IL109604A0 - Substituted mono- and bipyridylmethyl- pyridones, process for their preparation and pharmaceutical compositions containing them - Google Patents
Substituted mono- and bipyridylmethyl- pyridones, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL109604A0 IL109604A0 IL10960494A IL10960494A IL109604A0 IL 109604 A0 IL109604 A0 IL 109604A0 IL 10960494 A IL10960494 A IL 10960494A IL 10960494 A IL10960494 A IL 10960494A IL 109604 A0 IL109604 A0 IL 109604A0
- Authority
- IL
- Israel
- Prior art keywords
- pyridones
- substituted mono
- bipyridylmethyl
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4316077A DE4316077A1 (de) | 1993-05-13 | 1993-05-13 | Substituierte Mono- und Bihydridylmethylpyridone |
Publications (1)
Publication Number | Publication Date |
---|---|
IL109604A0 true IL109604A0 (en) | 1994-08-26 |
Family
ID=6488035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL10960494A IL109604A0 (en) | 1993-05-13 | 1994-05-10 | Substituted mono- and bipyridylmethyl- pyridones, process for their preparation and pharmaceutical compositions containing them |
Country Status (21)
Country | Link |
---|---|
US (1) | US5407948A (xx) |
EP (1) | EP0624583B1 (xx) |
JP (1) | JPH06329669A (xx) |
CN (1) | CN1102648A (xx) |
AT (1) | ATE155782T1 (xx) |
AU (1) | AU672679B2 (xx) |
CA (1) | CA2123243A1 (xx) |
CZ (1) | CZ117294A3 (xx) |
DE (2) | DE4316077A1 (xx) |
DK (1) | DK0624583T3 (xx) |
ES (1) | ES2105408T3 (xx) |
FI (1) | FI942160A (xx) |
GR (1) | GR3024465T3 (xx) |
HU (1) | HUT70485A (xx) |
IL (1) | IL109604A0 (xx) |
NO (1) | NO941770L (xx) |
NZ (1) | NZ260490A (xx) |
PH (1) | PH30908A (xx) |
SK (1) | SK55694A3 (xx) |
TW (1) | TW245718B (xx) |
ZA (1) | ZA943246B (xx) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19619950A1 (de) | 1996-04-17 | 1997-10-23 | Bayer Ag | Heterocyclisch-substituierte Phenylglycinolamide |
EP0802192A1 (de) * | 1996-04-17 | 1997-10-22 | Bayer Ag | Heterocyclisch-substituierte Phenylglycinolamide mit antiatherosklerotischer Wirkung und Verfahren zu ihrer Herstellung |
WO1999065897A1 (en) | 1998-06-19 | 1999-12-23 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
US7045519B2 (en) * | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
JP5082033B2 (ja) * | 2001-12-21 | 2012-11-28 | エグゼリクシス パテント カンパニー エルエルシー | Lxrのモジュレーター |
US7482366B2 (en) | 2001-12-21 | 2009-01-27 | X-Ceptor Therapeutics, Inc. | Modulators of LXR |
ES2334990T3 (es) * | 2002-02-14 | 2010-03-18 | Pharmacia Corporation | Piridinonas sustituidas como moduladores de p38 map quinasa. |
US6946479B2 (en) * | 2002-11-09 | 2005-09-20 | The Procter & Gamble Company | N-sulfonyl-4-methyleneamino-3-hydroxy-2-pyridones |
US6930117B2 (en) * | 2002-11-09 | 2005-08-16 | The Procter & Gamble Company | N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones |
US7691885B2 (en) * | 2005-08-29 | 2010-04-06 | Vertex Pharmaceuticals Incorporated | Pyridones useful as inhibitors of kinases |
ES2361338T3 (es) * | 2005-08-29 | 2011-06-16 | Vertex Pharmaceuticals Incorporated | Pirid-2-onas 3,5-disustituidas útiles como inhibidores de la familia tec de tirosina quinasas no ligadas a receptor. |
JP2009506123A (ja) | 2005-08-29 | 2009-02-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | 非受容体型チロシンキナーゼのtecファミリーの阻害剤として有用な3,5−二置換ピリド−2−オン |
TWI417095B (zh) * | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | 1,4-二取代之3-氰基-吡啶酮衍生物及其作為mGluR2-受體之正向異位性調節劑之用途 |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
EA019085B1 (ru) | 2007-09-14 | 2014-01-30 | Янссен Фармасьютикалз, Инк. | 1',3-двузамещенные 4-(арил-х-фенил)-1н-пиридин-2-оны |
TW200927731A (en) * | 2007-09-14 | 2009-07-01 | Ortho Mcneil Janssen Pharm | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
US9114138B2 (en) | 2007-09-14 | 2015-08-25 | Janssen Pharmaceuticals, Inc. | 1′,3′-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1′H-[1,4′] bipyridinyl-2′-ones |
JP5433582B2 (ja) * | 2007-11-14 | 2014-03-05 | ジャンセン ファーマシューティカルズ, インコーポレイテッド. | イミダゾ[1,2−a]ピリジン誘導体およびmGluR2受容体の正のアロステリック調節因子としてのその使用 |
WO2010025890A1 (en) | 2008-09-02 | 2010-03-11 | Ortho-Mcneil-Janssen Pharmaceuticals, Inc | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
AU2009304293B2 (en) | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
AU2009319387B2 (en) | 2008-11-28 | 2012-05-10 | Addex Pharma S.A. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
