CY1113112T1 - Παραγωγα θειενοπυριδονης ως ενεργοποιητες της πρωτεϊνικης κινασης (αμρκ) που ενεργοποιουνται απο το amρ - Google Patents
Παραγωγα θειενοπυριδονης ως ενεργοποιητες της πρωτεϊνικης κινασης (αμρκ) που ενεργοποιουνται απο το amρInfo
- Publication number
- CY1113112T1 CY1113112T1 CY20121100841T CY121100841T CY1113112T1 CY 1113112 T1 CY1113112 T1 CY 1113112T1 CY 20121100841 T CY20121100841 T CY 20121100841T CY 121100841 T CY121100841 T CY 121100841T CY 1113112 T1 CY1113112 T1 CY 1113112T1
- Authority
- CY
- Cyprus
- Prior art keywords
- amrk
- pyridonic
- amr
- activators
- sulfur
- Prior art date
Links
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 title 1
- 239000011593 sulfur Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Child & Adolescent Psychology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08290423 | 2008-05-05 | ||
| EP09741799A EP2280952B1 (en) | 2008-05-05 | 2009-04-08 | Thienopyridone derivatives as amp-activated protein kinase (ampk) activators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1113112T1 true CY1113112T1 (el) | 2016-04-13 |
Family
ID=40756916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20121100841T CY1113112T1 (el) | 2008-05-05 | 2012-09-13 | Παραγωγα θειενοπυριδονης ως ενεργοποιητες της πρωτεϊνικης κινασης (αμρκ) που ενεργοποιουνται απο το amρ |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US8604202B2 (enExample) |
| EP (1) | EP2280952B1 (enExample) |
| JP (1) | JP5536757B2 (enExample) |
| KR (2) | KR101648593B1 (enExample) |
| CN (1) | CN102015676B (enExample) |
| AR (1) | AR071530A1 (enExample) |
| AU (1) | AU2009243811B2 (enExample) |
| BR (1) | BRPI0910832B8 (enExample) |
| CA (1) | CA2723429C (enExample) |
| CO (1) | CO6331304A2 (enExample) |
| CY (1) | CY1113112T1 (enExample) |
| DK (1) | DK2280952T3 (enExample) |
| EA (1) | EA020773B1 (enExample) |
| EC (1) | ECSP10010654A (enExample) |
| ES (1) | ES2388485T3 (enExample) |
| HR (1) | HRP20120549T1 (enExample) |
| IL (1) | IL208988A (enExample) |
| MX (1) | MX2010011916A (enExample) |
| MY (1) | MY160357A (enExample) |
| NZ (1) | NZ589690A (enExample) |
| PL (1) | PL2280952T3 (enExample) |
| PT (1) | PT2280952E (enExample) |
| SI (1) | SI2280952T1 (enExample) |
| UA (1) | UA103617C2 (enExample) |
| WO (1) | WO2009135580A1 (enExample) |
| ZA (1) | ZA201008722B (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2552435A1 (en) | 2010-04-02 | 2013-02-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1) |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| JP5990170B2 (ja) * | 2010-09-01 | 2016-09-07 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | 除草活性を有するケトスルタム類及びジケトピリジン類 |
| KR101624020B1 (ko) * | 2011-03-07 | 2016-05-24 | 글락소스미스클라인 엘엘씨 | 퀴놀리논 유도체 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| EP2679591A1 (en) | 2012-06-29 | 2014-01-01 | Poxel | Thienopyridone derivatives useful as activators of AMPK |
| CA2905242C (en) | 2013-03-15 | 2016-11-29 | Pfizer Inc. | Indole compounds that activate ampk |
| US10143703B2 (en) | 2014-01-02 | 2018-12-04 | Massachusetts Eye And Ear Infirmary | Treating ocular neovascularization |
| WO2015114663A1 (en) | 2014-01-30 | 2015-08-06 | Council Of Scientific & Industrial Research | Novel thieno [2,3-d]pyrimidin-4(3h)-one compounds with antimycobacterial properties |
| EP3310355B1 (en) | 2015-06-16 | 2020-11-11 | University of Virginia Patent Foundation | Ptp4a3 inhibitor for the treatment of cancer |
| PL3322711T3 (pl) | 2015-06-25 | 2021-10-25 | University Health Network | Inhibitory hpk1 i sposoby ich zastosowania |
