CY2405B1 - Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes. - Google Patents

Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes.

Info

Publication number
CY2405B1
CY2405B1 CY0400006A CY0400006A CY2405B1 CY 2405 B1 CY2405 B1 CY 2405B1 CY 0400006 A CY0400006 A CY 0400006A CY 0400006 A CY0400006 A CY 0400006A CY 2405 B1 CY2405 B1 CY 2405B1
Authority
CY
Cyprus
Prior art keywords
taxanes
sidechain
lactams
preparation
beta
Prior art date
Application number
CY0400006A
Other languages
English (en)
Inventor
John K Thottathil
Ivan D Trifunovich
David J Kucera
Wen-Sen Li
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CY2405B1 publication Critical patent/CY2405B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
CY0400006A 1993-03-19 2004-01-12 Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes. CY2405B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3359893A 1993-03-19 1993-03-19

Publications (1)

Publication Number Publication Date
CY2405B1 true CY2405B1 (en) 2004-09-10

Family

ID=21871323

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0400006A CY2405B1 (en) 1993-03-19 2004-01-12 Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes.

Country Status (18)

Country Link
US (5) US6350887B1 (es)
EP (2) EP0617018B1 (es)
JP (1) JPH06321896A (es)
KR (1) KR100309973B1 (es)
CN (2) CN1080256C (es)
AT (1) ATE251134T1 (es)
CA (1) CA2116093A1 (es)
CY (1) CY2405B1 (es)
DE (1) DE69433188T2 (es)
DK (1) DK0617018T3 (es)
ES (1) ES2208649T3 (es)
FI (1) FI941286A (es)
HK (1) HK1002005A1 (es)
HU (1) HUT69733A (es)
IL (3) IL123063A (es)
PT (1) PT617018E (es)
SG (1) SG50463A1 (es)
TW (1) TW467896B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163837C (en) † 1994-12-13 1999-07-20 Robert K. Perrone Crystalline paclitaxel hydrates
MA23823A1 (fr) 1995-03-27 1996-10-01 Aventis Pharma Sa Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en) 1995-03-27 2002-04-16 Aventis Pharma S.A. Methods of treating cell lines expressing multidrug resistance P-glycoprotein
DE19703549C1 (de) * 1997-01-31 1999-03-04 Clariant Gmbh Verfahren zur Herstellung von Diacylimiden
FR2771092B1 (fr) * 1997-11-18 1999-12-17 Rhone Poulenc Rorer Sa Procede de preparation de derives de la classe des taxoides
US6346543B1 (en) * 1998-08-17 2002-02-12 Aventis Pharma S.A. Use of a taxoid to treat abnormal cell proliferation in the brain
US6403634B1 (en) 1999-01-13 2002-06-11 Aventis Pharma S.A. Use of taxoid derivatives
IL144976A0 (en) 1999-05-17 2002-06-30 Bristol Myers Squibb Co A process for the preparation of paclitaxel
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6956123B2 (en) * 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
US8703982B2 (en) * 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
US7202370B2 (en) 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
US7989490B2 (en) 2004-06-02 2011-08-02 Cordis Corporation Injectable formulations of taxanes for cad treatment
MXPA06012606A (es) * 2004-05-14 2007-01-31 Immunogen Inc Un metodo facil para sintetizar compuestos de bacatina iii.
US20080161324A1 (en) * 2006-09-14 2008-07-03 Johansen Lisa M Compositions and methods for treatment of viral diseases
EP2285792A2 (en) * 2008-05-07 2011-02-23 Ivax Research, Llc Processes for preparation of taxanes and intermediates thereof
CA2732508C (en) 2008-08-11 2016-03-15 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8785669B2 (en) 2010-06-30 2014-07-22 Gfv, Llc Taxane compounds, compositions and methods
US8697892B2 (en) 2010-06-30 2014-04-15 Gfv, Llc Taxane compounds, compositions and methods
US20130338216A1 (en) 2010-12-22 2013-12-19 Nektar Therapeutics Deuterated and/or fluorinated taxane derivatives
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE21105T1 (de) 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
US4680391A (en) 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2601675B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US4876399A (en) 1987-11-02 1989-10-24 Research Corporation Technologies, Inc. Taxols, their preparation and intermediates thereof
FR2629819B1 (fr) 1988-04-06 1990-11-16 Rhone Poulenc Sante Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
MY110249A (en) * 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
IL95436A (en) 1989-08-23 1996-07-23 Centre Nat Rech Scient Process for preparing the history of phenylisosarine
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5278324A (en) * 1990-08-28 1994-01-11 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
US5059699A (en) 1990-08-28 1991-10-22 Virginia Tech Intellectual Properties, Inc. Water soluble derivatives of taxol
FR2671799B1 (fr) * 1991-01-17 1993-03-12 Rhone Poulenc Rorer Sa La b-phenylisoserine-(2r, 3s), ses sels, sa preparation et son emploi.
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides
HU226369B1 (en) * 1991-09-23 2008-09-29 Univ Florida State Process for preparing substituted isoserine-esters using metal alkoxides and beta-lactams
US5274124A (en) 1991-09-23 1993-12-28 Florida State University Metal alkoxides
US5250683A (en) 1991-09-23 1993-10-05 Florida State University Certain substituted taxanes and pharmaceutical compositions containing them
US5227400A (en) 1991-09-23 1993-07-13 Florida State University Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
US5284864A (en) * 1991-09-23 1994-02-08 Florida State University Butenyl substituted taxanes and pharmaceutical compositions containing them
US5243045A (en) 1991-09-23 1993-09-07 Florida State University Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5272171A (en) 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
JPH069600A (ja) * 1992-05-06 1994-01-18 Bristol Myers Squibb Co タクソールのベンゾエート誘導体
US5646176A (en) 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives

