CY2279B1 - Use of 1- (2-napht-2-ylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine for preparing drugs for treating amyotrophic lateral sclerosis - Google Patents
Use of 1- (2-napht-2-ylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine for preparing drugs for treating amyotrophic lateral sclerosisInfo
- Publication number
- CY2279B1 CY2279B1 CY0200033A CY0200033A CY2279B1 CY 2279 B1 CY2279 B1 CY 2279B1 CY 0200033 A CY0200033 A CY 0200033A CY 0200033 A CY0200033 A CY 0200033A CY 2279 B1 CY2279 B1 CY 2279B1
- Authority
- CY
- Cyprus
- Prior art keywords
- ylethyl
- tetrahydropyridine
- trifluoromethylphenyl
- lateral sclerosis
- amyotrophic lateral
- Prior art date
Links
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- WJJYZXPHLSLMGE-UHFFFAOYSA-N xaliproden Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CCC=3C=C4C=CC=CC4=CC=3)CC=2)=C1 WJJYZXPHLSLMGE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9512635A FR2740343B1 (fr) | 1995-10-26 | 1995-10-26 | Utilisation de la 1-(2-napht-2-yl-ethyl)-4- (3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de la sclerose laterale amyotrophique |
| FR9607336 | 1996-06-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY2279B1 true CY2279B1 (en) | 2003-07-04 |
Family
ID=26232287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY0200033A CY2279B1 (en) | 1995-10-26 | 2002-05-15 | Use of 1- (2-napht-2-ylethyl)-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine for preparing drugs for treating amyotrophic lateral sclerosis |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6043251A (el) |
| EP (1) | EP0866704B1 (el) |
| JP (1) | JP3468526B2 (el) |
| KR (1) | KR100472793B1 (el) |
| CN (1) | CN1104241C (el) |
| AT (1) | ATE200423T1 (el) |
| AU (1) | AU719342B2 (el) |
| BR (1) | BR9611124A (el) |
| CA (1) | CA2235747C (el) |
| CY (1) | CY2279B1 (el) |
| CZ (1) | CZ293360B6 (el) |
| DE (1) | DE69612510T2 (el) |
| DK (1) | DK0866704T3 (el) |
| EE (1) | EE04177B1 (el) |
| ES (1) | ES2159362T3 (el) |
| GR (1) | GR3036027T3 (el) |
| HK (1) | HK1016904A1 (el) |
| HU (1) | HU222039B1 (el) |
| IL (1) | IL124091A (el) |
| IS (1) | IS1961B (el) |
| NO (1) | NO316256B1 (el) |
| NZ (1) | NZ320355A (el) |
| PT (1) | PT866704E (el) |
| SI (1) | SI0866704T1 (el) |
| SK (1) | SK284099B6 (el) |
| TR (1) | TR199800717T2 (el) |
| UA (1) | UA57004C2 (el) |
| WO (1) | WO1997015304A1 (el) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2782008B1 (fr) * | 1998-08-07 | 2003-04-25 | Sod Conseils Rech Applic | Utilisation d'extraits de ginkgo biloba pour preparer un medicament destine a traiter la sclerose laterale amyotrophique |
| EP2305252A1 (en) * | 2001-12-11 | 2011-04-06 | University Of Virginia Patent Foundation | Use of pramipexole to treat amyotrophic lateral sclerosis |
| US20060281797A1 (en) * | 2001-12-11 | 2006-12-14 | University Of Virginia Patent Foundation | Neurorestoration with R(+) Pramipexole |
| CN102727501A (zh) * | 2002-03-27 | 2012-10-17 | 菲特法姆股份有限公司 | 皂角苷配基及其衍生物的用途 |
| CA2619217A1 (en) * | 2005-08-15 | 2007-02-22 | University Of Virginia Patent Foundation | Neurorestoration with r(+) pramipexole |
| US8518926B2 (en) | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
| CA2652251A1 (en) | 2006-05-16 | 2007-11-29 | Knopp Neurosciences, Inc. | Compositions of r(+) and s(-) pramipexole and methods for using the same |
| US8524695B2 (en) | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
| WO2008113056A2 (en) | 2007-03-14 | 2008-09-18 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
