CY1118104T1 - Νεα κυτταροστατικα νουκλεοζιδια 7-αποαζαπουρινης - Google Patents

Νεα κυτταροστατικα νουκλεοζιδια 7-αποαζαπουρινης

Info

Publication number
CY1118104T1
CY1118104T1 CY20161101041T CY161101041T CY1118104T1 CY 1118104 T1 CY1118104 T1 CY 1118104T1 CY 20161101041 T CY20161101041 T CY 20161101041T CY 161101041 T CY161101041 T CY 161101041T CY 1118104 T1 CY1118104 T1 CY 1118104T1
Authority
CY
Cyprus
Prior art keywords
apoazapurini
new
nuclear cells
compounds
nuclear
Prior art date
Application number
CY20161101041T
Other languages
English (en)
Inventor
Michal Hocek
Petr Naus
Original Assignee
Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic filed Critical Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic
Publication of CY1118104T1 publication Critical patent/CY1118104T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H02J7/00032—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries characterised by data exchange
    • H02J7/00036—Charger exchanging data with battery
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J7/00—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
    • H02J7/00047—Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries with provisions for charging different types of batteries

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Power Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Η εφεύρεση παρέχει ενώσεις του τύπου (I), όπου R1 και R2 έχουν οποιαδήποτε από τις τιμές που ορίζονται στην προδιαγραφή και άλατα αυτών, καθώς επίσης συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις και θεραπευτικές μεθόδους που χρησιμοποιούν τέτοιες ενώσεις.
CY20161101041T 2008-01-18 2016-10-19 Νεα κυτταροστατικα νουκλεοζιδια 7-αποαζαπουρινης CY1118104T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2224708P 2008-01-18 2008-01-18
PCT/CZ2009/000004 WO2009089804A1 (en) 2008-01-18 2009-01-15 Novel cytostatic 7-deazapurine nucleosides

Publications (1)

Publication Number Publication Date
CY1118104T1 true CY1118104T1 (el) 2017-06-28

Family

ID=40434932

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20161101041T CY1118104T1 (el) 2008-01-18 2016-10-19 Νεα κυτταροστατικα νουκλεοζιδια 7-αποαζαπουρινης
CY20181101120T CY1121364T1 (el) 2008-01-18 2018-10-30 Νεοι κυτταροστατικοι νουκλεοζιτες 7-δεαζαπουρινης

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20181101120T CY1121364T1 (el) 2008-01-18 2018-10-30 Νεοι κυτταροστατικοι νουκλεοζιτες 7-δεαζαπουρινης

Country Status (18)

Country Link
US (1) US8093226B2 (el)
EP (2) EP2231689B1 (el)
JP (2) JP5485172B2 (el)
CN (1) CN101977923B (el)
AU (1) AU2009204568B2 (el)
CA (1) CA2711384C (el)
CY (2) CY1118104T1 (el)
DK (2) DK3133080T3 (el)
ES (2) ES2598503T3 (el)
HR (2) HRP20161344T1 (el)
HU (2) HUE030767T2 (el)
LT (2) LT2231689T (el)
NZ (1) NZ586610A (el)
PL (2) PL2231689T3 (el)
PT (2) PT2231689T (el)
SI (2) SI2231689T1 (el)
TR (1) TR201815961T4 (el)
WO (1) WO2009089804A1 (el)

