CY1118054T1 - Συστημα διαδερμικης μεταφορας - Google Patents
Συστημα διαδερμικης μεταφοραςInfo
- Publication number
- CY1118054T1 CY1118054T1 CY20161100988T CY161100988T CY1118054T1 CY 1118054 T1 CY1118054 T1 CY 1118054T1 CY 20161100988 T CY20161100988 T CY 20161100988T CY 161100988 T CY161100988 T CY 161100988T CY 1118054 T1 CY1118054 T1 CY 1118054T1
- Authority
- CY
- Cyprus
- Prior art keywords
- buprenorphine
- pressure
- acid
- sensitive adhesive
- adhesive layer
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive plasters or dressings
- A61F13/0246—Adhesive plasters or dressings characterised by the skin adhering layer
- A61F13/0256—Adhesive plasters or dressings characterised by the skin adhering layer characterized by the parametric properties of the adhesive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η εφεύρεση σχετίζεται με διαδερμικό θεραπευτικό σύστημα για τη διαδερμική χορήγηση βουπρενορφίνης, που αποτελείται από μια δομή αυτοκόλλητου στρώματος που περιέχει βουπρενορφίνη που αποτελείται από Α) ένα στρώμα υποστήριξης αδιαπέραστο σε βουπρενορφίνη, και Β) ένα ευαίσθητο σε πίεση αυτοκόλλητο στρώμα που περιέχει βουπρενορφίνη πάνω στο αναφερόμενο αδιαπέραστο σε βουπρενορφίνη στρώμα υποστήριξης, όπου το προσκολλητικό στρώμα περιλαμβάνει α) τουλάχιστον ένα βασισμένο σε πολυμερή ευαίσθητο σε πίεση προσκολλητικό μέσο, β) μια αναλγητικώς αποτελεσματική ποσότητα βάσης βουπρενορφίνης ή ενός φαρμακευτικώς αποδεκτού άλατος αυτής, γ) μια ουσία που αυξάνει το ιξώδες σε ποσοστό 0,1% ως 8% του αναφερόμενου ευαίσθητου σε πίεση αυτοκόλλητου στρώματος που περιέχει βουπρενορφίνη, και δ) ένα καρβοξυλικό οξύ που επιλέγεται από την ομάδα που αποτελείται από ελαϊκό οξύ, λινελαϊκό οξύ, λινολενικό οξύ, λεβουλινικό οξύ και μίγματα αυτών, σε ποσότητα που επαρκεί έτσι ώστε η αναφερόμενη αναλγητικώς αποτελεσματική ποσότητα βουπρενορφίνης να διαλυτοποιείται σε αυτό σχηματίζοντας μίγμα που περιλαμβάνει την αναφερόμενη ουσία που αυξάνει το ιξώδες, και όπου το μίγμα που περιέχει καρβοξυλικό οξύ, βουπρενορφίνη και ουσία που αυξάνει το ιξώδες σχηματίζει διεσπαρμένα αποθηκευτικά μέσα στο αναφερόμενο ευαίσθητο σε πίεση προσκολλητικό μέσο, και όπου το αναφερόμενο ευαίσθητο σε πίεση προσκολλητικό στρώμα που περιέχει βουπρενορφίνη είναι το στρώμα επαφής με το δέρμα.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361830975P | 2013-06-04 | 2013-06-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118054T1 true CY1118054T1 (el) | 2017-06-28 |
Family
ID=51022809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20161100988T CY1118054T1 (el) | 2013-06-04 | 2016-10-05 | Συστημα διαδερμικης μεταφορας |
Country Status (34)
| Country | Link |
|---|---|
| US (6) | US20160008294A1 (el) |
| EP (2) | EP3106153A1 (el) |
| JP (1) | JP6559121B2 (el) |
| KR (1) | KR102302505B1 (el) |
| CN (1) | CN105377245B (el) |
| AP (1) | AP2015008920A0 (el) |
| AR (1) | AR096521A1 (el) |
| AU (1) | AU2014276910B2 (el) |
| BR (1) | BR112015029920A2 (el) |
| CA (1) | CA2914425C (el) |
| CL (1) | CL2015003377A1 (el) |
| CR (1) | CR20150647A (el) |
| CY (1) | CY1118054T1 (el) |
| DE (1) | DE112014002664T5 (el) |
| DK (1) | DK2810646T3 (el) |
| EA (1) | EA201592246A1 (el) |
| ES (1) | ES2599802T3 (el) |
| GB (1) | GB2529789A (el) |
| HK (2) | HK1204766A1 (el) |
| HU (1) | HUE031662T2 (el) |
| LT (1) | LT2810646T (el) |
| MA (1) | MA38698B1 (el) |
| MX (1) | MX362614B (el) |
| NI (1) | NI201500170A (el) |
| PE (1) | PE20160002A1 (el) |
| PH (1) | PH12015502550A1 (el) |
| PL (1) | PL2810646T3 (el) |
| PT (1) | PT2810646T (el) |
| SG (1) | SG11201509218SA (el) |
| SI (1) | SI2810646T1 (el) |
| TN (1) | TN2015000493A1 (el) |
| TW (1) | TW201509416A (el) |
| WO (1) | WO2014195352A1 (el) |
| ZA (1) | ZA201509309B (el) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006054731B4 (de) | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| CN104114161A (zh) | 2011-12-12 | 2014-10-22 | Lts勒曼治疗系统股份公司 | 包含丁丙诺啡的经皮递送系统 |
| TW201431570A (zh) | 2012-11-22 | 2014-08-16 | Ucb Pharma Gmbh | 用於經皮投服羅替戈汀（Ｒｏｔｉｇｏｔｉｎｅ）之多天式貼片 |
| WO2014195352A1 (en) | 2013-06-04 | 2014-12-11 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system |
