CY1120908T1 - Μεθοδοι και συστηματα για τον καθαρισμο της μη συμπλεγμενης νευροτοξινης της αλλαντιασης - Google Patents
Μεθοδοι και συστηματα για τον καθαρισμο της μη συμπλεγμενης νευροτοξινης της αλλαντιασηςInfo
- Publication number
- CY1120908T1 CY1120908T1 CY181100988T CY181100988T CY1120908T1 CY 1120908 T1 CY1120908 T1 CY 1120908T1 CY 181100988 T CY181100988 T CY 181100988T CY 181100988 T CY181100988 T CY 181100988T CY 1120908 T1 CY1120908 T1 CY 1120908T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- systems
- neurotoxin
- chealth
- cleansing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 101710138657 Neurotoxin Proteins 0.000 title abstract 2
- 239000002581 neurotoxin Substances 0.000 title abstract 2
- 231100000618 neurotoxin Toxicity 0.000 title abstract 2
- 108030001720 Bontoxilysin Proteins 0.000 abstract 1
- 208000003508 Botulism Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 231100001103 botulinum neurotoxin Toxicity 0.000 abstract 1
- 238000011097 chromatography purification Methods 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25381009P | 2009-10-21 | 2009-10-21 | |
| PCT/US2010/053389 WO2011050072A1 (en) | 2009-10-21 | 2010-10-20 | Methods and systems for purifying non-complexed botulinum neurotoxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1120908T1 true CY1120908T1 (el) | 2019-12-11 |
Family
ID=43879799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY181100988T CY1120908T1 (el) | 2009-10-21 | 2018-09-25 | Μεθοδοι και συστηματα για τον καθαρισμο της μη συμπλεγμενης νευροτοξινης της αλλαντιασης |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US20120196349A1 (enExample) |
| EP (1) | EP2490986B2 (enExample) |
| JP (1) | JP5951490B2 (enExample) |
| KR (1) | KR101819129B1 (enExample) |
| CN (2) | CN104961812B (enExample) |
| AU (1) | AU2010310749B2 (enExample) |
| BR (1) | BR112012009227A2 (enExample) |
| CA (1) | CA2773396C (enExample) |
| CO (1) | CO6551670A2 (enExample) |
| CY (1) | CY1120908T1 (enExample) |
| DK (1) | DK2490986T4 (enExample) |
| ES (1) | ES2688065T5 (enExample) |
| HR (1) | HRP20181869T1 (enExample) |
| HU (1) | HUE041599T2 (enExample) |
| IL (2) | IL218532A (enExample) |
| LT (1) | LT2490986T (enExample) |
| MX (3) | MX2012004703A (enExample) |
| PH (1) | PH12012500549A1 (enExample) |
| PL (1) | PL2490986T3 (enExample) |
| PT (1) | PT2490986T (enExample) |
| RS (1) | RS58006B1 (enExample) |
| SI (1) | SI2490986T1 (enExample) |
| SM (1) | SMT201800487T1 (enExample) |
| WO (1) | WO2011050072A1 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2379104T (lt) | 2008-12-31 | 2018-04-10 | Revance Therapeutics, Inc. | Injekcinės botulino toksino vaisto formos |
| CN102869373B (zh) * | 2009-06-25 | 2017-05-10 | 雷文斯治疗公司 | 不含白蛋白的肉毒杆菌毒素制剂 |
| US8129139B2 (en) | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| US20120196349A1 (en) * | 2009-10-21 | 2012-08-02 | Revance Therapeutics, Inc. | Methods and Systems for Purifying Non-Complexed Botulinum Neurotoxin |
