Matthias Dr Muller-Gliemann
Martin Dr Beuck
Hilmar Dr Bischoff
Stefan Dr Wohlfeil
Dirk Dr Denzer
Stanislav Prof Dr Kazda
Johannes-Peter Dr Stasch
Andreas Dr Knorr
Siegfried Dr Zaiss
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of CZ117294A3 publication Critical patent/CZ117294A3/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CZ941172A 1993-05-13 1994-05-12 Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised CZ117294A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4316077A DE4316077A1 (de) 1993-05-13 1993-05-13 Substituierte Mono- und Bihydridylmethylpyridone

Publications (1)

Publication Number Publication Date
CZ117294A3 true CZ117294A3 (en) 1994-11-16

Family

ID=6488035

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ941172A CZ117294A3 (en) 1993-05-13 1994-05-12 Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised

Country Status (21)

Country Link
US (1) US5407948A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0624583B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH06329669A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1102648A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE155782T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU672679B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2123243A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ117294A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE4316077A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0624583T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2105408T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI942160L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3024465T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT70485A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL109604A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO941770L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ260490A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH30908A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK55694A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW245718B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA943246B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
AU4956699A (en) 1998-06-19 2000-01-05 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
CA2476012C (en) * 2002-02-14 2011-04-19 Pharmacia Corporation Substituted pyridinones as modulators of p38 map kinase
US6946479B2 (en) * 2002-11-09 2005-09-20 The Procter & Gamble Company N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
US6930117B2 (en) * 2002-11-09 2005-08-16 The Procter & Gamble Company N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
ATE499362T1 (de) * 2005-08-29 2011-03-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind
CA2620269A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
AU2006284900A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
TWI417095B (zh) * 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
EP2205565B1 (en) * 2007-09-14 2013-04-17 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
NZ584145A (en) 2007-09-14 2012-03-30 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1,4'] bipyridinyl-2'-ones
DK2200985T3 (da) 2007-09-14 2011-10-24 Ortho Mcneil Janssen Pharm 1,3-Disubstituerede 4-(aryl--X-phenyl)-1H-pyridin-2-oner
JP5433582B2 (ja) * 2007-11-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． イミダゾ［１，２−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用
BRPI0918055A2 (pt) 2008-09-02 2015-12-01 Addex Pharmaceuticals Sa derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato.
JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
EP2373649B1 (en) 2008-11-28 2013-01-23 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
SG176021A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
PH12012500789A1 (en) 2009-11-06 2012-11-26 Aerpio Therapeutics Inc Prolyl hydroxylase inhibitors
JP5852665B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
AU2011328194B2 (en) 2010-11-08 2015-04-16 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
WO2012062759A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
SMT202100103T1 (it) 2014-01-21 2021-03-15 Janssen Pharmaceutica Nv Combinazione comprendente modulatori allosterici postivi del recettore glutammatergico metabotropico sottotipo 2 e loro utilizzo
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
MX2023009059A (es) 2021-02-02 2023-09-15 Liminal Biosciences Ltd Antagonistas de gpr84 y usos de estos.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5196537A (en) * 1991-03-21 1993-03-23 G. D. Searle & Co. 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
US5128327A (en) * 1991-03-25 1992-07-07 Merck & Co., Inc. Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle
US5164403A (en) * 1991-04-05 1992-11-17 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
US5155117A (en) * 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5332750A (en) * 1991-09-04 1994-07-26 Merck Patent Gesellschaft Mit Beschrankter Haftung 1,2-dihydro-2-oxopyridines
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
FI942160A0 (fi) 1994-05-10
ZA943246B (en) 1995-01-18
AU6056194A (en) 1994-11-17
IL109604A0 (en) 1994-08-26
AU672679B2 (en) 1996-10-10
HU9401417D0 (en) 1994-08-29
FI942160A7 (fi) 1994-11-14
DE4316077A1 (de) 1994-11-17
TW245718B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1995-04-21
DK0624583T3 (da) 1998-03-02
EP0624583A1 (de) 1994-11-17
EP0624583B1 (de) 1997-07-23
ES2105408T3 (es) 1997-10-16
FI942160L (fi) 1994-11-14
NO941770L (no) 1994-11-14
US5407948A (en) 1995-04-18
NZ260490A (en) 1995-12-21
NO941770D0 (no) 1994-05-11
ATE155782T1 (de) 1997-08-15
CN1102648A (zh) 1995-05-17
GR3024465T3 (en) 1997-11-28
PH30908A (en) 1997-12-23
HUT70485A (en) 1995-10-30
DE59403427D1 (de) 1997-08-28
JPH06329669A (ja) 1994-11-29
SK55694A3 (en) 1995-02-08
CA2123243A1 (en) 1994-11-14

Similar Documents

Publication Publication Date Title
CZ117294A3 (en) Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised
CZ15793A3 (en) Sulfonylbenzyl-substituted pyridones
CZ289096B6 (cs) Heterocyklicky substituované deriváty kyseliny fenyl-cyklohexankarboxylové, způsob jejich výroby, jejich pouľití a farmaceutický prostředek tyto látky obsahující
CZ72393A3 (en) Sulfonylbenzyl-substituted benzopyridones and pyridopyridones
CZ29793A3 (en) Phenylacetic acid substituted amides
CZ297692A3 (en) Substituted derivatives of imidazolyl-propenoic acid
CZ283482B6 (cs) Trisubstituované bifenyly
CZ72193A3 (en) Biphenylmethyl substituted pyridones
CZ297792A3 (en) Cyclically substituted derivatives of imidazolyl-propenoic acid
CZ298892A3 (en) Derivatives of imidazolyl-propenoic acid
CZ29693A3 (en) Imidazolyl-substituted amides of phenylacetic acid
PT610698E (pt) Imidazo(4,5-b)piridinas e benzimidazoles substituidos como antagonistas de anguitensina ii
CZ62494A3 (en) Hetero-tricyclically substituted derivatives of phenyl-cyclohexanecarboxylic acid, process of their preparation, medicaments in which they are comprised, process for preparing such medicaments and their use
CZ71094A3 (en) Phenylglycinamides of heterocyclically substituted derivatives of phenylacetic acid, process of their preparation, medicaments in which said derivatives are comprised, process of their preparation and use
JPH0748369A (ja) 置換モノピリジルメチルおよびビピリジルメチル誘導体
CZ51693A3 (en) Propenoyl-imidazole derivatives
US5492923A (en) Substituted pyridines and 2-oxo-1,2-dihydropyridines
CZ117493A3 (en) Imidazolyl-substituted derivatives of phenylpropionic and cinnamic acids
CZ117393A3 (en) Imidazolyl-substituted cyclohexane derivatives
US5414003A (en) Pyridinylmethyl-substituted pyridines and pyridones
CZ221693A3 (en) Alkoxymethyl-substituted pyridonebiphenyls
CZ15993A3 (en) Sulfonylbenzyl-substituted derivatives of imidazolylpropenoic acid
CZ15893A3 (en) Sulfonylbenzyl-substituted imidazoles
CZ16093A3 (en) Sulfonylbenzyl-substituted imidazopyridines
SK27593A3 (en) Cycloalkyl and heterocyclyl substituted derivatives of imidazolylpropenoic acid