ATE499362T1 - 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind - Google Patents
3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sindInfo
- Publication number
- ATE499362T1 ATE499362T1 AT06813771T AT06813771T ATE499362T1 AT E499362 T1 ATE499362 T1 AT E499362T1 AT 06813771 T AT06813771 T AT 06813771T AT 06813771 T AT06813771 T AT 06813771T AT E499362 T1 ATE499362 T1 AT E499362T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- receptor tyrosine
- tyrosine kinases
- tec family
- ones useful
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/64—One oxygen atom attached in position 2 or 6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71245705P | 2005-08-29 | 2005-08-29 | |
PCT/US2006/033282 WO2007027528A2 (en) | 2005-08-29 | 2006-08-25 | 3,5-disubstituted pyrid-2-ones useful as inhibitors of tec family of non-.receptor tyrosine kinases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE499362T1 true ATE499362T1 (de) | 2011-03-15 |
Family
ID=37565557
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06813771T ATE499362T1 (de) | 2005-08-29 | 2006-08-25 | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin- kinasen nützlich sind |
Country Status (10)
Country | Link |
---|---|
US (1) | US7786120B2 (de) |
EP (1) | EP1919905B1 (de) |
JP (2) | JP5112317B2 (de) |
CN (1) | CN101291926A (de) |
AT (1) | ATE499362T1 (de) |
AU (1) | AU2006285145A1 (de) |
CA (1) | CA2620631A1 (de) |
DE (1) | DE602006020293D1 (de) |
ES (1) | ES2361338T3 (de) |
WO (1) | WO2007027528A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1919906B1 (de) | 2005-08-29 | 2011-10-12 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin-kinasen nützlich sind |
EP1919891B1 (de) * | 2005-08-29 | 2012-03-07 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor-tyrosinkinasen eignen |
EP2426109B1 (de) | 2007-10-23 | 2013-12-18 | F. Hoffmann-La Roche AG | Neue Kinaseinhibitoren |
US7683064B2 (en) | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
EP2297142B1 (de) | 2008-06-24 | 2015-10-14 | F. Hoffmann-La Roche AG | Neue substituierte pyridin-2-one und pyridazin-3-one |
KR101523451B1 (ko) | 2008-07-02 | 2015-05-27 | 에프. 호프만-라 로슈 아게 | 키나아제 억제제로서의 신규 페닐피라지논 |
AR082590A1 (es) | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
WO2013153539A1 (en) | 2012-04-13 | 2013-10-17 | Glenmark Pharmaceuticals S.A. | Tricyclic compounds as tec kinase inhibitors |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
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AU641769B2 (en) | 1990-06-18 | 1993-09-30 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
US5308854A (en) * | 1990-06-18 | 1994-05-03 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
NZ238624A (en) | 1990-06-19 | 1994-08-26 | Meiji Seika Co | Pyridine derivatives, compositions, preparations and use thereof |
IL99731A0 (en) | 1990-10-18 | 1992-08-18 | Merck & Co Inc | Hydroxylated pyridine derivatives,their preparation and pharmaceutical compositions containing them |
DE4221583A1 (de) | 1991-11-12 | 1993-05-13 | Bayer Ag | Substituierte biphenylpyridone |
US5290941A (en) * | 1992-10-14 | 1994-03-01 | Merck & Co., Inc. | Facile condensation of methylbenzoxazoles with aromatic aldehydes |
DE4314963A1 (de) * | 1993-05-06 | 1994-11-10 | Bayer Ag | Substituierte Pyridine und 2-Oxo-1,2-dihydropyridine |
DE4314964A1 (de) | 1993-05-06 | 1994-11-10 | Bayer Ag | Pyridinylmethyl-substiutierte Pyridine und Pyridone |
DE4316077A1 (de) * | 1993-05-13 | 1994-11-17 | Bayer Ag | Substituierte Mono- und Bihydridylmethylpyridone |
US6979695B2 (en) | 1996-04-23 | 2005-12-27 | Targacept, Inc. | Compounds capable of activating cholinergic receptors |
MXPA00010490A (es) | 1998-04-27 | 2002-10-17 | Ct Nat De La Rech S Scient | Derivados 3-(amino-o-aminoalquil) piridinona y su uso para el tratamiento de enfermedades relacionadas con el vih. |
US6774138B2 (en) | 1999-08-31 | 2004-08-10 | Merck & Co., Inc. | Thiazolyl(pyridyl)ethyne compounds |
CA2398388A1 (en) | 2000-01-20 | 2001-07-26 | Koji Kato | Novel piperidine compound and pharmaceutical thereof |
PT1300396E (pt) * | 2000-06-12 | 2009-04-20 | Eisai R&D Man Co Ltd | Compostos de 1,2-di-hidropiridina, processos para a sua preparação e sua utilização |
