CY1111151T1 - Αναστολεις φωσφολιπασης α2 του κυτταροδιαλυματος - Google Patents

Αναστολεις φωσφολιπασης α2 του κυτταροδιαλυματος

Info

Publication number
CY1111151T1
CY1111151T1 CY20101101135T CY101101135T CY1111151T1 CY 1111151 T1 CY1111151 T1 CY 1111151T1 CY 20101101135 T CY20101101135 T CY 20101101135T CY 101101135 T CY101101135 T CY 101101135T CY 1111151 T1 CY1111151 T1 CY 1111151T1
Authority
CY
Cyprus
Prior art keywords
phospholising
inhibitions
cell solution
inhibitors
phospholipase
Prior art date
Application number
CY20101101135T
Other languages
English (en)
Inventor
John C Mckew
Katherine L Lee
Lihren Chen
Richard Vargas
James D Clark
Cara Williams
Valerie Clerin
Suzana Marusic
Kevin Pong
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of CY1111151T1 publication Critical patent/CY1111151T1/el

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η εφεύρεση αυτή παρέχει χημικούς αναστολείς της δραστικότητας διαφόρων ενζύμων φωσφολιπάσης, ιδιαιτέρως ενζύμων φωσφολιπάσης Α2 του κυτταροδιαλύματος (cPLA2), ειδικότερα συμπεριλαμβάνοντας αναστολείς φωσφολιπάσης Α2 άλφα ενζύμων του κυτταροδιαλύματος (cPLAα). Σε μερικές πραγματοποιήσεις, οι αναστολείς έχουν τον Τύπο I: όπου οι μεταβλητές σύνταξης είναι όπως ορίζεται εδώ.
CY20101101135T 2005-05-27 2010-12-09 Αναστολεις φωσφολιπασης α2 του κυτταροδιαλυματος CY1111151T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68556405P 2005-05-27 2005-05-27
EP06771540A EP1891006B1 (en) 2005-05-27 2006-05-26 Inhibitors of cytosolic phospholipase a2

Publications (1)

Publication Number Publication Date
CY1111151T1 true CY1111151T1 (el) 2015-06-11

Family

ID=37188759

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101101135T CY1111151T1 (el) 2005-05-27 2010-12-09 Αναστολεις φωσφολιπασης α2 του κυτταροδιαλυματος

Country Status (33)

Country Link
US (3) US7557135B2 (el)
EP (2) EP2248801A1 (el)
JP (1) JP5116666B2 (el)
KR (1) KR101353982B1 (el)
CN (2) CN101184729B (el)
AR (1) AR054195A1 (el)
AT (1) ATE489364T1 (el)
AU (1) AU2006251946B2 (el)
BR (1) BRPI0610049A2 (el)
CA (1) CA2607857C (el)
CR (1) CR9520A (el)
CY (1) CY1111151T1 (el)
DE (1) DE602006018451D1 (el)
DK (1) DK1891006T3 (el)
ES (1) ES2354908T3 (el)
GT (1) GT200600228A (el)
HK (2) HK1113680A1 (el)
HN (1) HN2006019513A (el)
IL (1) IL186912A (el)
MX (1) MX2007014589A (el)
MY (1) MY144672A (el)
NI (1) NI200700287A (el)
NO (1) NO20075627L (el)
NZ (1) NZ563736A (el)
PE (1) PE20061426A1 (el)
PL (1) PL1891006T3 (el)
PT (1) PT1891006E (el)
RU (1) RU2433997C2 (el)
SI (1) SI1891006T1 (el)
SV (1) SV2008002551A (el)
TW (1) TW200718687A (el)
UA (1) UA91053C2 (el)
WO (1) WO2006128142A2 (el)

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Also Published As

Publication number Publication date
HN2006019513A (es) 2011-03-02
CN102040550B (zh) 2012-10-03
ES2354908T3 (es) 2011-03-21
CN101184729B (zh) 2011-02-16
WO2006128142A8 (en) 2007-12-27
US8283373B2 (en) 2012-10-09
US20070004719A1 (en) 2007-01-04
PL1891006T3 (pl) 2011-05-31
TW200718687A (en) 2007-05-16
JP2008542303A (ja) 2008-11-27
SI1891006T1 (sl) 2011-02-28
DE602006018451D1 (de) 2011-01-05
US20100029645A1 (en) 2010-02-04
RU2433997C2 (ru) 2011-11-20
MY144672A (en) 2011-10-31
EP1891006A2 (en) 2008-02-27
HK1152710A1 (en) 2012-03-09
ATE489364T1 (de) 2010-12-15
IL186912A (en) 2012-05-31
GT200600228A (es) 2006-12-26
AU2006251946A1 (en) 2006-11-30
US20100022536A1 (en) 2010-01-28
BRPI0610049A2 (pt) 2010-05-25
CA2607857A1 (en) 2006-11-30
RU2007140910A (ru) 2009-07-10
CR9520A (es) 2008-02-20
AR054195A1 (es) 2007-06-06
HK1113680A1 (en) 2008-10-10
WO2006128142A3 (en) 2007-03-29
CN102040550A (zh) 2011-05-04
EP2248801A1 (en) 2010-11-10
PE20061426A1 (es) 2007-01-24
UA91053C2 (en) 2010-06-25
CA2607857C (en) 2014-02-11
NO20075627L (no) 2008-01-03
AU2006251946B2 (en) 2011-05-12
JP5116666B2 (ja) 2013-01-09
EP1891006B1 (en) 2010-11-24
NZ563736A (en) 2010-11-26
PT1891006E (pt) 2011-01-26
MX2007014589A (es) 2008-01-21
KR20080021618A (ko) 2008-03-07
US7557135B2 (en) 2009-07-07
CN101184729A (zh) 2008-05-21
NI200700287A (es) 2008-05-27
WO2006128142A2 (en) 2006-11-30
DK1891006T3 (da) 2011-01-24
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KR101353982B1 (ko) 2014-02-18
IL186912A0 (en) 2008-02-09

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