CY1117080T1 - Θεραπευτικος παραγοντας για στενωση του σπονδυλικου σωληνα - Google Patents
Θεραπευτικος παραγοντας για στενωση του σπονδυλικου σωληναInfo
- Publication number
- CY1117080T1 CY1117080T1 CY20151101199T CY151101199T CY1117080T1 CY 1117080 T1 CY1117080 T1 CY 1117080T1 CY 20151101199 T CY20151101199 T CY 20151101199T CY 151101199 T CY151101199 T CY 151101199T CY 1117080 T1 CY1117080 T1 CY 1117080T1
- Authority
- CY
- Cyprus
- Prior art keywords
- strengthening
- therapeutic factor
- spinal tube
- present
- spinal stenosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Το κύριο αντικείμενο της παρούσας εφεύρεσης είναι η παροχή ενός νέου παράγοντα για την αντιμετώπιση στένωσης του σπονδυλικού σωλήνα. Η παρούσα εφεύρεση σχετίζεται με έναν παράγοντα για τη αντιμετώπιση στένωσης του σπονδυλικού σωλήνα ο οποίος περιέχει το ετεροκυκλικό παράγωγο το οποίο αντιπροσωπεύεται από τον ακόλουθο γενικό τύπο (1) ή ένα φαρμακευτικώς αποδεκτό άλας αυτού ως ένα δραστικό συστατικό˙
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008162638 | 2008-06-23 | ||
| EP09770106.4A EP2292231B1 (en) | 2008-06-23 | 2009-06-22 | Therapeutic agent for spinal canal stenosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1117080T1 true CY1117080T1 (el) | 2017-04-05 |
Family
ID=41444462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151101199T CY1117080T1 (el) | 2008-06-23 | 2015-12-29 | Θεραπευτικος παραγοντας για στενωση του σπονδυλικου σωληνα |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8629145B2 (el) |
| EP (1) | EP2292231B1 (el) |
| JP (1) | JP5527205B2 (el) |
| KR (1) | KR101626168B1 (el) |
| CN (3) | CN105168218A (el) |
| CA (1) | CA2728089C (el) |
| CY (1) | CY1117080T1 (el) |
| DK (1) | DK2292231T3 (el) |
| ES (1) | ES2557303T3 (el) |
| HR (1) | HRP20151443T1 (el) |
| HU (1) | HUE025885T2 (el) |
| PL (1) | PL2292231T3 (el) |
| PT (1) | PT2292231E (el) |
| SI (1) | SI2292231T1 (el) |
| WO (1) | WO2009157396A1 (el) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2246336T3 (da) * | 2008-02-28 | 2020-07-20 | Nippon Shinyaku Co Ltd | Fibroseinhibitor |
| KR102705198B1 (ko) | 2009-06-26 | 2024-09-11 | 니뽄 신야쿠 가부시키가이샤 | 결정 |
| WO2011024874A1 (ja) * | 2009-08-26 | 2011-03-03 | 日本新薬株式会社 | 塩基付加塩 |
| AU2016366073B2 (en) | 2015-12-02 | 2021-08-26 | Nippon Shinyaku Co., Ltd. | Pharmaceutical composition containing 2-{4-[N-(5,6- diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N- (methylsulfonyl)acetamide |
| CN109563055B (zh) * | 2016-07-29 | 2021-12-24 | 成都苑东生物制药股份有限公司 | 氨基吡嗪类化合物或盐、异构体、其制备方法及用途 |
| JOP20190204A1 (ar) | 2017-03-08 | 2019-09-05 | Actelion Pharmaceuticals Ltd | تركيبة صيدلانية تشتمل على سيليكسيباغ |
| TWI801421B (zh) | 2017-09-28 | 2023-05-11 | 日商日本新藥股份有限公司 | 結晶 |
| US10407396B2 (en) * | 2017-11-16 | 2019-09-10 | Apotex Inc. | Crystalline form of selexipag |
| BR112020008940A2 (pt) | 2017-11-16 | 2020-10-20 | Nippon Shinyaku Co., Ltd. | preparação de liberação controlada |
