CY1122721T1 - Αντισωματα που δεσμευουν αχl - Google Patents

Αντισωματα που δεσμευουν αχl

Info

Publication number
CY1122721T1
CY1122721T1 CY20201100192T CY201100192T CY1122721T1 CY 1122721 T1 CY1122721 T1 CY 1122721T1 CY 20201100192 T CY20201100192 T CY 20201100192T CY 201100192 T CY201100192 T CY 201100192T CY 1122721 T1 CY1122721 T1 CY 1122721T1
Authority
CY
Cyprus
Prior art keywords
antibodies
acl
bind
immunoconjugates
compositions
Prior art date
Application number
CY20201100192T
Other languages
Greek (el)
English (en)
Inventor
Esther BREIJ
David Satijn
Edward Norbert Van Den Brink
Dennis VERZIJL
Rob N. De Jong
Paul Parren
Riemke VAN DIJKHUIZEN RADERSMA
Original Assignee
Genmab A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genmab A/S filed Critical Genmab A/S
Publication of CY1122721T1 publication Critical patent/CY1122721T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • A—HUMAN NECESSITIES
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    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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US10512688B2 (en) 2019-12-24
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EA201790173A1 (ru) 2017-06-30
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JP2024026158A (ja) 2024-02-28
ZA201608609B (en) 2020-12-23
US20180214549A1 (en) 2018-08-02
BR112017000316A2 (pt) 2017-10-31
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CN114621347A (zh) 2022-06-14
PL3169706T3 (pl) 2020-05-18
PT3169706T (pt) 2020-03-13
ES2774428T3 (es) 2020-07-21
US10201607B2 (en) 2019-02-12
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