CY1124783T1 - Συνθεσεις για in situ ενεσιμα βιοαποδομησιμα εμφυτευματα - Google Patents
Συνθεσεις για in situ ενεσιμα βιοαποδομησιμα εμφυτευματαInfo
- Publication number
- CY1124783T1 CY1124783T1 CY20211101041T CY211101041T CY1124783T1 CY 1124783 T1 CY1124783 T1 CY 1124783T1 CY 20211101041 T CY20211101041 T CY 20211101041T CY 211101041 T CY211101041 T CY 211101041T CY 1124783 T1 CY1124783 T1 CY 1124783T1
- Authority
- CY
- Cyprus
- Prior art keywords
- biodegradable implants
- compositions
- substance
- injectable biodegradable
- lactic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
Τα ενέσιμα σκευάσματα μακράς διάρκειας δράσης, αποτελούμενα από βιοσυμβατό πολυμερές, το οποίο είναι ένα πολυμερές ή ένα συμπολυμερές με βάση το γαλακτικό οξύ ή/και το γαλακτικό οξύ μαζί με γλυκολικό οξύ με αναλογία σε ένα εύρος από 48:52 έως 100:0, έναν διαλύτη αναμίξιμο με νερό με διπολική ροπή περίπου 3,7-4,5 D και διηλεκτρική σταθερά ανάμεσα στο 30 και 50 και μια ουσία, κρίθηκαν κατάλληλα για τον in situ σχηματισμό βιοαποδομήσιμων εμφυτευμάτων που μπορούν να προκαλέσουν θεραπευτικά επίπεδα της ουσίας στο πλάσμα από την πρώτη ημέρα και για τουλάχιστον 14 ημέρες.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10382153.4A EP2394663B1 (en) | 2010-05-31 | 2010-05-31 | Compositions for injectable in-situ biodegradable implants |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124783T1 true CY1124783T1 (el) | 2022-11-25 |
Family
ID=43301929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211101041T CY1124783T1 (el) | 2010-05-31 | 2021-11-29 | Συνθεσεις για in situ ενεσιμα βιοαποδομησιμα εμφυτευματα |
Country Status (21)
Country | Link |
---|---|
US (2) | US10058504B2 (el) |
EP (2) | EP2394663B1 (el) |
JP (1) | JP5923493B2 (el) |
CN (1) | CN102933234A (el) |
BR (1) | BR112012030707A2 (el) |
CA (1) | CA2800641C (el) |
CY (1) | CY1124783T1 (el) |
DK (1) | DK2582395T3 (el) |
EA (1) | EA024211B1 (el) |
ES (2) | ES2897976T3 (el) |
FI (1) | FI2582395T3 (el) |
HR (2) | HRP20211853T1 (el) |
HU (3) | HUE057236T2 (el) |
LT (2) | LT2394663T (el) |
MX (1) | MX346167B (el) |
PL (2) | PL2394663T3 (el) |
PT (2) | PT2394663T (el) |
RS (2) | RS64451B1 (el) |
SI (2) | SI2394663T1 (el) |
WO (1) | WO2011151356A2 (el) |
ZA (1) | ZA201209394B (el) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
BRPI0811319A2 (pt) | 2007-05-25 | 2015-02-10 | Tolmar Therapeutics Inc | Composição fluida, método de formação de uma composição fluida, implante biodegrádavel formado in situ, método de formação de um implante biodegradável in situ, kit, implante e método de trataento |
US10285936B2 (en) | 2010-05-31 | 2019-05-14 | Laboratorios Farmacéuticos Rovi, S.A. | Injectable composition with aromatase inhibitor |
US10335366B2 (en) | 2010-05-31 | 2019-07-02 | Laboratorios Farmacéuticos Rovi, S.A. | Risperidone or paliperidone implant formulation |
US10350159B2 (en) | 2010-05-31 | 2019-07-16 | Laboratories Farmacéuticos Rovi, S.A. | Paliperidone implant formulation |
ES2390439B1 (es) * | 2012-08-03 | 2013-09-27 | Laboratorios Farmacéuticos Rovi, S.A. | Composición inyectable |
