CY1125258T1 - Νεοι παραγοντες απεικονισης για ανιχνευση νευρολογικης δυσλειτουργιας - Google Patents
Νεοι παραγοντες απεικονισης για ανιχνευση νευρολογικης δυσλειτουργιαςInfo
- Publication number
- CY1125258T1 CY1125258T1 CY20221100245T CY221100245T CY1125258T1 CY 1125258 T1 CY1125258 T1 CY 1125258T1 CY 20221100245 T CY20221100245 T CY 20221100245T CY 221100245 T CY221100245 T CY 221100245T CY 1125258 T1 CY1125258 T1 CY 1125258T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compound
- mammal
- disease
- brain tissue
- detection
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 239000012216 imaging agent Substances 0.000 title 1
- 230000009251 neurologic dysfunction Effects 0.000 title 1
- 208000015015 neurological dysfunction Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 208000024827 Alzheimer disease Diseases 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 3
- 210000005013 brain tissue Anatomy 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001716 carbazoles Chemical class 0.000 abstract 1
- -1 chromenones Chemical class 0.000 abstract 1
- 235000001671 coumarin Nutrition 0.000 abstract 1
- 150000004775 coumarins Chemical class 0.000 abstract 1
- 229930003944 flavone Natural products 0.000 abstract 1
- 150000002213 flavones Chemical class 0.000 abstract 1
- 235000011949 flavones Nutrition 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 150000002460 imidazoles Chemical class 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
- 229930185107 quinolinone Natural products 0.000 abstract 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Αποκαλυπτόμενες στο παρόν είναι ενώσεις και μέθοδοι διάγνωσης ασθένειας Alzheimer ή προδιάθεσης σε αυτή σε ένα θηλαστικό, η δε μέθοδος περιλαμβάνει χορήγηση στο θηλαστικό διαγνωστικώς αποτελεσματικής ποσότητας ραδιοεπισημασμένης ένωσης, όπου η ένωση επιλέγεται από την ομάδα που αποτελείται από ραδιοεπισημασμένες φλαβόνες, κουμαρίνες, καρβαζόλια, κινολινόνες, χρωμενόνες, ιμιδαζόλια και παράγωγα τριαζολίου, επιτρέποντας στην ένωση να κατανέμεται εντός του ιστού εγκεφάλου και απεικόνιση του ιστού εγκεφάλου, όπου μία αύξηση στη σύνδεση της ένωσης στον ιστό εγκεφάλου εν συγκρίσει προς κανονικό επίπεδο αναφοράς σύνδεσης δεικνύει ότι το θηλαστικό υποφέρει από Ασθένεια Alzheimer ή είναι σε κίνδυνο ανάπτυξης Ασθένειας Alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6610108P | 2008-02-14 | 2008-02-14 | |
PCT/US2009/000961 WO2009102498A1 (en) | 2008-02-14 | 2009-02-17 | Novel imaging agents for detecting neurological dysfunction |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1125258T1 true CY1125258T1 (el) | 2024-02-16 |
Family
ID=40627498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20221100245T CY1125258T1 (el) | 2008-02-14 | 2022-03-30 | Νεοι παραγοντες απεικονισης για ανιχνευση νευρολογικης δυσλειτουργιας |
Country Status (15)
Country | Link |
---|---|
US (2) | US20110046378A1 (el) |
EP (2) | EP2247558B1 (el) |
JP (1) | JP2011512354A (el) |
KR (1) | KR20100135235A (el) |
CA (1) | CA2715390A1 (el) |
CY (1) | CY1125258T1 (el) |
DK (1) | DK2247558T3 (el) |
ES (1) | ES2907992T3 (el) |
HR (1) | HRP20220401T3 (el) |
HU (1) | HUE058352T2 (el) |
LT (1) | LT2247558T (el) |
PL (1) | PL2247558T3 (el) |
PT (1) | PT2247558T (el) |
SI (1) | SI2247558T1 (el) |
WO (1) | WO2009102498A1 (el) |
Families Citing this family (46)
