CY1113315T1 - Ιμιδαζολοκαρβοξαμιδια - Google Patents
ΙμιδαζολοκαρβοξαμιδιαInfo
- Publication number
- CY1113315T1 CY1113315T1 CY20121101058T CY121101058T CY1113315T1 CY 1113315 T1 CY1113315 T1 CY 1113315T1 CY 20121101058 T CY20121101058 T CY 20121101058T CY 121101058 T CY121101058 T CY 121101058T CY 1113315 T1 CY1113315 T1 CY 1113315T1
- Authority
- CY
- Cyprus
- Prior art keywords
- preparation
- methods
- imidazolocarboxamides
- imidazolocarboxamide
- anxiety
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 102100036837 Metabotropic glutamate receptor 2 Human genes 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 108010038421 metabotropic glutamate receptor 2 Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/91—Nitro radicals
- C07D233/92—Nitro radicals attached in position 4 or 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Developing Agents For Electrophotography (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8177408P | 2008-07-18 | 2008-07-18 | |
| EP09790351A EP2318375B1 (en) | 2008-07-18 | 2009-07-14 | Imidazole carboxamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113315T1 true CY1113315T1 (el) | 2016-04-13 |
Family
ID=41128155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121101058T CY1113315T1 (el) | 2008-07-18 | 2012-11-07 | Ιμιδαζολοκαρβοξαμιδια |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7754742B2 (OSRAM) |
| EP (1) | EP2318375B1 (OSRAM) |
| JP (1) | JP5379227B2 (OSRAM) |
| KR (1) | KR101287713B1 (OSRAM) |
| CN (1) | CN102099344B (OSRAM) |
| AR (1) | AR074631A1 (OSRAM) |
| BR (1) | BRPI0915977A2 (OSRAM) |
| CA (1) | CA2731215C (OSRAM) |
| CY (1) | CY1113315T1 (OSRAM) |
| DK (1) | DK2318375T3 (OSRAM) |
| EA (1) | EA018434B1 (OSRAM) |
| ES (1) | ES2393243T3 (OSRAM) |
| HR (1) | HRP20120830T1 (OSRAM) |
| MX (1) | MX2011000611A (OSRAM) |
| PL (1) | PL2318375T3 (OSRAM) |
| PT (1) | PT2318375E (OSRAM) |
| SI (1) | SI2318375T1 (OSRAM) |
| TW (1) | TW201006801A (OSRAM) |
| WO (1) | WO2010009062A1 (OSRAM) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| SI2203439T1 (sl) | 2007-09-14 | 2011-05-31 | Ortho Mcneil Janssen Pharm | 1',3'-disubstituirani 4-fenil-3,4,5,6-tetrahidro-2H-1'H-(1,4')bipiridinil-2'-oni |
| US8722894B2 (en) | 2007-09-14 | 2014-05-13 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1H-pyridin-2-ones |
| AU2009289784B2 (en) | 2008-09-02 | 2012-03-22 | Addex Pharma S.A. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| CN102439008B (zh) | 2009-05-12 | 2015-04-29 | 杨森制药有限公司 | 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途 |
| BRPI1010831A2 (pt) | 2009-05-12 | 2016-04-05 | Addex Pharmaceuticals Sa | derivados de 1,2,4-triazolo[4,3-a]piridina e seu como moduladores alostéricos positivos de receptores de mglur2 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| PT2649069E (pt) | 2010-11-08 | 2015-11-20 | Janssen Pharmaceuticals Inc | Derivados de 1,2,4-triazolo[4,3-a]piridina e sua utilização como moduladores alostéricos positivos de recetores mglur2 |
| WO2012062759A1 (en) | 2010-11-08 | 2012-05-18 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
| US20150072396A1 (en) | 2011-03-04 | 2015-03-12 | Life Technologies Corporation | Compounds and Methods for Conjugation of Biomolecules |
| ES2602794T3 (es) | 2011-03-31 | 2017-02-22 | Pfizer Inc | Piridinonas bicíclicas novedosas |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| AU2015208233B2 (en) | 2014-01-21 | 2019-08-29 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| ES2860298T3 (es) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso |
| MX368391B (es) | 2015-02-03 | 2019-09-30 | Pfizer | Ciclopropabenzofuranil-piridopirazindionas novedosas. |
| JP6518789B2 (ja) * | 2015-04-23 | 2019-05-22 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 精神障害の処置において使用するためのテトラゾール誘導体 |
| CN104788694B (zh) * | 2015-04-29 | 2018-06-08 | 江苏亚宝绝缘材料股份有限公司 | 一种超低收缩率的聚酰亚胺薄膜 |
| EP3359537B1 (en) | 2015-10-06 | 2020-03-25 | H. Hoffnabb-La Roche Ag | Triazole derivatives |
| JP6905988B2 (ja) | 2016-02-02 | 2021-07-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｅａａｔ３阻害剤としてのピラゾール−ピリジン誘導体 |