Also Published As

Publication number Publication date
FI941286A (fi) 1994-09-20
KR940021522A (ko) 1994-10-19
JPH06321896A (ja) 1994-11-22
AU5791994A (en) 1994-09-22
EP1361222A1 (en) 2003-11-12
TW467896B (en) 2001-12-11
US6310201B1 (en) 2001-10-30
HUT69733A (en) 1995-09-28
ES2208649T3 (es) 2004-06-16
DK0617018T3 (da) 2004-01-26
IL108763A (en) 1998-07-15
CA2116093A1 (en) 1994-09-20
PT617018E (pt) 2004-02-27
US7176326B2 (en) 2007-02-13
US6350887B1 (en) 2002-02-26
FI941286A0 (fi) 1994-03-18
CN1097416A (zh) 1995-01-18
CN1080256C (zh) 2002-03-06
AU676879B2 (en) 1997-03-27
HK1002005A1 (en) 1998-07-24
DE69433188D1 (de) 2003-11-06
EP0617018B1 (en) 2003-10-01
SG50463A1 (en) 1998-07-20
US20020137927A1 (en) 2002-09-26
ATE251134T1 (de) 2003-10-15
US6350886B1 (en) 2002-02-26
EP0617018A1 (en) 1994-09-28
US20050107605A1 (en) 2005-05-19
IL123063A0 (en) 1998-09-24
CN1271729A (zh) 2000-11-01
DE69433188T2 (de) 2004-07-29
IL108763A0 (en) 1994-06-24
KR100309973B1 (ko) 2002-02-28
HU9400803D0 (en) 1994-06-28
IL123063A (en) 2000-02-17

Similar Documents

Publication Publication Date Title
HK1002005A1 (en) Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
CA2008391A1 (en) 1,2-cyclohexylaminoaryl amides useful as analgesic agents
PL300064A1 (en) Method of obtaining 7-(substituted)-9[(substituted glycil)amido]-6-demethyl-6-deoxy-tetracyclines
AU5581190A (en) Diarylstrylquinoline diacids
HUP9802487A2 (hu) Intermedierek félszintetikus taxánokhoz és eljárás előállításukra
AU5425794A (en) Process for the preparation of taxane derivatives, novel taxanes so obtained and antitumour and antileukaemia compositions containing same
GR3036070T3 (en) New process for the production of cephalosporines and novel intermediates in this process.
HU9904634D0 (en) New thiaazolidine-derivatives
GR3030722T3 (en) Improved synthesis of bisindolylmaleimides.
IL111966A0 (en) 4-Benzoylisoxazole derivatives, their preparation and herbicidal compositions containing them
ITMI931012A1 (it) Composti spiro-piranici dotati di caratteristiche fotocromatiche
GB9806409D0 (en) Processes for preparing intermediates
EP0574271A3 (es)
IL95313A0 (en) Benzopyran derivative
IL141304A0 (en) A method for the preparation of c-4 deacetyltaxane derivatives and the enzyme for use therein