CY1115138T1 - Παραγωγο 3,8-διαμινοτετραϋδροκινολινης - Google Patents
Παραγωγο 3,8-διαμινοτετραϋδροκινολινηςInfo
- Publication number
- CY1115138T1 CY1115138T1 CY20141100391T CY141100391T CY1115138T1 CY 1115138 T1 CY1115138 T1 CY 1115138T1 CY 20141100391 T CY20141100391 T CY 20141100391T CY 141100391 T CY141100391 T CY 141100391T CY 1115138 T1 CY1115138 T1 CY 1115138T1
- Authority
- CY
- Cyprus
- Prior art keywords
- group
- hydrogen atom
- alkyl group
- different
- diominetetrahrokinolin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Για παροχή μιας ένωσης η οποία έχει μια δυνητική αγωνιστική δραστικότητα σε GHS-R και η οποία είναι χρήσιμη ως ένας θεραπευτικός παράγοντας για συστημικές εξασθενητικές νόσους όπως η καχεξία. Ένα παράγωγο 3,8-διαμινοτετραϋδροκινολίνης που αναπαρίσταται από τον τύπο (la) (όπου Χ αναπαριστά CH2, C=Ο, CH-OR, CH-SR, ή CH-NRR’˙ m είναι ένας αριθμός από 1 ή 2˙ Ar αναπαριστά μια φαινυλική ομάδα, μια ναφθυλική ομάδα, μια 5-μελή ή 6-μελή αρωματική ετεροκυκλική ομάδα η οποία έχει ένα ή δύο στοιχεία επιλεγμένα από S, Ν και Ο, ή μια παρόμοια ομάδα˙ R1 και R2, τα οποία μπορεί να είναι πανομοιότυπα ή διαφορετικά το ένα από το άλλο, έκαστο αναπαριστά ένα άτομο υδρογόνου ή μια μεθυλική ομάδα˙ R3 αναπαριστά μια C1 έως C6 αλκυλική ομάδα ή μια παρόμοια ομάδα˙ n είναι ένας αριθμός από 0 ή 1˙ R4 και R5, τα οποία μπορεί να είναι πανομοιότυπα ή διαφορετικά το ένα από το άλλο, έκαστο αναπαριστά ένα άτομο υδρογόνου, ή μια C1 έως C6 αλκυλική ομάδα, κλπ.˙ και R6, R7, R και R', τα οποία μπορεί να είναι πανομοιότυπα ή διαφορετικά το ένα από το άλλο, έκαστο αναπαριστά ένα άτομο υδρογόνου ή μια C1 έως C6 αλκυλική ομάδα), ή ένα άλας αυτής.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008029781 | 2008-02-08 | ||
| JP2008277044 | 2008-10-28 | ||
| EP09707360.5A EP2241564B1 (en) | 2008-02-08 | 2009-02-06 | 3,8-diaminotetrahydroquinoline derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115138T1 true CY1115138T1 (el) | 2016-12-14 |
Family
ID=40951980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100391T CY1115138T1 (el) | 2008-02-08 | 2014-06-03 | Παραγωγο 3,8-διαμινοτετραϋδροκινολινης |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8299255B2 (el) |
| EP (1) | EP2241564B1 (el) |
| JP (1) | JP5493870B2 (el) |
| KR (1) | KR101553725B1 (el) |
| CN (1) | CN101939313B (el) |
| AU (1) | AU2009212645B2 (el) |
| BR (1) | BRPI0907749A2 (el) |
| CA (1) | CA2714480C (el) |
| CY (1) | CY1115138T1 (el) |
| DK (1) | DK2241564T3 (el) |
| ES (1) | ES2464342T3 (el) |
| HR (1) | HRP20140449T1 (el) |
| MX (1) | MX2010008740A (el) |
| PL (1) | PL2241564T3 (el) |
| PT (1) | PT2241564E (el) |
| RU (1) | RU2482117C2 (el) |
| SI (1) | SI2241564T1 (el) |
| TW (1) | TWI422585B (el) |
| WO (1) | WO2009098901A1 (el) |
| ZA (1) | ZA201005346B (el) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103328449A (zh) * | 2011-01-26 | 2013-09-25 | 霍夫曼-拉罗奇有限公司 | 新的四氢喹啉衍生物 |
| JP6295247B2 (ja) | 2013-03-25 | 2018-03-14 | ゼリア新薬工業株式会社 | 食後期の胃運動亢進剤 |
| CN104193722A (zh) * | 2014-08-27 | 2014-12-10 | 湖南华腾制药有限公司 | 一种n-叔丁氧羰基-3-甲胺噻吩的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
| JP3817746B2 (ja) | 1994-06-20 | 2006-09-06 | 株式会社竹屋 | パチンコ島台 |
| US6864250B1 (en) * | 1997-08-22 | 2005-03-08 | Kaken Pharmaceutical Co., Ltd. | N-acylated lipophilic amino acid derivatives |