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US20110046378A1 (en) | 2008-02-14 | 2011-02-24 | Siemens Medical Solutions Usa, Inc. | Novel Imaging Agents for Detecting Neurological Dysfunction |
US8932557B2 (en) * | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
CA2733499A1 (en) * | 2008-08-08 | 2010-02-11 | Neurosearch A/S | Novel diphenyl 1,2,3-triazole derivatives useful as modulators of nicotinic acetylcholine receptors |
MX349711B (es) * | 2008-09-18 | 2017-08-09 | Cedars Sinai Medical Center | Método óptico para la detección de la enfermedad de alzheimer. |
US8691187B2 (en) * | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
GB201016038D0 (en) | 2010-09-24 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method |
SG190126A1 (en) * | 2010-10-29 | 2013-06-28 | Clino Ltd | Tau imaging probe |
JP6122431B2 (ja) * | 2011-08-11 | 2017-04-26 | アーマロン バイオ ピーティーワイ リミテッド | フラボノイド化合物及びその使用方法 |
US20130315825A1 (en) * | 2012-05-03 | 2013-11-28 | Washington University | Tricyclic heteroaromatic compounds as alpha-synuclein ligands |
WO2013176698A1 (en) * | 2012-05-22 | 2013-11-28 | Eli Lilly And Company | Carboline and carbazole based imaging agents for detecting neurological dysfunction |
JP5422782B1 (ja) | 2012-12-21 | 2014-02-19 | 独立行政法人放射線医学総合研究所 | 脳内に蓄積したタウタンパク質をイメージングするための新規化合物 |
WO2014194169A1 (en) * | 2013-05-31 | 2014-12-04 | The General Hospital Corporation | Radiosynthesis of tau radiopharmaceuticals |
UY35625A (es) | 2013-06-25 | 2014-12-31 | Bristol Myers Squibb Company Una Corporación Del Estado De Delaware | Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa |
WO2014210087A1 (en) | 2013-06-25 | 2014-12-31 | Bristol-Myers Squibb Company | Carbazole carboxamide compounds useful as kinase inhibitors |
AU2014333996B2 (en) | 2013-10-08 | 2018-03-15 | F. Hoffmann-La Roche Ag | Diazacarbazole derivatives as tau-pet-ligands |
TWI667233B (zh) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
WO2015110263A1 (en) * | 2014-01-21 | 2015-07-30 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyolid-like proteins |
SG11201609281UA (en) | 2014-05-13 | 2016-12-29 | Hoffmann La Roche | Deuterated heterocyclic compounds and their use as imaging agents |
JP6487534B2 (ja) | 2014-09-05 | 2019-03-20 | シンビオミックス セラピューティクス、エルエルシー | 細菌性膣炎の治療に使用するためのセクニダゾール |
US10759792B2 (en) | 2014-09-05 | 2020-09-01 | The Johns Hopkins University | CaMKII inhibitors and uses thereof |
SG11201703188QA (en) | 2014-10-24 | 2017-05-30 | Bristol Myers Squibb Co | Indole carboxamides compounds useful as kinase inhibitors |
CN107074804B (zh) | 2014-10-24 | 2020-02-18 | 百时美施贵宝公司 | 咔唑衍生物 |
EP3209652B1 (en) | 2014-10-24 | 2020-04-15 | Bristol-Myers Squibb Company | Tricyclic atropisomer compounds |
MY191590A (en) * | 2015-02-02 | 2022-06-30 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
CN105566269B (zh) * | 2015-03-27 | 2018-07-10 | 北京大学 | 香豆素衍生物的制备、药理作用及治疗瘙痒的应用 |
CN105524034B (zh) * | 2015-03-27 | 2018-08-17 | 北京大学 | 香豆素衍生物的制备、药理作用及治疗脑缺血的应用 |
WO2016196653A1 (en) | 2015-06-01 | 2016-12-08 | Symbiomix Therapeutics, Llc | Novel nitroimidazole formulations and uses thereof |
WO2017009454A1 (en) | 2015-07-15 | 2017-01-19 | Ac Immune S.A. | Novel imaging compounds |
EP3118202A1 (en) | 2015-07-15 | 2017-01-18 | AC Immune S.A. | Dihydropyridopyrrole derivatives as tau-pet-ligands |
