CY2013033I2 - Φαρμοκολογικη λυση του υαλοειδους, με τη χρηση κολουρης πλασμινης - Google Patents
Φαρμοκολογικη λυση του υαλοειδους, με τη χρηση κολουρης πλασμινηςInfo
- Publication number
- CY2013033I2 CY2013033I2 CY2013033C CY2013033C CY2013033I2 CY 2013033 I2 CY2013033 I2 CY 2013033I2 CY 2013033 C CY2013033 C CY 2013033C CY 2013033 C CY2013033 C CY 2013033C CY 2013033 I2 CY2013033 I2 CY 2013033I2
- Authority
- CY
- Cyprus
- Prior art keywords
- plasmin
- vitreous
- colour
- pharmacological
- dissolution
- Prior art date
Links
- ORWQBKPSGDRPPA-UHFFFAOYSA-N 3-[2-[ethyl(methyl)amino]ethyl]-1h-indol-4-ol Chemical compound C1=CC(O)=C2C(CCN(C)CC)=CNC2=C1 ORWQBKPSGDRPPA-UHFFFAOYSA-N 0.000 title 1
- 238000004090 dissolution Methods 0.000 title 1
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 229940012957 plasmin Drugs 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24007—Interstitial collagenase (3.4.24.7), i.e. matrix metalloprotease 1 or MMP1
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02004—Chondroitin ABC lyase (4.2.2.4), i.e. chondroitinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02005—Chondroitin AC lyase (4.2.2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02019—Chondroitin B lyase (4.2.2.19)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inorganic Insulating Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0228409.9A GB0228409D0 (en) | 2002-12-06 | 2002-12-06 | Pharmacological vitreolysis |
| PCT/US2003/038714 WO2004052228A2 (en) | 2002-12-06 | 2003-12-05 | Pharmacological vitreolysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CY2013033I2 true CY2013033I2 (el) | 2015-11-04 |
| CY2013033I1 CY2013033I1 (el) | 2015-11-04 |
Family
ID=9949140
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100179T CY1112561T1 (el) | 2002-12-06 | 2012-02-21 | Φαρμοκολογικη λυση του υαλοειδους, με τη χρηση κολουρης πλασμινης |
| CY2013033C CY2013033I1 (el) | 2002-12-06 | 2013-08-23 | Φαρμοκολογικη λυση του υαλοειδους, με τη χρηση κολουρης πλασμινης |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100179T CY1112561T1 (el) | 2002-12-06 | 2012-02-21 | Φαρμοκολογικη λυση του υαλοειδους, με τη χρηση κολουρης πλασμινης |
Country Status (25)
| Country | Link |
|---|---|
| US (11) | US7547435B2 (el) |
| EP (3) | EP1581254B1 (el) |
| JP (4) | JP5426063B2 (el) |
| CN (1) | CN100577202C (el) |
| AT (1) | ATE534400T1 (el) |
| AU (1) | AU2003300821C1 (el) |
| BE (1) | BE2013C055I2 (el) |
| BR (2) | BR0317033A (el) |
| CA (1) | CA2508606C (el) |
| CY (2) | CY1112561T1 (el) |
| DK (1) | DK1581254T3 (el) |
| ES (2) | ES2377965T3 (el) |
| FR (1) | FR13C0052I2 (el) |
| GB (1) | GB0228409D0 (el) |
| HK (1) | HK1082419A1 (el) |
| HU (1) | HUS1300040I1 (el) |
| IL (3) | IL169008A (el) |
| LU (1) | LU92273I2 (el) |
| MX (1) | MXPA05006038A (el) |
| NO (4) | NO333837B1 (el) |
| NZ (1) | NZ541075A (el) |
| PT (2) | PT2327416T (el) |
| SI (1) | SI1581254T1 (el) |
| WO (1) | WO2004052228A2 (el) |
| ZA (1) | ZA200505193B (el) |
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| US7152975B2 (en) * | 2000-11-10 | 2006-12-26 | Cooper Vision, Inc. | Junctionless ophthalmic lenses and methods for making same |
| GB0228409D0 (en) | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
| MXPA06012236A (es) | 2004-04-22 | 2007-01-31 | Talecris Biotherapeutics Inc | Plasmina modificada en forma recombinante. |
| JP4796787B2 (ja) * | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | ラビリンチュラ類への遺伝子導入法 |
| US20060257391A1 (en) * | 2005-05-11 | 2006-11-16 | Bausch & Lomb Incorporated | Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
| US20080248021A1 (en) * | 2005-06-30 | 2008-10-09 | Ista Pharmaceuticals, Inc. | Use of Hyaluronidase in Combination with Plasmin for the Induction of Posterior Vitreous Detachment |
| US8231869B2 (en) * | 2005-10-20 | 2012-07-31 | Grifols Therapeutics Inc. | Recombinant plasmin for opthalmic indications |
| US20070134230A1 (en) * | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes |
| US20070134231A1 (en) * | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes and compositions thereof |
| US20070196350A1 (en) * | 2006-02-22 | 2007-08-23 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
| US20070212358A1 (en) * | 2006-03-10 | 2007-09-13 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
| US20090285826A1 (en) * | 2006-05-04 | 2009-11-19 | Fovea Pharmaceuticals Sa | Combination drugs comprising vegf inhibitor and serine proteases/thrombolytic compounds for treating neovascular disorders |
| NZ585715A (en) | 2007-11-29 | 2011-11-25 | Talecris Biotherapeutics Inc | Recombinantly modified plasmin |
| WO2009093970A1 (en) * | 2008-01-22 | 2009-07-30 | Omnio Healer Ab | Method of improving wound healing |
