CR9520A - Inhibidores de la fosfolipasa a2 citosolica - Google Patents

Inhibidores de la fosfolipasa a2 citosolica

Info

Publication number
CR9520A
CR9520A CR9520A CR9520A CR9520A CR 9520 A CR9520 A CR 9520A CR 9520 A CR9520 A CR 9520A CR 9520 A CR9520 A CR 9520A CR 9520 A CR9520 A CR 9520A
Authority
CR
Costa Rica
Prior art keywords
phospholipase
inhibitors
citosolica
enzymes
cytosolic
Prior art date
Application number
CR9520A
Other languages
English (en)
Inventor
C Mckew John
L Lee Katherine
Chen Lilhren
Vargas Richard
D Clark James
Williams Cara
Clerin Valerie
Marusic Suzana
Pong Kevin
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CR9520A publication Critical patent/CR9520A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion provee inhibidores quimicos de la actividad de diversas enzimas fosfolipasa, particularmente de las enzimas fosfolipasa A2 citosolica (cpla2), mas particularmente incluyendo inhibidores de las enzimas fosfolipasa A2 alfa citosolica (cpla2a)
CR9520A 2005-05-27 2007-11-14 Inhibidores de la fosfolipasa a2 citosolica CR9520A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68556405P 2005-05-27 2005-05-27

Publications (1)

Publication Number Publication Date
CR9520A true CR9520A (es) 2008-02-20

Family

ID=37188759

Family Applications (1)

Application Number Title Priority Date Filing Date
CR9520A CR9520A (es) 2005-05-27 2007-11-14 Inhibidores de la fosfolipasa a2 citosolica

Country Status (33)

Country Link
US (3) US7557135B2 (es)
EP (2) EP1891006B1 (es)
JP (1) JP5116666B2 (es)
KR (1) KR101353982B1 (es)
CN (2) CN101184729B (es)
AR (1) AR054195A1 (es)
AT (1) ATE489364T1 (es)
AU (1) AU2006251946B2 (es)
BR (1) BRPI0610049A2 (es)
CA (1) CA2607857C (es)
CR (1) CR9520A (es)
CY (1) CY1111151T1 (es)
DE (1) DE602006018451D1 (es)
DK (1) DK1891006T3 (es)
ES (1) ES2354908T3 (es)
GT (1) GT200600228A (es)
HK (2) HK1113680A1 (es)
HN (1) HN2006019513A (es)
IL (1) IL186912A (es)
MX (1) MX2007014589A (es)
MY (1) MY144672A (es)
NI (1) NI200700287A (es)
NO (1) NO20075627L (es)
NZ (1) NZ563736A (es)
PE (1) PE20061426A1 (es)
PL (1) PL1891006T3 (es)
PT (1) PT1891006E (es)
RU (1) RU2433997C2 (es)
SI (1) SI1891006T1 (es)
SV (1) SV2008002551A (es)
TW (1) TW200718687A (es)
UA (1) UA91053C2 (es)
WO (1) WO2006128142A2 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7605156B2 (en) * 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US7713964B2 (en) 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
HN2004000536A (es) 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
IL161579A0 (en) 2004-04-22 2004-09-27 Mor Research Applic Ltd ANTISENSE OLIGONUCLEOTIDES AGAINST cPLA2, COMPOSITIONS AND USES THEREOF
US8029815B2 (en) 2004-04-28 2011-10-04 Elford Howard L Methods for treating or preventing restenosis and other vascular proliferative disorders
TW200718687A (en) * 2005-05-27 2007-05-16 Wyeth Corp Inhibitors of cytosolic phospholipase A2
WO2007140317A2 (en) * 2006-05-26 2007-12-06 Wyeth Use of inhibitors of cytosolic ph0sph0lipase a2 in the treatment of thrombosis
IL178401A (en) 2006-09-28 2012-04-30 Univ Ben Gurion Use of antisense oligonucleotides against 2 cPLA in the treatment of cancer
JP2010508304A (ja) * 2006-10-31 2010-03-18 ワイス エルエルシー ホスホリパーゼ酵素阻害剤の半固体製剤
US20100113443A1 (en) * 2006-10-31 2010-05-06 Wyeth Liquid formulations of phospholipase enzyme inhibitors
AU2008233553A1 (en) 2007-03-29 2008-10-09 Daiichi Sankyo Company, Limited Indole derivative having cPLA2 inhibitory activity, use of the same and method for producing the same
EP2030615A3 (en) * 2007-08-13 2009-12-02 ELFORD, Howard L. Ribonucleotide reductase inhibitors for use in the treatment or prevention of neuroinflammatory or autoimmune diseases
US9011821B2 (en) 2010-06-18 2015-04-21 Whitehead Institute For Biomedical Research PLA2G16 as a target for antiviral compounds
WO2012031763A1 (en) 2010-09-08 2012-03-15 Twincore Zentrum Fuer Experimentelle Und Klinische Infektionsforschung Gmbh Use of inhibitors of phospholipase a2 for the treatment or prevention of flavivirus infection
GB201401904D0 (en) 2014-02-04 2014-03-19 Ziarco Pharma Ltd Pharmaceutical composition for topical administration
WO2015129592A1 (ja) * 2014-02-28 2015-09-03 住友化学株式会社 2-(ハロゲノメチル)-3-メチルニトロベンゼンの製造方法
CN103804150A (zh) * 2014-03-01 2014-05-21 江苏斯威森生物医药工程研究中心有限公司 一种3,4-二甲氧基苄基溴的制备方法
CN108017522B (zh) * 2017-11-16 2021-01-05 贵州大学 一种2,6-二溴苯甲磺酰氯的制备工艺
PL424613A1 (pl) 2018-02-16 2019-08-26 Paweł Wawrzyński Rower dwukołowy o zmiennej konfiguracji
US20220220482A1 (en) * 2019-05-20 2022-07-14 Saint Louis University Reprogramming of lipid metabolism to inhibit t cell senescence and enhance tumor immunotherapy
AU2021245924B2 (en) * 2020-04-02 2024-02-29 Gilead Sciences, Inc. Process for preparing a Cot inhibitor compound
WO2022031931A2 (en) * 2020-08-06 2022-02-10 The Children's Medical Center Corporation Compositions for altering a microglial cell, and methods of use therefore

