CY1122960T1 - Συνθεσεις γλυκοπεπτιδιου - Google Patents
Συνθεσεις γλυκοπεπτιδιουInfo
- Publication number
- CY1122960T1 CY1122960T1 CY20201100266T CY201100266T CY1122960T1 CY 1122960 T1 CY1122960 T1 CY 1122960T1 CY 20201100266 T CY20201100266 T CY 20201100266T CY 201100266 T CY201100266 T CY 201100266T CY 1122960 T1 CY1122960 T1 CY 1122960T1
- Authority
- CY
- Cyprus
- Prior art keywords
- acetyl
- solutions
- amino acid
- vancomycin
- alanine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Παρέχονται διαλύματα περιλαμβάνοντα ένα γλυκοπεπτιδικό αντιβιοτικό, για παράδειγμα, βανκομυκίνη και ένα αμινοξύ ή ένα παράγωγο αμινοξέος όπως Ν-ακετυλ-γλυκίνη ή Ν-ακετυλ-D-αλανίνη. Αυτά τα διαλύματα είναι σταθερά ή σταθεροποιημένα επί μακρές περιόδους σε συνθήκες κανονικής χρήσεως και αποθηκεύσεως και μπορεί να συσταθούν ως φαρμακευτικά διαλύματα για χρήση σε άτομα. Παρέχονται επίσης μέθοδοι κατασκευής και χρήσεως αυτών των διαλυμάτων, όπως επίσης μέθοδοι σταθεροποιήσεως ενός γλυκοπεπτιδικού αντιβιοτικού, για παράδειγμα, βανκομυκίνης, δια της χρήσεως αμινοξέων ή παραγώγων αμινοξέων όπως Ν-ακετυλ-γλυκίνης ή Ν-ακετυλ-D-αλανίνης.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462076400P | 2014-11-06 | 2014-11-06 | |
| US201562168749P | 2015-05-30 | 2015-05-30 | |
| PCT/EP2015/075918 WO2016071495A1 (en) | 2014-11-06 | 2015-11-06 | Glycopeptide compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122960T1 true CY1122960T1 (el) | 2021-10-29 |
Family
ID=54478023
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20201100266T CY1122960T1 (el) | 2014-11-06 | 2020-03-20 | Συνθεσεις γλυκοπεπτιδιου |
| CY20211100307T CY1124011T1 (el) | 2014-11-06 | 2021-04-09 | Συνθεσεις γλυκοπεπτιδιου |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20211100307T CY1124011T1 (el) | 2014-11-06 | 2021-04-09 | Συνθεσεις γλυκοπεπτιδιου |
Country Status (30)
| Country | Link |
|---|---|
| US (7) | US10188697B2 (el) |
| EP (4) | EP3215173B8 (el) |
| JP (2) | JP6797795B2 (el) |
| KR (2) | KR102603756B1 (el) |
| CN (1) | CN107073072B (el) |
| AU (1) | AU2015341763B2 (el) |
| BR (1) | BR112017009405B1 (el) |
| CA (1) | CA2964524A1 (el) |
| CL (1) | CL2017001139A1 (el) |
| CO (1) | CO2017005391A2 (el) |
| CR (1) | CR20170234A (el) |
| CY (2) | CY1122960T1 (el) |
| DK (2) | DK3215173T3 (el) |
| EA (1) | EA035368B1 (el) |
| ES (2) | ES2852550T3 (el) |
| HR (2) | HRP20200101T1 (el) |
| HU (2) | HUE053347T2 (el) |
| IL (1) | IL252120B (el) |
| MX (1) | MX2017005749A (el) |
| NZ (1) | NZ731955A (el) |
| PH (1) | PH12017500720A1 (el) |
| PL (2) | PL3215173T3 (el) |
| PT (2) | PT3215173T (el) |
| RS (2) | RS59851B1 (el) |
| SA (1) | SA517381446B1 (el) |
| SG (1) | SG11201703568WA (el) |
| SI (2) | SI3542812T1 (el) |
| TN (1) | TN2017000182A1 (el) |
| WO (1) | WO2016071495A1 (el) |
| ZA (1) | ZA201702767B (el) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS59851B1 (sr) * | 2014-11-06 | 2020-02-28 | Xellia Pharmaceuticals Aps | Kompozicije glikopeptida |
