CY1122088T1 - Φαρμακευτικeς συνθeσεις που περιλαμβaνουν εναν ρυθμιστh s1p - Google Patents

Φαρμακευτικeς συνθeσεις που περιλαμβaνουν εναν ρυθμιστh s1p

Info

Publication number
CY1122088T1
CY1122088T1 CY20191101023T CY191101023T CY1122088T1 CY 1122088 T1 CY1122088 T1 CY 1122088T1 CY 20191101023 T CY20191101023 T CY 20191101023T CY 191101023 T CY191101023 T CY 191101023T CY 1122088 T1 CY1122088 T1 CY 1122088T1
Authority
CY
Cyprus
Prior art keywords
pharmaceutical compositions
regulator
pharmaceutical composition
coating
receptor modulator
Prior art date
Application number
CY20191101023T
Other languages
English (en)
Inventor
Michael Ambühl
Jutta Beyer
Begona Carreno-Gomez
Colleen Ruegger
Stephen Valazza
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38904777&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1122088(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP06121302A external-priority patent/EP1923055A1/en
Priority claimed from EP06121301A external-priority patent/EP1923054A1/en
Priority claimed from EP06121299A external-priority patent/EP1923058A1/en
Priority claimed from EP06121276A external-priority patent/EP1905434A1/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CY1122088T1 publication Critical patent/CY1122088T1/el

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    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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Abstract

Η παρούσα εφεύρεση παρέχει διάφορες φαρμακευτικές συνθέσεις που περιλαμβάνουν έναν ρυθμιστή υποδοχέα S1P, π.χ. έναν αγωνιστή υποδοχέα S1P. Σύμφωνα με μία άποψη, παρέχεται μια φαρμακευτική σύνθεση που διαθέτει επικάλυψη. Σύμφωνα με άλλες απόψεις, παρέχονται συνθέσεις ταχείας αποσύνθεσης. Σε μια περαιτέρω άποψη, παρέχεται μια φαρμακευτική σύνθεση η οποία είναι απαλλαγμένη από αλκοόλες σακχάρων. Σύμφωνα με μια άλλη άποψη, η εφεύρεση παρέχει μια φαρμακευτική σύνθεση που περιλαμβάνει επικάλυψη η οποία περιλαμβάνει έναν ρυθμιστή υποδοχέα S1Ρ.
CY20191101023T 2006-09-26 2019-10-02 Φαρμακευτικeς συνθeσεις που περιλαμβaνουν εναν ρυθμιστh s1p CY1122088T1 (el)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP06121302A EP1923055A1 (en) 2006-09-26 2006-09-26 Freeze-dried pharmaceutical composition comprising an S1P agonist or modulator
EP06121301A EP1923054A1 (en) 2006-09-26 2006-09-26 Fast disintegrating pharmaceutical composition comprising an S1P agonist or modulator
EP06121299A EP1923058A1 (en) 2006-09-26 2006-09-26 Coated pharmaceutical composition comprising an S1P agonist or modulator
EP06121276A EP1905434A1 (en) 2006-09-26 2006-09-26 Organic compounds comprising an S1P receptor agonist and their therapeutic use
EP07818399A EP2086514A2 (en) 2006-09-26 2007-09-25 Pharmaceutical compositions comprising an s1p modulator
PCT/EP2007/008314 WO2008037421A2 (en) 2006-09-26 2007-09-25 Pharmaceutical compositions comprising an s1p modulator