LT2394663T (lt) | 2010-05-31 | 2022-02-10 | Laboratorios Farmaceuticos Rovi, S.A. | Kompozicijos, skirtos įšvirkščiamiems in situ biologiškai skaidiems implantams |
US10881605B2 (en) | 2010-05-31 | 2021-01-05 | Laboratorios Farmaceuticos Rovi, S.A. | Methods for the preparation of injectable depot compositions |
US10463607B2 (en) | 2010-05-31 | 2019-11-05 | Laboratorios Farmaceutics Rofi S.A. | Antipsychotic Injectable Depot Composition |
HUE029895T2 (en) | 2010-05-31 | 2017-04-28 | Farm Rovi Lab Sa | Antipsychotic injectable depot preparation |
GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
PL2529757T3 (pl) * | 2011-05-31 | 2014-04-30 | Farm Rovi Lab Sa | Formulacja implantu zawierającego paliperydon |
SI2529756T1 (sl) * | 2011-05-31 | 2021-09-30 | Laboratorios Farmaceuticos Rovi, S.A. | Formulacija vsadka z risperidonom in/ali paliperidonom |
US8935726B2 (en) | 2012-05-11 | 2015-01-13 | Comcast Cable Communications, Llc | Generation of dynamic content interfaces |
BR112015022023B1 (pt) | 2013-03-11 | 2022-12-06 | Durect Corporation | Composição de liberação controlada injetável compreendendo transportador líquido de alta viscosidade |
US20140308352A1 (en) | 2013-03-11 | 2014-10-16 | Zogenix Inc. | Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material |
GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
CN116942677A (zh) | 2015-09-21 | 2023-10-27 | 梯瓦制药国际有限责任公司 | 缓释奥氮平制剂 |
CN107811967B (zh) * | 2016-09-09 | 2021-08-24 | 中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心) | 抗寄生虫药物原位固化缓释注射剂及其制备方法 |
KR20190066608A (ko) * | 2016-09-23 | 2019-06-13 | 델포어, 인코포레이티드 | 소분자 치료제 화합물 조성물 |
WO2018070940A1 (en) * | 2016-10-14 | 2018-04-19 | Nanyang Technological University | An injectable composition for localized controlled and sustained delivery system |
EP3600258A1 (en) | 2017-03-20 | 2020-02-05 | Teva Pharmaceuticals International GmbH | Sustained release olanzapine formulaitons |
WO2019097242A1 (en) * | 2017-11-16 | 2019-05-23 | Persica Pharmaceuticals Ltd. | Linezolid formulations |
PE20210047A1 (es) * | 2018-06-12 | 2021-01-08 | Farm Rovi Lab Sa | Composicion inyectable |
US20240100012A1 (en) | 2021-01-18 | 2024-03-28 | Mark Hasleton | Pharmaceutical dosage form |
AU2022308198A1 (en) | 2021-07-06 | 2024-02-01 | Mark Hasleton | Treatment of serotonin reuptake inhibitor withdrawal syndrome |
TW202313047A (zh) | 2021-09-21 | 2023-04-01 | 西班牙商禾霏藥品實驗室有限公司 | 抗精神病可注射儲積型組合物 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
BE758156R (fr) | 1970-05-13 | 1971-04-28 | Ethicon Inc | Element de suture absorbable et sa |
US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
US4523591A (en) | 1982-10-22 | 1985-06-18 | Kaplan Donald S | Polymers for injection molding of absorbable surgical devices |
US4938763B1 (en) | 1988-10-03 | 1995-07-04 | Atrix Lab Inc | Biodegradable in-situ forming implants and method of producing the same |
US5620700A (en) | 1990-10-30 | 1997-04-15 | Alza Corporation | Injectable drug delivery system and method |
US5656297A (en) * | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
ATE288270T1 (de) | 1993-11-19 | 2005-02-15 | Janssen Pharmaceutica Nv | Mikroverkapselte 1,2-benzazole |