| WO2017111601A1 (en) * | 2015-12-24 | 2017-06-29 | Universiteit Leiden | Composition and method for treating infections caused by vancomycin-resistant infectious agents in a subject |
| EA201892413A1 (ru) * | 2016-05-09 | 2019-05-31 | Кселлия Фармасьютикалз Апс | Стабилизированные препараты гликопептидного антибиотика |
| WO2018096556A1 (en) * | 2016-11-23 | 2018-05-31 | Gufic Biosciences Limited | Lyophilized pharmaceutical compositions of dalbavancin |
| JP7118412B2 (ja) * | 2017-07-31 | 2022-08-16 | 東洋製薬化成株式会社 | バンコマイシン懸濁液充填カプセル製剤 |
| CN109725101B (zh) * | 2017-10-31 | 2021-11-19 | 正大天晴药业集团股份有限公司 | 盐酸特拉万星原料中有关物质的检测方法 |
| CN109078001B (zh) * | 2018-09-21 | 2021-05-07 | 深圳浦瑞健康科技有限公司 | 一种万古霉素纳米脂质体组合物及其制备方法 |
| US20220184173A1 (en) | 2019-03-08 | 2022-06-16 | Emphascience, Inc. | Stable pharmaceutical formulations of peptide and protein drugs |
| US11433115B2 (en) * | 2020-10-30 | 2022-09-06 | Somerset Therapeutics, Llc | Glycopeptide antibiotics liquid formulations and methods and uses thereof |
| EP4014969A1 (en) * | 2020-12-16 | 2022-06-22 | EVER Valinject GmbH | Aqueous solution |
| EP4014965A1 (en) | 2020-12-16 | 2022-06-22 | EVER Valinject GmbH | Aqueous solution |
| WO2022234036A1 (en) * | 2021-05-07 | 2022-11-10 | Xellia Pharmaceuticals Aps | Oral liquid vancomycin formulations |
| CN115804832A (zh) * | 2021-09-14 | 2023-03-17 | 海南普利制药股份有限公司 | 一种万古霉素水溶液组合物 |
| WO2023171588A1 (ja) * | 2022-03-08 | 2023-09-14 | 国立大学法人大阪大学 | 抗菌薬を含有するｐｌｇａ製剤 |
| GB202207344D0 (en) | 2022-05-19 | 2022-07-06 | Arecor Ltd | Novel composition |
| GB202207345D0 (en) | 2022-05-19 | 2022-07-06 | Arecor Ltd | Novel composition |
| WO2024079224A1 (en) * | 2022-10-12 | 2024-04-18 | Xellia Pharmaceuticals Aps | Liquid dalbavancin composition |
| WO2024079223A1 (en) * | 2022-10-12 | 2024-04-18 | Xellia Pharmaceuticals Aps | Liquid dalbavancin composition |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670258A (en) | 1984-02-10 | 1987-06-02 | Vanderbilt University | Storable prepackaged aqueous solutions of vancomycin |
| RU2145609C1 (ru) | 1994-01-28 | 2000-02-20 | Эли Лилли Энд Компани | Производные гликопептида или их соли, способ получения, фармацевтическая композиция |
| AU1407197A (en) | 1995-12-01 | 1997-06-19 | Eli Lilly And Company | Stable vancomycin hydrochloride solutions |
| JPH1180021A (ja) | 1997-09-02 | 1999-03-23 | Kayaku:Kk | バンコマイシン注射剤 |
| US6800608B2 (en) | 2001-06-22 | 2004-10-05 | Beckman Coulter, Inc. | Homogeneous assay of vancomycin using a stable particle-vancomycin conjugate, a novel rate enhancer, and a novel dose response modulator |
| JP2005521712A (ja) * | 2002-03-26 | 2005-07-21 | アリゾナ ボード オブ リージェンツ オン ビハーフ オブ ザ ユニバーシティー オブ アリゾナ | 弱塩基の可溶化 |
| GB0212622D0 (en) * | 2002-05-31 | 2002-07-10 | Natural Technologies Group Ltd | Bacterial transforming agent |
