AR074631A1 - Compuesto de imidazol carboxamida, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar la depresion - Google Patents

Compuesto de imidazol carboxamida, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar la depresion

Info

Publication number
AR074631A1
AR074631A1 ARP090102635A ARP090102635A AR074631A1 AR 074631 A1 AR074631 A1 AR 074631A1 AR P090102635 A ARP090102635 A AR P090102635A AR P090102635 A ARP090102635 A AR P090102635A AR 074631 A1 AR074631 A1 AR 074631A1
Authority
AR
Argentina
Prior art keywords
prepare
pharmaceutical composition
composite
treat depression
medicinal product
Prior art date
Application number
ARP090102635A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR074631A1 publication Critical patent/AR074631A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Un compuesto de imidazol carboxamidas de fórmula (1), o una sal del mismo farmacéuticamente aceptable, en donde: R1 es alquilo C1-5, cicloalquilo C3-5, o cicloalquilmetilo C3-5; R2 es alquilo C1-3, cloro, bromo, fluoro o trifluorometilo; A se selecciona a partir del grupo de fórmulas (2); R3 es hidrógeno o metilo; R4 es hidrógeno o alquilo C1-3; y R5 es un sustituyente seleccionado a partir del grupo que consiste de hidrógeno, metilo, metoxi, cloro y fluoro; o dos sustituyentes los cuales son fluoro. Composición farmacéutica que lo comprende y su uso para preparar un medicamento útil para tratar la depresión.
ARP090102635A 2008-07-18 2009-07-13 Compuesto de imidazol carboxamida, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar la depresion AR074631A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8177408P 2008-07-18 2008-07-18

Publications (1)

Publication Number Publication Date
AR074631A1 true AR074631A1 (es) 2011-02-02

Family

ID=41128155

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090102635A AR074631A1 (es) 2008-07-18 2009-07-13 Compuesto de imidazol carboxamida, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar la depresion

Country Status (19)

Country Link
US (1) US7754742B2 (es)
EP (1) EP2318375B1 (es)
JP (1) JP5379227B2 (es)
KR (1) KR101287713B1 (es)
CN (1) CN102099344B (es)
AR (1) AR074631A1 (es)
BR (1) BRPI0915977A2 (es)
CA (1) CA2731215C (es)
CY (1) CY1113315T1 (es)
DK (1) DK2318375T3 (es)
EA (1) EA018434B1 (es)
ES (1) ES2393243T3 (es)
HR (1) HRP20120830T1 (es)
MX (1) MX2011000611A (es)
PL (1) PL2318375T3 (es)
PT (1) PT2318375E (es)
SI (1) SI2318375T1 (es)
TW (1) TW201006801A (es)
WO (1) WO2010009062A1 (es)

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TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
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MX2010002537A (es) 2007-09-14 2010-08-10 Ortho Mcneil Janssen Pharm 4-fenil-1h-piridin-2-onas 1,3-disubstituidas.
JP5547194B2 (ja) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 代謝型グルタミン酸受容体の調節因子としての３−アザビシクロ［３．１．０］ヘキシル誘導体
MX2011003691A (es) 2008-10-16 2011-09-06 Ortho Mcneil Janssen Pharm Derivados de indol y benzomorfolina como moduladores de los receptores de glutamato metabotropico.
NZ596053A (en) 2009-05-12 2013-05-31 Janssen Pharmaceuticals Inc 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
CN102439008B (zh) 2009-05-12 2015-04-29 杨森制药有限公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其用于治疗或预防神经和精神病症的用途
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
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EP2681196B1 (en) 2011-03-04 2015-09-09 Life Technologies Corporation Compounds and methods for conjugation of biomolecules
EP2691393B1 (en) 2011-03-31 2016-09-14 Pfizer Inc Novel bicyclic pyridinones
UA110688C2 (uk) 2012-09-21 2016-01-25 Пфайзер Інк. Біциклічні піридинони
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
KR20220049612A (ko) 2014-01-21 2022-04-21 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도
ES2748633T3 (es) 2014-01-21 2020-03-17 Janssen Pharmaceutica Nv Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso
EP3253755B1 (en) 2015-02-03 2020-08-26 Pfizer Inc Novel cyclopropabenzofuranyl pyridopyrazinediones
US10577332B2 (en) 2015-04-23 2020-03-03 Hoffmann-La Roche Inc. Tetrazole derivatives
CN104788694B (zh) * 2015-04-29 2018-06-08 江苏亚宝绝缘材料股份有限公司 一种超低收缩率的聚酰亚胺薄膜
JP6831376B2 (ja) 2015-10-06 2021-02-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ トリアゾール誘導体
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CN109071451B (zh) 2016-05-27 2022-07-15 豪夫迈·罗氏有限公司 作为eaat3抑制剂的吡唑化合物
CN109563049B (zh) 2016-10-14 2022-11-29 豪夫迈·罗氏有限公司 作为eaat3抑制剂的咪唑化合物

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Also Published As

Publication number Publication date
SI2318375T1 (sl) 2012-11-30
KR20110022676A (ko) 2011-03-07
MX2011000611A (es) 2011-03-01
AU2009271105A1 (en) 2010-01-21
CA2731215A1 (en) 2010-01-21
US20100016373A1 (en) 2010-01-21
JP5379227B2 (ja) 2013-12-25
PL2318375T3 (pl) 2013-02-28
CY1113315T1 (el) 2016-04-13
TW201006801A (en) 2010-02-16
CA2731215C (en) 2013-08-27
DK2318375T3 (da) 2012-10-08
US7754742B2 (en) 2010-07-13
EP2318375B1 (en) 2012-09-19
KR101287713B1 (ko) 2013-07-23
CN102099344B (zh) 2013-10-30
EA201170227A1 (ru) 2011-06-30
HRP20120830T1 (hr) 2012-11-30
PT2318375E (pt) 2012-10-22
BRPI0915977A2 (pt) 2018-10-30
CN102099344A (zh) 2011-06-15
JP2011528658A (ja) 2011-11-24
WO2010009062A1 (en) 2010-01-21
ES2393243T3 (es) 2012-12-19
EA018434B1 (ru) 2013-07-30
EP2318375A1 (en) 2011-05-11

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