| KR101134146B1 (ko) * | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
| KR102272580B1 (ko) | 2013-07-30 | 2021-07-05 | 메르츠 파마 게엠베하 운트 코. 카가아 | 보툴리눔 독소의 고순도 신경독성 성분의 제조 방법 및 이의 용도 |
| KR101339349B1 (ko) * | 2013-08-02 | 2013-12-09 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
| US9480731B2 (en) | 2013-12-12 | 2016-11-01 | Medy-Tox, Inc. | Long lasting effect of new botulinum toxin formulations |
| GB201407525D0 (en) * | 2014-04-29 | 2014-06-11 | Syntaxin Ltd | Manufacture of recombinant clostridium botulinum neurotoxins |
| GB201517450D0 (en) * | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| KR101775682B1 (ko) * | 2015-11-30 | 2017-09-06 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
| KR102463881B1 (ko) | 2016-10-04 | 2022-11-07 | (주)메디톡스 | 보툴리눔 독소 함유 용액으로부터 보툴리눔 독소를 분리하는 방법 |
| EP3675900A4 (en) | 2017-08-28 | 2021-05-05 | Revance Therapeutics, Inc. | Transmucosal botulinum toxin compositions, kits, and methods for treating bladder disorders |
| CA3124535A1 (en) | 2018-12-21 | 2020-06-25 | The Research Foundation For Microbial Diseases Of Osaka University | Botulinum toxin producing method |
| KR102485146B1 (ko) | 2019-04-15 | 2023-01-06 | (주)제테마 | 보툴리눔 독소의 제조방법 |
| KR102447441B1 (ko) * | 2019-04-15 | 2022-09-27 | (주)제테마 | 보툴리눔 독소의 정제방법 |
| US10851363B1 (en) * | 2019-05-22 | 2020-12-01 | Boke Zhang | Multilayer nano-cell containing biomolecules |
| KR20230146049A (ko) * | 2021-02-26 | 2023-10-18 | 충칭 클라루비스 파마슈티컬 컴퍼니 리미티드 | 폴리펩티드를 제조하기 위한 세포 용해 버퍼 분리 장비, 시스템 및 이의 용도 |
| CN114958887B (zh) * | 2021-02-26 | 2024-10-25 | 重庆誉颜制药有限公司 | 一种经修饰的毒素多肽的制备方法 |
| KR102724650B1 (ko) * | 2021-07-05 | 2024-11-01 | 주식회사 파마리서치바이오 | 클로스트리디움 보툴리눔 독소 복합체 단백질의 정제방법 |
| KR102724651B1 (ko) * | 2021-07-08 | 2024-11-01 | 주식회사 파마리서치바이오 | 비-독소 단백질이 제거된 클로스트리디움 보툴리눔 신경독소 단백질의 정제방법 |
| KR102512757B1 (ko) * | 2021-07-22 | 2023-03-22 | (주)이니바이오 | 정제 수율이 향상된 보툴리눔 독소 복합체 정제방법 |
| US20250018016A1 (en) * | 2021-11-15 | 2025-01-16 | Medytox Inc. | Botulinum neurotoxin composition |
| TWI890364B (zh) * | 2023-03-16 | 2025-07-11 | 南韓商大熊股份有限公司 | 使用多模式層析法純化肉毒毒素的改進方法 |
| CN122514358A (zh) | 2023-09-19 | 2026-08-04 | 雷文斯治疗公司 | 需要快速起效美容效果和更平滑皮肤外观的患者中的使用肉毒毒素的治疗 |
| DE102025101336A1 (de) | 2024-01-19 | 2025-07-24 | Abbvie Inc. | Zusammensetzungen von clostridium botulinum neurotoxin serotyp a und verbesserte trocknungsprozesse |
| KR102945108B1 (ko) * | 2024-06-19 | 2026-04-02 | (주)제테마 | 클로스트리디움 보툴리눔 독소의 정제방법 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US796419A (en) | 1904-07-18 | 1905-08-08 | Carl Halbig | Doll-head. |
| SE303567B (enExample) * | 1959-02-17 | 1968-09-02 | Behringwerke Ag | |
| US7214787B1 (en) * | 1993-09-21 | 2007-05-08 | United States Of America As Represented By The Secretary Of The Army | Recombinant vaccine against botulinum neurotoxin |
| US5512547A (en) * | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
| WO1999037326A1 (en) * | 1998-01-26 | 1999-07-29 | University Of Massachusetts | Biologically active hemagglutinin from type a clostridium botulinum and methods of use |