US5620770A (en) | 1995-06-01 | 1997-04-15 | Superior Environmental Products, Inc. | Fifth wheel insert, laminate composite and method of construction |
ATE203157T1 (de) | 1996-12-20 | 2001-08-15 | Alza Corp | Injizierbare depotgelzubereitung und herstellungsverfahren |
KR100289471B1 (ko) * | 1998-01-19 | 2001-09-17 | 김충섭 | 휀타닐계마취제의이식형서방성제제 |
US6143314A (en) | 1998-10-28 | 2000-11-07 | Atrix Laboratories, Inc. | Controlled release liquid delivery compositions with low initial drug burst |
US6565874B1 (en) | 1998-10-28 | 2003-05-20 | Atrix Laboratories | Polymeric delivery formulations of leuprolide with improved efficacy |
US6461631B1 (en) | 1999-11-16 | 2002-10-08 | Atrix Laboratories, Inc. | Biodegradable polymer composition |
EP1248596B1 (de) * | 2000-01-11 | 2007-03-07 | Roland Bodmeier | Kit zur implantation enthaltend eine trägerphase und ein lösungsmittel |
US6604561B2 (en) * | 2000-02-11 | 2003-08-12 | Medical Instill Technologies, Inc. | Medicament vial having a heat-sealable cap, and apparatus and method for filling the vial |
WO2002038185A2 (en) | 2000-11-13 | 2002-05-16 | Atrix Laboratories, Inc. | Injectable sustained release delivery system with loperamide |
US6565080B1 (en) | 2001-12-17 | 2003-05-20 | Hewlett-Packard Development Company, L.P. | Imaging media loading guide |
WO2004064752A2 (en) * | 2003-01-22 | 2004-08-05 | Alkermes Controlled Therapeutics, Inc. | Method of preparing sustained release microparticles |
WO2004081196A2 (en) | 2003-03-11 | 2004-09-23 | Qlt Usa Inc. | Formulations for cell- schedule dependent anticancer agents |
US20050003007A1 (en) | 2003-07-02 | 2005-01-06 | Michele Boix | Method of sterilization of polymeric microparticles |
DK1660039T3 (en) | 2003-07-18 | 2017-01-16 | Oakwood Laboratories L L C | PREVENTION OF REDUCTION OF THE POLYMER MOLECULE WEIGHT, THE PREPARATION OF PURPOSES AND GELING IN POLYMER COMPOSITIONS |
US8444600B2 (en) * | 2003-09-17 | 2013-05-21 | Jae Sang Park | Replaceable heating cartridge for use with a warming device for medical treatment |
US8221778B2 (en) | 2005-01-12 | 2012-07-17 | The Trustees Of The University Of Pennsylvania | Drug-containing implants and methods of use thereof |
AU2005294382A1 (en) | 2004-10-04 | 2006-04-20 | Qlt Usa, Inc. | Ocular delivery of polymeric delivery formulations |
US8313763B2 (en) | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
DK1824460T3 (en) * | 2004-11-10 | 2015-01-19 | Tolmar Therapeutics Inc | Stabilized polymeric delivery system |
DE102005031868A1 (de) * | 2005-07-04 | 2007-01-18 | Biotronik Vi Patent Ag | Arzneimitteldepot zur parenteralen, insbesondere intravaskulären Arzneimittelfreisetzung |
US8852638B2 (en) * | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
SE0600876L (sv) * | 2006-04-20 | 2007-10-21 | Sandvik Intellectual Property | Verktyg och skär för spånavskiljande bearbetning med primära och sekundära ingreppsmedel med rotationssymmetrisk form |
US8076448B2 (en) | 2006-10-11 | 2011-12-13 | Tolmar Therapeutics, Inc. | Preparation of biodegradable polyesters with low-burst properties by supercritical fluid extraction |
PL2079767T3 (pl) * | 2006-10-11 | 2015-05-29 | Tolmar Therapeutics Inc | Wytwarzanie biodegradowalnych poliestrów z właściwościami niskiego wyrzutu przez ekstrakcję płynem nadkrytycznym |