| BR112015032929B1 (pt) | 2013-07-03 | 2022-08-23 | Lts Lohmann Therapie-Systeme Ag | Sistema terapêutico transdérmico com componente eletrônico e métodos de produção de um sistema terapêutico transdérmico |
| US11752110B2 (en) | 2014-05-20 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system including an interface mediator |
| CN106456566B (zh) | 2014-05-20 | 2020-06-16 | Lts勒曼治疗系统股份公司 | 含罗替戈汀的经皮递送系统 |
| CN106456567A (zh) | 2014-05-20 | 2017-02-22 | Lts勒曼治疗系统股份公司 | 在经皮递送系统中调节活性剂释放的方法 |
| US10406152B2 (en) | 2015-03-10 | 2019-09-10 | Rhodes Technologies | Acetate salt of buprenorphine and methods for preparing buprenorphine |
| US20180256562A1 (en) * | 2015-09-14 | 2018-09-13 | Amneal Pharmaceuticals Llc | Transdermal Delivery System |
| AR102214A1 (es) * | 2015-10-08 | 2017-02-15 | Amarin Tech S A | Un dispositivo para la administración transdermal de buprenorfina |
| US10486690B2 (en) * | 2016-12-14 | 2019-11-26 | Bendix Commerical Vehicle Systems, Llc | Front end motor-generator system and hybrid electric vehicle operating method |
| MX2019007391A (es) | 2016-12-20 | 2019-08-16 | Lts Lohmann Therapie Systeme Ag | Sistema terapeutico transdermico que contiene asenapina. |
| CN110087641B (zh) | 2016-12-20 | 2024-03-12 | 罗曼治疗系统股份公司 | 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗系统 |
| US20180221297A1 (en) * | 2017-02-03 | 2018-08-09 | Kirti H. Valia | System and Method for Improving Adhesion of Transdermal Delivery Devices |
| CN110799180A (zh) | 2017-06-26 | 2020-02-14 | 罗曼治疗系统股份公司 | 含阿塞那平和硅氧烷丙烯酸杂化聚合物的经皮治疗系统 |
| BR112020003314A2 (pt) * | 2017-09-04 | 2020-08-25 | Lts Lohmann Therapie-Systeme Ag | sistema de liberação transdérmico incluindo um emulsificante |
| WO2019064026A1 (en) | 2017-09-29 | 2019-04-04 | Orexo Ab | NEW PHARMACEUTICAL COMPOSITIONS |
| WO2019166572A1 (en) | 2018-02-28 | 2019-09-06 | Pharming Intellectual Property B.V. | Pharmaceutical system for transdermal administration of a c1 -esterase inhibitor |
| US20210000755A1 (en) | 2018-03-13 | 2021-01-07 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system for the transdermal administration of buprenorphine comprising a silicone acrylic hybrid polymer |
| AU2019261403A1 (en) * | 2018-04-25 | 2020-11-12 | Shinkei Therapeutics, Inc. | Tetrabenazine transdermal delivery device |
| WO2019243452A1 (en) | 2018-06-20 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
| GB201904767D0 (en) | 2019-04-04 | 2019-05-22 | Orexo Ab | New pharmaceutical compositions |
| CN113952319A (zh) * | 2021-11-30 | 2022-01-21 | 烟台大学 | 一种含丁丙诺啡的骨架型透皮贴剂及其制备方法 |
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| DE102006026578B4 (de) | 2006-06-08 | 2009-01-08 | Lts Lohmann Therapie-Systeme Ag | Wirkstoffpartikelhaltiges Transdermales Therapeutisches System mit erhöhtem Wirkstofffluss und Verfahren zu seiner Herstellung sowie Verwendung |
| DE102006054731B4 (de) * | 2006-11-21 | 2013-02-28 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System zur Verabreichung des Wirkstoffs Buprenorphin und Verwendung desselben in der Schmerztherapie |
| DE102006054732B4 (de) | 2006-11-21 | 2010-12-30 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Ionenpaar-Mikroreservoiren |
| JP5235384B2 (ja) | 2007-11-08 | 2013-07-10 | リンテック株式会社 | 貼付シート |
| GB0815435D0 (en) | 2008-08-22 | 2008-10-01 | Camurus Ab | Formulations |
| EP2366388A1 (de) * | 2010-03-17 | 2011-09-21 | Ratiopharm GmbH | Nicht-okklusives transdermales therapeutisches System zur Verabreichung von Buprenorphin |
| DK2640389T3 (en) * | 2010-11-17 | 2015-03-09 | Hexal Ag | Transdermal therapeutic system comprising buprenorphine |
| CN104114161A (zh) | 2011-12-12 | 2014-10-22 | Lts勒曼治疗系统股份公司 | 包含丁丙诺啡的经皮递送系统 |
| WO2014051128A1 (ja) | 2012-09-28 | 2014-04-03 | 株式会社 ケイ・エム トランスダーム | 貼付剤 |
| AU2013205080B2 (en) | 2012-12-12 | 2016-07-07 | Lts Lohmann Therapie-Systeme Ag | Transdermal Delivery System |
| WO2014195352A1 (en) | 2013-06-04 | 2014-12-11 | Lts Lohmann Therapie-Systeme Ag | Transdermal delivery system |
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2014
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