| TW574036B (en) * | 1998-09-11 | 2004-02-01 | Elan Pharm Inc | Stable liquid compositions of botulinum toxin |
| DE19925739A1 (de) † | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| GB9921592D0 (en) * | 1999-09-13 | 1999-11-17 | Microbiological Res Authority | Preparation of highly pure toxin fragments |
| DK1301213T3 (en) * | 2000-07-21 | 2017-03-27 | Revance Therapeutics Inc | MULTI-COMPONENT SYSTEMS FOR BIOLOGICAL TRANSPORT |
| US20040220100A1 (en) * | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
| JP2003009897A (ja) | 2001-07-03 | 2003-01-14 | Keiji Oguma | ボツリヌス毒素の分離・精製法 |
| GB2386246B (en) | 2001-11-01 | 2005-06-29 | Marconi Applied Techn Ltd | Electron beam tube apparatus |
| US7118901B2 (en) * | 2002-12-18 | 2006-10-10 | Roche Diagnostics Operations, Inc. | Recombinant bovine pancreatic desoxyribonuclease I with high specific activity |
| KR100498964B1 (ko) | 2003-03-05 | 2005-07-01 | 삼성전자주식회사 | 이동단말에서의 전자파 흡수율 제어 방법 및 장치 |
| AU2003271835A1 (en) * | 2003-06-06 | 2005-01-04 | Avecia Limited | Process for the separation of proteins |
| US7452697B2 (en) | 2003-09-25 | 2008-11-18 | Allergan, Inc. | Chromatographic method and system for purifying a botulinum toxin |
| JP2007535911A (ja) * | 2003-12-30 | 2007-12-13 | バハラ バイオテック インターナショナル リミテッド | 組換えタンパク質の製造及び精製方法 |
| KR20050074806A (ko) * | 2004-01-14 | 2005-07-19 | 팜텍(주) | 결정형 보툴리늄 독소의 제조방법 |
| HUE025656T2 (en) * | 2004-03-03 | 2016-04-28 | Revance Therapeutics Inc | Topical application and transdermal delivery of botulinum toxins |
| BRPI0508440A (pt) * | 2004-03-03 | 2007-07-24 | Revance Therapeutics Inc | composições e métodos para diagnóstico tópico e transporte terapêutico |
| CN1930186A (zh) * | 2005-03-03 | 2007-03-14 | 阿勒根公司 | 为获得梭菌毒素的梭菌细菌培养基及方法 |
| HRP20090382T1 (hr) * | 2005-06-17 | 2009-09-30 | Merz Pharma Gmbh & Co.Kgaa | Uređaj i postupak za proizvodnju biološko aktivnih spojeva fermentacijom |
| US8323666B2 (en) * | 2005-08-01 | 2012-12-04 | Allergan, Inc. | Botulinum toxin compositions |
| AR061669A1 (es) * | 2006-06-29 | 2008-09-10 | Merz Pharma Gmbh & Co Kgaa | Aplicacion de alta frecuencia de terapia con toxina botulinica |
| EP2085093B1 (en) * | 2006-10-27 | 2015-02-25 | The Chemo-Sero-Therapeutic Research Institute | Preparation containing highly purified botulinum toxin type a derived from infant botulism pathogen |
| CN100588706C (zh) * | 2007-04-06 | 2010-02-10 | 常州千红生化制药股份有限公司 | 纯化弹性蛋白酶的方法 |
| AU2008256418A1 (en) * | 2007-06-01 | 2008-12-04 | Merz Pharma Gmbh & Co. Kgaa | Process for providing a temperature - stable muscle relaxant on the basis of the neurotoxic component of botulinum toxin in solid form |
| JP5344558B2 (ja) * | 2008-10-31 | 2013-11-20 | 国立大学法人 東京医科歯科大学 | カチオン性ナノゲルを用いる粘膜ワクチン |
| LT2379104T (lt) * | 2008-12-31 | 2018-04-10 | Revance Therapeutics, Inc. | Injekcinės botulino toksino vaisto formos |
| US8440204B2 (en) * | 2009-04-30 | 2013-05-14 | Wisconsin Alumni Research Foundation | Subtype of Closteridium botulinum neurotoxin type A and uses thereof |
