HRP20140449T1 - Derivat 3,8-diaminotetrahidrokinolina - Google Patents
Derivat 3,8-diaminotetrahidrokinolina Download PDFInfo
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- HRP20140449T1 HRP20140449T1 HRP20140449AT HRP20140449T HRP20140449T1 HR P20140449 T1 HRP20140449 T1 HR P20140449T1 HR P20140449A T HRP20140449A T HR P20140449AT HR P20140449 T HRP20140449 T HR P20140449T HR P20140449 T1 HRP20140449 T1 HR P20140449T1
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- BZWGZEOWKRFPRY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline-3,8-diamine Chemical class C1=CC=C2CC(N)CNC2=C1N BZWGZEOWKRFPRY-UHFFFAOYSA-N 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 7
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 6
- 229910052757 nitrogen Inorganic materials 0.000 claims 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
- 125000005843 halogen group Chemical group 0.000 claims 5
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 3
- 125000001041 indolyl group Chemical group 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002541 furyl group Chemical group 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000001544 thienyl group Chemical group 0.000 claims 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004464 hydroxyphenyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000006301 indolyl methyl group Chemical group 0.000 claims 1
- 125000005956 isoquinolyl group Chemical group 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
- 125000005493 quinolyl group Chemical group 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
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- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
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- Biophysics (AREA)
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- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
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- Diabetes (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Claims (14)
1. Derivat 3,8-diaminotetrahidrokinolina, naznačen time, da je to spoj predstavljen formulom (1 a):
[image]
(pri čemu X predstavlja CH2, C=O, CH-OR, CH-SR, ili CH-NRR';
m je broj 1 ili 2;
Ar predstavlja fenilnu skupinu, naftilnu skupinu, 5-članu ili 6-članu aromatsku heterocikličku skupinu koji ima jedan ili dva elementa odabrana između S, N, i O, ili kondenziranu aromatsku heterocikličku skupinu formiranu između benzenskog prstena i 5-članog ili 6-članog heterocikličkog prstena koji ima jedan ili dva elementa odabrana između S, N, i O ( pri čemu fenil, naftil, ili aromatske heterocikličke skupine mogu biti supstituirane s 1 do 3 atoma halogena, C1 do C6 alkil skupinom, ili C1 do C6 alkoksi skupinom);
R1 i R2, koji mogu biti identični ili međusobno različiti, svaki predstavlja atom vodika ili metilnu skupinu;
R3 predstavlja C1 do C6 alkil skupinu (alkilna skupina može po izboru biti supstituirana s metiltio, ili benziloksi skupinom), fenilnom skupinom, alkilnom skupinom fenil-C1-4, ili indolil-C1-4 alkil skupinom (fenilna skupina ili indolilna skupina po izboru su supstituirane s C1 do C6 alkil skupinom, atomom halogena, ili C1 do C6 alkoksi skupinom); n je broj 0 ili 1;
R4 i R5, koji mogu biti identični ili međusobno različiti, svaki predstavlja atom vodika, ili linearni C1 do C6, razgranatu ili cikličku alkil skupinu (alkilna skupina je po izboru supstituirana atomom halogena, hidroksilnom skupinom, C1 do C6 alkoksi skupinom, fenilnom skupinom, benziloksi skupinom ili hidroksifenil skupinom), ili R4 ili R5 i R6 ili R7 mogu biti povezani sa susjednim atomom dušika te tvore pirolidinski prsten ili piperidinski prsten (pirolidinski prsten ili piperidinski prsten po izboru su supstituirani s hidroksilnom skupinom);
R6 i R7, koji mogu biti identični ili međusobno različiti, svaki predstavlja atom vodika ili C1 do C6 alkilnu skupinu; i
R i R', koji mogu biti identični ili međusobno različiti, svaki predstavlja atom vodika ili linearnu C1 do C6, razgranatu ili cikličku alkil skupinu), ili njegova sol.
2. Spoj ili sol prema zahtjevu 1, naznačen time, da je m 1.
3. Spoj ili sol prema zahtjevu 1 ili 2, naznačen time, da je Ar fenilna skupina, naftil skupina, piridil skupina, kinolilna skupina, izokinolilna skupina, tienilna skupina, furilna skupina, pirolil skupina, benzotienil skupina, benzofurilna skupina, indolil skupinu, tiazolil skupina, pirimidinil skupina, kinazolinil skupina, imidazolil skupina, benzimidazolilna skupina ili benzotiazolilna skupina (pri čemu ti prstenovi mogu biti supstituirani sa 1 do 3 atoma halogena, C1 do C6 alkilnom skupinom, ili C1 do C6 alkoksi skupinom).
4. Spoj ili sol prema zahtjevu 1 ili 2, naznačen time, da je Ar fenilna skupina, piridilna skupina, tienilna skupina, ili furil skupina.