WO2017083198A1 (en) | 2015-11-13 | 2017-05-18 | Eli Lilly And Company | Azetidine derivatives for tau imaging |
MA43954A (fr) * | 2016-02-03 | 2018-12-12 | Janssen Pharmaceutica Nv | Ligands d'imagerie tau-pet |
US10865207B2 (en) | 2016-07-22 | 2020-12-15 | Ac Immune S.A. | Compounds for imaging Tau protein aggregates |
CN109475648B (zh) * | 2016-07-22 | 2023-03-14 | Ac免疫有限公司 | 用于成像tau蛋白聚集体的化合物 |
WO2018024642A1 (en) | 2016-08-02 | 2018-02-08 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
WO2018024643A1 (en) | 2016-08-02 | 2018-02-08 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
SI3510031T1 (sl) | 2016-09-09 | 2021-03-31 | F. Hoffmann-La Roche Ag | Postopek za pripravo 2-(6-nitropiridin-3-il)-9H-dipirido(2,3-b;3',4'-d)pirola |
TW201906818A (zh) * | 2017-05-31 | 2019-02-16 | 美商511製藥公司 | 新穎氘取代之正子發射斷層掃描(pet)顯影劑及其藥理應用 |
US20210041447A1 (en) | 2018-01-24 | 2021-02-11 | Ac Immune Sa | Azacarboline compounds for the detection of tau aggregates |
EP3743423A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Gamma-carboline compounds for the detection of tau aggregates |
WO2019168170A1 (ja) * | 2018-03-02 | 2019-09-06 | 国立大学法人 長崎大学 | クロモン誘導体及びアミロイド関連疾患診断用組成物 |
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TW202334089A (zh) | 2021-11-02 | 2023-09-01 | 美商夫雷爾醫療公司 | Pparg反向激動劑及其用途 |
WO2023204967A1 (en) * | 2022-04-21 | 2023-10-26 | Virginia Commonwealth University | Nlrp3 inflammasome inhibitors and compositions and uses thereof |
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-
2009
- 2009-02-17 US US12/867,502 patent/US20110046378A1/en not_active Abandoned
- 2009-02-17 SI SI200932157T patent/SI2247558T1/sl unknown
- 2009-02-17 JP JP2010546795A patent/JP2011512354A/ja active Pending
- 2009-02-17 CA CA2715390A patent/CA2715390A1/en not_active Abandoned
- 2009-02-17 PT PT97111942T patent/PT2247558T/pt unknown
- 2009-02-17 HR HRP20220401TT patent/HRP20220401T3/hr unknown
- 2009-02-17 US US12/372,717 patent/US8318132B2/en active Active
- 2009-02-17 LT LTEPPCT/US2009/000961T patent/LT2247558T/lt unknown
- 2009-02-17 DK DK09711194.2T patent/DK2247558T3/da active
- 2009-02-17 PL PL09711194T patent/PL2247558T3/pl unknown
- 2009-02-17 KR KR1020107020589A patent/KR20100135235A/ko not_active Application Discontinuation
- 2009-02-17 WO PCT/US2009/000961 patent/WO2009102498A1/en active Application Filing
- 2009-02-17 EP EP09711194.2A patent/EP2247558B1/en active Active
- 2009-02-17 HU HUE09711194A patent/HUE058352T2/hu unknown
- 2009-02-17 ES ES09711194T patent/ES2907992T3/es active Active
- 2009-02-17 EP EP20130157487 patent/EP2599763A1/en not_active Withdrawn
-
2022
- 2022-03-30 CY CY20221100245T patent/CY1125258T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
HRP20220401T3 (hr) | 2022-05-27 |
US20110046378A1 (en) | 2011-02-24 |
LT2247558T (lt) | 2022-04-11 |
US20110091382A1 (en) | 2011-04-21 |
JP2011512354A (ja) | 2011-04-21 |
EP2247558A1 (en) | 2010-11-10 |
CA2715390A1 (en) | 2009-08-20 |
HUE058352T2 (hu) | 2022-07-28 |
PL2247558T3 (pl) | 2022-05-02 |
WO2009102498A1 (en) | 2009-08-20 |
EP2247558B1 (en) | 2022-02-02 |
DK2247558T3 (da) | 2022-02-21 |
US8318132B2 (en) | 2012-11-27 |
SI2247558T1 (sl) | 2022-07-29 |
ES2907992T3 (es) | 2022-04-27 |
KR20100135235A (ko) | 2010-12-24 |
PT2247558T (pt) | 2022-03-21 |
EP2599763A1 (en) | 2013-06-05 |
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