CY2312B1 - 4-Aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity. - Google Patents

4-Aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity.

Info

Publication number
CY2312B1
CY2312B1 CY0300004A CY0300004A CY2312B1 CY 2312 B1 CY2312 B1 CY 2312B1 CY 0300004 A CY0300004 A CY 0300004A CY 0300004 A CY0300004 A CY 0300004A CY 2312 B1 CY2312 B1 CY 2312B1
Authority
CY
Cyprus
Prior art keywords
alkyl
aryl
tetrahydropyridines
phenylalkyl
neurotrophic
Prior art date
Application number
CY0300004A
Other languages
English (en)
Inventor
Domenico Badone
Rosanna Cardamone
Umberto Guzzi
Marco Baroni
Jacqueline Fournier
Alessandra Ielmini
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of CY2312B1 publication Critical patent/CY2312B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CY0300004A 1995-06-28 2003-01-15 4-Aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity. CY2312B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9507760A FR2736053B1 (fr) 1995-06-28 1995-06-28 Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines

Publications (1)

Publication Number Publication Date
CY2312B1 true CY2312B1 (en) 2003-11-14

Family

ID=9480466

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300004A CY2312B1 (en) 1995-06-28 2003-01-15 4-Aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridines having neurotrophic and neuroprotective activity.

Country Status (30)

Country Link
US (1) US5981754A (de)
EP (2) EP1216996A3 (de)
JP (2) JP3147906B2 (de)
KR (1) KR100460581B1 (de)
CN (1) CN1153765C (de)
AT (1) ATE223897T1 (de)
AU (1) AU715090B2 (de)
BR (1) BR9608662A (de)
CA (1) CA2225746C (de)
CY (1) CY2312B1 (de)
CZ (1) CZ291075B6 (de)
DE (1) DE69623631T2 (de)
DK (1) DK0837848T3 (de)
EE (1) EE03870B1 (de)
ES (1) ES2183965T3 (de)
FR (1) FR2736053B1 (de)
HK (1) HK1014952A1 (de)
HU (1) HUP9900055A3 (de)
IL (1) IL122159A (de)
IS (1) IS1999B (de)
NO (1) NO310144B1 (de)
NZ (1) NZ312723A (de)
PL (2) PL192353B1 (de)
PT (1) PT837848E (de)
RU (1) RU2163237C2 (de)
SK (2) SK283707B6 (de)
TR (1) TR199701710T1 (de)
UA (1) UA62914C2 (de)
WO (1) WO1997001536A1 (de)
ZA (1) ZA965527B (de)