5. Spoj ili sol prema bilo kojem od zahtjeva 1 do 4, naznačen time, da je R3 C1 do C6 alkilna skupina, benzilna skupina, ili indolilmetilna skupina (indolilna skupina po izboru je supstituirana na dušikovom atomu s C1 do C6 alkilnom skupinom).
6. Spoj ili sol prema bilo kojem od zahtjeva 1 do 5, naznačen time, da je n 0.
7. Spoj ili sol prema bilo kojem od zahtjeva 1 do 6, naznačen time, da je svaki od R4 i R5, koji su jednaki ili različiti jedan od drugog, atom vodika, ili linearna C1 do C4, razgranata ili ciklična alkil skupina.
8. Spoj ili sol prema bilo kojem od zahtjeva 1 do 7, naznačen time, da je svaki od R6 i R7 atom vodika.
9. Spoj ili sol prema bilo kojem od zahtjeva 1 do 8, naznačen time, da je R3 C4 alkilna skupina.
10. Spoj ili sol prema bilo kojem od zahtjeva 1 do 9, naznačen time, da je svaki od R4 i R5, koji su jednaki ili različiti jedan od drugoga, vodikov atom, metilna skupina, ili etilna skupina, ili su R4 i R5 vezani zajedno da formiraju ciklobutil skupinu.
11. Lijek, naznačen time, da sadrži spoj ili sol kao što je navedeno u bilo kojem od zahtjeva 1 do 10.
12. Farmaceutski pripravak, naznačen time, da sadrži spoj ili sol kao što je navedeno u bilo kojem od zahtjeva 1 do 10, i farmaceutski prihvatljiv nosač.
13. Upotreba spoja ili soli kao što je navedeno u bilo kojem od zahtjeva 1 do 10, naznačena time, da se rabi za proizvodnju terapijskog sredstva za razorne sistemske bolesti.
14. Spoj naznačen time, da je to spoj predstavljen formulom (F1):
[image]
(pri čemu X predstavlja CH2 ili C=O, m je broj 1 ili 2, i
Ar predstavlja fenilnu skupinu, naftilnu skupinu, 5-članu ili 6-člana aromatsku heterocikličnu skupinu koji ima jedan ili dva elementa odabrana između S, N, i O, ili kondenziranu aromatsku heterocikličku skupinu formiranu između benzenskog prstena i 5- članog ili 6-članog heterocikličkog prstena koji ima jedan ili dva elementa odabrana između S, N, i O (pri čemu fenil, naftil, ili aromatske heterocikličke skupine mogu biti supstituirane s 1 do 3 atoma halogena, C1 do C6 alkilnom skupinom, ili C1 do C6 alkoksi skupinom), ili njegova sol.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008029781 | 2008-02-08 | ||
| JP2008277044 | 2008-10-28 | ||
| PCT/JP2009/000487 WO2009098901A1 (ja) | 2008-02-08 | 2009-02-06 | ３，８－ジアミノテトラヒドロキノリン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20140449T1 true HRP20140449T1 (hr) | 2014-06-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20140449AT HRP20140449T1 (hr) | 2008-02-08 | 2014-05-20 | Derivat 3,8-diaminotetrahidrokinolina |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8299255B2 (hr) |
| EP (1) | EP2241564B1 (hr) |
| JP (1) | JP5493870B2 (hr) |
| KR (1) | KR101553725B1 (hr) |
| CN (1) | CN101939313B (hr) |
| AU (1) | AU2009212645B2 (hr) |
| BR (1) | BRPI0907749A2 (hr) |
| CA (1) | CA2714480C (hr) |
| CY (1) | CY1115138T1 (hr) |
| DK (1) | DK2241564T3 (hr) |
| ES (1) | ES2464342T3 (hr) |
| HR (1) | HRP20140449T1 (hr) |
| MX (1) | MX2010008740A (hr) |
| PL (1) | PL2241564T3 (hr) |
| PT (1) | PT2241564E (hr) |
| RU (1) | RU2482117C2 (hr) |
| SI (1) | SI2241564T1 (hr) |
| TW (1) | TWI422585B (hr) |
| WO (1) | WO2009098901A1 (hr) |
| ZA (1) | ZA201005346B (hr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103328449A (zh) * | 2011-01-26 | 2013-09-25 | 霍夫曼-拉罗奇有限公司 | 新的四氢喹啉衍生物 |
| TWI662967B (zh) | 2013-03-25 | 2019-06-21 | 日商志瑞亞新藥工業股份有限公司 | 食後期之胃運動亢進劑 |
| CN104193722A (zh) * | 2014-08-27 | 2014-12-10 | 湖南华腾制药有限公司 | 一种n-叔丁氧羰基-3-甲胺噻吩的制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
| JP3817746B2 (ja) | 1994-06-20 | 2006-09-06 | 株式会社竹屋 | パチンコ島台 |