| JP2006506442A (ja) | 2002-07-09 | 2006-02-23 | ポイント セラピューティクス， インコーポレイテッド | ボロプロリン化合物併用療法 |
| CN1802090A (zh) * | 2002-07-09 | 2006-07-12 | 尖端医疗有限公司 | 硼脯氨酸化合物组合治疗 |
| HUE041133T2 (hu) | 2002-11-18 | 2019-05-28 | Vicuron Pharmaceuticals Llc | Dalbavancin adagolási módszer bakteriális fertõzések kezelésére |
| WO2006085337A1 (en) | 2005-02-14 | 2006-08-17 | Venus Remedies Limited | Parenteral combination therpy for infective conditions with drug resistant bacterium |
| CN1857716A (zh) * | 2006-03-14 | 2006-11-08 | 浙江大学 | 注射用盐酸万古霉素及其制备方法 |
| JP2008201778A (ja) * | 2007-01-25 | 2008-09-04 | Mochida Pharmaceut Co Ltd | バンコマイシン液状製剤 |
| WO2009075859A2 (en) * | 2007-12-11 | 2009-06-18 | Conjuchem Biotechnologies Inc. | Formulation of insulinotropic peptide conjugates |
| JP2011080021A (ja) | 2009-10-09 | 2011-04-21 | Bridgestone Corp | 熱可塑性エラストマー組成物及びその成形体 |
| MX346244B (es) * | 2011-05-19 | 2017-03-13 | Savara Inc | Composiciones de vancomicina en polvo seco y metodos asociados. |
| WO2014026052A1 (en) | 2012-08-08 | 2014-02-13 | Vanderbilt University | Composition with biofilm dispersal agents |
| MX2015006681A (es) | 2012-11-29 | 2016-04-06 | Insmed Inc | Formulaciones de vancomicina estabilizadas. |
| CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
| US9616098B2 (en) * | 2013-05-30 | 2017-04-11 | Scidose, Llc | Formulations of vancomycin |
| ES2903419T3 (es) | 2014-03-14 | 2022-04-01 | Azurity Pharmaceuticals Inc | Composición y método para líquido oral de vancomicina |
| RS59851B1 (sr) | 2014-11-06 | 2020-02-28 | Xellia Pharmaceuticals Aps | Kompozicije glikopeptida |
| EA201892413A1 (ru) | 2016-05-09 | 2019-05-31 | Кселлия Фармасьютикалз Апс | Стабилизированные препараты гликопептидного антибиотика |
| US11433115B2 (en) | 2020-10-30 | 2022-09-06 | Somerset Therapeutics, Llc | Glycopeptide antibiotics liquid formulations and methods and uses thereof |
| EP4014969A1 (en) | 2020-12-16 | 2022-06-22 | EVER Valinject GmbH | Aqueous solution |
| EP4014965A1 (en) | 2020-12-16 | 2022-06-22 | EVER Valinject GmbH | Aqueous solution |
-
2015
- 2015-11-06 RS RS20200080A patent/RS59851B1/sr unknown
- 2015-11-06 HU HUE19174849A patent/HUE053347T2/hu unknown
- 2015-11-06 SI SI201531539T patent/SI3542812T1/sl unknown
- 2015-11-06 HU HUE15791287A patent/HUE049857T2/hu unknown
- 2015-11-06 US US15/524,653 patent/US10188697B2/en active Active
- 2015-11-06 EP EP15791287.4A patent/EP3215173B8/en not_active Revoked
- 2015-11-06 KR KR1020177015221A patent/KR102603756B1/ko active IP Right Grant
- 2015-11-06 BR BR112017009405-3A patent/BR112017009405B1/pt active IP Right Grant
- 2015-11-06 MX MX2017005749A patent/MX2017005749A/es unknown
- 2015-11-06 EP EP20215453.0A patent/EP3834837A1/en active Pending
- 2015-11-06 SG SG11201703568WA patent/SG11201703568WA/en unknown
- 2015-11-06 CR CR20170234A patent/CR20170234A/es unknown