| CN102869373B (zh) * | 2009-06-25 | 2017-05-10 | 雷文斯治疗公司 | 不含白蛋白的肉毒杆菌毒素制剂 |
| US8129139B2 (en) * | 2009-07-13 | 2012-03-06 | Allergan, Inc. | Process for obtaining botulinum neurotoxin |
| JP2011074025A (ja) * | 2009-09-30 | 2011-04-14 | Chemo-Sero-Therapeutic Research Inst | ボツリヌス毒素の精製方法 |
| US20120196349A1 (en) * | 2009-10-21 | 2012-08-02 | Revance Therapeutics, Inc. | Methods and Systems for Purifying Non-Complexed Botulinum Neurotoxin |
| US8440104B2 (en) * | 2009-10-21 | 2013-05-14 | General Electric Company | Kimzeyite garnet phosphors |
| US20150204884A1 (en) * | 2012-06-01 | 2015-07-23 | Momenta Pharmaceuticals, Inc. | Methods of evaluating and making biologics |
| WO2014066916A2 (en) * | 2012-10-28 | 2014-05-01 | Revance Therapeutics, Inc. | Compositions and methods for safe treatment of rhinitis |
| GB201407525D0 (en) * | 2014-04-29 | 2014-06-11 | Syntaxin Ltd | Manufacture of recombinant clostridium botulinum neurotoxins |
| GB201517450D0 (en) * | 2015-10-02 | 2015-11-18 | Ipsen Biopharm Ltd | Method |
| CN109069608A (zh) * | 2015-10-29 | 2018-12-21 | 雷文斯治疗公司 | 具有长的治疗或美容效应持续时间的可注射肉毒杆菌毒素制剂以及其使用方法 |
| KR101775682B1 (ko) * | 2015-11-30 | 2017-09-06 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
| AU2018270092C1 (en) * | 2017-05-18 | 2026-01-08 | Revance Therapeutics, Inc. | Methods of treatment for cervical dystonia |
-
2010
- 2010-10-20 US US13/394,506 patent/US20120196349A1/en not_active Abandoned
- 2010-10-20 CA CA2773396A patent/CA2773396C/en active Active
- 2010-10-20 ES ES10825598T patent/ES2688065T5/es active Active
- 2010-10-20 BR BR112012009227A patent/BR112012009227A2/pt not_active IP Right Cessation
- 2010-10-20 EP EP10825598.5A patent/EP2490986B2/en active Active
- 2010-10-20 HU HUE10825598A patent/HUE041599T2/hu unknown
- 2010-10-20 LT LTEP10825598.5T patent/LT2490986T/lt unknown
- 2010-10-20 PT PT10825598T patent/PT2490986T/pt unknown
- 2010-10-20 HR HRP20181869TT patent/HRP20181869T1/hr unknown
- 2010-10-20 PL PL10825598T patent/PL2490986T3/pl unknown
- 2010-10-20 CN CN201510173705.8A patent/CN104961812B/zh active Active
- 2010-10-20 US US12/908,647 patent/US20110092682A1/en not_active Abandoned
- 2010-10-20 RS RS20181330A patent/RS58006B1/sr unknown
- 2010-10-20 SI SI201031746T patent/SI2490986T1/sl unknown
- 2010-10-20 AU AU2010310749A patent/AU2010310749B2/en active Active
- 2010-10-20 DK DK10825598.5T patent/DK2490986T4/da active
- 2010-10-20 MX MX2012004703A patent/MX2012004703A/es active IP Right Grant
- 2010-10-20 MX MX2015011592A patent/MX365496B/es unknown
- 2010-10-20 KR KR1020127012224A patent/KR101819129B1/ko active Active
- 2010-10-20 SM SM20180487T patent/SMT201800487T1/it unknown
- 2010-10-20 PH PH1/2012/500549A patent/PH12012500549A1/en unknown
- 2010-10-20 WO PCT/US2010/053389 patent/WO2011050072A1/en not_active Ceased
- 2010-10-20 CN CN201080045567.0A patent/CN102666396B/zh active Active
- 2010-10-20 JP JP2012535338A patent/JP5951490B2/ja active Active
-
2012