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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102579387A (zh) 2006-09-26 2012-07-18 诺瓦提斯公司 包含s1p调节剂的药物组合物
AU2012216630B2 (en) * 2007-10-12 2015-01-22 Novartis Ag Compositions comprising sphingosine 1 phosphate (S1P) receptor modulators
EP3120833A1 (en) * 2007-10-12 2017-01-25 Novartis Ag Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators
WO2009155475A1 (en) 2008-06-20 2009-12-23 Novartis Ag Paediatric compositions for treating1 multiple sclerosis
US8530522B2 (en) * 2008-11-11 2013-09-10 Novartis Ag Organic compounds
EP2560619A2 (en) * 2010-04-22 2013-02-27 Ratiopharm GmbH A method of preparing an oral dosage form comprising fingolimod
AR085749A1 (es) * 2011-04-01 2013-10-23 Novartis Ag Formulaciones
AU2011100881B4 (en) * 2011-07-14 2013-12-05 Novartis Ag Oral formulations
AU2011100879B4 (en) * 2011-07-14 2013-12-05 Novartis Ag Oral formulations
EA028950B1 (ru) 2011-08-01 2018-01-31 Тева Фармасьютикал Индастриз Лтд. Способ получения фармацевтических композиций, содержащих финголимод
WO2013091704A1 (en) 2011-12-22 2013-06-27 Synthon Bv Pharmaceutical composition comprising fingolimod
RU2482842C1 (ru) * 2012-04-26 2013-05-27 Открытое акционерное общество "Новосибхимфарм" Фармацевтическая композиция агониста рецептора s1p для лечения демиелинизационных заболеваний (варианты) и способ ее получения
RU2496486C1 (ru) * 2012-07-11 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция с улучшенной сыпучестью, лекарственное средство, способ получения и применение
MX2015009077A (es) * 2013-01-15 2015-09-10 Sun Pharmaceutical Ind Ltd Composicion estable que contiene fingolimod.
WO2014141298A2 (en) * 2013-03-11 2014-09-18 Astron Research Limited Stable pharmaceutical composition of fingolimod
WO2014013090A2 (en) * 2013-05-06 2014-01-23 Synthon B.V. Formulation comprising amorphous fingolimod
CA2920758A1 (en) * 2013-07-29 2015-02-05 Aizant Drug Research Solutions Pvt Ltd Pharmaceutical compositions of fingolimod
WO2016026461A1 (en) * 2014-08-22 2016-02-25 Sunshine Lake Pharma Co., Ltd. Solid composition of fingolimod and preparation thereof
WO2016042493A1 (en) 2014-09-19 2016-03-24 Aizant Drug Research Pvt. Ltd Pharmaceutical compositions of fingolimod
US9925138B2 (en) 2015-01-20 2018-03-27 Handa Pharmaceuticals, Llc Stable solid fingolimod dosage forms
JP2018502168A (ja) * 2015-01-20 2018-01-25 ハンダ ファーマシューティカルズ エルエルシー 安定な固体フィンゴリモド剤形
RU2577230C1 (ru) * 2015-04-09 2016-03-10 Общество с ограниченной ответственностью "Лонг Шенг Фарма Рус" Способ получения капсул финголимода гидрохлорида
RU2639424C2 (ru) * 2015-09-15 2017-12-21 Закрытое Акционерное Общество "Биокад" Твердая пероральная фармацевтическая композиция S1P-агониста или его фармацевтически приемлемой соли, способы ее получения и способы лечения и снижения частоты клинических обострений рассеянного склероза