FR2908775B1 (fr) * | 2006-11-17 | 2012-08-31 | Biomatlante | Hydrogel et ses applications biomedicales |
PL2115029T3 (pl) | 2007-02-15 | 2016-01-29 | Tolmar Therapeutics Inc | Poli(laktyd/glikolid) o niskim efekcie nagłego uwalniania i sposoby wytwarzania polimerów |
JP5009361B2 (ja) * | 2007-03-29 | 2012-08-22 | 京セラ株式会社 | 携帯無線機 |
JP5599705B2 (ja) * | 2007-05-18 | 2014-10-01 | デュレクト コーポレーション | 改良されたデポー製剤 |
BRPI0811319A2 (pt) | 2007-05-25 | 2015-02-10 | Tolmar Therapeutics Inc | Composição fluida, método de formação de uma composição fluida, implante biodegrádavel formado in situ, método de formação de um implante biodegradável in situ, kit, implante e método de trataento |
CL2008003305A1 (es) * | 2007-11-06 | 2009-06-05 | M/S Panacea Biotec Ltd | Composicion inyectable que comprende un agente activo seleccionado de un grupo definido; al menos un polimero bioerosionable, al menos un solvente no toxico y opcionalmente uno o mas excipientes; proceso de preparacion; uso para tratar enfermedades mentales o cancer. |
US8629172B2 (en) * | 2008-04-18 | 2014-01-14 | Warsaw Orthopedic, Inc. | Methods and compositions for treating post-operative pain comprising clonidine |
US10335366B2 (en) | 2010-05-31 | 2019-07-02 | Laboratorios Farmacéuticos Rovi, S.A. | Risperidone or paliperidone implant formulation |
ES2390439B1 (es) | 2012-08-03 | 2013-09-27 | Laboratorios Farmacéuticos Rovi, S.A. | Composición inyectable |
US10350159B2 (en) | 2010-05-31 | 2019-07-16 | Laboratories Farmacéuticos Rovi, S.A. | Paliperidone implant formulation |
US10285936B2 (en) | 2010-05-31 | 2019-05-14 | Laboratorios Farmacéuticos Rovi, S.A. | Injectable composition with aromatase inhibitor |
HUE029895T2 (en) | 2010-05-31 | 2017-04-28 | Farm Rovi Lab Sa | Antipsychotic injectable depot preparation |
LT2394663T (lt) | 2010-05-31 | 2022-02-10 | Laboratorios Farmaceuticos Rovi, S.A. | Kompozicijos, skirtos įšvirkščiamiems in situ biologiškai skaidiems implantams |
SI2529756T1 (sl) | 2011-05-31 | 2021-09-30 | Laboratorios Farmaceuticos Rovi, S.A. | Formulacija vsadka z risperidonom in/ali paliperidonom |
PL2529757T3 (pl) | 2011-05-31 | 2014-04-30 | Farm Rovi Lab Sa | Formulacja implantu zawierającego paliperydon |
-
2010
- 2010-05-31 LT LTEP10382153.4T patent/LT2394663T/lt unknown
- 2010-05-31 HU HUE10382153A patent/HUE057236T2/hu unknown
- 2010-05-31 PL PL10382153T patent/PL2394663T3/pl unknown
- 2010-05-31 HR HRP20211853TT patent/HRP20211853T1/hr unknown
- 2010-05-31 ES ES10382153T patent/ES2897976T3/es active Active
- 2010-05-31 PT PT103821534T patent/PT2394663T/pt unknown
- 2010-05-31 EP EP10382153.4A patent/EP2394663B1/en active Active
- 2010-05-31 SI SI201032097T patent/SI2394663T1/sl unknown
-
2011
- 2011-05-31 CA CA2800641A patent/CA2800641C/en active Active
- 2011-05-31 HU HUE11723441A patent/HUE063623T2/hu unknown
- 2011-05-31 SI SI201132088T patent/SI2582395T1/sl unknown
- 2011-05-31 DK DK11723441.9T patent/DK2582395T3/da active
- 2011-05-31 EP EP11723441.9A patent/EP2582395B1/en active Active
- 2011-05-31 PL PL11723441.9T patent/PL2582395T3/pl unknown