- 2012-03-07 IL IL218532A patent/IL218532A/en active IP Right Grant
- 2012-04-20 MX MX2019006519A patent/MX2019006519A/es unknown
- 2012-04-30 CO CO12070154A patent/CO6551670A2/es not_active Application Discontinuation
-
2015
- 2015-07-10 US US14/796,235 patent/US9469849B2/en active Active
-
2016
- 2016-10-17 US US15/295,134 patent/US20170029795A1/en not_active Abandoned
- 2016-10-25 IL IL248486A patent/IL248486A0/en unknown
-
2018
- 2018-09-25 CY CY181100988T patent/CY1120908T1/el unknown
-
2019
- 2019-12-02 US US16/700,728 patent/US11466262B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2019006519A (es) | Metodos y sistemas para purificar la neurotoxina botulinica no acomplejada. | |
| WO2013078170A8 (en) | Purification of anti-c-met antibodies | |
| MX362512B (es) | Composiciones purificadas de celulas madre mesenquimales y metodos para purificar composiciones de celulas madre mesenquimales. | |
| CY1121519T1 (el) | Καθαρισμος της υδουρονικης-2-σουλφατασης | |
| BR112015004467A2 (pt) | método para controlar a heterogeneidade de proteínas | |
| MX342388B (es) | Variantes y composiciones que comprenden variantes con alta estabilidad en presencia de un agente quelante. | |
| MX385713B (es) | Ciclodextrina y formulaciones de conjugados anticuerpo-fármaco. | |
| SG10201804869UA (en) | Purification of biological molecules | |
| MX348003B (es) | Metodos y medios para modificar un genoma vegetal. | |
| MX375183B (es) | Formulaciones de acamprosato, metodos de uso de las mismas, y combinaciones que comprenden las mismas. | |
| IN2012DN00801A (enExample) | ||
| MX372711B (es) | Metodos para la purificacion de arilsulfatasa a. | |
| MX2015015188A (es) | Metodo de clonacion, expresion y purificacion novedoso para la preparacion de ranibizumab. | |
| BRPI1014885A8 (pt) | "azetidinil diamidas como inibidores de monoacilglicerol lipase." | |
| ZA201202491B (en) | Process for the purification of recombinant human erythropoietin (epo), epo thus purified and pharmaceutical compositions comprising same | |
| MX2013013649A (es) | Compuestos de quinona para tratar enfermedades mediadas por ape1. | |
| IN2014DN00161A (enExample) | ||
| BR112012017393A2 (pt) | derivados de 2,5,7-oxazolpirimidina substituída | |
| CY1117210T1 (el) | Παραγωγα 2-οξο-1-ιμιδαζολιδινυλ ιμιδαζοθειαδιαζολης | |
| BR112014016803A8 (pt) | amidas macrocíclicas como inibidoras de protease | |
| CY1119064T1 (el) | Ινωδολυτικες συνθεσεις οι οποιες περιεχουν βρωμελαϊνη και ναττοκιναση για την προληψη και αγωγη φλεβοθρομβωτικων καταστασεων | |
| TR201009167A2 (tr) | Sefalosporin içeren farmasötik granüller. | |
| EP2910543A4 (en) | PROCESS FOR CLEANING 1,4-DIAMINOBUTANE, 1,4-DIAMINOBUTANE PURIFIED IN THIS PROCESS, AND POLYAMIDE PRODUCED FROM THE SAID PROCESS | |
| UA110131C2 (ru) | ПРОИЗВОДНЫЕ ТИЕНО[2,3-d]ПИРИМИДИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ АРИТМИИ | |
| MX355719B (es) | Composicion farmaceutica en forma de una suspension oral que comprende una fraccion flavonoica y goma de xantano. |