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CA2759131C (en) * 2009-04-22 2017-06-20 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 7-deazapurine nucleosides for therapeutic uses
TW201100429A (en) 2009-05-22 2011-01-01 Incyte Corp N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
UA106078C2 (uk) 2009-05-22 2014-07-25 Інсайт Корпорейшн 3-[4-(7H-ПІРОЛО[2,3-d]ПІРИМІДИН-4-ІЛ)-1H-ПІРАЗОЛ-1-ІЛ]ОКТАН- АБО ГЕПТАННІТРИЛ ЯК JAK-ІНГІБІТОРИ
WO2011028685A1 (en) 2009-09-01 2011-03-10 Incyte Corporation Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
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PE20130216A1 (es) 2010-05-21 2013-02-27 Incyte Corp Formulacion topica para un inhibidor de jak
AU2011330730B2 (en) * 2010-11-18 2016-02-18 Kasina Laila Innova Pharmaceuticals Private Limited Substituted 4-(selenophen-2(or 3)-ylamino)pyrimidine compounds and methods of use thereof
WO2012068440A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
JP5917545B2 (ja) 2010-11-19 2016-05-18 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｊａｋ阻害剤としてのシクロブチル置換ピロロピリジンおよびピロロピリミジン誘導体
AR086983A1 (es) 2011-06-20 2014-02-05 Incyte Corp Derivados de azetidinil fenil, piridil o pirazinil carboxamida como inhibidores de jak
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
US9193733B2 (en) 2012-05-18 2015-11-24 Incyte Holdings Corporation Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
NZ748448A (en) 2012-11-15 2019-12-20 Incyte Holdings Corp Sustained-release dosage forms of ruxolitinib
TWI634121B (zh) 2013-03-06 2018-09-01 英塞特控股公司 用於製備ｊａｋ抑制劑之方法及中間物
KR20220103810A (ko) 2013-08-07 2022-07-22 인사이트 코포레이션 Jak1 억제제용 지속 방출 복용 형태
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
EP3478701B1 (en) 2016-06-29 2022-08-10 Ustav organicke chemie a biochemie AV CR, v.v.i. Substituted thienopyrrolopyrimidine ribonucleosides for therapeutic use
CZ307334B6 (cs) 2016-08-02 2018-06-13 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v.v.i. Substituované heteropentadieno-pyrrolopyrimidinové ribonukleosidy pro terapeutické použití
AR113922A1 (es) 2017-12-08 2020-07-01 Incyte Corp Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas
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CZ308104B6 (cs) 2018-03-12 2020-01-08 Ăšstav organickĂ© chemie a biochemie AV ÄŚR, v. v. i. Pyridinopyrrolopyrimidinové ribonukleosidy pro terapeutické použití
SI3773593T1 (sl) 2018-03-30 2024-08-30 Incyte Corporation Zdravljenje hidradenitisa suppurative z zaviralci jak
WO2020206289A1 (en) * 2019-04-05 2020-10-08 Prelude Therapeutics, Incorporated Selective inhibitors of protein arginine methyltransferase 5
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Also Published As

Publication number Publication date
NZ586610A (en) 2012-08-31
JP2011509949A (ja) 2011-03-31
DK3133080T3 (en) 2018-11-26
LT3133080T (lt) 2018-11-12
EP2231689B1 (en) 2016-07-20
EP3133080B1 (en) 2018-08-01
SI3133080T1 (sl) 2018-12-31
PL3133080T3 (pl) 2018-12-31
AU2009204568B2 (en) 2013-10-03
JP2014058567A (ja) 2014-04-03
ES2598503T3 (es) 2017-01-27
US20090203637A1 (en) 2009-08-13
CY1121364T1 (el) 2020-05-29
TR201815961T4 (tr) 2018-11-21
US8093226B2 (en) 2012-01-10
PT2231689T (pt) 2016-10-07
JP5485172B2 (ja) 2014-05-07
ES2693551T3 (es) 2018-12-12
EP2231689A1 (en) 2010-09-29
HUE030767T2 (en) 2017-05-29
SI2231689T1 (sl) 2016-11-30
HRP20181774T1 (hr) 2018-12-28
DK2231689T3 (en) 2016-09-19
EP3133080A1 (en) 2017-02-22
CN101977923B (zh) 2014-10-08
LT2231689T (lt) 2016-10-25
CN101977923A (zh) 2011-02-16
CA2711384C (en) 2016-07-26
CA2711384A1 (en) 2009-07-23
PT3133080T (pt) 2018-11-16
HUE041598T2 (hu) 2019-05-28
PL2231689T3 (pl) 2017-01-31
HRP20161344T1 (hr) 2016-11-18
AU2009204568A1 (en) 2009-07-23
WO2009089804A1 (en) 2009-07-23

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