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FR2762514B1 (fr) 1997-04-29 1999-10-22 Sanofi Sa Utilisation de derives de la tetrahydropyridine pour la preparation de medicaments pour le traitement des maladies entrainant une demyelinisation
FR2763847B1 (fr) * 1997-05-28 2003-06-06 Sanofi Sa Utilisation de tetrahydropyridines 4-substituees pour fabriquer des medicaments agissant sur le tgf-beta-1
CO4980891A1 (es) * 1997-11-14 2000-11-27 Sanofi Sa Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
FR2771007B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
FR2771006B1 (fr) * 1997-11-14 2000-12-01 Sanofi Sa Association de principes actifs pour le traitement de la demence senile du type alzheimer
CA2334677A1 (en) * 1998-06-19 1999-12-23 Vincent Patrick Rocco Preparation of heteroaryl compounds
FR2803593B1 (fr) * 2000-01-06 2002-02-15 Sanofi Synthelabo Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
JP4324382B2 (ja) * 2001-04-20 2009-09-02 サノフィ−アベンティス テトラヒドロピリジル−アルキル−複素環、その製造方法およびそれを含む医薬組成物
FR2823748B1 (fr) * 2001-04-20 2004-02-20 Sanofi Synthelabo Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2840896B1 (fr) * 2002-06-18 2005-04-08 Sanofi Synthelabo Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
NZ541074A (en) * 2002-12-16 2008-04-30 Mitsubishi Pharma Corp 3-Substituted-4-pyrimidone derivatives
WO2005016910A1 (ja) 2003-08-18 2005-02-24 Sankio Chemical Co., Ltd. ピリジルテトラヒドロピリジン類およびピリジルピペリジン類とそれらの製造方法
TWI350168B (en) 2004-05-07 2011-10-11 Incyte Corp Amido compounds and their use as pharmaceuticals
BRPI0512535A (pt) * 2004-06-24 2008-03-25 Incyte Corp compostos de piperidinas n-substituìdas, suas composições e métodos de modulações
WO2006012173A1 (en) * 2004-06-24 2006-02-02 Incyte Corporation Amido compounds and their use as pharmaceuticals
US7687665B2 (en) * 2004-06-24 2010-03-30 Incyte Corporation 2-methylprop anamides and their use as pharmaceuticals
WO2006002350A1 (en) * 2004-06-24 2006-01-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
NZ551602A (en) * 2004-06-24 2010-11-26 Incyte Corp Amido compounds and their use as pharmaceuticals
CN101080226A (zh) * 2004-08-10 2007-11-28 因塞特公司 酰氨基化合物及它们作为药物的用途
US8110581B2 (en) 2004-11-10 2012-02-07 Incyte Corporation Lactam compounds and their use as pharmaceuticals
TWI400239B (zh) * 2004-11-10 2013-07-01 Incyte Corp 內醯胺化合物及其作為醫藥品之用途
EP1824842A4 (de) * 2004-11-18 2009-08-26 Incyte Corp Hemmer von 11- hydroxyl steroid dehydrogenase typ 1 und anwendungsverfahren
FR2883285B1 (fr) * 2005-03-17 2007-05-18 Sanofi Aventis Sa Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique
JP4864342B2 (ja) * 2005-04-27 2012-02-01 北興化学工業株式会社 ビアリール化合物の製造方法
CA2621255A1 (en) * 2005-09-21 2007-04-05 Incyte Corporation Amido compounds and their use as pharmaceuticals
CA2630492C (en) * 2005-12-05 2015-04-14 Incyte Corporation Spiro-lactam compounds
WO2007084314A2 (en) * 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
EP1979318A1 (de) * 2006-01-31 2008-10-15 Incyte Corporation Amidverbindungen und deren verwendung als arzneimittel
TW200808807A (en) * 2006-03-02 2008-02-16 Incyte Corp Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
US20070208001A1 (en) * 2006-03-03 2007-09-06 Jincong Zhuo Modulators of 11- beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
JP2009535420A (ja) * 2006-05-01 2009-10-01 インサイト・コーポレイション １１−βヒドロキシルステロイドデヒドロゲナーゼタイプ１のモジュレーターとしてのテトラ置換ウレア
JP2009537564A (ja) * 2006-05-17 2009-10-29 インサイト・コーポレイション １１−βヒドロキシルステロイドデヒドロゲナーゼタイプＩの複素環阻害剤およびそれを用いる方法
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
CN101945848A (zh) 2007-12-20 2011-01-12 英维沃医药有限公司 四取代的苯
ES2546487T3 (es) * 2010-01-19 2015-09-24 Bayer Intellectual Property Gmbh Procedimiento para la preparación de derivados de ácido aril- y heteroarilacético
US10858351B2 (en) 2017-04-26 2020-12-08 Alberta Research Chemicals Inc. Substituted tetrahydropyridine derivatives as IDO-1 inhibitors and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0398578B1 (de) * 1989-05-17 1997-03-12 Pfizer Inc. 2-Piperidino-1-alkanol-Derivate als antiischemische Wirkstoffe
FR2650505B1 (fr) * 1989-08-07 1994-06-03 Midy Spa Utilisation de trifluoromethylphenyltetrahydropyridines pour la preparation de medicaments destines a combattre les troubles de la motricite intestinale
FR2662355B1 (fr) * 1990-05-22 1994-11-10 Sanofi Sa Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
DE4325855A1 (de) * 1993-08-02 1995-02-09 Boehringer Ingelheim Kg Neue Benzoesäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
JP3302351B2 (ja) 2002-07-15
EE03870B1 (et) 2002-10-15
EP1216996A3 (de) 2003-10-15
CZ291075B6 (cs) 2002-12-11
HK1014952A1 (en) 1999-10-08
NO310144B1 (no) 2001-05-28
PL187087B1 (pl) 2004-05-31
FR2736053B1 (fr) 1997-09-19
IL122159A0 (en) 1998-04-05
HUP9900055A3 (en) 1999-11-29
PL192353B1 (pl) 2006-10-31
EP0837848A1 (de) 1998-04-29
JP2001114763A (ja) 2001-04-24
EE9700348A (et) 1998-06-15
WO1997001536A1 (fr) 1997-01-16
SK178197A3 (en) 1998-07-08
IS1999B (is) 2005-04-15
ATE223897T1 (de) 2002-09-15
CA2225746A1 (en) 1997-01-16
AU715090B2 (en) 2000-01-13
PT837848E (pt) 2002-12-31
MX9710472A (es) 1998-03-31
FR2736053A1 (fr) 1997-01-03
KR100460581B1 (ko) 2005-04-14
PL324216A1 (en) 1998-05-11
SK285433B6 (sk) 2007-01-04
NZ312723A (en) 1999-10-28
DK0837848T3 (da) 2003-01-06
SK283707B6 (sk) 2003-12-02
AU6461996A (en) 1997-01-30
ZA965527B (en) 1997-01-24
CA2225746C (en) 2004-05-18
IL122159A (en) 2001-06-14
IS4641A (is) 1997-12-23
DE69623631T2 (de) 2003-08-07
HUP9900055A2 (hu) 1999-04-28
JP3147906B2 (ja) 2001-03-19
JPH11506118A (ja) 1999-06-02
CN1189154A (zh) 1998-07-29
CZ422297A3 (cs) 1998-04-15
EP0837848B1 (de) 2002-09-11
DE69623631D1 (en) 2002-10-17
EP1216996A2 (de) 2002-06-26
RU2163237C2 (ru) 2001-02-20
KR19990028431A (ko) 1999-04-15
BR9608662A (pt) 1999-05-04
ES2183965T3 (es) 2003-04-01
NO976079L (no) 1997-12-23
UA62914C2 (en) 2004-01-15
TR199701710T1 (xx) 1998-05-21
NO976079D0 (no) 1997-12-23
US5981754A (en) 1999-11-09
CN1153765C (zh) 2004-06-16

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