| CA3154802A1 (en) | 2019-10-23 | 2021-04-29 | Marc Patrik SCHRADER | Pharmaceutical composition comprising selexipag |
| WO2021152060A1 (en) | 2020-01-31 | 2021-08-05 | Actelion Pharmaceuticals Ltd | Controlled release selexipag composition |
| TW202239408A (zh) | 2021-01-29 | 2022-10-16 | 瑞士商艾克泰聯製藥有限公司 | 包含二苯基吡𠯤衍生物的醫藥組成物 |
| TW202241425A (zh) | 2021-01-29 | 2022-11-01 | 瑞士商艾克泰聯製藥有限公司 | 用於製造二苯基吡𠯤衍生物之程序 |
| WO2022211052A1 (ja) * | 2021-03-31 | 2022-10-06 | 日本新薬株式会社 | 歩行障害治療剤 |
| JP7010404B1 (ja) | 2021-03-31 | 2022-02-10 | 日本新薬株式会社 | 歩行障害治療剤 |
| WO2023131608A1 (en) | 2022-01-04 | 2023-07-13 | Actelion Pharmaceuticals Ltd | Controlled release compositions |
| WO2023214059A1 (en) | 2022-05-06 | 2023-11-09 | Actelion Pharmaceuticals Ltd | Diphenylpyrazine compounds as prodrugs |
| WO2024017964A1 (en) | 2022-07-20 | 2024-01-25 | Actelion Pharmaceuticals Ltd | Injectable pharmaceutical composition comprising a diphenylpyrazine derivative |
| WO2024133620A1 (en) | 2022-12-22 | 2024-06-27 | Actelion Pharmaceuticals Ltd | In vitro dissolution test |
| WO2024194449A1 (en) | 2023-03-23 | 2024-09-26 | Actelion Pharmaceuticals Ltd | Pharmaceutical composition comprising a diphenylpyrazine derivative |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI316055B (el) | 2001-04-26 | 2009-10-21 | Nippon Shinyaku Co Ltd | |
| WO2003070707A1 (fr) * | 2002-02-19 | 2003-08-28 | Ono Pharmaceutical Co., Ltd. | Composes condenses derives de la pyridazine et medicaments contenant lesdits composes comme ingredients actifs |
| ES2584606T3 (es) * | 2002-10-10 | 2016-09-28 | Ono Pharmaceutical Co., Ltd. | Microesferas que comprenden ONO-1301 |
| DK2246336T3 (da) * | 2008-02-28 | 2020-07-20 | Nippon Shinyaku Co Ltd | Fibroseinhibitor |
-
2009
- 2009-06-22 WO PCT/JP2009/061285 patent/WO2009157396A1/ja active Application Filing
- 2009-06-22 HU HUE09770106A patent/HUE025885T2/en unknown
- 2009-06-22 PT PT97701064T patent/PT2292231E/pt unknown
- 2009-06-22 CA CA2728089A patent/CA2728089C/en active Active
- 2009-06-22 ES ES09770106.4T patent/ES2557303T3/es active Active
- 2009-06-22 PL PL09770106T patent/PL2292231T3/pl unknown
- 2009-06-22 DK DK09770106.4T patent/DK2292231T3/en active
- 2009-06-22 CN CN201510331290.2A patent/CN105168218A/zh active Pending
- 2009-06-22 CN CN2009801246839A patent/CN102065863A/zh active Pending
- 2009-06-22 CN CN201310697705.9A patent/CN103690541A/zh active Pending
- 2009-06-22 JP JP2010517991A patent/JP5527205B2/ja active Active
- 2009-06-22 KR KR1020107027945A patent/KR101626168B1/ko active IP Right Grant
- 2009-06-22 EP EP09770106.4A patent/EP2292231B1/en active Active
- 2009-06-22 SI SI200931341T patent/SI2292231T1/sl unknown
- 2009-06-22 US US13/000,758 patent/US8629145B2/en active Active
-
2015
- 2015-12-29 CY CY20151101199T patent/CY1117080T1/el unknown
- 2015-12-31 HR HRP20151443TT patent/HRP20151443T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20151443T1 (hr) | 2016-01-29 |
| PL2292231T3 (pl) | 2016-03-31 |
| US8629145B2 (en) | 2014-01-14 |