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548022A (en) 1976-10-06 1979-07-04 Wyeth John & Brother Ltd Pharmaceutial dosage forms
HU217629B (hu) * 1991-12-12 2000-03-28 Novartis Ag. Eljárás fluvasztatint tartalmazó stabilizált gyógyszerkészítmények előállítására
DK0627406T3 (da) 1992-10-21 1999-07-12 Taito Co 2-Amino-1,3-propandiolforbindelser og immunundertrykkende midler
KR100358922B1 (ko) 1994-08-22 2003-01-24 미쯔비시 웰 파마 가부시키가이샤 벤젠화합물및그의의약으로서의용도
CN1091600C (zh) * 1995-04-18 2002-10-02 上海延安制药厂 盐酸地尔硫䓬控释片的制备方法
CA2230748C (en) * 1997-03-14 2010-08-03 American Home Products Corporation Rapamycin formulations for oral administration
ATE271028T1 (de) 1997-04-04 2004-07-15 Mitsubishi Pharma Corp 2-aminopropan-1,3-diol-verbindungen, ihre medizinische anwendung und zwischenprodukte zu ihrer synthese
WO2000018374A1 (en) * 1998-10-01 2000-04-06 Elan Pharma International, Ltd. Controlled release nanoparticulate compositions
AU5248900A (en) * 1999-06-18 2001-01-09 Takeda Chemical Industries Ltd. Quickly disintegrating solid preparations
JP4627356B2 (ja) * 1999-06-30 2011-02-09 松森　　昭 ウイルス性心筋炎の予防または治療薬剤
KR20020027463A (ko) 1999-07-12 2002-04-13 우에노 도시오 스핀고신-1-인산 수용체 아고니스트 또는스핀고신-1-인산을 유효 성분으로서 함유하는 선유화 억제제
SK152003A3 (en) 2000-07-13 2004-07-07 Sankyo Co Amino alcohol derivatives
WO2002018395A1 (en) 2000-08-31 2002-03-07 Merck & Co., Inc. Phosphate derivatives as immunoregulatory agents
NL1016385C2 (nl) * 2000-10-11 2002-04-12 El O Matic Bv Aandrijving, afsluitklep en functiedeel.
EP1411901B1 (en) * 2001-07-04 2010-08-18 Sun Pharma Advanced Research Company Ltd Gastric retention controlled drug delivery system
WO2003020313A1 (fr) * 2001-09-04 2003-03-13 Ono Pharmaceutical Co., Ltd. Medicaments contre les maladies respiratoires renfermant un agent de regulation du recepteur de la sphingosine-1-phosphate
JP2005531506A (ja) 2002-03-01 2005-10-20 メルク　エンド　カムパニー　インコーポレーテッド Ｅｄｇ受容体作動薬としてのアミノアルキルホスホネートおよび関連化合物
JP2005531391A (ja) * 2002-06-27 2005-10-20 微創医療器械（上海）有限公司 薬剤放出ステント
FR2850576B1 (fr) * 2003-02-05 2007-03-23 Ethypharm Sa Composition comprenant un melange de principes actifs, et procede de preparation
CN100360124C (zh) * 2003-02-25 2008-01-09 杭州华东医药集团生物工程研究所有限公司 2-氨基-2（2-（4-辛基苯基）乙基）-1，3-丙二醇在制备预防或治疗免疫性肝损伤药物中的应用
JP4578124B2 (ja) * 2003-03-12 2010-11-10 武田薬品工業株式会社 高濃度に活性成分を球形核に付着させた医薬組成物
HUE028247T2 (en) 2003-04-08 2016-12-28 Novartis Ag A solid oral composition comprising S1P receptor agonist and sugar alcohol
DE602004027045D1 (de) * 2003-06-24 2010-06-17 Univ Connecticut Verfahren zur hemmung der gefässpermeabilität und apoptose
JP2007501256A (ja) * 2003-08-06 2007-01-25 ムルイェ、ニルマル 水溶性薬物を含有する医薬組成物
JP4947406B2 (ja) 2003-08-29 2012-06-06 小野薬品工業株式会社 Ｓ１ｐ受容体結合能を有する化合物およびその医薬用途
WO2005025553A2 (en) * 2003-09-12 2005-03-24 Neuronova Ab Treatment of disorders of nervous systemsystem with fty720
JP4547888B2 (ja) * 2003-10-10 2010-09-22 小野薬品工業株式会社 胃内浮遊性固形製剤
JP3841804B2 (ja) * 2003-10-15 2006-11-08 富士化学工業株式会社 口腔内速崩壊性錠剤用の組成物
RU2372893C2 (ru) * 2003-10-31 2009-11-20 Хексал Аг Содержащий фармацевтический агент состав с покрытием
JP2005160928A (ja) * 2003-12-05 2005-06-23 Bioserentack Co Ltd ジェット吹き出し法およびスクリーン印刷法による三層構造を有する非対称マイクロカプセルの製造方法
GB0329498D0 (en) * 2003-12-19 2004-01-28 Novartis Ag Organic compounds
JP2007530633A (ja) * 2004-04-02 2007-11-01 ノバルティス アクチエンゲゼルシャフト Ｖｅｇｆ受容体チロシンキナーゼ阻害剤被覆ステント
WO2005099698A1 (ja) * 2004-04-15 2005-10-27 Eisai R & D Management Co., Ltd. 安定化された４－アミノ－５－クロロ－Ｎ－［（１Ｒ，３ｒ，５Ｓ）－８－メチル－８－アザビシクロ［３．２．１］オクタ－３－イル]－２－［１－メチルブタ－２－インイルオキシ］ベンズアミド含有組成物
US8039674B2 (en) 2004-06-23 2011-10-18 Ono Pharmaceutical Co., Ltd. Compound having S1P receptor binding potency and use thereof
GB0504544D0 (en) * 2005-03-04 2005-04-13 Novartis Ag Organic compounds
CN102579387A (zh) 2006-09-26 2012-07-18 诺瓦提斯公司 包含s1p调节剂的药物组合物

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