DE4316077A1 - Substituierte Mono- und Bihydridylmethylpyridone - Google Patents

Substituierte Mono- und Bihydridylmethylpyridone

Info

Publication number
DE4316077A1
DE4316077A1 DE4316077A DE4316077A DE4316077A1 DE 4316077 A1 DE4316077 A1 DE 4316077A1 DE 4316077 A DE4316077 A DE 4316077A DE 4316077 A DE4316077 A DE 4316077A DE 4316077 A1 DE4316077 A1 DE 4316077A1
Authority
DE
Germany
Prior art keywords
carbon atoms
chain
straight
different
branched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4316077A
Other languages
German (de)
English (en)
Inventor
Peter Dr Fey
Walter Dr Huebsch
Juergen Dr Dressel
Rudolf Dr Hanko
Thomas Dr Kraemer
Ulrich Dr Mueller
Matthias Dr Mueller-Gliemann
Martin Dr Beuck
Hilmar Dr Bischoff
Stefan Dr Wohlfeil
Dirk Dr Denzer
Stanislav Prof Dr Kazda
Johannes-Peter Dr Stasch
Andreas Dr Knorr
Siegfried Dr Zaiss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Priority to DE4316077A priority Critical patent/DE4316077A1/de
Priority to TW083103408A priority patent/TW245718B/zh
Priority to AU60561/94A priority patent/AU672679B2/en
Priority to EP94106834A priority patent/EP0624583B1/de
Priority to DK94106834.8T priority patent/DK0624583T3/da
Priority to AT94106834T priority patent/ATE155782T1/de
Priority to ES94106834T priority patent/ES2105408T3/es
Priority to DE59403427T priority patent/DE59403427D1/de
Priority to US08/239,197 priority patent/US5407948A/en
Priority to HU9401417A priority patent/HUT70485A/hu
Priority to CA002123243A priority patent/CA2123243A1/en
Priority to IL10960494A priority patent/IL109604A0/xx
Priority to FI942160A priority patent/FI942160L/fi
Priority to JP6120653A priority patent/JPH06329669A/ja
Priority to NZ260490A priority patent/NZ260490A/en
Priority to SK556-94A priority patent/SK55694A3/sk
Priority to PH48253A priority patent/PH30908A/en
Priority to ZA943246A priority patent/ZA943246B/xx
Priority to NO941770A priority patent/NO941770L/no
Priority to CZ941172A priority patent/CZ117294A3/cs
Priority to CN94105814A priority patent/CN1102648A/zh
Publication of DE4316077A1 publication Critical patent/DE4316077A1/de
Priority to GR970402103T priority patent/GR3024465T3/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE4316077A 1993-05-13 1993-05-13 Substituierte Mono- und Bihydridylmethylpyridone Withdrawn DE4316077A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE4316077A DE4316077A1 (de) 1993-05-13 1993-05-13 Substituierte Mono- und Bihydridylmethylpyridone
TW083103408A TW245718B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-05-13 1994-04-18
AU60561/94A AU672679B2 (en) 1993-05-13 1994-04-19 Substituted mono- and bipyridylmethylpyridones
EP94106834A EP0624583B1 (de) 1993-05-13 1994-05-02 Substituierte Pyridylmethylpyridone als Angiotensin II Antagonisten
DK94106834.8T DK0624583T3 (da) 1993-05-13 1994-05-02 Substituerede pyridylmethylpyridoner som angiotensin II-antagonister
AT94106834T ATE155782T1 (de) 1993-05-13 1994-05-02 Substituierte pyridylmethylpyridone als angiotensin ii antagonisten
ES94106834T ES2105408T3 (es) 1993-05-13 1994-05-02 Piridilmetilpiridonas sustituidas como antagonistas de angiotensina ii.
DE59403427T DE59403427D1 (de) 1993-05-13 1994-05-02 Substituierte Pyridylmethylpyridone als Angiotensin II Antagonisten
US08/239,197 US5407948A (en) 1993-05-13 1994-05-06 Substituted mono- and bipyridylmethylpyridones
HU9401417A HUT70485A (en) 1993-05-13 1994-05-06 Substituted mono- and bipyridyl-methyl-pyridone derivatives and process for producing them
IL10960494A IL109604A0 (en) 1993-05-13 1994-05-10 Substituted mono- and bipyridylmethyl- pyridones, process for their preparation and pharmaceutical compositions containing them
CA002123243A CA2123243A1 (en) 1993-05-13 1994-05-10 Substituted mono- and bipyridylmethylpyridones
FI942160A FI942160L (fi) 1993-05-13 1994-05-10 Substituoituja mono- ja bipyridyylimetyylipyridoneja
JP6120653A JPH06329669A (ja) 1993-05-13 1994-05-10 置換モノ−およびビピリジルメチルピリドン類
NZ260490A NZ260490A (en) 1993-05-13 1994-05-10 Mono- and bi-pyridyl methyl pyridone derivatives, preparation and pharmaceutical compositions thereof
ZA943246A ZA943246B (en) 1993-05-13 1994-05-11 Substituted mono- and bipyridylmethylpyridones
PH48253A PH30908A (en) 1993-05-13 1994-05-11 Substituted mono-and dipyridylmethyl pyridones.
SK556-94A SK55694A3 (en) 1993-05-13 1994-05-11 Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, method of their production, their using and treatments containing these matters
NO941770A NO941770L (no) 1993-05-13 1994-05-11 Substituert mono- og bipyridylmetylpyridon
CZ941172A CZ117294A3 (en) 1993-05-13 1994-05-12 Substituted monopyridylmethylpyridones and bipyridylmethylpyridones, process of their preparation, their use and pharmaceutical preparations in which they are comprised
CN94105814A CN1102648A (zh) 1993-05-13 1994-05-13 取代的单-和双-吡啶基甲基吡啶酮类化合物
GR970402103T GR3024465T3 (en) 1993-05-13 1997-08-14 Substituted mono- and bipyridylmethylpyridone as angiotensine II antagonists.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4316077A DE4316077A1 (de) 1993-05-13 1993-05-13 Substituierte Mono- und Bihydridylmethylpyridone