| WO2009121761A1 (en) * | 2008-03-31 | 2009-10-08 | Scarcell Therapeutics | Method for the cosmetic treatment of skin ageing |
| JP2011522538A (ja) | 2008-06-04 | 2011-08-04 | タレクリス・バイオセラピユーテイクス・インコーポレーテツド | プラスミン製造のための組成物、方法およびキット |
| ES2552337T3 (es) | 2009-03-03 | 2015-11-27 | Grifols Therapeutics Inc. | Procedimientos para la preparación de plasminógeno |
| US8858924B2 (en) * | 2009-03-26 | 2014-10-14 | Warsaw Orthopedic, Inc. | Compositions and methods for treatment of hemorrhage |
| CA2767612A1 (en) * | 2009-07-10 | 2011-01-13 | Thrombogenics Nv | Variants of plasminogen and plasmin |
| WO2011023805A1 (en) | 2009-08-28 | 2011-03-03 | Thrombogenics N.V. | Use of plasmin for the treatment of filtration failure after trabeculectomy |
| US20110135626A1 (en) * | 2009-12-08 | 2011-06-09 | Alcon Research, Ltd. | Localized Chemical Lysis of Ocular Tissue |
| WO2012093132A1 (en) | 2011-01-05 | 2012-07-12 | Thrombogenics Nv | Plasminogen and plasmin variants |
| US20120329873A1 (en) * | 2011-06-17 | 2012-12-27 | Li yong-xin | D-serine for the treatment of visual system disorders |
| CN103764163A (zh) | 2011-08-12 | 2014-04-30 | 斯路姆基因公司 | 纤溶酶原和纤溶酶变体 |
| RU2484795C2 (ru) * | 2011-08-18 | 2013-06-20 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Способ индукции задней отслойки стекловидного тела с помощью миниплазмина |
| AU2012321082B2 (en) | 2011-12-01 | 2015-03-12 | Oxurion NV | Improving trabeculectomy outcome |
| CN103205410B (zh) * | 2012-01-13 | 2018-03-06 | 蔺莹莹 | 重组微纤维蛋白溶酶及其制备方法和应用 |
| EP2841454A1 (en) | 2012-04-24 | 2015-03-04 | ThromboGenics N.V. | Anti-pdgf-c antibodies |
| US9730888B2 (en) | 2013-03-14 | 2017-08-15 | Wayne State University | Method of enhancing delivery of therapeutic compounds to the eye |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| US9459201B2 (en) | 2014-09-29 | 2016-10-04 | Zyomed Corp. | Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing |
| FR3034992A1 (fr) | 2015-04-15 | 2016-10-21 | Arcadophta | Milieu plasmatique ex vivo autologue riche en plasmine et procede d'obtention |
| CN108778307A (zh) * | 2015-12-18 | 2018-11-09 | 泰伦基国际有限公司 | 一种预防和治疗糖尿病肾病的方法 |
| TWI653981B (zh) | 2015-12-18 | 2019-03-21 | 深圳瑞健生命科學硏究院有限公司 | Use of plasminogen for the preparation of a medicament for preventing or treating a condition associated with diabetic nerve injury |
| US10709771B2 (en) | 2015-12-18 | 2020-07-14 | Talengen International Limited | Method for preventing or treating diabetic retinopathy |
| CN108712911A (zh) | 2015-12-30 | 2018-10-26 | 科达制药股份有限公司 | 抗体及其缀合物 |
| RU2619991C1 (ru) * | 2016-02-18 | 2017-05-22 | Павел Владимирович Лыскин | Способ лечения витреомакулярного тракционного синдрома |
| US20190031762A1 (en) | 2016-03-10 | 2019-01-31 | Thrombogenics Nv | Posterior ocular fibrosis inhibition by antagonizing placental growth factor |
| US9554738B1 (en) | 2016-03-30 | 2017-01-31 | Zyomed Corp. | Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing |
| WO2018107701A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种新的降血糖和提高糖耐量的药物 |
| CN110506105B (zh) | 2017-03-28 | 2023-03-24 | 森永乳业株式会社 | 新型双歧杆菌属细菌 |
| RU2674926C1 (ru) * | 2018-02-01 | 2018-12-13 | Федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации (ФГАУ "НМИЦ "МНТК "Микрохирургия глаза" им. акад. С.Н. | Способ оценки эффективности витреолизиса помутнений стекловидного тела |
| CN110361242B (zh) * | 2019-08-14 | 2022-01-18 | 武汉赛维尔生物科技有限公司 | 一种用于眼球组织的固定液以及眼球组织制片的预处理方法 |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
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| JP4047170B2 (ja) | 2000-12-21 | 2008-02-13 | トロム−イクス・ナムローゼ・フエンノートシャップ | 酵母発現ベクターおよび酵母細胞における発現による組換えタンパク質の製造方法 |
| US20020139378A1 (en) * | 2001-03-28 | 2002-10-03 | Trese Michael T. | Method for creating a separation of posterior cortical vitreous from the retina of the eye |
| FI20011132A0 (fi) | 2001-05-30 | 2001-05-30 | Innovationsagentur | Markkeri hematopoieettisten kantasolujen tunnistamiseen |
| US7776026B2 (en) | 2002-02-06 | 2010-08-17 | Nuvue Technologies, Inc. | Method for vitreous liquefaction |
| US6787135B2 (en) | 2002-03-13 | 2004-09-07 | William Beaumont Hospital | Modification of vitreal matrix metalloproteinase activity |
| WO2004045558A2 (en) * | 2002-11-18 | 2004-06-03 | President And Fellows Of Harvard College | Compositions and methods for treating thrombotic disorders |
| GB0228409D0 (en) | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
| US20060257391A1 (en) | 2005-05-11 | 2006-11-16 | Bausch & Lomb Incorporated | Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
| US20070212358A1 (en) * | 2006-03-10 | 2007-09-13 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
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2002
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