- 2015-11-06 DK DK15791287.4T patent/DK3215173T3/da active
- 2015-11-06 ES ES19174849T patent/ES2852550T3/es active Active
- 2015-11-06 PT PT157912874T patent/PT3215173T/pt unknown
- 2015-11-06 SI SI201531067T patent/SI3215173T1/sl unknown
- 2015-11-06 ES ES15791287T patent/ES2769849T3/es active Active
- 2015-11-06 WO PCT/EP2015/075918 patent/WO2016071495A1/en active Application Filing
- 2015-11-06 PT PT191748490T patent/PT3542812T/pt unknown
- 2015-11-06 JP JP2017523438A patent/JP6797795B2/ja active Active
- 2015-11-06 CA CA2964524A patent/CA2964524A1/en active Pending
- 2015-11-06 EP EP22203229.4A patent/EP4147710A1/en active Pending
- 2015-11-06 PL PL15791287T patent/PL3215173T3/pl unknown
- 2015-11-06 PL PL19174849T patent/PL3542812T3/pl unknown
- 2015-11-06 CN CN201580060330.2A patent/CN107073072B/zh active Active
- 2015-11-06 AU AU2015341763A patent/AU2015341763B2/en active Active
- 2015-11-06 NZ NZ731955A patent/NZ731955A/en unknown
- 2015-11-06 EA EA201790997A patent/EA035368B1/ru unknown
- 2015-11-06 RS RS20210108A patent/RS61418B1/sr unknown
- 2015-11-06 DK DK19174849.0T patent/DK3542812T3/da active
- 2015-11-06 KR KR1020237020985A patent/KR20230096142A/ko not_active Application Discontinuation
- 2015-11-06 EP EP19174849.0A patent/EP3542812B1/en active Active
- 2015-11-06 TN TN2017000182A patent/TN2017000182A1/en unknown
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2017
- 2017-04-18 PH PH12017500720A patent/PH12017500720A1/en unknown
- 2017-04-19 ZA ZA2017/02767A patent/ZA201702767B/en unknown
- 2017-05-01 SA SA517381446A patent/SA517381446B1/ar unknown
- 2017-05-04 IL IL252120A patent/IL252120B/en active IP Right Grant
- 2017-05-05 CL CL2017001139A patent/CL2017001139A1/es unknown
- 2017-05-26 CO CONC2017/0005391A patent/CO2017005391A2/es unknown
- 2017-11-30 US US15/827,719 patent/US10039804B2/en active Active
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2018
- 2018-12-11 US US16/216,446 patent/US10849956B2/en active Active
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2019
- 2019-11-07 US US16/677,057 patent/US11000567B2/en active Active
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2020
- 2020-01-21 HR HRP20200101TT patent/HRP20200101T1/hr unknown
- 2020-03-20 CY CY20201100266T patent/CY1122960T1/el unknown
- 2020-07-20 JP JP2020123671A patent/JP7032488B2/ja active Active
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2021
- 2021-03-01 HR HRP20210342TT patent/HRP20210342T8/hr unknown
- 2021-03-29 US US17/215,675 patent/US11628200B2/en active Active
- 2021-04-09 CY CY20211100307T patent/CY1124011T1/el unknown
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2022
- 2022-07-08 US US17/860,642 patent/US11517609B2/en active Active
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2023
- 2023-01-06 US US18/151,155 patent/US20230158101A1/en active Pending
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