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH48411A (fr) 1909-07-19 1910-10-17 Stephen Alley Outillage pour mettre en place et enlever les bandages élastiques des roues de véhicules
GB1148908A (en) 1965-04-19 1969-04-16 Sumitomo Chemical Co Indole derivatives and processes for making them
FR1492929A (fr) 1966-05-11 1967-08-25 Roussel Uclaf Nouveaux 1-(omega-carboxyalcoyl) indoles substitués et procédé de préparation
US3505354A (en) 1967-05-18 1970-04-07 Geigy Chem Corp 2-methyl-3-p-halobenzoylindole-n-aliphatic acids
DE1816335A1 (de) 1968-12-21 1970-07-09 Thiemann Gmbh Chem Pharm Fabri Verfahren zur Herstellung von [2-Methyl-5-alkoxy-3-acyl-indol-1]-essigsaeuren und deren Estern
US3931229A (en) 1973-08-23 1976-01-06 Warner-Lambert Company 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4271263A (en) 1980-05-15 1981-06-02 Minnesota Mining And Manufacturing Company Thermally developable photosensitive compositions containing acutance agents
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4654360A (en) 1984-06-01 1987-03-31 Syntex (U.S.A.) Inc. 1,2,3-trisubstituted indoles for treatment of inflammation
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4894386A (en) 1987-04-15 1990-01-16 Ici Americas Inc. Aliphatic carboxamides
DE68904342T2 (de) 1988-04-13 1993-05-06 Ici America Inc Cyclische amide.
GB8906032D0 (en) 1988-04-14 1989-04-26 Ici America Inc Hetera-aliphatic carboxamides
US5166170A (en) 1989-07-03 1992-11-24 Hoechst-Roussel Pharmaceuticals Incorporated 2-(aminoaryl) indoles and indolines as topical antiinflammatory agents for the treatment of skin disorders
GB8916774D0 (en) 1989-07-21 1989-09-06 Bayer Ag New indole derivatives,a process for their preparation and their use in medicaments
US5229516A (en) 1989-10-27 1993-07-20 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
PT95692A (pt) 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5420289A (en) 1989-10-27 1995-05-30 American Home Products Corporation Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase
US5081145A (en) 1990-02-01 1992-01-14 Merck Frosst Canada, Inc. Indole-2-alkanoic acids compositions of and anti allergic use thereof
US5622832A (en) 1990-02-28 1997-04-22 Genetics Institute, Inc. Arachidonic acid releasing phospholipase A2 enzyme and methods of use
US5290798A (en) 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5206377A (en) 1991-12-05 1993-04-27 Whitby Research, Inc. Compounds useful as antiproliferative agents
US5212195A (en) 1992-05-13 1993-05-18 Syntex (U.S.A.) Inc. Substituted indole antagonists derivatives which are angiotensin II
DE69314786T2 (de) 1992-05-13 1998-02-19 Syntex Inc Substituierte indole als angiotensin ii antagonisten
US5288743A (en) 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
IL109311A0 (en) 1993-04-16 1994-07-31 Lilly Co Eli 1H-indole-3-acetamide sPla2 inhibitors
IL109309A (en) 1993-04-16 2000-06-29 Lilly Co Eli 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them
US5424329A (en) 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
DE4338770A1 (de) 1993-11-12 1995-05-18 Matthias Dr Lehr Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶
US5686481A (en) 1993-12-21 1997-11-11 Smithkline Beecham Corporation Endothelin receptor antagonists
US5641800A (en) 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
US5482960A (en) 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
WO1998005637A1 (de) 1996-08-01 1998-02-12 Merckle Gmbh Acylpyrroldicarbonsäuren und acylindoldicarbonsäuren sowie ihre derivate als hemmstoffe der cytosolischen phospholipase a¿2?
AU717430B2 (en) 1996-08-26 2000-03-23 Genetics Institute, Llc Inhibitors of phospholipase enzymes
US6630496B1 (en) 1996-08-26 2003-10-07 Genetics Institute Llc Inhibitors of phospholipase enzymes
US5994398A (en) 1996-12-11 1999-11-30 Elan Pharmaceuticals, Inc. Arylsulfonamides as phospholipase A2 inhibitors
ID26123A (id) 1998-02-25 2000-11-23 Genetics Inst Penghambat-penghambat phospholipase a2
CA2322161A1 (en) * 1998-02-25 1999-09-02 Yibin Xiang Inhibitors of phospholipase enzymes
SK12752000A3 (sk) * 1998-02-25 2001-03-12 Genetics Institute, Inc. Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
CN1178915C (zh) 1999-01-27 2004-12-08 惠氏控股有限公司 含有炔基的异羟肟酸衍生物、其制备及其作为基质金属蛋白酶抑制剂/TNF-α转变酶抑制剂的用途
US6424105B1 (en) 1999-06-08 2002-07-23 Camco International, Inc. Real-time control of feedback signals to a motor for optimum performance
WO2002057323A1 (fr) 2001-01-22 2002-07-25 Sony Corporation Resine absorbant les solvants et procede de preparation de celle-ci
US7605156B2 (en) 2001-12-03 2009-10-20 Wyeth Methods for the use of inhibitors of cytosolic phospholipase A2
US6635771B2 (en) 2001-12-03 2003-10-21 Wyeth N-benzhydryl indole compounds
US7101875B2 (en) 2001-12-03 2006-09-05 Wyeth Methods for treating arthritic disorders
US6984735B2 (en) 2001-12-03 2006-01-10 Wyeth Process for making an aldehyde
US6797708B2 (en) * 2001-12-03 2004-09-28 Wyeth Inhibitors of cytosolic phospholipase A2
US7713964B2 (en) * 2001-12-03 2010-05-11 Wyeth Llc Methods for treating asthmatic conditions
DK1892239T3 (da) * 2001-12-03 2013-03-25 Wyeth Llc Inhibitorer af cytosol-phospholipase A2
WO2004060878A2 (en) 2002-12-31 2004-07-22 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatases
US7439249B2 (en) 2002-12-31 2008-10-21 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatases
TW200510305A (en) 2003-07-25 2005-03-16 Wyeth Corp Process for the preparation of CPLA2 inhibitors
US7582771B2 (en) 2003-09-03 2009-09-01 Wyeth Process for the synthesis of cPLA2 inhibitors
US20050053600A1 (en) 2003-09-09 2005-03-10 Lane Thomas E. Methods for treating rheumatoid arthritis
US7342119B2 (en) 2003-09-30 2008-03-11 Wyeth Holdings Corporation Process for the synthesis of a CPLA2 inhibitor
HN2004000536A (es) 2003-12-16 2009-02-18 Wyeth Corp Un procediemiento de sintesis para la alquilacion reductiva de la posicon c-3 de indoles
AR053410A1 (es) 2004-08-19 2007-05-09 Wyeth Corp Proceso para la sintesis de indoles n-alquilados c-2, c-3 sustituidos. compuestos intermediarios
TW200718687A (en) 2005-05-27 2007-05-16 Wyeth Corp Inhibitors of cytosolic phospholipase A2
WO2007140317A2 (en) * 2006-05-26 2007-12-06 Wyeth Use of inhibitors of cytosolic ph0sph0lipase a2 in the treatment of thrombosis