| CN109071451B (zh) | 2016-05-27 | 2022-07-15 | 豪夫迈·罗氏有限公司 | 作为eaat3抑制剂的吡唑化合物 |
| JP7068277B2 (ja) | 2016-10-14 | 2022-05-16 | エフ．ホフマン－ラ ロシュ アーゲー | Ｅａａｔ３阻害剤としてのイミダゾール化合物 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK377780A (da) | 1979-09-05 | 1981-03-06 | Glaxo Group Ltd | Fremgangsmaade til fremstilling af phenolderivater |
| US4666928A (en) | 1984-08-30 | 1987-05-19 | Merck Frosst Canada, Ind. | Propylphenoxy pyridine carboxylates as leukotriene antagonists |
| TW204343B (OSRAM) | 1991-05-31 | 1993-04-21 | Sumitomo Pharmaceutics Co Ltd | |
| US6800651B2 (en) | 2000-02-03 | 2004-10-05 | Eli Lilly And Company | Potentiators of glutamate receptors |
| EP1556038A2 (en) * | 2002-08-26 | 2005-07-27 | Merck & Co., Inc. | Acetophenone potentiators of metabotropic glutamate receptors |
| US20080293684A1 (en) | 2004-07-30 | 2008-11-27 | Anthony B Pinkerton | Heterocyclic Acetophenone Potentiators of Metabotropic Glutamate Receptors |
| EP1773792A1 (en) | 2004-07-30 | 2007-04-18 | Merck & Co., Inc. | Indanone potentiators of metabotropic glutamate receptors |
| TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| AU2005299797A1 (en) | 2004-10-25 | 2006-05-04 | Merck & Co., Inc. | Heterocyclic indanone potentiators of metabotropic glutamate receptors |
| DK1817301T3 (da) | 2004-11-22 | 2012-02-27 | Lilly Co Eli | Forstærkere af glutamat-receptorer |
| CN101128435A (zh) | 2004-12-27 | 2008-02-20 | 阿斯利康(瑞典)有限公司 | 作为代谢型谷氨酸受体激动剂用于治疗神经病学及精神病学病症的吡唑酮化合物 |
| EP1912940A1 (en) | 2005-08-12 | 2008-04-23 | AstraZeneca AB | Substituted isoindolones and their use as metabotropic glutamate receptor potentiators |
-
2009
- 2009-07-10 TW TW098123468A patent/TW201006801A/zh unknown
- 2009-07-13 AR ARP090102635A patent/AR074631A1/es not_active Application Discontinuation
- 2009-07-14 MX MX2011000611A patent/MX2011000611A/es active IP Right Grant
- 2009-07-14 BR BRPI0915977A patent/BRPI0915977A2/pt not_active IP Right Cessation
- 2009-07-14 PT PT09790351T patent/PT2318375E/pt unknown
- 2009-07-14 EA EA201170227A patent/EA018434B1/ru not_active IP Right Cessation
- 2009-07-14 KR KR1020117001166A patent/KR101287713B1/ko not_active Expired - Fee Related
- 2009-07-14 EP EP09790351A patent/EP2318375B1/en active Active
- 2009-07-14 PL PL09790351T patent/PL2318375T3/pl unknown
- 2009-07-14 DK DK09790351.2T patent/DK2318375T3/da active
- 2009-07-14 ES ES09790351T patent/ES2393243T3/es active Active
- 2009-07-14 WO PCT/US2009/050440 patent/WO2010009062A1/en not_active Ceased
- 2009-07-14 SI SI200930350T patent/SI2318375T1/sl unknown
- 2009-07-14 US US12/502,252 patent/US7754742B2/en not_active Expired - Fee Related
- 2009-07-14 CN CN2009801274345A patent/CN102099344B/zh not_active Expired - Fee Related
- 2009-07-14 JP JP2011518823A patent/JP5379227B2/ja not_active Expired - Fee Related
- 2009-07-14 CA CA2731215A patent/CA2731215C/en not_active Expired - Fee Related
- 2009-07-14 HR HRP20120830AT patent/HRP20120830T1/hr unknown
-
2012
- 2012-11-07 CY CY20121101058T patent/CY1113315T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR074631A1 (es) | 2011-02-02 |
| EA018434B1 (ru) | 2013-07-30 |
| KR20110022676A (ko) | 2011-03-07 |
| PL2318375T3 (pl) | 2013-02-28 |
| DK2318375T3 (da) | 2012-10-08 |
| AU2009271105A1 (en) | 2010-01-21 |
| EA201170227A1 (ru) | 2011-06-30 |
| CA2731215C (en) | 2013-08-27 |
| US20100016373A1 (en) | 2010-01-21 |
| EP2318375A1 (en) | 2011-05-11 |
| CA2731215A1 (en) | 2010-01-21 |
| EP2318375B1 (en) | 2012-09-19 |
| JP5379227B2 (ja) | 2013-12-25 |
| KR101287713B1 (ko) | 2013-07-23 |
| MX2011000611A (es) | 2011-03-01 |
| CN102099344A (zh) | 2011-06-15 |
| CN102099344B (zh) | 2013-10-30 |
| US7754742B2 (en) | 2010-07-13 |
| WO2010009062A1 (en) | 2010-01-21 |
| HRP20120830T1 (hr) | 2012-11-30 |
| BRPI0915977A2 (pt) | 2018-10-30 |
| SI2318375T1 (sl) | 2012-11-30 |
| ES2393243T3 (es) | 2012-12-19 |
| JP2011528658A (ja) | 2011-11-24 |
| TW201006801A (en) | 2010-02-16 |
| PT2318375E (pt) | 2012-10-22 |
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