| EP3355876A2 (en) | 2015-09-30 | 2018-08-08 | Instituto de Medicina Molecular | Methods for attenuating parasite virulence |
| US11584755B2 (en) | 2017-09-26 | 2023-02-21 | Ideaya Biosciences, Inc. | Dihydrothieno[3,2-b]pyridine compounds |
| WO2019106087A1 (en) * | 2017-11-29 | 2019-06-06 | Syddansk Universitet | Ampk inhibitors |
| JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
| EP4221700A1 (en) | 2020-09-30 | 2023-08-09 | Bioverativ Therapeutics Inc. | Ampk activators and methods of use thereof |
| WO2022106892A1 (en) | 2020-11-17 | 2022-05-27 | Instituto De Medicina Molecular | Anti-malarial compounds |
| US12404348B2 (en) | 2021-11-19 | 2025-09-02 | The Brigham And Women's Hospital, Inc. | Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8627698D0 (en) * | 1986-11-20 | 1986-12-17 | Boots Co Plc | Therapeutic agents |
| DE4444815A1 (de) * | 1994-12-15 | 1996-06-20 | Merck Patent Gmbh | Thienopyridone |
| AR040123A1 (es) * | 2002-05-31 | 2005-03-16 | Upjohn Co | Compuestos tiofeno, antihelminticos e insecticidas |
| US7119205B2 (en) * | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
| WO2006093518A2 (en) * | 2004-06-25 | 2006-09-08 | Apath, Llc | Thienyl compounds for treating virus-related conditions |
| US7563813B2 (en) * | 2005-05-13 | 2009-07-21 | Wyeth | Iminothiazolidinone derivatives as SFRP-1 antagonists |
| EP1754483A1 (en) * | 2005-08-18 | 2007-02-21 | Merck Sante | Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them |
| US20090149495A1 (en) * | 2005-12-20 | 2009-06-11 | Katalin Nogradi | Compounds |
| MX2010011047A (es) * | 2008-04-11 | 2010-10-26 | Merck Patent Gmbh | Derivados de tienopiridonas como activadores de proteina cinasa activada por amp (ampk). |
-
2009
- 2009-04-08 MY MYPI2010005160A patent/MY160357A/en unknown
- 2009-04-08 BR BRPI0910832A patent/BRPI0910832B8/pt not_active IP Right Cessation
- 2009-04-08 AU AU2009243811A patent/AU2009243811B2/en not_active Ceased
- 2009-04-08 ES ES09741799T patent/ES2388485T3/es active Active
- 2009-04-08 DK DK09741799.2T patent/DK2280952T3/da active
- 2009-04-08 CA CA2723429A patent/CA2723429C/en active Active
- 2009-04-08 EP EP09741799A patent/EP2280952B1/en active Active
- 2009-04-08 MX MX2010011916A patent/MX2010011916A/es active IP Right Grant
- 2009-04-08 KR KR1020107027208A patent/KR101648593B1/ko not_active Expired - Fee Related
- 2009-04-08 KR KR1020167007434A patent/KR20160038065A/ko not_active Ceased
- 2009-04-08 PL PL09741799T patent/PL2280952T3/pl unknown
- 2009-04-08 CN CN200980116120.5A patent/CN102015676B/zh not_active Expired - Fee Related
- 2009-04-08 WO PCT/EP2009/002606 patent/WO2009135580A1/en not_active Ceased
- 2009-04-08 NZ NZ589690A patent/NZ589690A/en not_active IP Right Cessation
- 2009-04-08 UA UAA201014384A patent/UA103617C2/ru unknown
- 2009-04-08 EA EA201001733A patent/EA020773B1/ru not_active IP Right Cessation
- 2009-04-08 SI SI200930319T patent/SI2280952T1/sl unknown
- 2009-04-08 US US12/991,028 patent/US8604202B2/en active Active
- 2009-04-08 JP JP2011507805A patent/JP5536757B2/ja not_active Expired - Fee Related
- 2009-04-08 PT PT09741799T patent/PT2280952E/pt unknown
- 2009-04-08 HR HRP20120549AT patent/HRP20120549T1/hr unknown
- 2009-04-30 AR ARP090101562A patent/AR071530A1/es active IP Right Grant
-
2010
- 2010-10-28 IL IL208988A patent/IL208988A/en active IP Right Grant
- 2010-10-28 CO CO10134194A patent/CO6331304A2/es active IP Right Grant
- 2010-12-02 EC EC2010010654A patent/ECSP10010654A/es unknown
- 2010-12-03 ZA ZA2010/08722A patent/ZA201008722B/en unknown
-
2012
- 2012-09-13 CY CY20121100841T patent/CY1113112T1/el unknown
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