| SI2292231T1 (sl) | 2016-03-31 |
| JP5527205B2 (ja) | 2014-06-18 |
| ES2557303T3 (es) | 2016-01-25 |
| KR101626168B1 (ko) | 2016-05-31 |
| US20110105518A1 (en) | 2011-05-05 |
| JPWO2009157396A1 (ja) | 2011-12-15 |
| KR20110033125A (ko) | 2011-03-30 |
| DK2292231T3 (en) | 2015-12-14 |
| CA2728089A1 (en) | 2009-12-30 |
| CA2728089C (en) | 2017-04-11 |
| EP2292231A4 (en) | 2012-03-28 |
| HUE025885T2 (en) | 2016-05-30 |
| CN102065863A (zh) | 2011-05-18 |
| PT2292231E (pt) | 2015-12-31 |
| EP2292231B1 (en) | 2015-10-21 |
| CN103690541A (zh) | 2014-04-02 |
| EP2292231A1 (en) | 2011-03-09 |
| CN105168218A (zh) | 2015-12-23 |
| WO2009157396A1 (ja) | 2009-12-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1117080T1 (el) | Θεραπευτικος παραγοντας για στενωση του σπονδυλικου σωληνα | |
| CY1117776T1 (el) | Εναντιομερη ενωσεων σπειρο-οξινδολιου και οι χρησεις τους ως θεραπευτικοι παραγοντες | |
| MX2021013472A (es) | Moduladores de thr-? y metodos de uso de estos. | |
| CY1118969T1 (el) | Ενωσεις πυριμιδινο-2-αμινης και η χρηση τους ως αναστολεις των κινασων jak | |
| CY1117719T1 (el) | Παραγωγα αμινοπυριμιδινης ως διαμορφωτες της lrrk2 | |
| CY1119056T1 (el) | Παραγωγα 2',4',-διφθορο-2'-μεθυλ υποκατεστημενου νουκλεοσιδιου ως αναστολεις αντιγραφης hcv rna | |
| EA201992126A1 (ru) | Ингибиторы jak, содержащие 4-членный гетероциклический амид | |
| CY1116628T1 (el) | Ενωσεις σπειρο-οξινδολιου και χρηση αυτων ως θεραπευτικοι παραγοντες | |
| CY1122610T1 (el) | Αλκοξυ πυραζολια ως ενεργοποιητες διαλυτης γουανυλικης κυκλασης | |
| EA201100447A1 (ru) | Органические соединения | |
| EA201100750A1 (ru) | Замещенные диоксопиперидинилфталимидные производные | |
| CY1117122T1 (el) | Παραγωγα πυραζολοσπειροκετονης για χρηση ως αναστολεις ακετyλ-coa καρβοξυλασης | |
| CY1116315T1 (el) | Παραγωγα κιναζολιν-4(3η)-ονης που χρησιμοποιουνται ως αναστολεις κινασης ρι3 | |
| ATE517882T1 (de) | Chinolinderivate | |
| EA201390908A1 (ru) | Производные бицикло[3.2.1]октиламида и их применение | |
| EA201071329A1 (ru) | Диамидные производные адамантана и их применение | |
| TR201906123T4 (tr) | P13 kinazı ve mtor inhibitörleri olarak triazin bileşikleri. | |
| EA201170922A1 (ru) | Производные сульфонамида | |
| UY32025A (es) | Derivados sustituídos de la 6-cloro-2-hidroxi-3-(3,4-dioxo-ciclobut-1-enil-amino)-n-metoxi-n-metil-bencen-sulfonamida, solvatos, hidratos o sales farmacéuticamente aceptables de los mismos, proceso de preparación, composiciones y aplicaciones. | |
| EA201100503A1 (ru) | Глюкозидные производные и их применения | |
| CY1114689T1 (el) | C7-φθορο υποκατεστημενες ενωσεις τετρακυκλινης | |
| EA201270492A1 (ru) | Соединения для лечения дислипидемии и связанных с ней заболеваний | |
| EA201170722A1 (ru) | Лактамы в качестве ингибиторов бета-секретазы | |
| EA201200875A1 (ru) | Ингибиторы сфингозинкиназы | |
| EA201792071A2 (ru) | Производные глутаримидов, их применение, фармацевтическая композиция на их основе, способы их получения |