| US20110190356A1 (en) * | 2008-08-19 | 2011-08-04 | Knopp Neurosciences Inc. | Compositions and Methods of Using (R)- Pramipexole |
| WO2013096816A1 (en) | 2011-12-22 | 2013-06-27 | Biogen Idec Ma Inc. | Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
| US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
| US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
| CN105764507B (zh) | 2013-07-12 | 2019-07-19 | 诺普生物科学有限责任公司 | 治疗升高的嗜酸性粒细胞和/或嗜碱性粒细胞的水平 |
| ES2871556T3 (es) | 2013-08-13 | 2021-10-29 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de la urticaria crónica |
| ES2813674T3 (es) | 2013-08-13 | 2021-03-24 | Knopp Biosciences Llc | Composiciones y métodos para el tratamiento de trastornos de células plasmáticas y trastornos prolinfocíticos de células b |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2662355B1 (fr) * | 1990-05-22 | 1994-11-10 | Sanofi Sa | Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux. |
| FR2672213B1 (fr) * | 1991-02-05 | 1995-03-10 | Sanofi Sa | Utilisation de derives 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridiniques comme capteurs de radicaux libres. |
| FR2672731A1 (fr) * | 1991-02-07 | 1992-08-14 | France Telecom | Procede d'oxydation localisee enterree d'un substrat de silicium et circuit integre correspondant. |
| FR2688138B1 (fr) * | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
-
1996
- 1996-10-25 UA UA98042073A patent/UA57004C2/uk unknown
- 1996-10-25 PT PT96934975T patent/PT866704E/pt unknown
- 1996-10-25 WO PCT/FR1996/001674 patent/WO1997015304A1/fr active IP Right Grant
- 1996-10-25 NZ NZ320355A patent/NZ320355A/xx unknown
- 1996-10-25 CA CA002235747A patent/CA2235747C/en not_active Expired - Fee Related
- 1996-10-25 TR TR1998/00717T patent/TR199800717T2/xx unknown
- 1996-10-25 HU HU9802945A patent/HU222039B1/hu not_active IP Right Cessation
- 1996-10-25 CN CN96198508A patent/CN1104241C/zh not_active Expired - Fee Related
- 1996-10-25 BR BR9611124A patent/BR9611124A/pt not_active Application Discontinuation
- 1996-10-25 EP EP96934975A patent/EP0866704B1/fr not_active Expired - Lifetime
- 1996-10-25 EE EE9800132A patent/EE04177B1/xx not_active IP Right Cessation
- 1996-10-25 IL IL12409196A patent/IL124091A/xx not_active IP Right Cessation
- 1996-10-25 SI SI9630299T patent/SI0866704T1/xx unknown
- 1996-10-25 DE DE69612510T patent/DE69612510T2/de not_active Expired - Fee Related
- 1996-10-25 JP JP51637097A patent/JP3468526B2/ja not_active Expired - Fee Related
- 1996-10-25 SK SK526-98A patent/SK284099B6/sk unknown
- 1996-10-25 AT AT96934975T patent/ATE200423T1/de not_active IP Right Cessation
- 1996-10-25 KR KR10-1998-0702997A patent/KR100472793B1/ko not_active IP Right Cessation
- 1996-10-25 ES ES96934975T patent/ES2159362T3/es not_active Expired - Lifetime
- 1996-10-25 CZ CZ19981296A patent/CZ293360B6/cs not_active IP Right Cessation
- 1996-10-25 DK DK96934975T patent/DK0866704T3/da active
- 1996-10-25 AU AU73084/96A patent/AU719342B2/en not_active Ceased
- 1996-10-25 US US09/051,740 patent/US6043251A/en not_active Expired - Fee Related
-
1998
- 1998-04-21 IS IS4722A patent/IS1961B/is unknown
- 1998-04-24 NO NO19981856A patent/NO316256B1/no unknown
-
1999
- 1999-05-24 HK HK99102262A patent/HK1016904A1/xx not_active IP Right Cessation
-
2001
- 2001-06-13 GR GR20010400880T patent/GR3036027T3/el not_active IP Right Cessation
-
2002
- 2002-05-15 CY CY0200033A patent/CY2279B1/xx unknown
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