| CA2301566A1 (en) | 1997-08-22 | 1999-03-04 | Kaken Pharmaceutical Co., Ltd. | N-acylated lipophilic amino acid derivatives |
| US6211174B1 (en) * | 1997-10-31 | 2001-04-03 | Merck & Co., Inc. | Naphtho-fused lactams promote release of growth hormone |
| UA73530C2 (uk) | 1999-11-10 | 2005-08-15 | Ново Нордіск А/С | Сполука з властивостями вивільнювати гормон росту |
| RU2277092C2 (ru) * | 2000-09-15 | 2006-05-27 | Анормед, Инк. | Гетероциклические соединения, их применение и фармацевтическая композиция для лечения состояний, опосредованных схсr4 и ccr5 |
| WO2005007628A1 (en) * | 2003-07-11 | 2005-01-27 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
| WO2008116107A2 (en) | 2007-03-21 | 2008-09-25 | Takeda San Diego, Inc. | Piperazine derivatives as glucokinase activators |
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2009
- 2009-02-06 RU RU2010137336/04A patent/RU2482117C2/ru not_active IP Right Cessation
- 2009-02-06 SI SI200930930T patent/SI2241564T1/sl unknown
- 2009-02-06 MX MX2010008740A patent/MX2010008740A/es active IP Right Grant
- 2009-02-06 BR BRPI0907749-9A patent/BRPI0907749A2/pt not_active Application Discontinuation
- 2009-02-06 ES ES09707360.5T patent/ES2464342T3/es active Active
- 2009-02-06 KR KR1020107016651A patent/KR101553725B1/ko active IP Right Grant
- 2009-02-06 EP EP09707360.5A patent/EP2241564B1/en active Active
- 2009-02-06 CN CN2009801045187A patent/CN101939313B/zh not_active Expired - Fee Related
- 2009-02-06 PL PL09707360T patent/PL2241564T3/pl unknown
- 2009-02-06 WO PCT/JP2009/000487 patent/WO2009098901A1/ja active Application Filing
- 2009-02-06 JP JP2009552416A patent/JP5493870B2/ja active Active
- 2009-02-06 US US12/866,843 patent/US8299255B2/en active Active
- 2009-02-06 AU AU2009212645A patent/AU2009212645B2/en not_active Ceased
- 2009-02-06 CA CA2714480A patent/CA2714480C/en not_active Expired - Fee Related
- 2009-02-06 DK DK09707360.5T patent/DK2241564T3/da active
- 2009-02-06 PT PT97073605T patent/PT2241564E/pt unknown
- 2009-02-06 TW TW098103925A patent/TWI422585B/zh not_active IP Right Cessation
-
2010
- 2010-07-27 ZA ZA2010/05346A patent/ZA201005346B/en unknown
-
2012
- 2012-09-14 US US13/617,469 patent/US8501772B2/en active Active
-
2014
- 2014-05-20 HR HRP20140449AT patent/HRP20140449T1/hr unknown
- 2014-06-03 CY CY20141100391T patent/CY1115138T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI422585B (zh) | 2014-01-11 |
| CA2714480A1 (en) | 2009-08-13 |
| JP5493870B2 (ja) | 2014-05-14 |
| US8299255B2 (en) | 2012-10-30 |
| WO2009098901A1 (ja) | 2009-08-13 |
| JPWO2009098901A1 (ja) | 2011-05-26 |
| MX2010008740A (es) | 2010-08-30 |
| CA2714480C (en) | 2017-03-28 |
| CN101939313B (zh) | 2013-05-22 |
| DK2241564T3 (da) | 2014-05-19 |
| RU2482117C2 (ru) | 2013-05-20 |
| ZA201005346B (en) | 2011-11-30 |
| RU2010137336A (ru) | 2012-03-20 |
| US8501772B2 (en) | 2013-08-06 |
| TW200940530A (en) | 2009-10-01 |
| BRPI0907749A2 (pt) | 2015-07-21 |
| PL2241564T3 (pl) | 2014-09-30 |
| KR20100116175A (ko) | 2010-10-29 |
| KR101553725B1 (ko) | 2015-09-16 |
| CY1115138T1 (el) | 2016-12-14 |
| AU2009212645B2 (en) | 2012-07-19 |
| US20130012537A1 (en) | 2013-01-10 |
| EP2241564A4 (en) | 2011-07-20 |
| SI2241564T1 (sl) | 2014-06-30 |
| US20100317693A1 (en) | 2010-12-16 |
| ES2464342T3 (es) | 2014-06-02 |
| CN101939313A (zh) | 2011-01-05 |
| EP2241564B1 (en) | 2014-04-30 |
| EP2241564A1 (en) | 2010-10-20 |
| PT2241564E (pt) | 2014-06-12 |
| AU2009212645A1 (en) | 2009-08-13 |
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