- 2011-05-31 FI FIEP11723441.9T patent/FI2582395T3/fi active
- 2011-05-31 ES ES11723441T patent/ES2950857T3/es active Active
- 2011-05-31 LT LTEPPCT/EP2011/059001T patent/LT2582395T/lt unknown
- 2011-05-31 BR BR112012030707A patent/BR112012030707A2/pt not_active Application Discontinuation
- 2011-05-31 PT PT117234419T patent/PT2582395T/pt unknown
- 2011-05-31 HR HRP20230890TT patent/HRP20230890T1/hr unknown
- 2011-05-31 RS RS20230619A patent/RS64451B1/sr unknown
- 2011-05-31 CN CN2011800265312A patent/CN102933234A/zh active Pending
- 2011-05-31 WO PCT/EP2011/059001 patent/WO2011151356A2/en active Application Filing
- 2011-05-31 MX MX2012013867A patent/MX346167B/es active IP Right Grant
- 2011-05-31 EA EA201201570A patent/EA024211B1/ru unknown
- 2011-05-31 JP JP2013512880A patent/JP5923493B2/ja active Active
-
2012
- 2012-05-31 RS RS20140075A patent/RS53205B/en unknown
- 2012-05-31 HU HUE12170362A patent/HUE054922T2/hu unknown
- 2012-11-30 US US13/690,707 patent/US10058504B2/en active Active
- 2012-12-11 ZA ZA2012/09394A patent/ZA201209394B/en unknown
-
2018
- 2018-07-11 US US16/032,270 patent/US10195138B2/en active Active
-
2021
- 2021-11-29 CY CY20211101041T patent/CY1124783T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1124783T1 (el) | Συνθεσεις για in situ ενεσιμα βιοαποδομησιμα εμφυτευματα | |
CY1124206T1 (el) | Αναστολεις πυριδοπυριμδινονης cdk2/4/6 | |
CY1119531T1 (el) | Ενωσεις και συνθεσεις για την ρυθμιση της δραστηριοτητας toy egfr | |
CY1122475T1 (el) | Μια μορφοποιηση φαρμακου καθυστερημενης εκλυσης | |
CY1124369T1 (el) | Συνθεση εμφυτευματος ρισπεριδονης ή/και παλιπεριδονης | |
CY1121700T1 (el) | Σχηματισμοι οξινου αλατος ενος συζυγους πολυμερους-φαρμακου | |
CY1114975T1 (el) | Σκευασμα εμφυτευματος παλιπεριδονης | |
CY1117207T1 (el) | Ιξωδοελαστικες γελες ως νεα υλικα πληρωσης | |
CY1123626T1 (el) | Ετεροκυκλικοι αναστολεις πρωτεϊνικης κινασης | |
CY1118771T1 (el) | Μακροκυκλικα παραγωγα για την αγωγη υπερπλαστικων παθησεων | |
CY1120460T1 (el) | Παραγωγο πυραζολοπυριμιδινης με υποκατεστημενη τη θεση 4, και χρηση αυτου στην παρασκευη φαρμακων | |
CY1122252T1 (el) | Ενεσιμο παρασκευασμα | |
CY1119843T1 (el) | Φαινυλοξικη l-ορνιθινη και μεθοδοι παρασκευης αυτης | |
CY1116150T1 (el) | Παραγωγα οξαδιαζολης και η χρηση τους ως ενισχυτων μεταβοτροπικου υποδοχεα γλουταμικου - 842 | |
CO6640285A2 (es) | 5-alquinil-pirimidinas | |
UA111162C2 (uk) | Ін'єкційна композиція ацетоніду триамцинолону для лікування болю | |
CY1125114T1 (el) | Συνθεσεις και μεθοδοι για τη μειωση μειζωνων ανεπιθυμητων καρδιαγγειακων συμβαντων | |
CY1125157T1 (el) | Ενεσιμες συνθεσεις που εμπεριεχουν λετροζολη ή αναστροζολη | |
EA201691194A1 (ru) | Стимуляторы ргц | |
IN2014CN00827A (el) | ||
CY1109644T1 (el) | 2,4-διαμινο-πυριμιδινες ως αναστολεις audora | |
CY1123056T1 (el) | Νεα μορφη χορηγησης της ρασεκαδοτριλης | |
WO2012009661A3 (en) | Conductive biopolymer implant for enhancing tissue repair and regeneration using electromagnetic fields | |
ITPD20050146A1 (it) | Fillers riassorbibili costituiti da liposomi e acido ialuronico e o suoi derivati | |
CY1123582T1 (el) | Προφαρμακα των αναστολεων αντιστροφης μεταγραφασης hiv |