JP5634506B2 (ja) | 2009-05-12 | 2014-12-03 | ジャンセン ファーマシューティカルズ, インコーポレイテッド | 1,2,3−トリアゾロ[4,3−a]ピリジン誘導体ならびに神経障害および精神障害の治療または予防のためのその使用 |
CA2760259C (en) | 2009-05-12 | 2018-05-01 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
AU2010314973B9 (en) * | 2009-11-06 | 2015-03-19 | Aerpio Therapeutics Inc. | Methods for increasing the stabilization of hypoxia inducible factor-1 alpha |
JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
JP5852666B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | 1,2,4−トリアゾロ[4,3−a]ピリジン誘導体およびmGluR2受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
LT3096790T (lt) | 2014-01-21 | 2019-10-10 | Janssen Pharmaceutica, N.V. | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
WO2015110435A1 (en) | 2014-01-21 | 2015-07-30 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL100917A0 (en) * | 1991-02-16 | 1992-11-15 | Fisons Plc | Pyridinone and pyrimidinone derivatives,their preparation and pharmaceutical compositions containing them |
US5196537A (en) * | 1991-03-21 | 1993-03-23 | G. D. Searle & Co. | 5-apylheteroarylalkyl-1,3,5-trisubstituted-1,2,4-triazole compounds for treatment of circulatory disorders |
US5128327A (en) * | 1991-03-25 | 1992-07-07 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a nitrogen containing six membered ring heterocycle |
US5164403A (en) * | 1991-04-05 | 1992-11-17 | G. D. Searle & Co. | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders |
US5155117A (en) * | 1991-04-12 | 1992-10-13 | G. D. Searle & Co. | 1-arylheteroarylalkyl substituted-1h-1,2,4-triazole compounds for treatment of circulatory disorders |
US5332750A (en) * | 1991-09-04 | 1994-07-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1,2-dihydro-2-oxopyridines |
DE4129340A1 (de) * | 1991-09-04 | 1993-03-11 | Merck Patent Gmbh | 1,2-dihydro-2-oxopyridine |
US5149699A (en) * | 1991-10-24 | 1992-09-22 | American Home Products Corporation | Substituted pyridopyrimidines useful as antgiotensin II antagonists |
-
1993
- 1993-05-13 DE DE4316077A patent/DE4316077A1/de not_active Withdrawn
-
1994
- 1994-04-18 TW TW083103408A patent/TW245718B/zh active
- 1994-04-19 AU AU60561/94A patent/AU672679B2/en not_active Ceased
- 1994-05-02 DK DK94106834.8T patent/DK0624583T3/da active
- 1994-05-02 DE DE59403427T patent/DE59403427D1/de not_active Expired - Fee Related
- 1994-05-02 EP EP94106834A patent/EP0624583B1/de not_active Expired - Lifetime
- 1994-05-02 ES ES94106834T patent/ES2105408T3/es not_active Expired - Lifetime
- 1994-05-02 AT AT94106834T patent/ATE155782T1/de active
- 1994-05-06 HU HU9401417A patent/HUT70485A/hu unknown
- 1994-05-06 US US08/239,197 patent/US5407948A/en not_active Expired - Fee Related
- 1994-05-10 CA CA002123243A patent/CA2123243A1/en not_active Abandoned
- 1994-05-10 NZ NZ260490A patent/NZ260490A/en unknown
- 1994-05-10 IL IL10960494A patent/IL109604A0/xx unknown
- 1994-05-10 FI FI942160A patent/FI942160A/fi unknown
- 1994-05-10 JP JP6120653A patent/JPH06329669A/ja active Pending
- 1994-05-11 NO NO941770A patent/NO941770L/no unknown
- 1994-05-11 ZA ZA943246A patent/ZA943246B/xx unknown
- 1994-05-11 SK SK556-94A patent/SK55694A3/sk unknown
- 1994-05-11 PH PH48253A patent/PH30908A/en unknown
- 1994-05-12 CZ CZ941172A patent/CZ117294A3/cs unknown
- 1994-05-13 CN CN94105814A patent/CN1102648A/zh active Pending
-
1997
- 1997-08-14 GR GR970402103T patent/GR3024465T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH06329669A (ja) | 1994-11-29 |
HUT70485A (en) | 1995-10-30 |
ATE155782T1 (de) | 1997-08-15 |
DE4316077A1 (de) | 1994-11-17 |
AU672679B2 (en) | 1996-10-10 |
NO941770D0 (no) | 1994-05-11 |
CZ117294A3 (en) | 1994-11-16 |
NZ260490A (en) | 1995-12-21 |
EP0624583B1 (de) | 1997-07-23 |
SK55694A3 (en) | 1995-02-08 |
DE59403427D1 (de) | 1997-08-28 |
GR3024465T3 (en) | 1997-11-28 |
AU6056194A (en) | 1994-11-17 |
ES2105408T3 (es) | 1997-10-16 |
EP0624583A1 (de) | 1994-11-17 |
FI942160A0 (fi) | 1994-05-10 |
US5407948A (en) | 1995-04-18 |
NO941770L (no) | 1994-11-14 |
CA2123243A1 (en) | 1994-11-14 |
FI942160A (fi) | 1994-11-14 |
PH30908A (en) | 1997-12-23 |
DK0624583T3 (da) | 1998-03-02 |
ZA943246B (en) | 1995-01-18 |
TW245718B (xx) | 1995-04-21 |
CN1102648A (zh) | 1995-05-17 |
HU9401417D0 (en) | 1994-08-29 |
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