Publications (1)

Publication Number Publication Date
DE4316077A1 true DE4316077A1 (de) 1994-11-17

Family

ID=6488035

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4316077A Withdrawn DE4316077A1 (de) 1993-05-13 1993-05-13 Substituierte Mono- und Bihydridylmethylpyridone
DE59403427T Expired - Fee Related DE59403427D1 (de) 1993-05-13 1994-05-02 Substituierte Pyridylmethylpyridone als Angiotensin II Antagonisten

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59403427T Expired - Fee Related DE59403427D1 (de) 1993-05-13 1994-05-02 Substituierte Pyridylmethylpyridone als Angiotensin II Antagonisten

Country Status (21)

Country Link
US (1) US5407948A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0624583B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH06329669A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1102648A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE155782T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU672679B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2123243A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ117294A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (2) DE4316077A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0624583T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2105408T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI942160L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3024465T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT70485A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL109604A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO941770L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ260490A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH30908A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SK (1) SK55694A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW245718B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA943246B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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EP0802192A1 (de) * 1996-04-17 1997-10-22 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung
DE19619950A1 (de) 1996-04-17 1997-10-23 Bayer Ag Heterocyclisch-substituierte Phenylglycinolamide
AU4956699A (en) 1998-06-19 2000-01-05 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US7045519B2 (en) 1998-06-19 2006-05-16 Chiron Corporation Inhibitors of glycogen synthase kinase 3
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
US7998986B2 (en) 2001-12-21 2011-08-16 Exelixis Patent Company Llc Modulators of LXR
CA2476012C (en) * 2002-02-14 2011-04-19 Pharmacia Corporation Substituted pyridinones as modulators of p38 map kinase
US6946479B2 (en) * 2002-11-09 2005-09-20 The Procter & Gamble Company N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones
US6930117B2 (en) * 2002-11-09 2005-08-16 The Procter & Gamble Company N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones
ATE499362T1 (de) * 2005-08-29 2011-03-15 Vertex Pharma 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind
CA2620269A1 (en) * 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-receptor tyrosine kinases
AU2006284900A1 (en) 2005-08-29 2007-03-08 Vertex Pharmaceuticals Incorporated 3, 5-disubstituted pyrid-2-ones useful as inhibitors of Tec family of non-receptor tyrosine kinases
TWI417095B (zh) * 2006-03-15 2013-12-01 Janssen Pharmaceuticals Inc １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途
TW200845978A (en) * 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
EP2205565B1 (en) * 2007-09-14 2013-04-17 Janssen Pharmaceuticals, Inc. 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones
NZ584145A (en) 2007-09-14 2012-03-30 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h, 1'h-[1,4'] bipyridinyl-2'-ones
DK2200985T3 (da) 2007-09-14 2011-10-24 Ortho Mcneil Janssen Pharm 1,3-Disubstituerede 4-(aryl--X-phenyl)-1H-pyridin-2-oner
JP5433582B2 (ja) * 2007-11-14 2014-03-05 ジャンセン ファーマシューティカルズ， インコーポレイテッド． イミダゾ［１，２−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体の正のアロステリック調節因子としてのその使用
BRPI0918055A2 (pt) 2008-09-02 2015-12-01 Addex Pharmaceuticals Sa derivados de 3-azabiciclo[3,1,0]hexila como moduladores de receptores metabotrópicos de glutamato.
JP5656848B2 (ja) 2008-10-16 2015-01-21 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体モジュレーターとしてのインドールおよびベンゾモルホリンの誘導体
EP2373649B1 (en) 2008-11-28 2013-01-23 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
BRPI1010831A2 (pt) 2009-05-12 2016-04-05 Addex Pharmaceuticals Sa derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2
SG176021A1 (en) 2009-05-12 2011-12-29 Janssen Pharmaceuticals Inc 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
PH12012500789A1 (en) 2009-11-06 2012-11-26 Aerpio Therapeutics Inc Prolyl hydroxylase inhibitors
JP5852665B2 (ja) 2010-11-08 2016-02-03 ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用
AU2011328194B2 (en) 2010-11-08 2015-04-16 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
WO2012062759A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
SMT202100103T1 (it) 2014-01-21 2021-03-15 Janssen Pharmaceutica Nv Combinazione comprendente modulatori allosterici postivi del recettore glutammatergico metabotropico sottotipo 2 e loro utilizzo
HUE045610T2 (hu) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv 2-es altípusú metabotróp glutamáterg receptor pozitív allosztérikus modulátorait vagy ortosztérikus agonistáit tartalmazó kombinációk és alkalmazásuk
MX2023009059A (es) 2021-02-02 2023-09-15 Liminal Biosciences Ltd Antagonistas de gpr84 y usos de estos.

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IL100917A0 (en) * 1991-02-16 1992-11-15 Fisons Plc Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them
US5196537A (en) * 1991-03-21 1993-03-23 G. D. Searle & Co. 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders
US5128327A (en) * 1991-03-25 1992-07-07 Merck & Co., Inc. Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle
US5164403A (en) * 1991-04-05 1992-11-17 G. D. Searle & Co. N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders
US5155117A (en) * 1991-04-12 1992-10-13 G. D. Searle & Co. 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders
DE4129340A1 (de) * 1991-09-04 1993-03-11 Merck Patent Gmbh 1,2-dihydro-2-oxopyridine
US5332750A (en) * 1991-09-04 1994-07-26 Merck Patent Gesellschaft Mit Beschrankter Haftung 1,2-dihydro-2-oxopyridines
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
FI942160A0 (fi) 1994-05-10
ZA943246B (en) 1995-01-18
AU6056194A (en) 1994-11-17
IL109604A0 (en) 1994-08-26
CZ117294A3 (en) 1994-11-16
AU672679B2 (en) 1996-10-10
HU9401417D0 (en) 1994-08-29
FI942160A7 (fi) 1994-11-14
TW245718B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1995-04-21
DK0624583T3 (da) 1998-03-02
EP0624583A1 (de) 1994-11-17
EP0624583B1 (de) 1997-07-23
ES2105408T3 (es) 1997-10-16
FI942160L (fi) 1994-11-14
NO941770L (no) 1994-11-14
US5407948A (en) 1995-04-18
NZ260490A (en) 1995-12-21
NO941770D0 (no) 1994-05-11
ATE155782T1 (de) 1997-08-15
CN1102648A (zh) 1995-05-17
GR3024465T3 (en) 1997-11-28
PH30908A (en) 1997-12-23
HUT70485A (en) 1995-10-30
DE59403427D1 (de) 1997-08-28
JPH06329669A (ja) 1994-11-29
SK55694A3 (en) 1995-02-08
CA2123243A1 (en) 1994-11-14

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Legal Events

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8139 Disposal/non-payment of the annual fee