Also Published As

Publication number Publication date
EP2248801A1 (en) 2010-11-10
DK1891006T3 (da) 2011-01-24
AR054195A1 (es) 2007-06-06
CA2607857A1 (en) 2006-11-30
MX2007014589A (es) 2008-01-21
DE602006018451D1 (de) 2011-01-05
NO20075627L (no) 2008-01-03
HK1152710A1 (en) 2012-03-09
ATE489364T1 (de) 2010-12-15
BRPI0610049A2 (pt) 2010-05-25
EP1891006A2 (en) 2008-02-27
PL1891006T3 (pl) 2011-05-31
EP1891006B1 (en) 2010-11-24
UA91053C2 (en) 2010-06-25
US8283373B2 (en) 2012-10-09
NZ563736A (en) 2010-11-26
SV2008002551A (es) 2008-07-23
RU2007140910A (ru) 2009-07-10
IL186912A0 (en) 2008-02-09
WO2006128142A8 (en) 2007-12-27
WO2006128142A3 (en) 2007-03-29
PE20061426A1 (es) 2007-01-24
KR20080021618A (ko) 2008-03-07
CN102040550A (zh) 2011-05-04
SI1891006T1 (sl) 2011-02-28
JP5116666B2 (ja) 2013-01-09
AU2006251946B2 (en) 2011-05-12
CN102040550B (zh) 2012-10-03
US20100022536A1 (en) 2010-01-28
GT200600228A (es) 2006-12-26
CA2607857C (en) 2014-02-11
US7557135B2 (en) 2009-07-07
CN101184729B (zh) 2011-02-16
US20070004719A1 (en) 2007-01-04
IL186912A (en) 2012-05-31
RU2433997C2 (ru) 2011-11-20
TW200718687A (en) 2007-05-16
KR101353982B1 (ko) 2014-02-18
CN101184729A (zh) 2008-05-21
WO2006128142A2 (en) 2006-11-30
US20100029645A1 (en) 2010-02-04
CY1111151T1 (el) 2015-06-11
HN2006019513A (es) 2011-03-02
HK1113680A1 (en) 2008-10-10
NI200700287A (es) 2008-05-27
ES2354908T3 (es) 2011-03-21
MY144672A (en) 2011-10-31
PT1891006E (pt) 2011-01-26
JP2008542303A (ja) 2008-11-27
AU2006251946A1 (en) 2006-11-30

Similar Documents

Publication Publication Date Title
CR9520A (es) Inhibidores de la fosfolipasa a2 citosolica
PA8667201A1 (es) Nuevos compuestos farmaceuticos
HN2003000227A (es) Inhibidores de quinasas
SV2006002001A (es) Inhibidores de quinasa ref. x - 16437
CY1109911T1 (el) Πυρρολοβενζοδιαζεπινες
NO20071309L (no) Fremgangsmate for ekspansjon
CR8312A (es) Nuevas sulfonamidas como agentes fitosanitarios
DK1848718T3 (da) E1 aktiveringsenzymhæmmere
CR9223A (es) 18-metil-19-nor-17-pregn-4-en-21, 17-carbolactonas,asi como preparaciones farmaceuticas que las contienen
MY144590A (en) Glutamate aggrecanase inhibitors
BRPI0612409B8 (pt) composições de tensoativos à base de ácido peroxicarboxílico e método de reduzir a população de microorganismos em um objeto
ATE400567T1 (de) Kinaseinhibitoren
NO20076413L (no) Multisykliske forbindelser og fremgangsmater for deres anvendelse
EA200702529A1 (ru) Фунгицидная комбинация биологически активных веществ
PA8618901A1 (es) Biaril sulfonamidas y metodo para el uso de las mismas
DE602005018653D1 (de) Aktive auswahl der bestätigungsquelle
EA201000566A1 (ru) Гетероциклические сетр ингибиторы
DK2179035T3 (da) Modificeret bakteriofag omfattende et alfa/beta-sasp-(small acid-soluble spore protein)-gen
CR8813A (es) Nueva asociacion de un inhibidor de la corriente sinusual l1 y de un inhibidor calcico y las composiciones farmaceuticas que la contienen
DK1912954T3 (da) Hidtil ukendte cysteinproteaseinhibitorer og deres terapeutiske applikationer
UY29555A1 (es) Nuevos compuestos quimicos
ATE462574T1 (de) Abbildungskopfhalterung
PA8795401A1 (es) Asociacion entre un antiaterotrombotico y un inhibidor de la enzima de conversion de la angiotensina
SE0400475D0 (sv) Collecton of a specimen
ITPD20050169A1 (it) Markers biologici periferici per la diagnosi-prognosi della sclerosi multipla.

Legal Events

Date Code Title Description
FA Abandonment or withdrawal (granting procedure)