| US6211174B1 (en) * | 1997-10-31 | 2001-04-03 | Merck & Co., Inc. | Naphtho-fused lactams promote release of growth hormone |
| UA73530C2 (uk) | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| RU2277092C2 (ru) * | 2000-09-15 | 2006-05-27 | Анормед, Инк. | Гетероциклические соединения, их применение и фармацевтическая композиция для лечения состояний, опосредованных схсr4 и ccr5 |
| EP1644335A4 (en) * | 2003-07-11 | 2008-06-04 | Bristol Myers Squibb Co | TETRAHYDROQUINOLINE DERIVATIVES COMPRISING MODULATORS OF CANNABINOID RECEPTORS |
| WO2008116107A2 (en) | 2007-03-21 | 2008-09-25 | Takeda San Diego, Inc. | Piperazine derivatives as glucokinase activators |
-
2009
- 2009-02-06 KR KR1020107016651A patent/KR101553725B1/ko active IP Right Grant
- 2009-02-06 SI SI200930930T patent/SI2241564T1/sl unknown
- 2009-02-06 AU AU2009212645A patent/AU2009212645B2/en not_active Ceased
- 2009-02-06 PT PT97073605T patent/PT2241564E/pt unknown
- 2009-02-06 DK DK09707360.5T patent/DK2241564T3/da active
- 2009-02-06 EP EP09707360.5A patent/EP2241564B1/en active Active
- 2009-02-06 TW TW098103925A patent/TWI422585B/zh not_active IP Right Cessation
- 2009-02-06 RU RU2010137336/04A patent/RU2482117C2/ru not_active IP Right Cessation
- 2009-02-06 JP JP2009552416A patent/JP5493870B2/ja active Active
- 2009-02-06 ES ES09707360.5T patent/ES2464342T3/es active Active
- 2009-02-06 CN CN2009801045187A patent/CN101939313B/zh not_active Expired - Fee Related
- 2009-02-06 BR BRPI0907749-9A patent/BRPI0907749A2/pt not_active Application Discontinuation
- 2009-02-06 CA CA2714480A patent/CA2714480C/en not_active Expired - Fee Related
- 2009-02-06 WO PCT/JP2009/000487 patent/WO2009098901A1/ja active Application Filing
- 2009-02-06 PL PL09707360T patent/PL2241564T3/pl unknown
- 2009-02-06 US US12/866,843 patent/US8299255B2/en active Active
- 2009-02-06 MX MX2010008740A patent/MX2010008740A/es active IP Right Grant
-
2010
- 2010-07-27 ZA ZA2010/05346A patent/ZA201005346B/en unknown
-
2012
- 2012-09-14 US US13/617,469 patent/US8501772B2/en active Active
-
2014
- 2014-05-20 HR HRP20140449AT patent/HRP20140449T1/hr unknown
- 2014-06-03 CY CY20141100391T patent/CY1115138T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101939313A (zh) | 2011-01-05 |
| HRP20140449T1 (hr) | 2014-06-20 |
| BRPI0907749A2 (pt) | 2015-07-21 |
| MX2010008740A (es) | 2010-08-30 |
| CN101939313B (zh) | 2013-05-22 |
| US8501772B2 (en) | 2013-08-06 |
| US8299255B2 (en) | 2012-10-30 |
| JPWO2009098901A1 (ja) | 2011-05-26 |
| KR20100116175A (ko) | 2010-10-29 |
| US20100317693A1 (en) | 2010-12-16 |
| US20130012537A1 (en) | 2013-01-10 |
| JP5493870B2 (ja) | 2014-05-14 |
| EP2241564B1 (en) | 2014-04-30 |
| AU2009212645A1 (en) | 2009-08-13 |
| EP2241564A4 (en) | 2011-07-20 |
| RU2010137336A (ru) | 2012-03-20 |
| TWI422585B (zh) | 2014-01-11 |
| WO2009098901A1 (ja) | 2009-08-13 |
| CA2714480C (en) | 2017-03-28 |
| ES2464342T3 (es) | 2014-06-02 |
| PL2241564T3 (pl) | 2014-09-30 |
| PT2241564E (pt) | 2014-06-12 |
| DK2241564T3 (da) | 2014-05-19 |
| TW200940530A (en) | 2009-10-01 |
| EP2241564A1 (en) | 2010-10-20 |
| KR101553725B1 (ko) | 2015-09-16 |
| SI2241564T1 (sl) | 2014-06-30 |
| RU2482117C2 (ru) | 2013-05-20 |
| AU2009212645B2 (en) | 2012-07-19 |
| CA2714480A1 (en) | 2009-08-13 |
| ZA201005346B (en) | 2011-11-30 |
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