CY1122174T1 - Βακτηριακο στελεχος ξενιστη που περιεχει ενα μεταλλαγμενο γονιδιο spr και ενα γονιδιο αγριου-τυπου tsp - Google Patents

Βακτηριακο στελεχος ξενιστη που περιεχει ενα μεταλλαγμενο γονιδιο spr και ενα γονιδιο αγριου-τυπου tsp

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Publication number
CY1122174T1
CY1122174T1 CY20191101071T CY191101071T CY1122174T1 CY 1122174 T1 CY1122174 T1 CY 1122174T1 CY 20191101071 T CY20191101071 T CY 20191101071T CY 191101071 T CY191101071 T CY 191101071T CY 1122174 T1 CY1122174 T1 CY 1122174T1
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CY
Cyprus
Prior art keywords
gene
wild
mutant spr
bacterial host
host strain
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Application number
CY20191101071T
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English (en)
Inventor
Mark Ellis
David Paul Humphreys
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Ucb Biopharma Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Biopharma Sprl filed Critical Ucb Biopharma Sprl
Publication of CY1122174T1 publication Critical patent/CY1122174T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/22—Processes using, or culture media containing, cellulose or hydrolysates thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/26—Processes using, or culture media containing, hydrocarbons
    • C12N1/28—Processes using, or culture media containing, hydrocarbons aliphatic
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει ένα ανασυνδυασμένο gram-αρνητικό βακτηριακό κύτταρο που περιέχει ένα μεταλλαγμένο γονίδιο spr που κωδικοποιεί μια μεταλλαγμένη πρωτεΐνη spr και όπου το κύτταρο περιλαμβάνει ένα μη-ανασυνδυασμένο άγριου- τύπου χρωμοσωμικό γονίδιο Tsp.
CY20191101071T 2010-01-14 2019-10-11 Βακτηριακο στελεχος ξενιστη που περιεχει ενα μεταλλαγμενο γονιδιο spr και ενα γονιδιο αγριου-τυπου tsp CY1122174T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1000590.8A GB201000590D0 (en) 2010-01-14 2010-01-14 Bacterial host strain
PCT/EP2011/050415 WO2011086138A1 (en) 2010-01-14 2011-01-13 Bacterial host strain comprising a mutant spr gene and a wild-type tsp gene

Publications (1)

Publication Number Publication Date
CY1122174T1 true CY1122174T1 (el) 2020-11-25

Family

ID=42028360

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191101071T CY1122174T1 (el) 2010-01-14 2019-10-11 Βακτηριακο στελεχος ξενιστη που περιεχει ενα μεταλλαγμενο γονιδιο spr και ενα γονιδιο αγριου-τυπου tsp

Country Status (23)

Country Link
US (2) US8969037B2 (el)
EP (1) EP2523975B1 (el)
JP (1) JP5960607B2 (el)
KR (1) KR101741865B1 (el)
CN (1) CN102712694B (el)
AU (2) AU2011206586B2 (el)
BR (1) BR112012016807B1 (el)
CA (1) CA2785931C (el)
CY (1) CY1122174T1 (el)
DK (1) DK2523975T3 (el)
ES (1) ES2747981T3 (el)
GB (1) GB201000590D0 (el)
HK (1) HK1176942A1 (el)
HR (1) HRP20191815T1 (el)
HU (1) HUE046420T2 (el)
LT (1) LT2523975T (el)
ME (1) ME03561B (el)
PL (1) PL2523975T3 (el)
PT (1) PT2523975T (el)
RS (1) RS59417B1 (el)
SG (1) SG182279A1 (el)
SI (1) SI2523975T1 (el)
WO (1) WO2011086138A1 (el)

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JP2013516965A (ja) 2013-05-16
CA2785931A1 (en) 2011-07-21
HK1176942A1 (zh) 2013-08-09
AU2017200545B2 (en) 2018-10-25
SI2523975T1 (sl) 2019-10-30
PT2523975T (pt) 2019-10-14
BR112012016807B1 (pt) 2019-09-10
US20150166651A1 (en) 2015-06-18
KR20120125569A (ko) 2012-11-15
ME03561B (me) 2020-07-20
HUE046420T2 (hu) 2020-03-30
SG182279A1 (en) 2012-08-30
US9493558B2 (en) 2016-11-15
GB201000590D0 (en) 2010-03-03
CA2785931C (en) 2019-07-30
WO2011086138A1 (en) 2011-07-21
BR112012016807A2 (pt) 2017-06-27
EP2523975A1 (en) 2012-11-21
HRP20191815T1 (hr) 2019-12-27
ES2747981T3 (es) 2020-03-12
BR112012016807A8 (pt) 2019-08-06
AU2011206586B2 (en) 2016-10-27
LT2523975T (lt) 2019-09-25
AU2017200545A1 (en) 2017-02-23
EP2523975B1 (en) 2019-07-17
JP5960607B2 (ja) 2016-08-02
CN102712694A (zh) 2012-10-03
US8969037B2 (en) 2015-03-03
AU2011206586A1 (en) 2012-07-19
CN102712694B (zh) 2015-09-09
DK2523975T3 (da) 2019-09-23
RS59417B1 (sr) 2019-11-29
KR101741865B1 (ko) 2017-05-30
PL2523975T3 (pl) 2020-01-31
US20120301920A1 (en) 2012-11-29

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