US7115608B2 (en) * | 2000-09-19 | 2006-10-03 | Centre National De La Recherche Schentifique | Pyridinone and pyridinethione derivatives having HIV inhibiting properties |
WO2002040448A1 (en) | 2000-11-20 | 2002-05-23 | Bristol-Myers Squibb Company | Pyridone derivatives as ap2 inhibitors |
PT1357111E (pt) | 2000-12-28 | 2009-10-20 | Shionogi & Co | Derivados de 2-piridona com afinidade para receptores de canabinóides do tipo 2 |
WO2002079192A1 (en) * | 2001-03-28 | 2002-10-10 | Bristol-Myers Squibb Company | Novel tyrosine kinase inhibitors |
JP2002371078A (ja) * | 2001-06-12 | 2002-12-26 | Sankyo Co Ltd | キノリン誘導体及びキノロン誘導体 |
GB0129260D0 (en) * | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
JP4164031B2 (ja) * | 2002-02-14 | 2008-10-08 | ファルマシア コーポレーション | P38mapキナーゼのモジュレータとしての置換されたピリジノン |
JP4208512B2 (ja) | 2002-07-23 | 2009-01-14 | 株式会社クラレ | 5−(2’−ピリジル)−2−ピリドン誘導体の製造方法 |
WO2004035563A1 (en) | 2002-10-17 | 2004-04-29 | Syngenta Participations Ag | 3-heterocyclylpyridine derivatives useful as herbicides |
WO2004035564A1 (en) | 2002-10-17 | 2004-04-29 | Syngenta Participations Ag | Pyridine derivatives useful as herbicides |
JP2006509790A (ja) | 2002-11-27 | 2006-03-23 | アルテシアン セラピューティック,インコーポレイティド | 心不全の治療のための混合されたPDE阻害およびβアドレナリン拮抗薬活性または部分的作用薬活性を有する化合物 |
AU2003300297A1 (en) | 2002-12-23 | 2004-07-22 | Artesian Therapeutics, Inc. | CARDIOTONIC COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST Beta-ADRENERGIC RECEPTORS AND PHOSPHODIESTERASE |
US20070010541A1 (en) | 2003-07-14 | 2007-01-11 | The General Hospital Corporation | Methods for treating vascular diseases |
CL2004002050A1 (es) * | 2003-08-13 | 2005-06-03 | Pharmacia Corp Sa Organizada B | Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros. |
PE20060285A1 (es) * | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
CA2575808A1 (en) | 2004-08-02 | 2006-02-16 | Osi Pharmaceuticals, Inc. | Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds |
EP1831168B1 (de) * | 2004-12-16 | 2014-07-02 | Vertex Pharmaceuticals Inc. | Als inhibitoren der proteinkinasen der tec-familie geeignete pyrid-2-one zur behandlung entzündlicher, proliferativer und immunologisch vermittelter krankheiten |
MX2007011041A (es) | 2005-03-10 | 2008-02-22 | Cgi Pharmaceuticals Inc | Ciertas amidas sustituidas, metodo de elaboracion y metodo de uso de las mismas. |
EP1919891B1 (de) | 2005-08-29 | 2012-03-07 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituierte pyrid-2-one, die sich als inhibitoren der tec-familie von nicht-rezeptor-tyrosinkinasen eignen |
EP1919906B1 (de) | 2005-08-29 | 2011-10-12 | Vertex Pharmaceuticals Incorporated | 3,5-disubstituierte pyrid-2-one, die als hemmer der tec-familie von nicht-rezeptor tyrosin-kinasen nützlich sind |
-
2006
- 2006-08-25 CA CA002620631A patent/CA2620631A1/en not_active Abandoned
- 2006-08-25 AU AU2006285145A patent/AU2006285145A1/en not_active Abandoned
- 2006-08-25 EP EP06813771A patent/EP1919905B1/de not_active Not-in-force
- 2006-08-25 CN CNA2006800393748A patent/CN101291926A/zh active Pending
- 2006-08-25 DE DE602006020293T patent/DE602006020293D1/de active Active
- 2006-08-25 US US11/510,126 patent/US7786120B2/en not_active Expired - Fee Related
- 2006-08-25 WO PCT/US2006/033282 patent/WO2007027528A2/en active Application Filing
- 2006-08-25 ES ES06813771T patent/ES2361338T3/es active Active
- 2006-08-25 AT AT06813771T patent/ATE499362T1/de not_active IP Right Cessation
- 2006-08-25 JP JP2008529133A patent/JP5112317B2/ja not_active Expired - Fee Related
-
2012
- 2012-06-20 JP JP2012138966A patent/JP2012184260A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US20070185125A1 (en) | 2007-08-09 |
AU2006285145A1 (en) | 2007-03-08 |
ES2361338T3 (es) | 2011-06-16 |
CN101291926A (zh) | 2008-10-22 |
EP1919905B1 (de) | 2011-02-23 |
CA2620631A1 (en) | 2007-03-08 |
DE602006020293D1 (de) | 2011-04-07 |
JP2009507790A (ja) | 2009-02-26 |
US7786120B2 (en) | 2010-08-31 |
JP2012184260A (ja) | 2012-09-27 |
WO2007027528A2 (en) | 2007-03-08 |
EP1919905A2 (de) | 2008-05-14 |
WO2007027528A3 (en) | 2007-05-03 |
JP5112317B2 (ja) | 2013-01-09 |
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